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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang shuo Zhang Mengjie Li Chunyan Zuo Chengyuan mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Microwave sintering of Ca_(0.6)La_(0.2667)TiO_3 microwave dielectric ceramics

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 245-251页

作者： Jia-mao Li Tai qiu College of Materials Science and Engineering Nanjing University of Technology Nanjing 210009 China School of Materials Science and Engineering Anhui University of Technology Ma＇anshan 243002 China

Ca0.6La0.2667TiO3 ceramics were prepared by conventional and microwave sintering techniques and their sinterability, microstructure, and microwave dielectric properties were investigated in detail for comparison. Densified Ca0.6La0.E667TiO3 ceramics were obtained by microwave sintering at 1350℃ for 30 min and by conventional sintering at 1450℃ for 4 h. An unusual phenomenon was found that some larger grains （grain size range： 8-10 pan） inclined to assemble in one area but some smaller ones （grain size range： 2-4 μm） inclined to gather in another area in the microwave sintered ceramics. The microwave dielectric properties of Ca0.6La0.2667TiO3 ceramics prepared by micro- wave sintering at 1350℃ were as follows＂ dielectric constant （er） = 119.6, quality factor （Qf） = 17858.5 GHz, and temperature coefficient of resonant fi＇equency （rf）= 155.5 ppm/℃. In contrast, the microwave dielectric properties of the ceramics prepared by conventional sintering at 1450℃ were er = 117.4, Qf= 13375 GHz, and rf= 217.2 ppm/℃.

关键词： pcrovskite microwave sintering microstructure dielectric properties

Peptides encoded by noncoding genes: challenges and perspectives

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Signal Transduction and Targeted Therapy 2019年第1期4卷 127-138页

作者： shuo Wang Chuanbin mao Shanrong Liu Changhai Hospital Shanghai200433China Department of Chemistry and Biochemistry Stephenson Life Sciences Research CenterInstitute for Biomedical EngineeringScience and TechnologyUniversity of Oklahoma101 Stephenson ParkwayNormanOK73019-5300USA

In recent years,noncoding gene(NCG)translation events have been frequently *** resultant peptides,as novel findings in the life sciences,perform unexpected functions of increasingly recognized importance in many fundamental biological and pathological *** emergence of these novel peptides,in turn,has advanced the field of genomics while indispensably aiding living *** peptides from NCGs serve as important links between extracellular stimuli and intracellular adjustment *** peptides are also important entry points for further exploration of the mysteries of life that may trigger a new round of revolutionary biotechnological *** into NCG-derived peptides will assist in understanding the secrets of life and the causes of diseases,and will also open up new paths to the treatment of diseases such as ***,a critical review is presented on the action modes and biological functions of the peptides encoded by *** challenges and future trends in searching for and studying NCG peptides are also critically discussed.

关键词： has searching finding

Mixed Conduction in BaCe0.8Pr0.2O3-α Ceramic

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Chinese Journal of Chemical Physics 2008年第3期21卷 286-290页

作者： mao-yuan Wang Li-gan qiu School of Chemistry and Chemical Engineering Yancheng Teachers College Yancheng 224051 China

BaCe0.8Pr0.2O3-α ceramic was synthesized by high temperature solid-state reaction. The structural characteristics and the phase purity of the crystal were determined using powder X-ray diffraction analysis. By using the methods of AC impedance spectroscopy, gas concentration cell and electrochemical pumping of hydrogen, the conductivity and ionic transport number of BaCe0.8Pr0.2O3-α were measured, and the electrical conduction behavior of the material was investigated in different gases in the temperature range of 500-900℃. The results indicate that the material was of a single perovskite-type orthorhombic phase. From 500℃ to 900 ℃, electronic-hole conduction was dominant in dry and wet oxygen, air or nitrogen, and the total conductivity of the material increased slightly with increasing oxygen partial pressure in the oxygen partial pressure range studied. Ionic conduction was dominant in wet hydrogen, and the total conductivity was about one or two orders of magnitude higher than that in hydrogen-free atmosphere （oxygen, air or nitrogen）

关键词： BaCe0.8Pr0.2O3-α AC impedance Gas concentration cell Electrochemical pumping of hy-drogen Mixed conduction

Hidden policy ciphertext-policy attribute-based encryption with keyword search against keyword guessing attack

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Science China(Information Sciences) 2017年第5期60卷 130-141页

作者： shuo qiu Jiqiang LIU Yanfeng SHI Rui ZHANG School of Computer and Information Technology Beijing Jiaotong University State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of Sciences

Attribute-based encryption with keyword search(ABKS) enables data owners to grant their search capabilities to other users by enforcing an access control policy over the outsourced encrypted data. However,existing ABKS schemes cannot guarantee the privacy of the access structures, which may contain some sensitive private information. Furthermore, resulting from the exposure of the access structures, ABKS schemes are susceptible to an off-line keyword guessing attack if the keyword space has a polynomial size. To solve these problems, we propose a novel primitive named hidden policy ciphertext-policy attribute-based encryption with keyword search(HP-CPABKS). With our primitive, the data user is unable to search on encrypted data and learn any information about the access structure if his/her attribute credentials cannot satisfy the access control policy specified by the data owner. We present a rigorous selective security analysis of the proposed HP-CPABKS scheme, which simultaneously keeps the indistinguishability of the keywords and the access structures. Finally,the performance evaluation verifies that our proposed scheme is efficient and practical.

关键词： earch access structure privacy hidden policy keyword guessing attack

On the stochastic dynamics of molecular conformation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1401-1407页

作者： DENG mao-lin ZHU Wei-qiu Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two strands with side chains facing each other, and its stochastic dynamics including the statistics of stationary motion and the statistics of conformational transition is studied by using the stochastic averaging method for quasi Hamikonian systems. The theoretical results are confirmed with the results from Monte Carlo simulation.

关键词： Biological macromolecule Thermal fluctuation Stationary statistics Transition time Stochastic averaging method

Numerical simulation of the effects of global warming on vegetation in Asia

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Advances in Climate Change Research 2022年第5期13卷 688-699页

作者： Zheng-qiu ZHANG Pan-mao ZHAI Chinese Academy of Meteorological Sciences Beijing 100081China

The response of vegetation to global warming is closely related to human living environment,and uncertainty in understanding the response *** study aims to investigate the effects of CO_(2),temperature and precipitation changes under global warming on natural vegetation in *** biophysical/dynamic vegetation model SSiB4/TRIFFID was employed to perform numerical experiments under different climate scenarios for Asia using the Princeton global forcing dataset(1948–2006).The results showed that precipitation and CO_(2) were the key factors for vegetation *** effect of temperature on natural vegetation varied among the study ***,an increase in temperature was conducive to vegetation growth in eastern Asia,but not in the arid and semi-arid areas of western *** arid and semi-arid areas or in the vicinity of desert,the forcing effects of temperature,precipitation and CO_(2) were more remarkable,which led to a noticeable change in the area of bare *** terms of the distribution of vegetation species,the above forcing had a greater impact on shrubs,C3 grasses and C4 plants,but less of an impact on broadleaf and coniferous *** was also found that,although there was a notable positive correlation between precipitation and vegetation leaf area index in northern high latitudes,the vegetation cover did not increase with precipitation,which was countered by the negative effect of surface cooling in summer.

关键词： Global warming Temperature Precipitation CO_(2) SSiB4/TRIFFID Model simulation Vegetation dynamics

A Novel Synergy Selection Mechanism among Multi- Devices for Ubiquitous Services

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China Communications 2014年第A01期11卷 128-134页

作者： RUI Lanlan mao Xiyue qiu Xuesong StateKeyLaboratoryofNetworkingandSwitchingTechnology BeijingUniversityofPostsandTelecommunicationsBeijingChina

It is a challenge to select an optimal set of devices to accomplish a graph-based ubiquitous service and execute it continuously under the circumstances of dynamic environments and limited device capability. We elaborate a Synergy- aware Selection Mechanism （SSM） considering synergetic among devices. In the SSM, we design a distributed algorithm to integrate the devices and a dynamic updating weight method. The simulation results show that SSM can make devices composed together to ensure the continuity and smoothness of service

关键词： ubiquitous service synergy-aware quality of service sustainability

Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

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Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen mao-mao Zhang Wen-Jing Xiao Liang-qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines