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一种多级轴流压气机不同工况叶尖间隙预估模型

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航空动力学报 2014年第11期29卷 2579-2586页

作者：杨栋李绍斌李秋实北京航空航天大学能源与动力工程学院航空发动机气动热力国家级重点实验室北京100191 先进航空发动机协同创新中心北京100191

考虑热负荷以及机械负荷的影响,建立了一种多级轴流压气机不同工况叶尖间隙的预估模型.模型针对多级轴流压气机考虑了温度在径向和轴向的分布,保证了模型的准确性.通过与通用电气公司E3发动机试验结果的对比,计算模型预估叶尖间隙在第3,... 详细信息

考虑热负荷以及机械负荷的影响,建立了一种多级轴流压气机不同工况叶尖间隙的预估模型.模型针对多级轴流压气机考虑了温度在径向和轴向的分布,保证了模型的准确性.通过与通用电气公司E3发动机试验结果的对比,计算模型预估叶尖间隙在第3,5,10级的相对误差分别为0.8%,5.6%,3.7%,显示该方法能很好地揭示叶尖间隙在不同工况下的变化规律.模型在叶尖间隙随轮盘内腔冷气流量的变化趋势上预估与试验是一致的,在第3,10级叶尖间隙预估值的相对误差分别为9.7%,6.7%.试验中使用主动控制技术,得到其所能达到的最大叶尖间隙关小量在第10级转子处为0.203 2mm,而模型预估所得调节流量所能达到的最大叶尖间隙关小量在第10级转子处为0.14mm,显示模型较好地反映了主动叶尖间隙控制技术的效果.

关键词：多级轴流压气机叶尖间隙不同工况温度分布预估模型

Terahertz Spectroscopy for Accurate Identification of Panax quinquefolium Basing on Nonconjugated 24(R)-Pseudoginsenoside F_(11)

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Plant Phenomics 2021年第1期3卷 57-64页

作者： Tianyi Kou Ji Ye Jing Wang Yan Peng Zefang Wang Chenjun shi xu Wu Xitian Hu Haihong Chen Ling Zhang Xiaohong Chen Yiming Zhu Huiliang Li Songlin Zhuang Terahertz Technology Innovation Research Institute Shanghai Key Lab of Modern Optical SystemTerahertz Science Cooperative Innovation CenterUniversity of Shanghai for Science and TechnologyShanghai Institute of Intelligent Science and TechnologyShanghaiChina Department of Pharmacy Second Military Medical UniversityShanghaiChina School of Pharmacy Nanjing Medical UniversityNanjingChina Shanghai Institute of Intelligent Science and Technology Tongji University ShanghaiChina

Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to ***,a useful biomarker for distinguishing this species from other related ***,because of its nonconjugated property and the complexity of existing detection methods,this biomarker cannot be used as the identification *** herein present a stable 24(R)-pseudoginsenoside F_(11)fingerprint spectrum in the terahertz band,thereby proving that F_(11)can be detected and quantitatively analyzed via terahertz *** also analyzed the sample by high-performance liquid chromatography-triple quadrupole mass *** difference between the normalized data for the two analytical methods was less than 5%.Furthermore,*** from different areas and other substances can be clearly distinguished based on these terahertz spectra with a standard principal component *** method is a fast,simple,and cost-effective approach for identifying and quantitatively analyzing ***.

关键词： ginsenoside conjugated thereby

SpinalP2X7R contributes to streptozotocin-induced mechanical allodynia in mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第2期21卷 155-165页

作者： Cheng-ming NI He-ping SUN Xiang xu Bing-yu LING Hui JIN Yu-qiu ZHANG Zhi-qi ZHAO Hong CAO Lan xu Department of Endocrinology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023China Department of Translational Neuroscience Jing’an District Centre Hospital of ShanghaiInstitutes of Brain ScienceState Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai 200032China Department of Endocrinology the Affiliated Kunshan First People’s Hospital of Jiangsu UniversityKunshan 215300China Department of Emergency Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China

Painful diabetic neuropathy(PDN)is a diabetes mellitus ***,the mechanisms underlying PDN are still poorly *** triphosphate(ATP)-gated P2X7 receptor(P2X7R)plays a pivotal role in non-diabetic neuropathic pain,but little is known about its effects on streptozotocin(STZ)-induced peripheral ***,we explored whether spinal cord P2X7R was correlated with the generation of mechanical allodynia(MA)in STZ-induced type 1 diabetic neuropathy in *** was assessed by measuring paw withdrawal thresholds and western *** was applied to analyze the protein expression levels and localization of ***-induced mice expressed increased P2X7R in the dorsal horn of the lumbar spinal cord during *** injected intrathecally with a selective antagonist of P2X7R and P2X7R knockout(KO)mice both presented attenuated progression of ***-immunofluorescent labeling demonstrated that P2X7R-positive cells were mostly co-expressed with Iba1(a microglia marker).Our results suggest that P2X7R plays an important role in the development of MA and could be used as a cellular target for treating PDN.

关键词： P2X7 receptor(P2X7R) Mechanical allodynia Streptozotocin Diabetic mice

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微机械陀螺检测接口建模及前置放大器优化

光学精密工程 2013年第7期21卷 1734-1740页

作者：赵阳裘安萍施芹赵健南京理工大学MEMS惯性技术研究中心江苏南京210094

为了进一步提高微机械陀螺的极限分辨率,建立了基于SOI工艺的微机械陀螺的检测接口模型,并设计了与之相匹配的前置接口放大器。首先,根据陀螺表头的实际结构建立了微机械陀螺表头的RC集总参数模型和微机械陀螺检测接口的噪声模型,分析... 详细信息

为了进一步提高微机械陀螺的极限分辨率,建立了基于SOI工艺的微机械陀螺的检测接口模型,并设计了与之相匹配的前置接口放大器。首先,根据陀螺表头的实际结构建立了微机械陀螺表头的RC集总参数模型和微机械陀螺检测接口的噪声模型,分析了检测接口主导噪声源及提高极限分辨率的措施。然后,在跨阻式前置放大器的基础上设计了改进的与检测接口匹配的T型前置放大器。实验结果表明:相比于跨阻式前置放大器,采用改进的T型前置放大器的等效噪声输入电流由1.18pA/√Hz降低至0.27pA/√Hz,对应的电容极限分辨率可达到0.62aF/√Hz。结果显示,采用与检测接口匹配的T型前置放大器提高了微机械陀螺的极限分辨率。

关键词：微机械陀螺接口模型极限分辨率 T型前置放大器

Prevalence and Years of Life Lost due to Disability from Dental Caries among Children and Adolescents in Western China,1990-2015

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Biomedical and Environmental Sciences 2017年第10期30卷 701-707页

作者： WANG Zhuo DENG Ying LIU shi Wei HE Jun JI Kui ZENG Xin Ying YANG Shu Juan xu Xin Yin LUO Yu ZHOU Mai Geng ZHANG Jian Xin West China School of Public Health Sichuan University Sichuan Provincial Center for Disease Control and Prevention Center for Chronic and Noncommunicable Disease Control and Prevention National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Department of Obstetrics and Gynecology West China Second University HospitalSichuan University

Objective To analyze the prevalence and years lived with disability （YLD） from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. Methods Based on the Global Burden of Disease Study 2015 （GBD2015）, which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China. We then used the Bayesian meta-regression method to estimate the sex- and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period. Results In 2015, there were almost 6 million cases of dental caries in children and adolescents （aged 〈 15 years） in Sichuan province, accounting for 6% of the total cases in China. For children under 5 years, the prevalence of deciduous caries was 55.9%, and the YLDs value was 10.8 per 100,000, while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds; for those aged 5 to 14 years, the prevalence of permanent caries was 21.5%, and the YLDs value was 11.5 per 100,000. From 1990 to 2015, the prevalence of dental caries for children under 5 years increased substantially, by 16.2%, and the YLDs increased by 8.7%. Among those aged 5 to 14 years, the prevalence increased and the YLDs decreased. Conclusion Dental caries remains a huge health burden in Western China. In contrast to the global and national data, the trend has increased rapidly over the past 25 years in this region. This work provides suggestions for the prevention and control for oral health in China with the policy of two-child.

关键词： Children and adolescents Dental caries YLD Disease burden

Facile metagrating holograms with broadband and extreme angle tolerance

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Light(Science & Applications) 2018年第1期7卷 305-312页

作者： Zi-Lan Deng Junhong Deng Xin Zhuang Shuai Wang Tan shi Guo Ping Wang Yao Wang Jian xu Yaoyu Cao Xiaolei Wang Xing Cheng Guixin Li Xiangping Li Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan University510632 GuangzhouChina Department of Materials Science and Engineering Southern University of Science and Technology518055 ShenzhenChina Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology518055 ShenzhenChina College of Electronic Science and Technology Shenzhen University518060 ShenzhenChina Materials Characterization and Preparation Center Southern University of Science and Technology518055 ShenzhenChina Institute of Modern Optics Key Laboratory of Optical Information Science and TechnologyNankai University300350 TianjinChina

The emerging meta-holograms rely on arrays of intractable meta-atoms with various geometries and sizes for customized phase profiles that can precisely modulate the phase of a wavefront at an optimal incident angle for given *** stringent and band-limited angle tolerance remains a fundamental obstacle for their practical application,in addition to high fabrication precision *** a different design principle,we determined that facile metagrating holograms based on extraordinary optical diffraction can allow the molding of arbitrary wavefronts with extreme angle tolerances(near-grazing incidence)in the visible–near-infrared *** modulating the displacements between uniformly sized meta-atoms rather than the geometrical parameters,the metagratings produce a robust detour phase profile that is irrespective of the wavelength or incident *** demonstration of high-fidelity meta-holograms and in-site polarization multiplexing significantly simplifies the metasurface design and lowers the fabrication demand,thereby opening new routes for flat optics with high performances and improved practicality.

关键词： angle extreme uniformly

Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 277-284页

作者： Hong-Lian Gui Chang-Qing Zhao Yan Wang Hong-Tu Gu Wei-Jing Wang Wei Cai Qing Guo shi-San Bao Lie-Ming xu Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Liver Cirrhosis Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Infectious Diseases Ruijin North HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Discipline of Pathology School of Medicine Sciences and Bosch InstituteCharles Perkin CentreUniversity of SydneyNew South WalesAustralia

Publications>Journals>Journal of Clinical and Translational Hepatology>Article Full Text ORIGINAL ARTICLE OPEN ACCESS Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis Hong-Lian Gui#,1,Chang-Qing Zhao#,2,Yan Wang3,Hong-Tu Gu2,Wei-Jing Wang1,4,Wei Cai1,Qing Guo1,shi-San Bao5,Lie-Ming xu*,2 and Qing Xie*,1 Author information Journal of Clinical and Translational Hepatology 2020;8(3):277-284DOI:10.14218/JCTH.2020.00004 Abstract Background and Aims:To evaluate the efficacy of Fuzheng Huayu(FZHY),a Chinese herbal formula,plus entecavir(ETV)in regression of liver fibrosis in chronic hepatitis B(CHB)patients with significant fibrosis/***:The current study was a two-center,randomized,double-blind and placebo-controlled pilot ***-two currently untreated chronic hepatitis B patients with Ishak fibrosis score≥3 points were identified and 1:1 randomized into FZHY plus ETV combination and placebo plus ETV *** second liver biopsy was performed after 48-week *** improvement and regression of fibrosis were *** changes in different collagen features in paired liver biopsies were evaluated by dual-photon microscopy for both ***:Forty-nine patients completed the full course of treatment;forty-six of them underwent second liver biopsy(for which twenty-two were in the combination group and twenty-four were in the control group).Compared to those in the control group,patients in the combination group had significantly higher rate of fibrosis regression(82%vs.54%)(p<0.05).Furthermore,the necroinflammatory improvement was greater in the combination group than in the control group(59%vs.25%,p<0.05).Among the more than 80 collagen parameters in the dual-photon analysis,5 decreased significantly in the combination group compared to the control group(p<0.05).However,no significant improvement was detected in either biochemical,virologi

关键词： Chronic hepatitis B Fibrosis Fuzheng Huayu tablet Entecavir

Catalytic Asymmetric Substitution of ortho-Hydroxybenzyl Alcohols with Tetronic Acid-Derived Enaminones:Enantioselective Synthesis of Tetronic Acid-Derived Diarylmethanes

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Catalytic Asymmetric Substitution of ortho-Hydroxybenzyl Alc...

中国化学会第十三届全国有机合成化学学术研讨会

作者： xu Meng-Meng shi Feng School of Chemistry and Chemical Engineering Jiangsu Normal University

Tetronic acid derivatives belong to one of the most important classes of natural products and pharmaceuticals,so the synthesis and biological evaluation of tetronic acid derivatives have absorbed great attention from the organic and medicinal chemists.1 the enantioselective synthesis of chiral tetronic acid-derived diarylmethanes has scarcely been reported in the literature.2 It is well-known that the bioactivity of one enantiomer may differ from another enantiomer or from the racemates,which reflects the significance of asymmetric catalysis and *** this context,developing catalytic asymmetric methods for the enantioselective synthesis of tetronic acid-derived diarylmethanes is highly desired and *** order to develop catalytic asymmetric methods for the enantioselective synthesis of tetronic acid-derived diarylmethanes,based on our previous work on CPA-catalyzed transformations,3-5 we designed a chiral phosphoric acid（CPA） catalyzed substitution reaction of ortho-hydroxybenzyl alcohols 1 by using tetronic acid-derived enaminones 2 as ***,we report the first catalytic asymmetric substitution of ortho-hydroxybenzyl alcohols with enaminones,which provided an efficient method for the enantioselective synthesis of tetronic acid-derived diarylmethanes 3（up to 89% yield,98:2 er） by using tetronic acid-derived enaminones as competent nucleophiles.

关键词： asymmetric organocatalysis ortho-hydroxybenzyl alcohol chiral phosphoric acid

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计算机多尺度辅助定位车牌算法

电子学报 2018年第9期46卷 2188-2193页

作者：魏亭邱实李晨王锐西安工业大学陕西西安710021 中国科学院西安光学精密机械研究所陕西西安710119 中国科学院深海科学与工程研究所海南三亚572000 西安市公安局陕西西安710002

违法占道拍摄出的单帧车辆图像具有数据量大、时效性强,检测环境复杂等特点.对其检测需要花费大量的人力与物力.并且人们在定位过程中,无法避免因经验、疲劳等方面的干扰,导致遗漏和错误定位.为此本文从视觉感知角度提出计算机多尺度辅... 详细信息

违法占道拍摄出的单帧车辆图像具有数据量大、时效性强,检测环境复杂等特点.对其检测需要花费大量的人力与物力.并且人们在定位过程中,无法避免因经验、疲劳等方面的干扰,导致遗漏和错误定位.为此本文从视觉感知角度提出计算机多尺度辅助定位车牌算法.模拟视觉感知原理,从车辆特征、纹理特征、颜色特征尺度,逐次聚焦至车牌所在区域.提出了完整的单帧图像车牌定位流程.并且提出基于边界对的车牌区域准确定位算法.通过对实拍的交通图像实验,表明本算法对于正对的车辆有较高的准确率,符合人类视觉感知的过程可实时的对图像进行车牌检测,可同时检测单幅图片的多个车牌.但对于光线过暗、过强或者颜色失真的情况,仍需要进一步的研究.

关键词：计算机辅助定位视觉感知车牌多尺度边缘对