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Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity scorematched analysis

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World Journal of Gastroenterology 2024年第15期30卷 2118-2127页

作者： Yang Zhou yin-qiu Zhang Shuai-Jing Huang Yan Liang Xiao Liang Masoom Wali Ya-Dong Feng Department of Gastroenterology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Gastroenterology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical UniversityNanjing 210019Jiangsu ProvinceChina

BACKGROUND During emergency endoscopic retrograde cholangiopancreatography(ERCP),the safety and feasibility of performing one-stage endoscopic treatment for patients with acute cholangitis(AC)due to choledocholithiasis are *** To investigate the safety and feasibility of one-stage endoscopic treatment for moderate to severe *** We enrolled all patients diagnosed with moderate to severe cholangitis due to common bile duct stones from January 2019 to July *** outcomes were compared in this study between patients who underwent ERCP within 24 h and those who underwent ERCP 24 h later,employing a propensity score(PS)*** primary outcomes were intensive care unit(ICU)admission rates,ICU length of stay,and duration of antibiotic *** In total,we included 254 patients and categorized them into two groups based on the time elapsed between admission and intervention:The urgent group(≤24 h,n=102)and the elective group(>24 h,n=152).Ninety-three pairs of patients with similar characteristics were selected by PS *** urgent ERCP group had more ICU admissions(34.4%vs 21.5%,P=0.05),shorter ICU stays(3 d vs 9 d,P<0.001),fewer antibiotic use(6 d vs 9 d,P<0.001),and shorter hospital stays(9 d vs 18.5 d,P<0.001).There were no significant differences observed in adverse events,in-hospital mortality,recurrent cholangitis occurrence,30-d readmission rate or 30-d *** Urgent one-stage ERCP provides the advantages of a shorter ICU stay,a shorter duration of antibiotic use,and a shorter hospital stay.

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography One-stage treatment Optimal time

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Acupuncture for cervical dystonia associated with anxiety and depression: A case report

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World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-Ting Zhang Jin-Jing Zhang Bi-Xiang Zha yin-qiu Fan Yuan-Bo Xu Jun Yang Qing-Ping Zhang The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of *** SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be *** This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression Neurological disease Acupuncture Case report

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效力体系视角下的法律行为成立理论构建

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当代法学 2024年第2期38卷 41-52页

作者：殷秋实中央财经大学法学院

现有的法律行为成立理论聚焦于成立与效力的区分、成立为事实判断和成立要件,并未关注不成立,未能明晰成立与不成立的效果与功能,导致理论的不自恰和法条解释基础的缺失。这些问题的解决需要在效力体系的视角下构建法律行为成立理论。... 详细信息

现有的法律行为成立理论聚焦于成立与效力的区分、成立为事实判断和成立要件,并未关注不成立,未能明晰成立与不成立的效果与功能,导致理论的不自恰和法条解释基础的缺失。这些问题的解决需要在效力体系的视角下构建法律行为成立理论。基于我国法的具体规定,在非决议的法律行为中,不成立具有和无效不同的效果,成立具有和有效不同的效果。不成立否定行为的存在及其意思自治意义,成立则意味着法律认可当事人行为具有意思自治上的重要性,是法律行为全部规范的适用前提。据此,成立是法律行为效力评价体系的一部分,并非事实判断,而是法律判断。重塑后的成立理论要求成立要件符合准入门槛低、由法律强制规定、不成立会导致无任何法律行为效力可能等标准。

关键词：法律行为不成立无效效力体系成立要件

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Using choroidal thickness to detect myopic macular degeneration

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 317-323页

作者： Ran Liu Meng Xuan De-Cai Wang Ou Xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui qiu-Xia yin Ming-Guang He Zhi-Xi Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina New England College of Optometry BostonMassachusetts 02115USA Wilmer Eye Institute Johns Hopkins UniversityBaltimoreMD 21231USA Brien Holden Vision Institute Sydney 2052Australia School of Optometry and Vision Science University of New South WalesSydney 2052Australia Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan School of Optometry the Hong Kong Polytechnic UniversityHong Kong SARChina Research Centre for SHARP Vision the Hong Kong Polytechnic UniversityHong Kong SARChina Center for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkHong Kong SARChina

AIM:To explore the usage of choroidal thickness measured by swept-source optical coherence tomography(SS-OCT)to detect myopic macular degeneration(MMD)in high myopic ***:Participants with bilateral high myopia(≤−6 diopters)were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort ***-OCT was performed to determine the choroidal thickness,and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia(META-PM)Classiﬁ*** of MMD was defined as META-PM category 2 or ***:A total of 568 right eyes were included for *** with MMD(n=106,18.7%)were found to have older age,longer axial lengths(AL),higher myopic spherical equivalents(SE),and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study(ETDRS)grid sector(P<0.001).The area under the receiver operating characteristic(ROC)curves(AUC)for subfoveal choroidal thickness(0.907)was greater than that of the model,including age,AL,and SE at 0.6249,0.8208,and 0.8205,*** choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD(AUC of 0.928 and 0.923,respectively).An outer nasal sector choroidal thickness of less than 74μm demonstrated the highest odds of predicting MMD(OR=33.8).CONCLUSION:Choroidal thickness detects the presence of MMD with high agreement,particularly of the inner and outer nasal sectors of the posterior pole,which appears to be a biometric parameter more precise than age,AL,or SE.

关键词： high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography

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Research on vertical spatial characteristic of satellite infrared hyperspectral atmospheric sounding data

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Frontiers of Earth Science 2022年第2期16卷 265-276页

作者： Ci SONG qiu yin School of Communication and Information Engineering Shanghai UniversityShanghai 200444China College of Science Zhongyuan University of TechnologyZhengzhou 450007China Shanghai Meteorological Service Shanghai 200030China User Office of Meteorological Satellites China Meteorological AdministrationShanghai 200030China

Spatial characteristic is an important indicator of remote sensor performance,and space-borne infrared hyperspectral sounder is the frontier of atmospheric vertical sounding *** this paper,the formation mechanism of the vertical spatial characteristics involved in the space-borne infrared hyperspectral sounding data are analyzed in detail,which shows that the vertical spatial characteristics of sounding data depends not only on the spectral channels and their waveband coverage,but also the specific atmospheric parameter and its specific variation *** indicators of vertical spatial characteristics are defined and their mathematical models are established based on the mechanism *** models are applied to the vertical spatial characteristic evaluation of atmospheric temperature sounding for FY-4A GIIRS,which is the first space-borne infrared hyperspectral atmospheric sounder in geostationary *** is concluded that FY-4A GIIRS can sound the vertical temperature distribution in whole troposphere and lower stratosphere with height<35 *** study can provide basic information to support the improvement of infrared hyperspectral sounder and the trace of vertical spatial characteristics of atmospheric inversion products.

关键词： infrared hyperspectral atmospheric sounding vertical spatial characteristic atmospheric temperature FY-4A GIIRS

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A high precision model for the terminal settling velocity of drops in fluid medium

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Frontiers of Earth Science 2021年第4期15卷 947-955页

作者： qiu yin Ci SONG Shanghai Meteorological Service China Meteorological AdministrationShanghai 200030China College of Science Zhongyuan University of TechnologyZhengzhou 450007China School of Communication and Information Engineering Shanghai UniversityShanghai 200444China

The terminal settling velocity(TSV)calcula-tion of drops and other spherical objects in fluid medium is a classical problem,which has important application values in many fields such as the study of cloud and precipitation processes,the evaluation of soil erosion,and the determination of fluid viscosity coefficient *** this paper,a new explicit approximation model of TSV is established,which combines the theoretical solution of N-S equation about fluid motion around spherical objects and the statistical regression of solution dimensionless coeffi-cients with measurement *** new model can adapt to different values of drop parameters and medium parameters in a large range of *** this model,the relative and absolute calculation errors of TSV are in range of 3.42%+4.34%and 0.271 m/s-+0.128 m/s respec-tively for drop radius 0.005-2.9 *** corresponding root mean square values are 1.77%and 0.084 rn/s respectively,which are much smaller than that of past theoretical and empirical models.

关键词： terminal settling velocity drag coefficient viscous resistance drop fluid medium

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溶酶体半乳糖脑苷酯酶的作用机制及疾病

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中国生物化学与分子生物学报 2024年第4期40卷 493-503页

作者：沈畅尹秋媛孟明耀孙建伟云南大学生命科学中心云南省细胞代谢与疾病重点实验室省部共建云南生物资源保护与利用国家重点实验室生命科学学院昆明650500 昆明市延安医院云南省肿瘤免疫防治研究重点实验室昆明650051

溶酶体贮积症(lysosomal storage diseases,LSD)是一类遗传性代谢障碍疾病,其发病机制主要源于溶酶体酸性水解酶的基因突变,导致酶的功能缺陷,进而触发生物大分子在溶酶体内的异常积累,继而对细胞、组织及器官功能造成显著损害。β-半... 详细信息

溶酶体贮积症(lysosomal storage diseases,LSD)是一类遗传性代谢障碍疾病,其发病机制主要源于溶酶体酸性水解酶的基因突变,导致酶的功能缺陷,进而触发生物大分子在溶酶体内的异常积累,继而对细胞、组织及器官功能造成显著损害。β-半乳糖脑苷酯酶(galactocerebrosidase,GALC)的突变或缺失导致鞘氨醇半乳糖苷(galactosylsphingosine)的累积,造成了进行性的脱髓鞘病变,诱发神经鞘脂贮积症-克拉伯病(Krabbe disease),其在疾病调控中的具体机制尚未完全阐明。目前,越来越多的有关GALC基因的致病突变被报道,结合GALC蛋白的三维结构解析,已逐渐了解GALC蛋白的突变造成克拉伯病的机制,这将为开发相关治疗药物提供有力的证据。此外,GALC在不同的肿瘤进程中扮演着双重角色,一些癌症中充当着抑癌因子的作用,而在另一些癌症中则发挥着致癌因子的作用,然而剖析GALC对癌症的影响仍需进一步深入的研究,这将为GALC作为潜在的肿瘤促进或抑制的靶点提供借鉴。GALC还与多种神经退行性疾病,包括阿尔茨海默病、帕金森氏病以及多发性硬化症有关。由于GALC作用机制的复杂性,目前,针对GALC缺乏所致的克拉伯病的治疗主要通过单一模式疗法(single-modality therapies)及多模式疗法(multi-modality therapies),但要开发出真正有效的治疗方法,仍需深入研究GALC基因缺陷导致的发病机制。本文综述了GALC的结构和功能特性,汇总并讨论了其在神经系统及肿瘤发生发展中的作用及相关研究的最新进展,旨在为未来深入探讨GALC的调控机制及开发治疗相关疾病的创新药物提供理论基础和参考。

关键词： β-半乳糖脑苷酯酶克拉伯病癌症

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帕金森病医药联合门诊药学服务路径的建立与实践

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中国处方药 2024年第8期22卷 83-85页

作者：江艳殷秋忆常熟市第二人民医院/南通大学附属常熟医院药学部江苏常熟215500

目的建立帕金森病医药联合门诊药学服务路径,规范药学门诊服务工作。方法根据现状调查结果,建立帕金森病医药联合门诊药学服务路径,包括用药方案评估、提供用药咨询及个体化宣教。对2022年7~12月就诊于帕金森病医药联合门诊的50例PD患... 详细信息

目的建立帕金森病医药联合门诊药学服务路径,规范药学门诊服务工作。方法根据现状调查结果,建立帕金森病医药联合门诊药学服务路径,包括用药方案评估、提供用药咨询及个体化宣教。对2022年7~12月就诊于帕金森病医药联合门诊的50例PD患者按该药学服务路径开展工作,并评价药学服务成效。结果按该药学服务路径工作6个月后,50例PD患者UPDRS综合评分Ⅲ、Ⅳ部分均低于服务前,且差异有统计学意义(P<0.05)。服务前后依从性Morisky评分为0分的(依从性好)从7例增加至25例,评分为3~4分(依从性差)的从13例减少至2例。此外,随访期间,未见严重不良反应。结论建立帕金森病医药联合门诊药学服务路径,有助于提高患者服药依从性,改善临床疗效,减少不良反应发生,并促进药学门诊服务工作规范化。

关键词：帕金森病医药联合门诊药学服务

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耕地“非粮化”特征识别与优化调控研究——以广西百色市右江区为例

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安徽农业科学 2024年第9期52卷 51-54,62页

作者：王钰尹秋月广西壮族自治区国土测绘院广西南宁530015

准确识别耕地“非粮化”空间特征,并提出优化管控措施,对耕地“非粮化”精确管控具有积极意义。以广西百色市右江区为例,从地类构成、坡度、景观格局、空间邻接、居民点耕作距离和交通便利度等方面对右江区耕地“非粮化”空间特征进行分... 详细信息

准确识别耕地“非粮化”空间特征,并提出优化管控措施,对耕地“非粮化”精确管控具有积极意义。以广西百色市右江区为例,从地类构成、坡度、景观格局、空间邻接、居民点耕作距离和交通便利度等方面对右江区耕地“非粮化”空间特征进行分析,并以引导耕地趋粮化为目的,针对不同耕地“非粮化”类型提出优化调控措施。结果表明,右江区“非粮化”耕地总量达到308.38 km^(2),以旱地为主,其次为园地和林地。“非粮化”耕地坡度以大于6°为主,地形坡度低于25°时,“非粮化”面积随着坡度增加而增加。“非粮化”耕地破碎,与园地和林地的空间邻近度较高,相互作用强度较大。距农村居民点(低于800 m)和道路(低于1200 m)越近,“非粮化”耕地面积占比越大,“非粮化”耕地空间分布受耕作距离和交通便利程度影响。

关键词：非粮化耕地形态特征优化调控右江区

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An Analysis on the Blended Teaching Mode of College English

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Sino-US English Teaching 2024年第1期21卷 1-5页

作者： YAN Hong-cai SONG yin-qiu HAN Yun-ying Jilin Agricultural University ChangchunChina Wuzhou University WuzhouChina

This paper explores blended teaching in college English from five aspects:the connotation,theoretical basis,design principles,advantages,and challenges of blended teaching and blended teaching *** purpose is to attrac... 详细信息

关键词： college English blended teaching mode constructivism online and offline

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