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Journal of Rare Earths 2024年第1期42卷 36-45,I0002页

作者： xiaoli luo Qichen Chen Hongbo Guo Heng Zhang xiaowei He Wu Zhao School of Mathematics and Computer Science Ningxia Normal UniversityGuyuan756099China School of Information Science and Technology Northwest UniversityXi'an710127China

Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical *** this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modifiedα-NaYbF_(4):2%Er^(3+)nanocrystals was *** introduction of various doping ions into NaYbF_(4):2%Er^(3+)and the different valence states of the same ions affect both the crystal size and upconversion luminesce *** fore,we investigated the upconversion luminesce nce enha ncement of NaYbF_(4):2%Er^(3+)by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol%Fe^(2+)ions shows the greatest enhancement,especially for red emission at654 ***,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detectio *** laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF_(4):2%Er/5%Fe^(2+)leads to a clear outline and improves visualization of the cell *** addition,the CA coated NaYbF_(4):2%Er^(3+)/5%Fe^(2+)nanoparticles and NaYbF_(4):2%Er^(3+)/5%Fe^(2+)show low cytotoxicity in HeLa *** imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and ***,these results indicate that the Cit-NaYbF_(4):2%Er^(3+)/5%Fe^(2+)UCNPs are efficient nanoprobes for fluorescence molecular to mography.

关键词： Hydrothermal method Fe^(2+)ion doping Tuning size Nanoprobes Fluorescence imaging Rare earths

家庭功能在先天性心脏病手术患儿父母家庭抗逆力与养育压力间的中介效应

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中国健康教育 2024年第2期40卷 168-171,181页

作者：罗曦邹萍天津市儿童医院天津300134

目的探讨家庭功能在先天性心脏病(Congenital Heart Disease, CHD)手术患儿父母家庭抗逆力与养育压力间的中介效应。方法采用一般资料调查表、家庭关怀度指数问卷(Family APGAR Index, APGAR)、家庭坚韧性量表(Family Hardiness Index... 详细信息

目的探讨家庭功能在先天性心脏病(Congenital Heart Disease, CHD)手术患儿父母家庭抗逆力与养育压力间的中介效应。方法采用一般资料调查表、家庭关怀度指数问卷(Family APGAR Index, APGAR)、家庭坚韧性量表(Family Hardiness Index, FHI)以及父母养育压力量表(Parenting Stress Index-Short Form, PSI-SF),对天津市某三级甲等儿童医院的部分CHD手术患儿父母进行调查。采用t检验、单因素方差分析、Pearson相关和结构方程模型对数据进行分析。结果 CHD手术患儿父母家庭功能得分为(6.92±1.75)分;家庭抗逆力得分为(64.25±14.24)分;父母养育压力得分为(90.83±29.04)分。Pearson相关分析结果显示,养育压力得分与家庭功能得分、家庭抗逆力得分呈显著负相关(P<0.05)。Bootstrap检验结果显示,家庭功能在CHD手术患儿父母家庭抗逆力与养育压力间起部分中介作用,其直接效应为-0.259,中介作用为-0.136,总效应为-0.395,间接效应占总效应量34.43%。结论家庭功能在CHD手术患儿父母家庭抗逆力与父母养育压力间起到中介作用,故临床医护人员应采取有效措施提升CHD手术患儿父母家庭功能和家庭抗逆力水平,进而降低他们的养育压力水平。

关键词：家庭功能家庭抗逆力养育压力先心病中介效应

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： luo-xi xiAO Zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

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Journal of Geriatric Cardiology 2024年第5期21卷 542-549页

作者： Qian LI Yue YU Ya-qiong ZHOU Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian WANG Tao ZHENG Department of Cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(P<0.001).Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal MI,and mortality in patients within the high tertile than those in the low and intermediate groups(all P<0.001).Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[CI]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%CI:1.56-6.52;P=0.001),MI(HR=2.61;95%CI:1.35-5.03;P=0.043)and mortality(HR=3.78;95%CI:1.65-8.77;P=0.001).CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO.

关键词： patients coronary occlusion

Three-dimensional-printed Ni-based scaffold design accelerates bubble escape for ampere-level alkaline hydrogen evolution reaction

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Interdisciplinary Materials 2024年第4期3卷 595-606页

作者： Jingxuan Chen Gangwen Fu Yu Tian xingchuan Li Mengqi luo xiaoyu Wei Ting Zhang Tian Gao Cheng Chen Somboon Chaemchuen xi Xu xing Sun Tongle Bu Francis Verpoort John Wang Zongkui Kou State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina Marine New Materials and Equipment Technology Center Sanya Science and Education Innovation Park of Wuhan University of TechnologySanyaChina Frontiers Science Center for Flexible Electronics Institute of Flexible ElectronicsNorthwestern Polytechnical UniversityXi'anChina Key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingboChina School of Astronautics Northwestern Polytechnical UniversityXi'anChina Department of Materials Science and Engineering College of Design and EngineeringNational University of SingaporeSingaporeSingapore National University of Singapore(Chongqing)Research Institute Chongqing Liang Jiang New AreaChongqingChina

Alkaline hydrogen evolution reaction(HER)for scalable hydrogen production largely hinges on addressing the sluggish bubble-involved kinetics on the traditional Ni-based electrode,especially for ampere-level current densities and ***,3D-printed Ni-based sulfide(3DPNS)electrodes with varying scaffolds are designed and *** situ observations at microscopic levels demonstrate that the bubble escape velocity increases with the number of hole sides(HS)in the ***,we conduct multiphysics field simulations to illustrate that as the hole shapes transition from square,pentagon,and hexagon to circle,where a noticeable reduction in the bubble-attached HS length and the pressure balance time around the bubbles results in a decrease in bubble size and an acceleration in the rate of bubble ***,the 3DPNS electrode with circular hole configura-tions exhibits the most favorable HER performance with an overpotential of 297 mV at the current density of up to 1000 mA cm^(-2) for 120 *** present study highlights a scalable and effective electrode scaffold design that promotes low-cost and low-energy green hydrogen production through the ampere-level alkaline HER.

关键词： 3D printing alkaline hydrogen evolution reaction ampere-level current densities bubble escape hole sides

Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis

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Nano Research 2024年第7期17卷 6443-6474页

作者： Haowen luo Lejie Tian Yaoming Zhang Yang Wu Bin Li Jianxi Liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Advanced Materials and Green ManufacturingYantai 264006China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

With the increasing emphasis on ecological safety and physical health,the detection and treatment of harmful substances and diseases are becoming more and more ***,efficiently monitoring these biological behaviors with high accuracy and sensitivity in real-time has shown prominent research *** use of fluorescent probes to analyze organisms has gained momentum in recent years,especially in the field of organ imaging and assisted cancer therapy,where fluorescent bioanalysis demonstrates significant *** this review,we explored the latest advancements in fluorescent molecular probes(e.g.,small-molecule,macro-molecule,supramolecule)and fluorescent nanoparticle probes(e.g.,quantum dots or nanoclusters,metal-organic frameworks,polymers,complexes)used as bioanalytical tools in various assays over the last three *** also delved into their detective mechanisms,specific application areas,and characterization tools for responsive *** review aims to showcase the most recent and comprehensive research progress in fluorescent bioanalysis based on molecular and nanoparticle probes,offering guidance for future developments in the design and fabrication of fluorescent probes and their potential applications.

关键词： fluorescent biosensing bioimaging disease diagnosis tumor detection and treatment

Two-dimensional particle-in-cell modeling of blow-off impulse by X-ray irradiation

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Nuclear Science and Techniques 2024年第3期35卷 53-69页

作者： Ruibo Li Jin-Long Jiao Hui luo Dezhi Zhang Dengwang Wang Kai Wang Graduate School of China Academy of Engineering Physics Beijing 100193China Zhejiang Institute of Modern Physics Institute of AstronomySchool of PhysicsZhejiang UniversityHangzhou 310027China National Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China

Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe *** reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significant *** blow-off impulse(BOI)is a crucial physical quantity for investigating material damage induced by X-ray ***,the accurate calculation of BOI is challenging,particularly for large deformations of materials with complex *** this study,we develop a novel two-dimensional particle-in-cell code,Xablation2D,to calculate BOIs under far-field X-ray *** significantly reduces the dependence of the numerical simulation on the grid *** reliability of this code is verified by simulation results from open-source codes,and the calculated BOIs are consistent with the experimental and analytical results.

关键词： X-ray irradiation Energy deposition Blow-off impulse Particle in cells

Integrating BIM and machine learning to predict carbon emissions under foundation materialization stage:Case study of China’s 35 public buildings

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Frontiers of Architectural Research 2024年第4期13卷 876-894页

作者： Haining Wang Yue Wang Liang Zhao Wei Wang Zhixing luo Zixiao Wang Jinghui luo Yihan Lv School of Architecture Southeast UniversityNanjing 210096China Key Laboratory of Urban and Architectural Heritage Conservation(Southeast University) Ministry of EducationNanjing 210096China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China Hubei Haizheng Technology Co. LtdWuhan 430000China School of Energy and Environment Engineering Hebei University of EngineeringHandan 056038China State Key Laboratory of Green Building Xi’an University of Architecture and TechnologyXi’an 710055China

For the significant energy consumption and environmental impact,it is crucial to identify the carbon emission characteristics of building foundations construction during the design *** study would like to establish a process-based carbon evaluating model,by adopting Building Information Modeling(BIM),and calculated the materialization-stage carbon emissions of building foundations without basement space in China,and identifying factors influencing the emissions through correlation *** five factors include the building function type,building structure type,foundation area,foundation treatment method,and foundation ***,this study develops several machine learning-based predictive models,including Decision Tree,Random Forest,XGBoost,and Neural *** these models,XGBoost demonstrates a relatively higher degree of accuracy and minimal errors,can achieve the RMSE of 206.62 and R2 of 0.88 based on testing group *** study reveals a substantial variability carbon emissions per building’s floor area of foundations,ranging from 100 to 2000 kgCO_(2)e/m^(2),demonstrating the potential for optimizing carbon emissions during the design phase of ***,materials contribute significantly to total carbon emissions,accounting for 78%e97%,suggesting a significant opportunity for using BIM technology in the design phase to optimize carbon reduction efforts.

关键词： Building foundations Carbon emissions Building information modeling Machine learning Sustainable architectural design

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang xifang Zhang xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

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湖北大学生返乡创业创新问题与对策探究

广东蚕业 2024年第7期58卷 133-135页

作者：罗琼武汉工程职业技术学院湖北武汉430415

近年来,越来越多的人选择返乡创业,大学生作为新时代的中坚力量,是返乡创业创新的重要构成部分,在乡村振兴中发挥着重要作用。文章以湖北省大学生为例,通过问卷调查法、访谈法展开分析,探讨了现阶段湖北省大学生返乡创业创新过程中存在... 详细信息

近年来,越来越多的人选择返乡创业,大学生作为新时代的中坚力量,是返乡创业创新的重要构成部分,在乡村振兴中发挥着重要作用。文章以湖北省大学生为例,通过问卷调查法、访谈法展开分析,探讨了现阶段湖北省大学生返乡创业创新过程中存在的现实问题,提出了注重实践教育、拓宽融资渠道、建立社交网络等一系列优化对策,以期助力湖北省大学生返乡创业创新。

关键词：大学生返乡创业创新问题与对策湖北省