检索结果-南通市图书馆

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai qiong wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis on Pseudo Excitation of Random Vibration for Structure of Time Flight Counter

引用

Chinese Journal of Mechanical Engineering 2015年第2期28卷 325-330页

作者： wu qiong LI Dapeng Beijing Engineering Technological Research Center of High-efficient & Green CNC Machining Process and Equipment Beihang University

Traditional computing method is inefficient for getting key dynamical parameters of complicated *** Excitation Method（PEM）is an effective method for calculation of random *** to complicated and coupling random vibration in rocket or shuttle launching,the new staging white noise mathematical model is deduced according to the practical launch *** deduced model is applied for PEM to calculate the specific structure of Time of Flight Counter（ToFC）.The responses of power spectral density and the relevant dynamic characteristic parameters of ToFC are obtained in terms of the flight acceptance test *** stiffness of fixture structure,the random vibration experiments are conducted in three directions to compare with the revised *** experimental results show the structure can bear the random vibration caused by launch without any damage and key dynamical parameters of ToFC are *** revised PEM is similar with random vibration experiment in dynamical parameters and responses are proved by comparative *** maximum error is within 9%.The reasons of errors are analyzed to improve reliability of *** research provides an effective method for solutions of computing dynamical characteristic parameters of complicated structure in the process of rocket or shuttle launching.

关键词： pseudo excitation method power spectral density random processes dynamic response vibration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

类胰岛素生长因子1对自然衰老小鼠的抗肥胖作用

引用

中国组织工程研究 2025年第12期29卷 2536-2543页

作者：朱鹏李瑛玉卢小倩吴琼广西高校重点实验室干细胞与医药生物技术(广西师范大学) 广西壮族自治区桂林市541004 广西师范大学生命科学学院广西壮族自治区桂林市541006

背景:实验室前期研究发现青年脂肪干细胞移植到老年小鼠体内会有减重效果,并且能改善老年小鼠体内炎症状态,推测类胰岛素生长因子1可能对于衰老和肥胖具有重要作用。目的:探究类胰岛素生长因子1对自然衰老小鼠的抗肥胖作用。方法:①生... 详细信息

背景:实验室前期研究发现青年脂肪干细胞移植到老年小鼠体内会有减重效果,并且能改善老年小鼠体内炎症状态,推测类胰岛素生长因子1可能对于衰老和肥胖具有重要作用。目的:探究类胰岛素生长因子1对自然衰老小鼠的抗肥胖作用。方法:①生物信息学分析:对GEO数据库中肥胖患者的脂肪组织测序,并对青年小鼠脂肪干细胞和老年小鼠脂肪干细胞进行转录组学测序,分析类胰岛素生长因子1表达情况。②动物实验验证:2月龄雄性C57BL/6J小鼠(青年小鼠)6只,20月龄雄性C57BL/6J小鼠(老年小鼠)12只。采用ELISA和qRT-PCR检测青年小鼠和老年小鼠的腹部脂肪组织和血清类胰岛素生长因子1的表达情况。将老年小鼠12只随机分为2组:实验组连续4周注射类胰岛素生长因子1蛋白(50μg/kg),对照组注射同等剂量的PBS。定期监测实验组和对照组小鼠体质量变化,实验结束时测量小鼠葡萄糖耐受,ELISA检测小鼠血清炎症因子、腹部脂肪组织炎症因子,苏木精-伊红染色观察肝、肾及腹部脂肪组织病理变化,qRT-PCR检测腹部脂肪组织炎症因子、PI3K-AKT信号通路mRNA的表达水平。结果与结论:①肥胖患者脂肪组织低表达类胰岛素生长因子1,并在接受减肥手术后类胰岛素生长因子1表达上升;②老年脂肪干细胞低表达类胰岛素生长因子1;③老年小鼠腹部脂肪组织和血清均低表达类胰岛素生长因子1;④注射类胰岛素生长因子1蛋白能显著降低老年小鼠的体质量并改善胰岛素抵抗;⑤老年小鼠肝脏病理切片发现有脂肪堆积情况,注射类胰岛素生长因子1蛋白后,脂肪堆积情况显著改善,并且显著降低了脂肪组织的脂滴大小;⑥注射类胰岛素生长因子1能显著降低老年小鼠血清肿瘤坏死因子α、白细胞介素1β、白细胞介素6的表达水平,显著增加脂肪组织PI3K-AKT信号通路的表达;⑦结论:外源性类胰岛素生长因子1能降低老年小鼠体质量、减小脂肪组织脂滴大小及改善肝脏脂肪堆积情况,改善老年小鼠的炎症状态,可能是通过激活PI3K-AKT信号通路改善老年小鼠的炎症状态,从而改善自然衰老小鼠的肥胖。

关键词：类胰岛素生长因子1 老年肥胖脂肪组织胰岛素抵抗炎症 PI3K-AKT信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integral inference method for da/dN-ΔK and P-da/dN-ΔK curves

引用

航空动力学报 2011年第6期26卷 1251-1256页

作者： FU Hui-min wu qiong Research Center of Small Sample Technology Beijing University o~ Aeronautics and Astronautics Beijing 100191 China

The integral inference method for fatigue crack growth(FCG) curve was established based on the two-variance regression *** estimates of da/dN-ΔK curve and P-da/dN-ΔK curve with high confidence level and high survival probability were also *** data scatter with stress intensity factor ranges in reality,which limits the group test method's *** presented method analyzes FCG curve as an integration,thus it can exploit the lengthwise information among the FCG rates corresponding to different stress intensity factor ***,compared with group test method,the presented method can not only save specimens,but also have higher precision in the evaluations of da/dN-ΔK and P-da/dN-ΔK curves.

关键词： aero-engine fatigue crack growth(FCG) crack growth rate integral estimate reliability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment and remediation of a wastewater lagoon using microelectrolysis and modified DAT/IAT methods

引用

Journal of Environmental Sciences 2011年第3期23卷 388-395页

作者： qiong wu Tao Hua Qixing Zhou Tianjin Key Laboratory of Environmental Remediation and Pollution Control/Key Laboratory of Pollution Process and Environmental Criteria (Ministry of Education) College of Environmental Science and Engineering Nankai University Tianjin 300071 China Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

To examine treatment and remediation of a wastewater lagoon with poor biodegradability, a typical wastewater lagoon in Tianjin, China, was treated and remedied using microelectrolysis and modified demand aeration tank （DAT）/intermittent aeration tank （IAT） methods. After pretreatment by microelectrolysis, the removal efficiency of chemical oxygen demand （COD） was up to 64.6% and the ratio of BOC/COD in the effluent increased from 0.013 to 0.609. The removal rates of CODcr and NH4＋-N were affected by sludge backflow rate, mixed liquor suspended solids （MLSS）, and hydraulic retention time （HRT） in the modified DAT/IAT reactor. The highest removal rates of CODcr and NH4＋-N were up to 78.9% and 62.6%, respectively, when the sludge backflow rate was 38.0 mL/min, the total HRT was 8.0 hr and MLSS was 4088.0 mg/L. In this case, some protozoa and metazoa were observed in activated sludge and biofilm carriers. Most of chrominance was removed by microelectrolysis treatment, while the modified DAT/IAT methods were more effective for CODcr and NH4＋-N removal.

关键词： wastewater lagoon biodegradability microelectrolysis DAT/IAT ecological remediation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Characteristic Analysis and Experiment for Integral Impeller Based on Cyclic Symmetry Analysis Method

引用

Chinese Journal of Aeronautics 2012年第5期25卷 804-810页

作者： wu qiong ZHANG Yidu ZHANG Hongwei State Key Laboratory of Virtual Reality Technology and Systems School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China

A cyclic symmetry analysis method is proposed for analyzing the dynamic characteristic problems of thin walled integral im- peller. Reliability and feasibility of the present method are investigated by means of simulation and experiment. The fundamental cyclic symmetry equations and the solutions of these equations are derived for the cyclic symmetry structure. The computational efficiency analysis between whole and part is performed. Comparison of results obtained by the finite element analysis （FEA） and experiment shows that the local dynamic characteristic of integral impeller has consistency with the single cyclic symmetry blade. When the integral impeller is constrained and the thin walled blade becomes a concerned object in analysis, the dynamic characteristic of integral impeller can be replaced by the cyclic symmetry blade approximately. Hence, a cyclic symmetry analy- sis method is effectively used to improve efficiency and obtain more information of parameters for dynamic characteristic of integral impellers.

关键词： dynamic characteristic cyclic symmetry impellers simulation finite element analysis blade

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Characteristics Analysis and Vibration Experiment of Upper-time of Flight Counter (U-ToFC)

引用

Chinese Journal of Mechanical Engineering 2012年第5期25卷 868-874页

作者： wu qiong ZHANG Yidu SONG Sunguang State Key Lab of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China School of Mechanical Engineering andAutomation Beihang UniversityBeijing 100191China

The dynamic characteristic parameters of Up-time of Flight Counter （U-ToFC） are important for research of structure optimization and reliability. However, the current simulation is performed based on homogenous material and simplified constraint model, the correct and reliability of results are difficult to be guaranteed. The finite element method based on identification of material parameters is proposed for this investigation on dynamic analysis, simulation and vibration experiment of the U-ToFC. The structure of the U-ToFC is complicated. Its＇ outside is made of aluminum alloy and inside contains electronic components such as capacitors, resistors, inductors, and integrated circuits. The accurate material parameters of model are identified difficultly. Hence, the parameters identification tests are performed to obtain the material parameters of this structure. On the basis of the above parameters, the experiment and FEA are conducted to the U-ToFC. In terms of the flight acceptance test level, and two kinds of joints condition between the U-ToFC and fixture are considered. The natural frequencies, vibration shapes and the response of the power spectral density of the U-ToFC are obtained. The results show simulation which is based on parameters identification is similar with vibration experiment in natural frequencies and responses. The errors are less than 10%. The vibration modes of simulation and experiment are consistent. The paper provides a more reliable computing method for the dynamic characteristic analysis of large complicated structure.

关键词： random vibration dynamical characteristic parameters finite element analysis identification of material parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Intelligent Control System of Traffic Light Based on Fog Computing

引用

Chinese Journal of Electronics 2018年第6期27卷 1265-1270页

作者： wu qiong HE Fanfan FAN Xiumei Department of Automation and Information Engineering Xi’an University of Technology

The continuous increase of city motors with the improvement of society has introduced extraordinary demanding situations for the traffic situation of the *** traffic has proposed a diversity of solutions to relieve urban traffic accidents and congestion and other troubles. It cannot regulate the cycle of traffic light in real time in keeping with the occurring traffic flux which additionally, may produce the traffic jam to result in the increase for the range of automobiles and the longer of passage time. In purpose to surmount the shortcomings of traditional traffic light control, this paper is presenting a form of intelligent control system for traffic light founding on fog computing. It calculates and shares the traffic flux situation at the intersection and the surrounding intersection through fog computing platform. Regarding the traffic flow at the intersection and the traffic flow at the surrounding intersection as the parameters, the intelligent control algorithm of traffic light is designed for achieving mutual coordination and mutual influence between different intersections, so that the traffic efficiency of each intersection is improved and the traffic flow of the entire transport network is alleviated. The simulation results showed this intelligent control system progress the traffic efficiency of every intersection and relieve the traffic flow of the whole transport network.

关键词： Traffic lights Intersection Fog computing Real-time Traffic efficiency

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

L(j,k)-number of Direct Product of Path and Cycle

引用

Acta Mathematica Sinica,English Series 2013年第8期29卷 1437-1448页

作者： Wai Chee SHIU qiong wu Department of Mathematics Hong Kong Baptist University

For positive numbers j and k, an L（j,k）-labeling f of G is an assignment of numbers to vertices of G such that ｜f（u）-f（v）｜≥j if uv∈E（G）, and ｜f（u）-f（v）｜≥k if d（u,v）=2. Then the span of f is the difference between the maximum and the minimum numbers assigned by f. The L（j,k）-number of G, denoted by λj,k（G）, is the minimum span over all L（j,k）-labelings of G. In this paper, we give some results about the L（j,k）-number of the direct product of a path and a cycle for j≤k.

关键词： L(j k)-labeling product of a path and a cycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of polycarboxylate-type superplasticizer on the paste fluidity based on the water film thickness of flocs

引用

Science China(Technological Sciences) 2014年第8期57卷 1522-1531页

作者： wu qiong AN XueHui LIU ChunNa State Key Laboratory of Hydroscience and Engineering Tsinghua University

The excess water film theory and the properties of flocs are integrated to examine the effect of the polycarboxylate-type superplasticizer on the paste fluidity. The theory states that excess water can surround the flocs rather than the particles and that the cell consists of a floc and a superficial water film. Experiments on limestone powder pastes were conducted to verify the theory. The superplasticizer dosage （sp%） and the water-powder ratio by volume （Vw/Vv） were systematically varied. A sedimentation balance method was used to measure the size distribution of the flocs in the limestone powder pastes. The water film thickness （WFT） of flocs was then calculated and shown to determine the paste fluidity. Based on this WFT of flocs, the effect of the sp on the paste fluidity was determined and then compared with the effect of water.

关键词： water film thickness of flocs superplasticizer sedimentation balance method fluidity limestone powder paste

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：