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Genes & Diseases 2024年第3期11卷 39-42页

作者： Haoyu Ruan Zhe Wang Xuemei Tang qiong zhan Kun Chen Lu Gao Ming Guan Department of Laboratory Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Physiology Naval Medical UniversityShanghai 200433China Department of Oncology Huashan HospitalFudan UniversityShanghai 200040China

Cancer of unknown primary(CUP)is a rare disease characterized by metastases in which the primary tumor is of unknown *** cerebrospinal fluid(CSF)tumor microenvironment of CUP is still unknown.A Chinese male was diagnosed with leptomeningeal metastases from CUP(CUP-LM)based on the following medical examination results:partial leptomeningeal enhancement by brain magnetic resonance imaging,few malignant cells of diverse morphology in CSF,and no abnormalities or lymphadenopathy by systemic examination.

关键词： metastases cerebrospinal fluid

Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

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Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： Jinyan zhang Fen Liu Qian Jin Xueyi Li qiong zhan Mu Chen Sisi Wang Zhenlong Wu Wencai Ye Lei Wang State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative Drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

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实体瘤脑膜转移鞘内药物治疗进展

肿瘤 2024年第1期44卷 70-76页

作者：詹琼梁晓华复旦大学附属华山医院肿瘤科上海200400

实体瘤脑膜转移是肿瘤晚期一种灾难性的合并症,预后很差,目前缺乏有效的治疗方法。鞘内化疗作为脑膜转移癌治疗的一种方法,虽然得到了许多指南或者专家共识的推荐,在临床实践中也经常应用,但鞘内化疗的疗效一直缺乏高质量研究证据的支... 详细信息

实体瘤脑膜转移是肿瘤晚期一种灾难性的合并症,预后很差,目前缺乏有效的治疗方法。鞘内化疗作为脑膜转移癌治疗的一种方法,虽然得到了许多指南或者专家共识的推荐,在临床实践中也经常应用,但鞘内化疗的疗效一直缺乏高质量研究证据的支持。甲氨蝶呤、阿糖胞苷、塞替派等鞘内化疗常用的药物疗效并不理想。本文对新型鞘内注射药物的用法、疗效和安全性进行总结。

关键词：脑膜转移鞘内化疗

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圆电流在非均匀磁场中所受的安培力

物理通报 2024年第3期 18-20页

作者：詹琼张兴刚贵州大学物理学院贵州贵阳550025

给出了计算圆电流在非均匀磁场中所受的安培力的两种方法:换元积分法和复变函数法,对教师在教学中处理有关的积分问题以及培养学生的计算能力有一定指导意义.

关键词：圆电流磁场安培力

心理弹性和共情能力在临床医学专业研究生工作压力与职业倦怠间中介效应分析

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中国职业医学 2024年第1期51卷 60-64页

作者：艾海提·尼亚孜占琼新疆医科大学第一附属医院教学科研工作部研究生教育管理科新疆乌鲁木齐830001

目的探讨心理弹性和共情能力在临床医学专业研究生工作压力与职业倦怠间的中介效应。方法采用分层抽样法,选择437名临床医学相关专业硕士研究生为研究对象,采用《Connor-Davidson心理弹性量表》《人际反应指针量表》《压力感知量表》《M... 详细信息

目的探讨心理弹性和共情能力在临床医学专业研究生工作压力与职业倦怠间的中介效应。方法采用分层抽样法,选择437名临床医学相关专业硕士研究生为研究对象,采用《Connor-Davidson心理弹性量表》《人际反应指针量表》《压力感知量表》《Maslach职业倦怠量表》测量其心理弹性、共情能力、工作压力和职业倦怠情况。结果研究对象心理弹性、共情能力、工作压力、职业倦怠得分分别为(90.2±13.4)、(93.8±10.1)、(53.7±12.2)和(47.3±12.6)分。职业倦怠检出率为37.5%。结构方程模型结果显示,心理弹性和共情能力在工作压力和职业倦怠之间起部分中介作用,其中,心理弹性占13.6%,共情能力占41.3%。结论心理弹性和共情能力在临床医学专业研究生的工作压力和职业倦怠间中介效应明显。

关键词：临床医学专业研究生心理弹性共情能力工作压力职业倦怠中介效应

Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics

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Current Medical Science 2020年第3期40卷 563-569页

作者： Xue-lin CHAO Shu-zhen JIANG Jian-wen XIONG Jin-qiong zhan Bo WEI Chun-nuan CHEN Yuan-jian YANG Department of Psychosomatic Medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Department of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Department of Neurology The Second Clinical Medical CollegeThe Second Affiliated HospitalFujian Medical UniversityQuanzhou362000China

Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of *** previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with *** we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia ***-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this *** symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS)and serum IGF-2 levels were determined using *** found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline(P<0.05).After 2 months of atypical antipsychotic treatment,a significant improvement in each PANSS subscore and total score was observed in patients(all P<0.01),and the serum IGF-2 levels of patients were significantly increased compared with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,P<0.001).Correlation analysis revealed that the changes of serum IGF-2 levels in patients were significantly correlated with the improvements of negative symptoms(r=−0.522,P=0.006).Collectively,our findings demonstrated changes of serum IGF-2 response to improvements of negative symptoms in schizophrenia patients treated with atypical antipsychotics,suggesting that serum IGF-2 might be a treatment biomarker for schizophrenia.

关键词： schizophrenia atypical antipsychotic insulin-like growth factor-2 negative symptoms

Synaptosomal-associated protein 25 may be an intervention target for improving sensory and locomotor functions after spinal cord contusion

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Neural Regeneration Research 2017年第6期12卷 969-976页

作者： zhan-qiong Zhong Yang Xiang Xi Hu You-cui Wang Xi Zeng Xiao-meng Wang Qing-jie Xia Ting-hua Wang Xiao zhang Experiment Technology Center of Preclinical Medicine of Chengdu Medical College School of Basic Medicine Chengdu University of Traditional Chinese Medicine Institute of Neurological Diseases Center for Translational Neuroscience Western China Hospital Sichuan University

Synaptosomal-associated protein 25 k Da（SNAP-25） is localized on the synapse and participates in exocytosis and neurotransmitter release. Decreased expression of SNAP-25 is associated with Alzheimer＇s disease and attention deficit/hyperactivity disorder. However, the expression of SNAP-25 in spinal cord contusion injury is still unclear. We hypothesized that SNAP-25 is associated with sensory and locomotor functions after spinal cord injury. We established rat models of spinal cord contusion injury to detect gene changes with a gene array. A decreased level of SNAP-25 was detected by quantitative real time-polymerase chain reaction and western blot assay at 1, 3, 7, 14 and 28 days post injury. SNAP-25 was localized in the cytoplasm of neurons of the anterior and posterior horns, which are involved in locomotor and sensory functions. Our data suggest that reduced levels of SNAP-25 are associated with sensory and locomotor functions in rats with spinal cord contusion injury.

关键词： sensory hyperactivity deficit cytoplasm localized unclear Chengdu autism neuronal minutes

Effect of Combined Jin's Three-needle and Rehabilitation Care on Post-stroke Hemiplegia

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Journal of Acupuncture and Tuina Science 2013年第4期11卷 218-221页

作者： Zhou Zhao-hui Zhuang Li-xing Xu zhan-qiong Liao Mu-xi zhang Bin Han Chou-ping Acupuncture Department the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine

Objective:To observe and compare the efficacy differences between combined Jin's three-needle and rehabilitation training and rehabilitation training alone for hemiplegia following an ischemic stroke. Methods:A total of 94 cases who met the inclusion criteria were randomized into an observation group using combined Jin's three-needle and rehabilitation training and a control group using rehabilitation training alone. The therapeutic efficacies were then assessed respectively before treatment, 14 d and 28 d after treatment using neurological deficient scale (NDS) and short-form Fugl-Meyer assessment (SFFMA) scale. Results:After treatment, the NDS and SFFMA scores in both groups were significantly improved (P<0.05); after 28-day treatment, the inter-group comparison showed a statistical significance (P<0.05). Conclusion:Combined Jin's three-needle and rehabilitation training and rehabilitation training alone can both enhance the nerve function recovery of patients with post-stroke hemiplegia and improve their motor function; however, the former could obtain better effects than the latter.

关键词： Acupuncture Therapy Scalp Stimulation Areas Stroke Complications Hemiplegia Rehabilitation

Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties

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Nano Research 2024年第3期17卷 927-938页

作者： Beibei zhan Yanling Hao Xiaosi Qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu Gong Yanli Chen qiong Peng Wei Zhong College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and ***,effective integrating the multiple functions into a single material remains a huge ***,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the *** obtained results revealed that the thermal treated temperature and g-C_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of CCFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the special cellular structure,the designed CCFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the as-prepared CCFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal ***,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning thermal insulation

一种新型开关磁阻电机软开关功率变换器的研究(英文)

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中国电机工程学报 2005年第17期25卷 142-149页

作者：罗建武詹琼华邓琼华中科技大学电气与电子工程学院湖北省武汉市430074 CorrLogic有限公司

为了实现开关磁阻电机(SRM)绕组电流或磁链的精确控制,必须提高SRM功率变换器的工作频率以提高系统的动态响应速度。然而,较高的工作频率会引起严重的电磁干扰(EMI)和开关损耗从而导致系统整体效率降低,文中结合谐振开关(RS)、直流谐振... 详细信息

为了实现开关磁阻电机(SRM)绕组电流或磁链的精确控制,必须提高SRM功率变换器的工作频率以提高系统的动态响应速度。然而,较高的工作频率会引起严重的电磁干扰(EMI)和开关损耗从而导致系统整体效率降低,文中结合谐振开关(RS)、直流谐振环(RDCL)和脉冲宽度调制(PWM)的优点,提出了一种新型的软开关SRM功率变换器,基工作原理为通过在非对称桥式电路的基础上增加一套换流电路,以此实现功率器件的软开关。在对变换器工作原理详细分析的基础上,导出了实现软开关的条件并给出了设计实例。仿真和实验研究证实了新型软开关SRM变换器的可行性。

关键词：开关磁阻电机软开关准谐振