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Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

Neural Regeneration Research 2024年第8期19卷 1842-1848页

作者： Lu He qinming zhou Chaoyang Xiu Yaping Shao Dingding Shen Huanyu Meng Weidong Le Sheng Chen Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Center for Translational Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengduSichuan ProvinceChina Department of Neurology Xinrui HospitalWuxiJiangsu ProvinceChina

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive *** is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke *** this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy *** bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral *** biomarke rs were selected based on functionality and expression *** validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent *** substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle ***,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and transl

关键词： amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide hemoglobin label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein zyxin

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target

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Frontiers of Medicine 2022年第5期16卷 723-735页

作者： qinming zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen Department of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology the First Hospital of Jiaxing&the Affiliated Hospital of Jiaxing UniversityJiaxing 314000China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226007China Department of Dermatology The People’s Hospital of RushanWeihai 264500China Department of Neurology Xinrui HospitalWuxi 214000China Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengdu 610072China

Amyotrophic lateral sclerosis(ALS)is the most common motor neuron *** present,no definite ALS biomarkers are *** this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were *** them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the ***1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS ***1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were ***1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of ***,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and *** inhibition of calcineurin activation by cyclosporin A reversed the damaged *** conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic ***,CORO1A might be a potential biomarker and therapeutic target for ALS.

关键词： amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis

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Recent Advances in the Synthesis of Zeolites from Solid Wastes

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Chemical Research in Chinese Universities 2024年第4期40卷 646-656页

作者： LIU Pei WU qinming CHEN Zhenghai XIAO Feng-Shou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and College of Chemical and Biological Engineering Zhejiang UniversityHangzhou310028P.R.China Zhejiang Provincial Innovation Center of Green Petrochemical Technology Ningbo315048P.R.China Kente Catalysts Inc. Xianju317300P.R.China

With the rapid development of industrialization,it is inevitable to produce solid wastes in the fields of energy petrochemical ***,the storage and utilization of these solid wastes have become a considerable *** to the main element composition of these solid wastes including silicon and aluminum,it has attracted extensive attention for synthesizing *** review summarized the properties of major solid wastes including coal fly ash,coal gangue,spent fluid catalytic cracking(FCC)catalyst,lithium slag,bauxite residue,and waste ***,the preparation of LTA,FAU,ZSM-5,SSZ-13,Beta,and MOR zeolites from these solid wastes were ***,the current challenges and perspectives were discussed.

关键词： Solid waste Zeolite Utilization Sustainable route Application

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A perspective on therapies for amyotrophic lateral sclerosis:can disease progression be curbed?

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Translational Neurodegeneration 2021年第3期10卷 367-384页

作者： Xiaojiao Xu Dingding Shen Yining Gao qinming zhou You Ni Huanyu Meng Hongqin Shi Weidong Le Shengdi Chen Sheng Chen School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054China Department of Neurology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200020China Department of Neurology Xinrui HospitalWuxi 214028China Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengdu 610031China Center for Clinical Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalian 116021China

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually *** treatments such as inhibition of salivation,alleviation of muscle cramps,and relief of spasticity and pain still play an important role in enhancing the quality of *** date,riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few *** there is adequate consensus on the modest efficacy of riluzole,there are still open questions concerning the efficacy of edaravone in slowing the disease ***,identification of novel therapeutic strategies is urgently *** autophagic process plays a critical role in ALS *** this review,we focus on therapies modulating autophagy in the context of ***,stem cell therapies,gene therapies,and newly-developed biomaterials have great potentials in alleviating neurodegeneration,which might halt the disease *** this review,we will summarize the current and prospective therapies for ALS.

关键词： Amyotrophic lateral sclerosis Motor neurons Autophagy Stem cells Gene editing

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医学院校科技伦理教育共同体的逻辑建构

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医学与哲学 2024年第13期45卷 61-64页

作者：刘杨于钦明黑龙江大学政府管理学院黑龙江哈尔滨150006 黑龙江中医药大学人文与管理学院黑龙江哈尔滨150040

随着现代科技手段在医学领域的广泛应用,为积极促进医学院校科技伦理教育与时俱进创新发展,从科学共同体、新医科教育范式、培养科技向善的医学创新人才三个层面,阐述了医学院校科技伦理教育共同体的生成逻辑,从科技伦理教育的定位、教... 详细信息

随着现代科技手段在医学领域的广泛应用,为积极促进医学院校科技伦理教育与时俱进创新发展,从科学共同体、新医科教育范式、培养科技向善的医学创新人才三个层面,阐述了医学院校科技伦理教育共同体的生成逻辑,从科技伦理教育的定位、教育理念、育人主体三个维度,梳理了医学院校科技伦理教育共同体所包含的价值取向,进而从科技向善、多元融合、共生发展等理念出发,探讨了通过成立医学院校科技伦理教育联盟实现科技伦理教育的协同育人机制、开发科技伦理教育共享资源,以及推动科技伦理治理制度化发展等实践路径。

关键词：科技伦理科学共同体医学教育

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四川盆地川西气田多层系成藏条件及勘探开发关键技术

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石油学报 2024年第3期45卷 595-614页

作者：熊亮隆轲曹勤明章顺利中国石油化工股份有限公司西南油气分公司四川成都610041 中国石油化工股份有限公司西南油气分公司勘探开发研究院四川成都610041

四川盆地油气资源丰富,在纵向上从海相到陆相发育多个成藏系统。近年来,川西气田在多个层系均取得了重大油气勘探成果。为了深化油气成藏富集规律认识,指导勘探开发,进一步扩大油气成果,梳理了川西气田的勘探开发历程并系统剖析了油气... 详细信息

四川盆地油气资源丰富,在纵向上从海相到陆相发育多个成藏系统。近年来,川西气田在多个层系均取得了重大油气勘探成果。为了深化油气成藏富集规律认识,指导勘探开发,进一步扩大油气成果,梳理了川西气田的勘探开发历程并系统剖析了油气成藏条件。研究结果表明:川西坳陷发育多套优质烃源岩,物质条件充足;川西地区中三叠统雷口坡组四段发育局限台地潮坪相白云岩孔隙型储层,可实现四川盆地海相勘探领域由高能礁滩、岩溶等气藏向局限台地潮坪相白云岩气藏的拓展,丰富海相油气的勘探类型;上三叠统须家河组二段发育河口坝和水下分流河道高能砂体,呈广覆叠置发育,与下伏小塘子组烃源岩或自身烃源岩构成了完整的源-储组合;中侏罗统沙溪庙组发育近物源扇三角洲和辫状河三角洲水下分流河道高能砂体,与下伏须家河组五段烃源岩构成了完整的源-储组合。川西地区从二叠系到三叠系雷口坡组发育的“直接式”和“接力式”通源断层、雷口坡组网状分布的微断层和裂缝、须家河组断裂-裂缝-砂体复合输导体系、沙溪庙组断层-砂体输导体系,这些均为高效的油气输导体系,确保了天然气能够高效运移成藏。建立了超深层潮坪相薄互层储层精细预测技术序列,形成了须家河组二段的薄储层预测及中—小尺度裂缝空间刻画技术,实现了储层的精细刻画,支撑了水平井的成功实施。通过量身打造开发方案并攻关钻完井工艺,实现了“少井高产”的开发目标和储量的有效动用。川西地区超深层复杂构造带潮坪相白云岩气藏的开发建产、须家河组的高效开发和沙溪庙组致密砂岩的勘探突破推动了相关领域的勘探开发及方法技术创新。

关键词：雷口坡组须家河组沙溪庙组成藏条件川西气田

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煤化工业园区土壤中多氯萘的浓度及来源分析

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环境污染与防治 2024年第2期46卷 200-207页

作者：范智超白昭张秦铭周弛陕西省环境监测中心站陕西西安710054 陕西省环境介质痕量污染物监测预警重点实验室陕西西安710054

为了解煤化工业园区表层土壤中多氯萘(PCNs)的污染水平、空间分布特征和来源,建立了同位素稀释气相色谱-三重四极杆质谱的检测方法,对陕西某煤化工业园区表层土壤中的PCNs含量进行检测分析。结果表明,煤化工业园区表层土壤中PCNs质量浓... 详细信息

为了解煤化工业园区表层土壤中多氯萘(PCNs)的污染水平、空间分布特征和来源,建立了同位素稀释气相色谱-三重四极杆质谱的检测方法,对陕西某煤化工业园区表层土壤中的PCNs含量进行检测分析。结果表明,煤化工业园区表层土壤中PCNs质量浓度为0.358~1.349 ng/g,相对于2,3,7,8-四氯二苯并二噁英(PCDD/Fs)的毒性当量(TEQ)为3.000×10^(-4)~0.197 pg/g,与国内外各地区土壤PCNs相比,煤化工业园区土壤PCNs的浓度和毒性均处于中等水平。煤化工业园区土壤PCNs以低氯代为主,其中二氯萘和三氯萘占比高,分别为23.7%(质量分数,下同)~43.0%和41.7%~56.8%,焦化生产热过程为该煤化工业园区土壤PCNs污染的主要来源。

关键词：多氯萘土壤煤化工业园区来源

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多源传感器数据下基于注意力机制与长短期记忆网络的轴承故障诊断与寿命预测

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信息与控制 2024年第2期53卷 211-225页

作者：陈翔刘勤明胡家瑞上海理工大学管理学院上海200093

针对滚动轴承故障在噪声环境下诊断效果不佳的问题,提出了一种多源传感器数据下基于注意力机制与长短期记忆(long short-term memory,LSTM)网络的轴承故障诊断新方法。首先,将多源传感器采集的1维数据进行归一化处理,通过构建带AdaBN(Ad... 详细信息

针对滚动轴承故障在噪声环境下诊断效果不佳的问题,提出了一种多源传感器数据下基于注意力机制与长短期记忆(long short-term memory,LSTM)网络的轴承故障诊断新方法。首先,将多源传感器采集的1维数据进行归一化处理,通过构建带AdaBN(Adaptive Batch Normalization)技术的双通道孪生卷积网络提取有效特征并进行数据融合。其次,将融合数据输入具有同时考虑通道间关系和位置信息功能的改进1维CoordAtt(Coordinate Attention)中。再次,通过LSTM层提取时间特征,通过标签平滑正则化改进后的损失函数来评估诊断效果,使用新型优化器Adan进行优化。最后,将得到的诊断模型应用于测试集,输出故障类别诊断结果。将模型在不同测试集比例下进行诊断精度对比实验,判断出最佳比例为0.3,并在噪声环境下进行测试。实验结果表明,所提方法能更好地对抗噪声环境的影响。在C-MAPSS数据集上的实验结果验证了CoordAtt-LSTM模型在寿命预测中的有效性。

关键词：多源传感器数据注意力机制标签平滑正则化故障诊断寿命预测

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Defective/Doped Graphene-Based Materials as Cathodes for Metal-Air Batteries

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Energy & Environmental Materials 2022年第4期5卷 1103-1116页

作者： qinming Zhang Chengyi Wang Zhaojun Xie Zhen zhou School of Materials Science and Engineering Institute of New Energy Material ChemistryNankai UniversityTianjin 300350China Engineering Research Center of Advanced Functional Material Manufacturing of Ministry of Education School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001China

Graphene,as a proof-of-concept two-dimensional material,has proven to have excellent physical and chemical *** derivatives,such as defective or doped graphene,are also applied as catalytic materials for metal-air batteries(MABs).MABs have been recognized as possible candidates for new-generation energy storage systems due to their ultra-high theoretical energy *** far,graphene and its derivatives with optimized structures have been widely explored to improve the electrochemical performance in *** speaking,perfect graphene crystalline is inert for many catalytic processes,while defects and heteroatoms can endow graphene with high activity for many electrocatalytic *** this circumstance,recent progress is summarized for defective/doped graphene as air cathodes in aqueous or organic MABs,which are actually different electrochemical systems with distinct requirements for air ***,the relationship is clarified between graphene defects/doping and electrocatalytic mechanisms that can be the guidance for catalyst *** directions are also prospected for the development of graphene-based MAB cathodes.

关键词： defective/doped graphene electrocatalysts metal-air batteries OER ORR

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半规管阻塞术

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临床耳鼻咽喉头颈外科杂志 2024年第2期38卷 122-126页

作者：蔡沁明冷杨名孙宇华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科武汉430022

半规管阻塞术(semicircular canal occlusion,SCO)是一种广泛应用于治疗眩晕相关疾病的手术术式,主要用于治疗良性阵发性位置性眩晕、梅尼埃病、迷路瘘管与上半规管裂综合征等。本综述旨在全面总结SCO的发展演变,相关基础研究和临床应用... 详细信息

半规管阻塞术(semicircular canal occlusion,SCO)是一种广泛应用于治疗眩晕相关疾病的手术术式,主要用于治疗良性阵发性位置性眩晕、梅尼埃病、迷路瘘管与上半规管裂综合征等。本综述旨在全面总结SCO的发展演变,相关基础研究和临床应用,特别是近年来内镜技术在其中的应用,探讨其在眩晕外科领域中的应用价值。

关键词：半规管阻塞术眩晕梅尼埃病耳内镜手术

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