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微波辐射氧化法联合脱除煤中有机硫的研究

微波学报 2002年第2期18卷 80-84页

作者：赵景联张银元陈庆云傅清水西安交通大学西安710049 太原煤炭运销公司太原030002

研究了微波辐射冰醋酸和过氧化氢氧化法联合脱除原煤中有机硫的技术。采用单因子法考察了微波照射时间、微波照射功率、煤的粒度、煤与氧化剂的配比、冰醋酸与过氧化氢配制比等因素对脱硫率的影响 ,优选出了微波氧化联合法脱除原煤中有... 详细信息

研究了微波辐射冰醋酸和过氧化氢氧化法联合脱除原煤中有机硫的技术。采用单因子法考察了微波照射时间、微波照射功率、煤的粒度、煤与氧化剂的配比、冰醋酸与过氧化氢配制比等因素对脱硫率的影响 ,优选出了微波氧化联合法脱除原煤中有机硫的最佳工艺条件为 :微波功率为 85 0W ,照射时间为 2 0min ,煤与氧化剂的配比为 3g :5 0mL ,煤的粒度为d≤ 0 .2 3mm ,冰醋酸与过氧化氢的体积比为 1:1(摩尔比为 11.5 :38.5 ) ,脱硫率可达到6 0 .2 %。结果表明微波辐射下冰醋酸与过氧化氢氧化法是脱除原煤中有机硫的一种有效方法。

关键词：煤炭脱硫,微波辐射,氧化,洁净煤

混合式教学模式下“食品微生物学”“三环六阶”教学方法的探索与实践

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微生物学通报 2024年第4期51卷 1055-1066页

作者：王青云刘小波李文任佳丽付湘晋李婷林亲录中南林业科技大学食品科学与工程学院湖南长沙410004

为探讨在混合式教学模式下建立基础理论、实验技能与创新实践能力培养一体化的食品微生物学教学方法,本文结合食品微生物学的课程特点和以往教学中有待改进的问题,将混合式教学过程中的课前、课堂和课后“三环”教学与布鲁姆教育目标的... 详细信息

为探讨在混合式教学模式下建立基础理论、实验技能与创新实践能力培养一体化的食品微生物学教学方法,本文结合食品微生物学的课程特点和以往教学中有待改进的问题,将混合式教学过程中的课前、课堂和课后“三环”教学与布鲁姆教育目标的记忆、理解、应用、分析、评价和创造6个层次相结合,建立了“三环六阶”逐阶深入教学法,并采取了明确教学主线、开拓创新思维和加强课程思政教学等辅助举措来保障教学效果。“三环六阶”教学方法和辅助举措的实施,突出了学生在教学过程中的主体地位,提高了课堂教学效率,调动了学生自主学习理论知识和自觉开展实验研究的积极性,锻炼了学生的综合素质和创新实践能力。该教学方法为探索在网络信息化时代建设符合以成果为导向理念(outcome-based education,OBE)和新工科发展要求的理论、实践一体化的教学模式提供借鉴。

关键词：混合式教学食品微生物学教学实践

基于生物信息学分析DNASE1L3在肝细胞癌中表达及对预后的影响

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武汉大学学报（医学版） 2024年第8期45卷 939-945页

作者：符赞美蔡伟国龙清云卢伟武汉大学中南医院介入诊疗中心湖北武汉430071

目的:探究DNASE1L3在肝细胞癌中的表达情况以及对患者预后的影响,并通过生物信息学方法探索其潜在的影响途径。方法:基于TCGA、GSE14520和HPA数据库肝细胞癌数据分析DNASE1L3在正常和肿瘤组织中的表达差异。通过单因素及多因素COX回归... 详细信息

目的:探究DNASE1L3在肝细胞癌中的表达情况以及对患者预后的影响,并通过生物信息学方法探索其潜在的影响途径。方法:基于TCGA、GSE14520和HPA数据库肝细胞癌数据分析DNASE1L3在正常和肿瘤组织中的表达差异。通过单因素及多因素COX回归分析及Kaplan-Meier生存分析探究DNASE1L3对肝细胞癌预后影响。基于GSE6764数据分析DNASE1L3在肿瘤不同进展时期的表达变化。使用ESTIMATE算法分析DNASE1L3与免疫和基质细胞浸润及肿瘤纯度的关系。使用Limma包对GSVA富集结果进行差异分析,并通过GeneMINIA在线工具挖掘DNASE1L3共表达基因。结果:DNASE1L3在肿瘤组织中表达减低,并且与患者预后不良相关。DNASE1L3在较大的肿瘤、较高的甲胎蛋白(AFP)水平和较晚期的肿瘤组织中的表达水平减低,并且随着肿瘤进展逐步减低。DNASE1L3低表达肿瘤组织中的免疫基质细胞丰度较低,而肿瘤纯度较高,数种免疫检查点基因表达也会增高。富集差异分析及共表达基因富集发现DNASE1L3主要涉及肝细胞癌的DNA损伤修复、细胞周期、脂肪酸代谢、糖酵解等过程,并涉及了免疫细胞浸润的调节过程。结论:DNASE1L3在肝细胞癌组织中低表达,影响肿瘤进展和肿瘤免疫过程,是一种有前途的预后分子标志物及治疗靶点,需要进一步地探索和研究。

关键词： DNASE1L3 肝细胞癌生物信息学分析肿瘤免疫

A two-step three dimensional marine magnetotelluric inversion method with considering rugged seafloor topography:Synthetic studies

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Science China Earth Sciences 2023年第4期66卷 765-780页

作者： Pengfei LIANG qingyun DI Changmin fu Ruo WANG Qihui ZHEN Zhe YUN Jiagang ZHANG CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Exploration Surveying Institute of Baogang Group Baotou 014010China

Inversion of magnetotelluric(MT) responses has been used to explore the electrical conductivity distribution of the Earth’s interior. In three-dimensional(3-D) inversions, it is significant to use a good initial model, because final model obtained by most 3-D inversion methods is influenced by the initial model. Although uniform initial models are widely used in 3-D inversions, one-dimensional(1-D) initial models are alternatives, which could more appropriately represent the actual conductivity variations in the Earth’s interior. This study presents a two-step 3-D inversion method, especially for marine cases. This inversion method first concentrates on obtaining a 1-D initial model and then inverts for 3-D conductivity structures with it, in both of which the 3-D topography is carefully taken into consideration. This method was tested by synthetic models of different topography variations(depression-shaped, smoothly varying, channel-shaped and square-shaped plateau topography) and of heterogeneous layers with different checkerboard-type anomalies(sharp or smooth lateral conductivity variations) embedded in1-D model of depth-dependent conductivity. The comparisons were done about obtaining an initial model by the proposed method and that inverted from the corrected responses. The results of 3-D inversions by using the method of this study were also compared to that with different uniform initial models. Results of synthetic tests and comparisons were discussed by using directional information of newly introduced model-vector parameters. The performance and validity of this method was *** also revealed that some of the newly introduced model-vector parameters could be used to show the convergence of inversions and help to select inverse model.

关键词： Magnetotelluric Integral equation Topography Inversion Convergence

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翻转课堂在农学本科遗传学教学中的应用

河南科技学院学报（社会科学版） 2018年第12期38卷 70-72页

作者：进茜宁孙润润李小军董娜付庆云李成奇河南科技学院生命科技学院河南新乡453003

"翻转课堂"从2007年发展至今,已经引发了全球范围内的教学改革热潮,在很多学科中应用实践并且教学成果显著。遗传学作为生命科学专业中十分重要的一门理论学科,因其内容的系统性和严谨性,以及生命科学近年的快速发展,传统教学存在课时... 详细信息

"翻转课堂"从2007年发展至今,已经引发了全球范围内的教学改革热潮,在很多学科中应用实践并且教学成果显著。遗传学作为生命科学专业中十分重要的一门理论学科,因其内容的系统性和严谨性,以及生命科学近年的快速发展,传统教学存在课时安排与教学内容冲突、学生学习积极性不高、考核评价方式单一等问题。引入翻转课堂,通过制作多媒体微视频、建立网络教学平台、课内小组汇报和随堂测验等环节,提高遗传学的教学质量。

关键词：翻转课堂农学遗传学

小麦杂交后代衡9966与亲本及近缘品种抗旱性比较

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种子 2019年第7期38卷 30-33页

作者：时丽冉崔兴国白丽荣赵明辉李慧敏孙利付庆云王梅菊李扬衡水学院生命科学系河北衡水053000 河北省农作物抗旱研究重点实验室河北省农林科学院旱作农业研究所河北衡水053000 深州市种业有限公司河北深州053800

通过水培方法培养小麦杂交后代衡9966与亲本及近缘品种,在幼苗期通过PEG-6000控制水分吸收进行干旱胁迫。15d后测定幼苗鲜重、根冠比、叶绿素含量、过氧化产物丙二醛含量和脯氨酸含量,同时测定保护酶系统过氧化氢酶、过氧化物酶及超氧... 详细信息

通过水培方法培养小麦杂交后代衡9966与亲本及近缘品种,在幼苗期通过PEG-6000控制水分吸收进行干旱胁迫。15d后测定幼苗鲜重、根冠比、叶绿素含量、过氧化产物丙二醛含量和脯氨酸含量,同时测定保护酶系统过氧化氢酶、过氧化物酶及超氧化物歧化酶活性,探究各品种抗旱性能的差异。结果表明,干旱胁迫下4个品种的鲜重下降、叶绿素含量均有所提升,且根冠比增大。丙二醛含量上升,脯氨酸含量显著升高。3种抗氧化酶活性变化不一致,其中超氧化物歧化酶活性均增大,而过氧化氢酶活性均降低,过氧化物酶活性除衡9966升高外,其它3个品种均降低。通过隶属函数计算分析,4个品种中,杂交后代衡9966隶属度最高,抗旱性最强。

关键词：杂交后代抗旱性丙二醛含量脯氨酸含量抗氧化酶隶属函数

A viscosity model of waxy-hydrate slurry

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Petroleum 2021年第4期7卷 496-501页

作者： Hongju Chen Shunkang fu Shuai Chai qingyun Liao Bohui Shi Jing Gong State Key Laboratory of Natural Gas Hydrate/National Engineering Laboratory for Pipeline Safety/MOE Key Laboratory of Petroleum Engineering/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China Key Lab of Deepwater Engineering CNOOC Research InstitutePR China Sinopec Engineering Incorporation Beijing100101PR China

With the exploration and development of oil and gas fileds going towards into deep-water fields,high waxy reservoir has much more flow assurance issues of encourage complex solids depositions in the transportation system,especially hydrates and *** risk management such as hydrate slurry technology to control hydrate blockage,has much more economic and technical advantages,comparing to the traditional *** is significant to understand the viscosity of the waxy-hydrate slurry using hydrate slurry technology in high wax content *** this work,based on a simplification idea by coupling the wax content effect into the viscosity,volume and density of the water-in-waxy oil emulsion,a new viscosity model of waxy-hydrate slurry is established according to the Einstein effective medium theory,based on the experiments carried out in a high-pressure rheology system with different wax contents ranging from 0.5 wt%~2.0 wt%.The effect of the complex aggregate coupling wax-hydrate-water is considered by function the non-Newtonian coefficient by four dimensionless ***-fitting results within an improved deviation of±15%indicate the feasibility of this method is *** work can provide a valuable reference for the application of hydrate slurry technology in deep-water fields with high wax content reservoir.

关键词： Waxy-hydrate slurry Viscosity Flow assurance

Insight into skywave theory and breakthrough applications in resource exploration

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National Science Review 2021年第12期8卷 55-62页

作者： qingyun Di Changmin fu Guoqiang Xue Miaoyue Wang Zhiguo An Ruo Wang Zhongxing Wang Da Lei Xianjun Zhuo CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of Sciences Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of Sciences Innovation Academy for Earth Science Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences China Ship Research and Development Academy

Skywave refers to the electromagnetic wave reflected or refracted from the ionosphere and propagated in the form of a guided wave between the ionosphere and the Earth’s *** the skywave can propagate over large distances,it has been widely used in long-distance *** paper explores and demonstrates the feasibility of skywave for deep resource and energy exploration at depths of up to 10 *** and technical advancements were accomplished in furthering skywave applications.A new solution method based on Green’s function has been developed to study skywave propagation in a fully coupled lithosphere-air-ionosphere full space *** the first time,the model allows one to study skywave distribution characteristics in the lithosphere containing inhomogeneity such as ore deposits or oil and gas *** model also lays a foundation for skywave data processing and *** a parallel line,we have developed a multi-channel,broadband,low-noise,portable data acquisition system suitable for receiving skywave *** the skywave field excited by a high-power fixed source located in central China,actual field surveys have been carried out in some areas in China including the Biyang depression of Henan *** initial results appear encouraging—the interpreted resistivity models prove to be consistent with those of seismic exploration and known geological information,and the exploration cost is only～1/4 to 1/10 that of seismic *** initial successful applications of the skywave theory lay a solid foundation for further verification of the new method.

关键词： skywave theory instrument development electromagnetic exploration deep resources

科尔沁沙坨地—草甸地冻融期地温与最大冻结深度的变化规律

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水土保持通报 2016年第6期36卷 84-91页

作者：岳翠桐刘小燕刘廷玺付青云曹文梅刘巧玲内蒙古农业大学水利与土木建筑工程学院内蒙古呼和浩特010018

[目的]探究科尔沁沙坨地—草甸地土壤温度与冻结深度的变化规律,为合理指导该区农工生产和建设提供支持。[方法]基于2007—2015年冻融期人工观测数据,对比分析科尔沁沙坨地与草甸地冻融期多年土壤温度与最大冻结深度变化规律。[结果]研... 详细信息

[目的]探究科尔沁沙坨地—草甸地土壤温度与冻结深度的变化规律,为合理指导该区农工生产和建设提供支持。[方法]基于2007—2015年冻融期人工观测数据,对比分析科尔沁沙坨地与草甸地冻融期多年土壤温度与最大冻结深度变化规律。[结果]研究区100cm处沙坨地与草甸地多年土壤温度的标准差变化规律基本一致,草甸地要小于沙坨地,但融解后期由于草甸地融解期历时较长,其标准差大于沙坨地;同时考虑土壤温度和土壤水分对最大冻结深度的影响时,沙坨地在200cm处和草甸地在140cm处的R2分别为0.959和0.788。[结论]研究区内沙坨地先冻结与先融解,沙坨地最大冻结深度较草甸地深,同时考虑土壤温度与土壤水分的最大冻结深度的拟合优度最好,沙坨地与草甸地中最大冻结深度与土壤温度和土壤水分均呈负相关关系。

关键词：科尔沁沙坨地—草甸地季节冻土区冻融期最大冻结深度