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外泌体治疗骨科疾病的研究进展

中国临床研究 2024年第2期37卷 290-294,299页

作者：柯义兵阳庆林秦庆庆王一坤郭浩然王勇平兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院骨科甘肃兰州730000

外泌体是直径为30~200 nm的细胞外囊泡的一种亚型,是几乎存在于所有细胞中的分泌性囊泡,在其表面或管腔内携带大量分子,如蛋白质、脂类和RNA。外泌体在细胞间信号传递过程中发挥重要作用,此外,外泌体还含有许多生长因子,这些生长因子与... 详细信息

外泌体是直径为30~200 nm的细胞外囊泡的一种亚型,是几乎存在于所有细胞中的分泌性囊泡,在其表面或管腔内携带大量分子,如蛋白质、脂类和RNA。外泌体在细胞间信号传递过程中发挥重要作用,此外,外泌体还含有许多生长因子,这些生长因子与改善受损组织的愈合有关。近年来研究表明,外泌体可以通过刺激再生、减轻炎症反应等方式对骨关节炎、肌肉组织损伤、骨折、骨质疏松、脊髓损伤、椎间盘退变等骨科疾病有潜在的治疗作用,本文对该方面的研究进展作一综述。

关键词：外泌体骨关节炎肌肉损伤骨折骨质疏松脊髓损伤椎间盘退变

Indium-based electrocatalysts for CO_(2) reduction to C1 products

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Chinese Chemical Letters 2024年第6期35卷 134-145页

作者： qin Cheng Ming Huang qingqing Ye Bangwei Deng Fan Dong Research Center for Carbon-Neutral Environmental&Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313000China Suzhou Industrial Technology Research Institute of Zhejiang University Suzhou 215163China

Electrocatalytic CO_(2) reduction at mild conditions is a promising strategy to transform greenhouse gases into fuels or value-added chemicals to solve the increasingly serious environmental and energy *** most crucial factor in determining the CO_(2) reduction performance is to develop efficient electrocatalysts with high selectivity and *** the various electrocatalysts,indium-based catalysts have attracted extensive attention due to their non-toxicity,low cost,and high formic acid/formate *** this work,we comprehensively review the recent development and research progress of indium-based electrocatalysts for CO_(2)*** reaction mechanism,reaction pathways,structure-activity relationship,and strategies to enhance the activity of CO_(2)RR on indium-based catalysts have also been briefly presented and ***,the existing challenges and future developments for indium-based highperformance catalysts for CO_(2)RR are proposed.

关键词： Electrocatalytic CO_(2) reduction In-based catalysts Formate Reaction mechanism Structure-activity relationship

阿贝西利联合非甾体类芳香化酶抑制剂一线治疗HR+/HER2-绝经后晚期乳腺癌患者的效果观察

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科技与健康 2024年第15期3卷 113-116页

作者：陈燕红王玮刘玉娟覃清清黄江昌玉林市红十字会医院广西玉林537000 广西医科大学广西南宁530021

探讨针对激素受体阳性/人类表皮生长因子受体2阴性(HR+/HER2-)绝经后晚期乳腺癌患者应用阿贝西利联合非甾体类芳香化酶抑制剂一线治疗的效果。以玉林市红十字会医院在2022年1月—2023年4月收治的92例HR+/HER2-绝经后晚期乳腺癌患者为研... 详细信息

探讨针对激素受体阳性/人类表皮生长因子受体2阴性(HR+/HER2-)绝经后晚期乳腺癌患者应用阿贝西利联合非甾体类芳香化酶抑制剂一线治疗的效果。以玉林市红十字会医院在2022年1月—2023年4月收治的92例HR+/HER2-绝经后晚期乳腺癌患者为研究对象,采用随机数字表法将其分为对照组(n=46,应用非甾体类芳香化酶抑制剂一线治疗)和研究组(n=46,在对照组基础上应用阿贝西利治疗),对比两组疗效、不良反应发生率、生活质量。研究发现,针对HR+/HER2-绝经后晚期乳腺癌患者应用阿贝西利联合非甾体类芳香化酶抑制剂一线治疗,疗效有所提高,不良反应未增加,安全性较高,患者生活质量显著提高,值得推广。

关键词：激素受体阳性晚期乳腺癌阿贝西利人类表皮生长因子受体2阴性

OsRFPH2-10,a RING-H2 Finger E3 Ubiquitin Ligase,Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection

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Molecular Plant 2014年第6期7卷 1057-1060页

作者： Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li qingqing qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li The State Key Laboratory of Protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Peking-Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101People’s Republic of China Department of Molecular Genetics and Center for RNA Biology The Ohio State UniversityColumbusOH 43210USA

Dear Editor,Rice dwarf virus(RDV),a member of the Phytoreoviurs genus,is transmitted to rice(Oryza sativa)plants by leaf-hopper(Nephotettix cincticeps)in a propagative *** by RDV results in severe stunting growth pheno-types and a dramatic reduction in grain *** genome of RDV is composed of 12-segmented double-stranded RNAs(S1-S12 based on their migration rates in agarose gel electro-phoresis).The 12 segments encode seven structural proteins(P1,P2,P3,P5,P7,P8,and P9 as the products of Sl,S2,S3,S5,S7,S8,and S9,respectively)and five nonstructural proteins(Pns4,Pns6,Pnsl0,Pns11,and Pns12 as the products of S4,S6,S10,S11,and S12,respectively).The outer capsid protein P2 is essential for RDV infection of insects and thus influences transmission of RDV by the insect vector(Omura et al.,1998;Zhou et al.,2007).P2 also contributes to the dwarf phenotype of infected rice by interfering with gibberellic acid synthesis(Zhu et al.,2005).When RDV-infected rice plants were main-tained via vegetative propagation for several years without insect transmission,they regained normal growth height due to loss of RDV P2 and Pnsl0 proteins(Pu et al.,2011).

关键词： P2 PROTEIN PHYTOREOVIRUS STRESS CELLS

Impact of organic interlayer anions on the CO2 adsorption performance of Mg-Al layered double hydroxides derived mixed oxides

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Journal of Energy Chemistry 2017年第3期26卷 346-353页

作者： qingqing qin Junya Wang Tuantuan Zhou Qianwen Zheng Liang Huang Yu Zhang Peng Lu Ahmad Umar Benoit Louis Qiang Wang College of Environmental Science and Engineering Beijing Forestry University Faculty of Environmental Science and Engineering Kunming University of Science and Technology Department of Chemistry College of Science and ArtsNajran University Promising Centre for Sensors and Electronic Devices(PCSED) Najran University Universitéde Strasbourg CNRSCHIMIE

Herein we report a systematical investigation on the promoting effect of the carbon chain length of the intercalated carboxylic anions on the COcapture performance of Mg-Al layer double hydroxides（LDHs）.A series of organo-LDHs were successfully synthesized via co-precipitation and calcination-rehydration methods. All as-prepared samples were characterized by many techniques including XRD, ATR-FTIR, BET,and TGA. The XRD and ATR-FTIR studies indicated that organic anions were successfully intercalated into LDHs. The influence of some important parameters such as calcination temperature, adsorption temperature, and coating with（Li-Na-K）NOmolten salt was investigated. The results exhibited that when the number of carbon is greater than 10, the COcapture capacity steadily increased with the increase in carbon number. After coating with 55 mol%（Li-Na-K）NOmolten salt, the COuptake of LDH-C16 sample with high Mg/Al ratios can be increased up to 3.25 mmol/g. The COadsorption/desorption cycling stability was also studied using temperature swing adsorption, which showed a stable COcapture performance even after 22 cycles. Considering its high COcapture capacity and good cycling stability, this novel COadsorbent is very promising in the sorption-enhanced water gas shift（SEWGS） processes.

关键词： Pre-combustion CO2 capture capacity Organo-LDHs Carboxylates Cycling stability Molten salts coating

A Brassica carinata pan-genome platform for Brassica crop improvement

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Plant Communications 2024年第1期5卷 20-23页

作者： Yan Niu qingqing Liu Zhesi He Rosy Raman Hao Wang Xinxin Long Han qin Harsh Raman Isobel A.P.Parkin Ian Bancroft Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina Department of Biology University of YorkHeslingtonYork YO105DDUK NSW Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNSW 2650Australia Agriculture and Agri-Food Canada Saskatoon Research and Development CentreSaskatoonSKCanada

Dear Editor,Brassica carinata(Bc Bc Cc Cc),an important agricultural crop cultivated for the edible oil,leafy vegetable,high-value protein stockfeed,and biofuel markets,contains favorable genetic variation that can be exploited to develop climate-resilient and wateruse-efficient Brassica crops(Seepaul et al.,2021).Although several quantitative trait loci(QTLs)for flowering time,seed quality traits,and pod shatter resistance(PSR)have been identified based on high-density genetic linkage maps(Zou et al.,2014;Raman et al.,2017;Zhang et al.,2017),this information alone is insufficient for practical genetic improvement and breeding applications.

关键词： breeding crops cultivated

Constraints on the primordial curvature power spectrum by pulsar timing array data:a polynomial parameterization approach

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Communications in Theoretical Physics 2024年第1期76卷 96-104页

作者： qin Fei School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003China

The recent stochastic signal observed jointly by NANOGrav,parkes pulsar timing array,European pulsar timing array,and Chinese pulsar timing array can be accounted for by scalarinduced gravitational waves(SIGWs).The source of the SIGWs is from the primordial curvature perturbations,and the main contribution to the SIGWs is from the peak of the primordial curvature power *** effectively model this peak,we apply the Taylor expansion to parameterize *** the Taylor expansion parameterization,we apply Bayesian methods to constrain the primordial curvature power spectrum based on the NANOGrav 15 year data *** constraint on the primordial curvature power spectrum possesses a degree of generality,as the Taylor expansion can effectively approximate a wide range of function profiles.

关键词： pulsar timing array scalar-induced gravitational waves inflation

The occurrence,inheritance,and segregation of complex genomic structural variation in synthetic Brassica napus

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The Crop Journal 2024年第2期12卷 515-528页

作者： Dandan Hu Jin Lu Wenwen Li Yinghui Yang Junxiong Xu Han qin Hao Wang Yan Niu Huaiqi Zhang qingqing Liu Xiangxiang He Annaliese S.Mason JChris Pires Zhiyong Xiong Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Agronomy Henan Agricultural UniversityZhengzhou 450002HenanChina Key Laboratory of Herbage and Endemic Crop Biotechnology Inner Mongolia UniversityHohhot 010070Inner MongoliaChina Plant Breeding Department University of BonnBonn 53115Germany Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCO 80523USA

"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop *** synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding ***,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome *** observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger ***,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic ***,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for *** results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.

关键词： Allopolyploid Large Genome structural variation Linkage mapping Synthetic polyploids Inheritance and segregation

腐殖质来源、特征及其与土壤中重金属作用机制的研究进展

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环境化学 2023年第6期42卷 1899-1910页

作者：秦晴晴张琢宋子文中国地质大学(北京)土地科学技术学院北京100083 自然资源部土地整治重点实验室北京100035

近年来,土壤重金属污染成为全球性的环境问题,给人类的生产、生活带来了极大的危害.腐殖质(HS)作为土壤有机质的主体部分,含有羧基、酚羟基等众多官能团,能够通过络合、吸附、氧化还原等作用影响重金属离子的活性和迁移转化规律.为了更... 详细信息

近年来,土壤重金属污染成为全球性的环境问题,给人类的生产、生活带来了极大的危害.腐殖质(HS)作为土壤有机质的主体部分,含有羧基、酚羟基等众多官能团,能够通过络合、吸附、氧化还原等作用影响重金属离子的活性和迁移转化规律.为了更好地了解HS和HS与土壤重金属之间的相互作用关系,本文对HS的来源、分类、化学特征做了详细的概述,重点介绍了HS与土壤中重金属之间的相互作用及其影响因素,并分析了HS对重金属活性的影响,最后提出了HS在土壤重金属迁移转化中存在的问题与展望.

关键词：腐殖质化学特征重金属相互作用

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