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Facile intercalation of alkali ions in WO_(3)for modulated electronic and optical properties:Implications for artificial synapses and chromogenic application

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 149-160页

作者： Changmeng Huan Zihan Lu Silin Tang Yongqing cai qingqing Ke School of Microelectronics Science and Technology Sun Yat-sen UniversityZhuhai 519082China Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and Systems Sun Yat-sen UniversityZhuhai 519082China Institute of Applied Physics and Materials Engineering University of MacaoTaipaMacao 999078China

Tungsten oxides(WO_(3))are widely recognized as multifunctional systems owing to the existence of rich *** diverse phases exhibit distinct octahedra-tilting patterns,generating substantial tunnels that are ideally suited for ***,a quantitative comprehension regarding the impact of distinct phases on the kinetics of intercalated conducting ions remains ***,we employ first-principles calculations to explore the spatial and orientational correlations of ion transport inγ-and h-WO_(3),shedding light on the relationship between diffusion barriers and the size of the conducting *** findings reveal that different types and concentrations of alkali-metals induce distinct and continuous lattice distortions in WO_(3)***,γ-WO_(3)is more appropriate to accommodate Li+ions,exhibiting a diffusion barrier and coefficient of 0.25 eV and 9.31×10^(-8)cm^(2)s^(-1),***,h-WO_(3)features unidirectional and sizeable tunnels that facilitate the transport of K+ions with an even lower barrier and a high coefficient of 0.11 e V and 2.12×10^(-5)cm^(2)s^(-1),***,the introduction of alkali-metal into WO_(3)tunnels tends to introduce n-type conductivity by contributing s-electrons to the unoccupied W 5d states,resulting in enhanced conductivity and tunable electronic *** alkali metals in WO_(3)tunnels are prone to charge transfer,forming small polaronic states and modulating the light absorption in the visible and nearinfrared *** tunable electronic and optical properties,combined with the high diffusion coefficient,underscore the potential of WO_(3)in applications such as artificial synapses and chromogenic devices.

关键词： WO_(3)polymorphs ion insertion kinetic activity tunable electronic and optical properties iontronics

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Prediction of multiple drug resistance phenotype in cancer cell lines using gene expression profiles and phylogenetic trees

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Chinese Science Bulletin 2010年第33期55卷 3778-3786页

作者： LIU XmYi LI ZuoFeng WEN JingRan cai qingqing XU Ye ZHANG XiaoYan Department of Bioinformatics School of Life Sciences and Technology Tongji University Shanghai 200092 China Shanghai Center for Bioinformation Technology Shanghai 200235 China Department of Colorectal Surgery Cancer Hospital Fudan University Shanghai 200032 China

When microarray gene expression data are used to predict multiple drug resistance(MDR)phenotypes for anticancer drugs,the normalization strategy and the quality of the selected signature genes are usually the main causes of inconsistency among different experiments.A stable statistical drug response prediction model is urgently required in *** this study,the microarray gene expression data of multiple cancer cell lines with MDR was *** each probe-set,the expression value was defined as present/absent(1/0)and was classified into a gene set defined with protein domain organization(PDO).After employing the gene content method of phylogenetic analysis,a phylogenetic model(cell tree)for MDR phenotype prediction was built at the PDO gene set *** results indicate that classification of cancer cell lines is predominantly affected by both the histopa-thological features and the MDR phenotype(paclitaxel and vinblastine).When applying this model to predict the MDR phenotype of independent samples,the phylogenetic model performs better than signature gene *** the utility of our procedure is limited due to sample heterogeneity,it still has potential application in MDR research,especially for hematological tumors or established cell lines.

关键词：肿瘤细胞株基因表达谱多药耐药模型预测表型进化抗癌药物系统进化树基因表达数据

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Combination of anti-PD-1 antibody with P-GEMOX as apotentially effective immunochemotherapy for advancednatural killer/T cell lymphoma

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Signal Transduction and Targeted Therapy 2021年第1期6卷 184-192页

作者： Jun cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li qingqing cai State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Lymphoma and Hematology Hunan Cancer HospitalChangsha 410013P.R.China Department of Lymphoma and Hematology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013P.R.China

Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available ***,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced *** patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 *** death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)*** were assessed using ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)FDG-PET)and computed tomography or magnetic resonance *** patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete *** most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and *** produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy *** in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to *** conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced ***-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.

关键词： alterations killer lymphoma

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以临床病例为基础的团队角色扮演教学模式在肿瘤内科见习中的应用

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白血病．淋巴瘤 2024年第4期33卷 228-232页

作者：邹琪华王家辉王金妮夏奕邹碧君王淑珍张庆龙蔡清清华南恶性肿瘤防治全国重点实验室、广东省恶性肿瘤临床医学研究中心、中山大学肿瘤防治中心内科广州510060 华南恶性肿瘤防治全国重点实验室、广东省恶性肿瘤临床医学研究中心、中山大学肿瘤防治中心教学与研究生科广州510060 中山大学中山医学院广州510080

目的探讨以临床病例为基础的团队角色扮演的教学模式在肿瘤内科见习中的效果。方法单中心队列研究。纳入2023年2月至5月在中山大学肿瘤防治中心肿瘤内科见习的192名临床医学(五年制)大四本科生,通过随机数字表法分为试验组(96名)和对照... 详细信息

目的探讨以临床病例为基础的团队角色扮演的教学模式在肿瘤内科见习中的效果。方法单中心队列研究。纳入2023年2月至5月在中山大学肿瘤防治中心肿瘤内科见习的192名临床医学(五年制)大四本科生,通过随机数字表法分为试验组(96名)和对照组(96名)。试验组采用以临床病例为基础的团队角色扮演的新型教学模式;对照组采用传统教学模式。比较两组学生的技能考核成绩以及对自己、他人、指导老师和课堂形式的评分结果。结果192名学生中位年龄为22岁(范围:21~26岁),男性多于女性[56.25%(108/192)比43.75%(84/192)];试验组及对照组学生性别及年龄差异均无统计学意义(均P>0.05)。整体学生技能成绩为(83±6)分,试验组的技能成绩高于对照组[(86±6)分比(81±4)分,t=5.66,P0.05)。结论以临床病例为基础的团队角色扮演教学模式可提升临床见习的教学效果,值得进一步推广。

关键词：临床见习角色扮演教育,医学,本科以临床病例为基础

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中医药联合音乐疗法对老年晚期肠道肿瘤患者临床疗效及其机制探讨

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辽宁中医药大学学报 2024年第8期26卷 217-220页

作者：范春来蔡青青季晓杭邢科徐广飞南通市中医院江苏南通226001

目的分析中医药联合音乐疗法对老年晚期肠道肿瘤的临床疗效及其机制。方法选取2021年1月—2022年3月南通市中医院老年科收治的90例老年晚期肠道肿瘤患者为研究对象,随机分为治疗组A(中药汤剂口服+音乐疗法+姑息治疗)、治疗组B(中药汤剂... 详细信息

目的分析中医药联合音乐疗法对老年晚期肠道肿瘤的临床疗效及其机制。方法选取2021年1月—2022年3月南通市中医院老年科收治的90例老年晚期肠道肿瘤患者为研究对象,随机分为治疗组A(中药汤剂口服+音乐疗法+姑息治疗)、治疗组B(中药汤剂口服+姑息治疗)、对照组(姑息治疗)各30例,对比3组疗效、治疗前后负性情绪[焦虑自评量表(SAS)、抑郁自评量表(SDS)]、炎症反应[中性粒细胞与淋巴细胞比值(NLR)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30 V3.0中文版)、匹茨堡睡眠质量指数(PSQI)、不良反应。结果治疗组A总有效率90.00%高于对照组66.66%(P0.05);治疗后治疗组A的SAS评分、SDS评分低于治疗组B和对照组(P0.05)。结论中医药联合音乐疗法对老年晚期肠道肿瘤患者有较好临床疗效,其机制可能与下调炎症因子有关,利于减轻焦虑抑郁情绪,提高生命质量及睡眠。

关键词：中医药音乐疗法老年肠道肿瘤临床疗效机制

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Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma

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Cancer Biology & Medicine 2021年第3期18卷 833-840页

作者： Meiting Chen Zhao Wang Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan Xiaoqian Li Zhiming Li qingqing cai He Huang Tongyu Lin Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Senior Ward/PhaseⅠClinical Trial Ward Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China

Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt ***:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer *** studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle ***-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based ***-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC ***:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,*** grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,*** observed 4 cases(3.3%)of septic shock after *** treatment-related deaths occurred from severe ***:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens.

关键词： Sporadic Burkitt lymphoma modified chemotherapy toxicity R-CODOX-M/IVAC adults

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Residual fluoride self-activated effect enabling upgraded utilization of recycled graphite anode

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Journal of Energy Chemistry 2024年第6期93卷 24-31,I0002页

作者： Shuzhe Yang qingqing Gao Yukun Li Hongwei cai Xiaodan Li Gaoxing Sun Shuxin Zhuang Yujin Tong Hao Luo Mi Lu School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina Faculty of Physics University of Duisburg-EssenDuisburg D-47057Germany

Recycling graphite anode from spent lithium-ion batteries(SLIBs)is regarded as a crucial approach to promoting sustainable energy storage ***,the recycled graphite(RG)generally presents degraded structure and ***,the residual fluoride self-activated effect is proposed for the upgraded utilization of *** and low-energy water immersion treatment not only widens the interlayer spacing,but also retains appropriate fluoride on the surface of *** analysis and experiments demonstrate that the residual fluoride can optimize Li~+migration and deposition kinetics,resulting in better Li~+intercalation/deintercalation in the interlayer and more stable Li metal plating/stripping on the surface of RG,As a result,the designed LFP||RG full cells achieve ultrahigh reversibility(~100%Coulombic efficiency),high capacity retention(67%after 200 cycles,0.85 N/P ratio),and commendable adaptability(stable cycling without short-circuiting,0.15 N/P ratio).The energy density is improved from 334 Wh kg^(-1)of 1.1 N/P ratio to 367 Wh kg^(-1)of 0.85 N/P ratio(total mass based on cathode and anode).The exploration of RG by residual fluoride self-activated effect achieves upgraded utilization beyond fresh commercial graphite and highlights a new strategy for efficient reuse of SLIBs.

关键词： Spent lithium-ion batteries Recycled graphite anode Fluoride Self-activated effect Upgraded utilization

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Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma

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Blood Science 2023年第4期5卷 249-257页

作者： Ning Su Yu Fang Xu Chen Xiaoqin Chen Zhongjun Xia Huiqiang Huang Yi Xia Panpan Liu Xiaopeng Tian qingqing cai Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Department of Oncology Guangzhou Chest HospitalGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

T-cell lymphoblastic lymphoma(T-LBL)is a highly aggressive non-Hodgkin lymphoma with a poor prognosis.P21-activated kinase(PAK)is a component of the gene expression-based classifier that can predict the prognosis of ***,the role of PAK in T-LBL progression and survival remains poorly ***,we found that the expression of PAK1 was significantly higher in T-LBL cell lines(Jurkat,SUP-T1,and CCRF-CEM)compared to the human T-lymphoid cell ***,PAK2 mRNA level of 32 relapsed T-LBL patients was significantly higher than that of 37 cases without relapse(P=.012).T-LBL patients with high PAK1 and PAK2 expression had significantly shorter median RFS than those with low PAK1 and PAK2 expression(PAK1,P=.028;PAK2,P=.027;PAK1/2,P=.032).PAK inhibitors,PF3758309(PF)and FRAX597,could suppress the proliferation of T-LBL cells by blocking the G1/S cell cycle phase ***,PF could enhance the chemosensitivity to doxorubicin in vitro and in ***,through western blotting and RNA sequencing,we identified that PF could inhibit the phosphorylation of PAK1/2 and downregulate the expression of cyclin D1,NF-κB and cell adhesion signaling pathways in T-LBL cell *** findings suggest that PAK might be associated with T-LBL recurrence and further found that PAK inhibitors could suppress proliferation and enhance chemosensitivity of T-LBL cells treated with ***,our present study underscores the potential therapeutic effect of inhibiting PAK in T-LBL therapy.

关键词： P21-activated kinase PAK inhibitor Proliferation Relapse T-cell lymphoblastic lymphoma

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Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma

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Blood Science 2022年第3期4卷 155-160页

作者： Qihua Zou Shuyun Ma Xiaopeng Tian qingqing cai Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060P.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China

Adult T-cell lymphoblastic lymphoma(T-LBL)is a rare and aggressive subtype of non-Hodgkin’s lymphoma that differs from pediatric T-LBL and has a worse *** to its rarity,little is known about the genetic and molecular characteristics,optimal treatment modalities,and prognostic factors of adult ***,we summarized the existing studies to comprehensively discuss the above issues in this *** mutations of NOTCH1/FBXW7,PTEN,RAS,and KMT2D,together with abnormal activation of signaling pathways,such as the JAK-STAT signaling pathway were *** also discussed the therapeutic *** diagnosed,adult T-LBL patients should receive intensive or pediatric acute lymphoblastic leukemia regimen and central nervous system prophylaxis as soon as possible,and cranial radiation-free protocols are *** radiotherapy improves clinical outcomes,but adverse events are of *** stem cell transplantation may be considered for adult T-LBL patients with high-risk factors or those with relapsed/refractory ***,several novel prognostic models have been constructed,such as the 5-miRNAs-based classifier,11-gene-based classifier,and 4-CpG-based classifier,which have presented significant prognostic value in adult T-LBL.

关键词： Genetic features Prognostic models T-cell lymphoblastic lymphoma Therapeutic modalities

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Experimental and theoretical analysis of loading characteristics of electret fi lter media for charged particles

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PARTICUOLOGY 2024年第10期93卷 87-98页

作者： cai, Yiqi cai, Rongrong Zhang, Lizhi South China Univ Technol Sch Chem & Chem Engn Key Lab Enhanced Heat Transfer & Energy Conservat Educ Minist Guangzhou 510640 Peoples R China South China Univ Technol State Key Lab Subtrop Bldg Sci Guangzhou 510640 Peoples R China

The degradation of filtration performance in electret filter media during usage poses a significant challenge. Pre-charging of aerosols has been identified as an effective method to mitigate this issue. However, the effects of particle charging characteristics on the loading characteristics of electret filters still need a comprehensive understanding. In this study, a needle-cylinder corona charger was employed to pre-charge aerosols, and the particle charge state was determined by multiphysics simulation. The effects of particle charge polarity and charge quantity on the loading performance of the electret filter were quantitatively investigated. The results showed that the particle charge polarity had a negligible impact on the loading performance under the condition of the equivalent particle charge quantity. In addition, the charged particles effectively improved the efficiency degradation during the loading process of electret media, with higher charge quantities resulting in more pronounced improvements. The electrostatic attenuation factor showed a negative exponential correlation with the particle charge quantity. This was attributed to the uneven particle deposition on fiber surface due to the attraction of charged particles by the opposite charges on the electret fibers, which alleviated the effect of electrostatic shielding. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences.

关键词： Electret filter Charged particles Loading characteristic Corona charging Electrostatic screening NUMERICAL-SIMULATION FILTER FILTRATION AEROSOL PERFORMANCE COLLECTION TRANSPORT MODEL

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