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Phylogenetic study on Scenedesmacae with the description of a new genus Coccoidesmus ***.(Chlorophyceae,Chlorophyta)and chloroplast genome analyses

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Journal of Oceanology and Limnology 2024年第4期42卷 1272-1285页

作者： qinghua wang Ying HOU Yanhui LI Ying SHI Guoxiang LIU College of Biological Sciences and Technology Taiyuan Normal UniversityJinzhong 030619China Shanxi Vocational University of Engineering Science and Technology Jinzhong 030619China Key Laboratory of Algal Biology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

Members of the family Scenedesmaceae are some of the most common algal taxa in inland ecosystems,and they are widely distributed in freshwaters,aerial,and sub-aerial *** the continuous updating of methods,the classic morphological taxonomy of this family needs to be *** recent years,many genera of Scenedesmaceae have been established via the use of molecular *** phylogenetic relationships within Scenedesmaceae were analyzed using different molecular markers and morphological data,and the new freshwater genus Coccoidesmus wang,Hou et Liu *** *** new species in this genus were also *** analysis based on tufA genes revealed that the new genus formed an independent clade closely related to ***,these two genera are characterized by significant morphological differences in colony arrangement and cell *** chloroplast genome of the type species was assembled and annotated,and analyses of genome structure and sequences were *** genome data could help clarify the phylogenetic relationships within this family.

关键词： phylogenetic Scenedesmaceae Coccoidesmus morphology chloroplast genome

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

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Research 2024年第1期2023卷 663-674页

作者： Yang Yu Zhe wang Lingling wang qinghua wang Rongfan Tang Sutong Xiang Qirui Deng Tingjun Hou Huiyong Sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous *** there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the ***,most of the drug resistance mechanisms still remain ***,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the *** this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

Biological function of miRNA-145-5p in angiotensin II induced renal inflammation

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BIOCELL 2024年第4期48卷 601-611页

作者： BIN LI YUCHENG SHENG XIAOYING XU SHENGCUN wang HONGYAN SONG JINGYUAN LI HAONAN JI qinghua wang XIAODI ZHOU LONGJU QI Department of Pediatrics Affiliated Hospital of Nantong UniversityNantong226001China Department of Science and Education Affiliated Nantong Hospitalof Nantong UniversityNantong226001China Laboratory Animal Center Nantong UniversityNantong226001China Department of Gynecology and Obstetrics and Department of Oncology Hai’an Hospital Affiliated to Nantong UniversityNantong226600China

Objective:Chronic kidney disease(CKD)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative ***,the therapeutic promise of miR-145-5p in addressing renal pathologies has been *** investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells(HGMCs)to stimulation with Angiotensin II(AngII).Materials and Methods:Cellular viability and the levels of inﬂammatory mediators were evaluated utilizing Cell Counting Kit-8(CCK-8),quantitative real-time polymerase chain reaction(qRT-PCR),and western blot methodologies,both in the presence of AngII incubation and in scenarios of miR-145p overexpression and ***,the cell cycle dynamics were elucidated through Fluorescence-activated Cell Sorting(FACS)***:AngII incubation induced an upregulation of miR-145-5p and inﬂammatory factors including Intercellular Adhesion Molecule 1(ICAM-1),Interleukin 6(IL-6),Interleukin 8(IL-8),and Interleukin 1β(IL-1β).Additionally,it elevated the expression of Cyclin A2,Cyclin D1,and the G2/M cell cycle ***,inhibition of miR-145-5p heightened the levels of inﬂammatory factors and cell cycle regulators induced by AngII *** expression of miR-145-5p correlated with a downregulation of Interleukin 10(IL-10)expression,concurrently promoting HGMC proliferation under AngII ***,ectopic miR-145-5p expression demonstrated a reduction in inﬂammatory factors,cell cyclin regulators,G2/M cell cycle ratio,and overall ***:MiR-145-5p exhibited inhibitory effects on the inﬂammatory response and proliferation induced by Angiotensin II in HGMCs,showcasing its potential as a therapeutic avenue for the treatment of kidney injury.

关键词： miR-145-5p Kidney Angiotensin II Cell cycle Inflammation

Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling Wu Xiangchuan Meng Qingyang Zhang Xiaowan Han Feiya Yang qinghua wang Hai-Yu Hu Nianzeng Xing Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Photoacoustic agents combining photodynamic therapy(PDT) and photothermal therapy(PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2), X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2),X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-Se-NO_(2)-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect Phototherapy Photoacoustic imaging Hypoxia-responsive Prostate cancer

塔北西部喀拉玉尔衮构造带上寒武统下丘里塔格组油气勘探突破及意义

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石油学报 2024年第4期45卷 615-628页

作者：王清华中国石油塔里木油田公司新疆库尔勒841000 中国石油天然气集团有限公司超深层复杂油气藏勘探开发技术研发中心新疆库尔勒841000 新疆维吾尔自治区超深层复杂油气藏勘探开发工程研究中心新疆库尔勒841000

2023年9月,塔里木盆地塔北隆起西部喀拉玉尔衮构造带雄探1井在上寒武统下丘里塔格组获重大油气勘探突破,继白垩系、古近系后,塔北地区又获一重要层系发现,标志着塔北地区具备多层系立体成藏特征。基于构造样式、断裂特征及雄探1井钻井... 详细信息

2023年9月,塔里木盆地塔北隆起西部喀拉玉尔衮构造带雄探1井在上寒武统下丘里塔格组获重大油气勘探突破,继白垩系、古近系后,塔北地区又获一重要层系发现,标志着塔北地区具备多层系立体成藏特征。基于构造样式、断裂特征及雄探1井钻井、测井、测试资料的综合分析,明确了喀拉玉尔衮构造带烃源岩条件、油源通道和储、盖条件及圈闭类型,系统梳理了喀拉玉尔衮构造带寒武系下丘里塔格组的油气成藏要素及成藏模式。塔北隆起深层发育两套烃源岩,其中,寒武系玉尔吐斯组为主要烃源岩层,前寒武系裂陷槽烃源岩为潜在烃源岩。研究区构造运动活跃,发育加里东期、海西期和喜马拉雅期断裂,NNW向走滑断裂叠加NW向及EW向逆冲断裂,形成相互交错的断裂体系,垂向沟通深部烃源岩与储集层。研究区上寒武统下丘里塔格组具有早期成圈、多期成藏的特点,晚海西期受强烈挤压作用的影响,多条通源断裂及相关构造圈闭雏形形成,后期构造运动叠加,研究区持续隆升,形成上寒武统大面积连片分布的构造圈闭,捕获多期油气充注。建立了下丘里塔格组“下生上储、断裂输导、近源成藏”的构造油气成藏模式。研究认识揭示,塔北西部寒武系下丘里塔格组具有巨大的油气勘探潜力,有望成为盆地台盆区新的油气增储上产战略接替区。

关键词：构造圈闭储-盖组合裂陷槽烃源岩成藏期次下丘里塔格组喀拉玉尔衮构造带塔北西部

习近平总书记《在文艺工作座谈会上的讲话》研究的三个维度学理化阐释、习近平文化思想视域、中国自主文论话语建构

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文学遗产 2024年第5期 19-26页

作者：王庆华华东师范大学中文系

学理化研究习近平总书记《在文艺工作座谈会上的讲话》集中于阐释其蕴含的思想内涵、精神实质、重大意义,挖掘其所关联的古今中外文艺理论渊源,取得丰硕成果,但在研究格局、阐释模式、学理分析等方面也存在需进一步拓展之处。将“文艺... 详细信息

学理化研究习近平总书记《在文艺工作座谈会上的讲话》集中于阐释其蕴含的思想内涵、精神实质、重大意义,挖掘其所关联的古今中外文艺理论渊源,取得丰硕成果,但在研究格局、阐释模式、学理分析等方面也存在需进一步拓展之处。将“文艺讲话”纳入习近平文化思想视域再研究,应探讨其对建构习近平总书记整体文艺思想的历史意义和习近平文化思想的历史贡献,并以习近平文化思想的理论体系深入阐释其思想内涵和理论渊源。深刻理解“文艺讲话”的国家政治话语性质、实践本质、以人民为中心的立场、“两个结合”的根本方法,在中国自主文论话语体系建构中应避免简单化、机械化运用,脱离中国文学实践的理论中心倾向,疏离社会文化建设的为学术而学术,创造性转化中华优秀传统文化和古代文论不足等问题。

关键词：《在文艺工作座谈会上的讲话》习近平文化思想视域中国自主文论话语建构

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医疗可及性对透析患者临床预后的影响

中华肾脏病杂志 2024年第6期40卷 506-510页

作者：王清华董捷北京大学第一医院肾内科北京大学肾脏病研究所卫健委肾脏疾病重点实验室教育部慢性肾脏病防治重点实验室中国医学科学院免疫介导肾病诊治创新单元北京100034

医疗可及性反映了患者实际使用医疗服务的能力,是从供给端和需求端两个角度评价医疗服务质量的重要指标。透析患者中普遍存在医疗可及性不足的问题,对临床预后产生不利影响。近年来,中国腹膜透析患者数量激增,医疗可及性不平等问题尤为... 详细信息

医疗可及性反映了患者实际使用医疗服务的能力,是从供给端和需求端两个角度评价医疗服务质量的重要指标。透析患者中普遍存在医疗可及性不足的问题,对临床预后产生不利影响。近年来,中国腹膜透析患者数量激增,医疗可及性不平等问题尤为突出。然而,腹膜透析医疗可及性与临床预后的关系尚不确定,需要进一步研究,从而为制定相关卫生政策提供依据。该文综述了医疗可及性的概念、研究指标以及医疗可及性对透析人群临床预后的影响,以提高社会对医疗可及性不充分问题的重视,改善透析患者的治疗质量和长期生存率。

关键词：透析预后卫生服务易得程度医疗可及性终末期肾病

资源依赖下社会组织参与社区微治理的自主性何以生成?——以上海市Y组织为例

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上海大学学报（社会科学版） 2024年第1期41卷 135-149页

作者：汪庆华白蕾上海大学社会学院上海200444

我国社会组织对其他主体尤其是政府主体存在资源依赖,这对其自主性有所限制。已有研究对社会组织自主性的理解和操作化集中于社会组织的财务、人事、组织发展规划等方面,但对其业务活动过程中的自主性讨论较少且与其他方面自主性的区分... 详细信息

我国社会组织对其他主体尤其是政府主体存在资源依赖,这对其自主性有所限制。已有研究对社会组织自主性的理解和操作化集中于社会组织的财务、人事、组织发展规划等方面,但对其业务活动过程中的自主性讨论较少且与其他方面自主性的区分不够。聚焦Y组织在参与社区微治理过程中的自主性进行研究,发现在面向不同主体时,社会组织谋求自主性的主导逻辑有所不同:因对街道的资源依赖程度较深,Y组织采取“有底线地遵从”策略以管理对街道的资源依赖,并以专业逻辑为主导获得自主性;面对社区相关利益主体时,Y组织采取“操纵式地满足”策略,并以合法性逻辑为主导,拓展其在社区中的自主性。

关键词：资源依赖社会组织社区微治理自主性

激光-热处理复合工艺制备油水分离表面及性能研究

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表面技术 2024年第10期53卷 216-229页

作者：刘超余忠杰王泰源冶孟琦王青华东南大学机械工程学院南京211189 江苏省微纳生物医疗与器械设计与制造重点实验室南京211189

目的研发一种高效、低成本的激光-热处理复合工艺,制备具有油水分离性能的泡沫铜表面,为石油污染的净化提供一种有效的参考方法。方法首先利用纳秒激光在泡沫铜表面上诱导出多级微纳米结构,然后将泡沫铜放入低温烘箱中加热处理,通过调... 详细信息

目的研发一种高效、低成本的激光-热处理复合工艺,制备具有油水分离性能的泡沫铜表面,为石油污染的净化提供一种有效的参考方法。方法首先利用纳秒激光在泡沫铜表面上诱导出多级微纳米结构,然后将泡沫铜放入低温烘箱中加热处理,通过调控激光参数和热处理相互作用制备出了超疏水超亲油泡沫铜表面,并使用扫描电子显微镜、光电子能谱仪和接触角测量仪,对激光加工前后泡沫铜表面的微纳结构、表面化学元素组成和油水在表面的润湿性进行了表征。结果泡沫铜表面经纳秒激光加工后诱导生成的多级微纳结构受到包括激光扫描速率、激光加工功率和扫描间距等激光加工参数的显著影响。同时,配合低温热处理工艺,激光制备泡沫铜表面的化学成分快速转变,表面能显著降低,使得泡沫铜表面获得了超疏水超亲油的润湿特性。本工作制备的泡沫铜表面在空气中的最大水接触角为158.5°,油接触角为0°。并利用油水分离试验装置验证了激光-热处理复合工艺制备的超疏水超亲油泡沫铜表面可以使油和水选择性通过,分离效率超过90%。结论激光-热处理复合工艺制备的具有多级微纳结构的泡沫铜表面具备优异的超疏水超亲油特性,展现出了良好的油水分离性能,有望实现海洋生态中石油污染的净化。

关键词：激光加工泡沫铜微纳结构超疏水超亲油表面油水分离

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