检索结果-南通市图书馆

Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infltration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第3期32卷 545-561页

作者： JIECHUAN QIU TIANMIN YANG YANNING sun KAI sun YINGKUN XU qinghua XIA Department of Urology Shandong Provincial Hospital A fliated to Shandong First Medical UniversityJinan250021China Depatment of Urology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan250021China Depatment of Breast and Thyroid Surgery The First Afiliated Hospital of Chongqing Medical UniversityChongqing400042China

This research aims to identify the key fatty acid beta-oxidation(FAO)genes that are altered in kidney renal clear cell carcinoma(KIRC)and to analyze the role of these genes in KIRC The Gene Expression Omnibus(GEO)and FAO datasets were used to identify these key genes.Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain(ACADM)between KIRC and non cancer samples.The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features.The diagnostic performance of ACADM for KIRC was asessed using a diagnostic receiver operating ch aracteristic(ROC)curve.The co-expressed genes of ACADM were identifed in LinkedOmics database,and their function and pathway enrichment were analyzed.The correlation between ACADM expression level and immune infitration was analyzed by Gene Set Variation Analysis(GSVA)method Additionally,the proliferation,migration,and invasion abilities of KIRC cells were assessed after overexpressing ACADM.Following differential analysis and intersection,we identifed six hub genes,induding ACADM.We found that the expression level of ACADM was decreased in KIRC tissues and had a better diagnostic efect(AUC=0.916).Survival analysis suggested that patients with decreased ACADM expression had a worse prognosis.According to correlation analysis,a variety of dinical features were associated with the expression level of ACADML By analyzing the infiltration level of immune cells,we found that ACADM may be related to the enrichment of immune cells.Finally,ACADM overexpression inhibited proliferation,migration,and invasion of KIRC cells.In conclusion,our findings suggest that reduced ACADM expression in KIRC patients is indicative of poor prognosis.These results imply that ACADM may be a diagnostic and prognostic marker for individuals with KIRC,offering a reference for dinicians in diagnosis and treatment.

关键词： Kidney renal clear cell carcinoma Acyl CoA dehydrogenase medium chain Immune infiltration Fatty acid oxidation Prognosis

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju Wang Lv-hui sun Xu Wang qinghua Wu Aimei Liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research Institute Xianning Medical College Hubei University of Science and Technology Hubei Hongshan Laboratory College of Animal Science and Technology Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University College of Life Science Yangtze University

T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing. Therefore, suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue. Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature, but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized. In this review, we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects. Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option. This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

关键词： T-2 toxin Organ toxicity Protective agent Detoxification mechanism

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 663-674页

作者： Yang Yu Zhe Wang Lingling Wang qinghua Wang Rongfan Tang Sutong Xiang Qirui Deng Tingjun Hou Huiyong sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous malignancies.Although there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the drugs.Unfortunately,most of the drug resistance mechanisms still remain obscure.Therefore,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the mutations.In this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

Design and fabrication of self-suspending aluminum-plastic/semiconductor photocatalyst devices for solar energy conversion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 615-625页

作者： Zhi-Ang Zhao Jingyun Mao Chengjing Lu Shuangqiao Yang Qingrong Qian qinghua Chen Hun Xue Xiaoli sun Min-Quan Yang College of Environmental and Resource Sciences College of Carbon Neutral Modern IndustryFujian Key Laboratory of Pollution Control and Resource ReuseFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

The design and synthesis of self-suspending photocatalyst device with easy recyclability is important for practical application.Here,this work utilizes aluminum-plastic package waste as raw material to prepare an aluminum-plastic supported TiO_(2)(AP-TiO_(2))photocatalyst device through 3D printing design and surface deposition method.A series of characterizations were carried out to explore the structure,morphology and performance of the AP-TiO_(2)device.Under UV light illumination,the AP-TiO_(2)-50 efficiently degrade 93.6%tetracycline hydrochloride(THC)after 4 hr,which increases by 8.3%compared with that of TiO_(2)powder suspension system with the same catalyst amount.Based on it,AP-ZnO,AP-CdS,AP-g-C_3N_4and AP-Pt-TiO_(2)are also fabricated,and applied in photocatalytic degradation and hydrogen evolution,which all exhibit higher photoactivities than powder suspension systems.This work provides a new avenue for the fabrication of advanced recyclable photocatalyst device.Moreover,the work offers a novel sight for the high-value utilization of aluminum-plastic package waste,which has positive implications for environmental protection.

关键词： TiO_(2) Self-suspending Photocatalyst device Aluminum plastic

Let-7i-5p maintains the stemness via R-spondin2/Wnt pathway in hepatocellular carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 20-23页

作者： qinghua Wei Xueshan Dai Jiahui Wei Wenwei sun Xiaoqian Yang Yuxin Zhang Xin Guo Yi Chen College of Pharmaceutical Sciences&Chinese Medicine Southwest UniversityChongqing 400716China Center for Basic Medical Research TEDA International Cardiovascular HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300457China Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine Chongqing 400716China pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine Chongqing 400716China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China National Demonstration Center for Experimental Pharmacy Education(Southwest University) Chongqing 400716China Engineering Research Center of Coptis Development and Utilization(Ministry of Education) College of Pharmaceutical Sciences and Chinese MedicineSouthwest UniversityChongqing 400716China

Cancer stem cells(CSCs)are related to tumorigenesis,recurrence,metastasis,and drug resistance in hepatocellular carcinoma(HCC).1 Let-7i is a noncoding small RNA,belonging to the famous miRNA let-7 family.Recently,let-... 详细信息

关键词： hepatocellular Cancer metastasis

CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第3期48卷 491-499页

作者： MIN SHEN XIAOMAN XU GUANGLING sun LIANGZHU WANG TAO YING HANG SU WEI WANG qinghua CAO ZHEZHE sun Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingbo315010China School of Medicine Ningbo UniversityNingbo315211China

Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms.Methods:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected.Hippocampal neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro model.The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope.Cell apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byﬂow cytometry and western blotting.The binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and veriﬁed.Results:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated neurons.Overexpressed circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA treatment.Mechanistically,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 expression.miR-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced apoptosis.Conclusion:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis.

关键词： Ischemic stroke circR-ZC3HC1 miR-384-5p SIRT1 Autophagy

Early Warning Interventions for Environmental Risk Factors at China CDC

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2023年第29期5卷 651-654页

作者： qinghua sun Chen Chen Qing Wang Tiantian Li China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major functionalities of the National Bureau of Disease Control and Prevention(2).As an integral division of the National Bureau of Disease Control and Prevention,the Center for Disease Control and Prevention(CDC)is responsible for executing early surveillance and warning procedures in the realm of public health.Nonetheless,a deficiency persists concerning the early warning of public health risk factors.

关键词： concerning warning CDC

Increased Mortality Risks from a Spectrum of Causes of Tropical Cyclone Exposure — China, 2013–2018

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2023年第6期5卷 119-124,I0001-I0007页

作者： Yuanyuan Liu Meilin Yan Hang Du qinghua sun G.Brooke Anderson Tiantian Li China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina School of Ecology and Environment Beijing Technology and Business UniversityBeijingChina Department of Environmental&Radiological Health Sciences Colorado State UniversityFort CollinsCOUSA

What is already known about this topic?Tropical cyclone(TC)has a substantial and adverse impact on non-accidental mortality.However,whether heterogeneity exists when examining deaths from subcauses and how TC impacts non-accidental mortality in the short term remain unclear.What is added by this report?This study found substantial associations at lag 0 between TC exposure and circulatory and respiratory mortality.TC exposures were associated with increased risks for several mortality sub-causes at lag 0 day,including ischemic heart disease,myocardial infarction,cardiac arrest,cerebrovascular disease,stroke,chronic obstructive pulmonary disease,and Parkinson’s disease.What are the implications for public health practice?This finding suggests an urgent need to expand the public health focus of natural disaster management to include non-accidental mortality and sub-causes.

关键词： mortality disaster Tropical

Case study of dust event sources from the Gobi and Taklamakan deserts:An investigation of the horizontal evolution and topographical effect using numerical modeling and remote sensing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第6期29卷 62-70页

作者： Jin Fan Xiaoying Yue qinghua sun Shigong Wang College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000GansuChina College of Geography and Environmental Science Northwest Normal UniversityLanzhou 7S0070GansuChina Division of Environmental Health Sciences College of Public HealthThe Ohio State UniversityColumbusOH 43210USA College of Atmospheric Sciences Chengdu University of Information TechnologyChengdu 610103SichuanChina

A severe dust event occurred from April 23 to April 27, 2014, in East Asia. A state-of-the-art online atmospheric chemistry model, WRF/Chem, was combined with a dust model, GOCART, to better understand the entire process of this event. The natural color images and aerosol optical depth （AOD） over the dust source region are derived from datasets of moderate resolution imaging spectroradiometer （MODIS） loaded on a NASA Aqua satellite to trace the dust variation and to verify the model results. Several meteorological conditions, such as pressure, temperature, wind vectors and relative humidity, are used to analyze meteorological dynamic. The results suggest that the dust emission occurred only on April 23 and 24, although this event lasted for 5 days. The Gobi Desert was the main source for this event, and the Taklamakan Desert played no important role. This study also suggested that the landform of the source region could remarkably interfere with a dust event. The Tarim Basin has a topographical effect as a ＂dust reservoir＂ and can store unsettled dust, which can be released again as a second source, making a dust event longer and heavier.

关键词： East Asia dustWRFMODISTarim BasinTopographical effect