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Activation of skeletal carbohydrate-response element binding protein(ChREBP)-mediated de novo lipogenesis increases intramuscular fat content in chickens

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Animal Nutrition 2024年第3期18卷 107-118页

作者： Peng Wang Haihan Xiao Tian Wu qinghua fu Xudong Song Yameng Zhao Yan Li Jieping Huang Ziyi Song Guangxi Key Laboratory of Animal Breeding Disease Control and PreventionCollege of Animal Science and TechnologyGuangxi UniversityNanningGuangxi 530004China

The intracellular lipids in muscle cells of farm animals play a crucial role in determining the overall intramuscular fat(IMF)content,which has a positive impact on meat ***,the mechanisms underlying the deposition of lipids in muscle cells of farm animals are not yet fully *** purpose of this study was to determine the roles of carbohydrate-response element binding protein(ChREBP)and fructose in IMF deposition of *** virus-mediated ChREBP overexpression in tibialis anterior(TA)muscle of chickens,seven 5-d-old male yellow-feather chickens were *** 10 d after virus injection,the chickens were slaughtered to obtain TA muscles for *** fructose administration trial,sixty 9-wk-old male yellow-feather chickens were randomly divided into 2 groups,with 6 replicates per group and 5 chickens per *** chickens were fed either a basal diet or a basal diet supplemented with 10%fructose(purity≥99%).At 4 wk later,the chickens were slaughtered,and breast and thigh muscles were collected for *** results showed that the skeletal ChREBP mRNA levels were positively associated with IMF content in multiple species,including the chickens,pigs,and mice(Pfurthermore,the lipidomics analysis revealed that ChREBP activation altered the lipid composition of chicken IMF and tented to improve the flavor profile of the *** conclusion,this study found that ChREBP plays a pivotal role in mediating the deposition of fat in chicken muscles in response to fructose-rich diets,which provides a novel strategy for improving meat quality in the livestock industry.

关键词： Chicken Meat quality Intramuscular fat Carbohydrate-response element binding protein Fructose

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公共开放空间的公共性演变研究

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中外建筑 2024年第2期 123-128页

作者：付清华黄春晓南京大学建筑与城市规划学院

公共性是影响城市公共开放空间品质与活力的重要指标。随着人民城市理念的提出,公共开放空间的价值内涵从注重物质功能向普惠公共群体转变。以公共开放空间为研究对象,探究概念的理论内涵。参考哈贝马斯的“公共领域”理论,基于历史维... 详细信息

公共性是影响城市公共开放空间品质与活力的重要指标。随着人民城市理念的提出,公共开放空间的价值内涵从注重物质功能向普惠公共群体转变。以公共开放空间为研究对象,探究概念的理论内涵。参考哈贝马斯的“公共领域”理论,基于历史维度分析中西方公共开放空间公共性的历史演变进程,总结公共开放空间公共性演变的特征,透过比较视角得出中西方规划实践中公共开放空间所体现的公共性呈现“殊途同归”的趋势。既丰富了对公共开放空间理论层面的研究,同时对有效实施城市更新行动具有积极意义。

关键词：公共开放空间公共性公共领域人民城市历史比较视角

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粤港澳大湾区水安全要素“天-空-地-水”立体观测体系建设探讨

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中国水利 2024年第9期 56-60页

作者：刘超群扶卿华珠江水利委员会珠江水利科学研究院广州510611 水利部粤港澳大湾区水安全保障重点实验室广州510611 水利部珠江河口治理与保护重点实验室广州510611

聚焦粤港澳大湾区的复杂水情及严峻水安全问题,分析当前大湾区水安全观测主要依赖传统观测方法的不足,提出基于卫星遥感、无人机、高精度传感器、5G、移动互联网等高新技术,构建粤港澳大湾区水安全要素“天-空-地-水”立体观测体系,实... 详细信息

聚焦粤港澳大湾区的复杂水情及严峻水安全问题,分析当前大湾区水安全观测主要依赖传统观测方法的不足,提出基于卫星遥感、无人机、高精度传感器、5G、移动互联网等高新技术,构建粤港澳大湾区水安全要素“天-空-地-水”立体观测体系,实现对水安全要素的全覆盖、多尺度、高精度、智能化立体观测,为大湾区推进水治理、保障水安全、实现水利现代化提供支撑。

关键词：粤港澳大湾区水安全要素 “天-空-地-水”立体观测水安全保障

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基于卫星遥感影像的水资源监测研究进展

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中国水利 2024年第1期 28-33页

作者：扶卿华顾祝军丰江帆珠江水利科学研究院广州510610 重庆邮电大学重庆400065

卫星遥感技术可在影像空间监测水资源的时空分布,为分析水资源空间分布及其变化规律提供全覆盖、定量化和快速更新的基础信息。对基于卫星遥感影像数据的地表水资源、地下水资源监测研究进展进行综述,分析了卫星遥感影像监测存在的挑战... 详细信息

卫星遥感技术可在影像空间监测水资源的时空分布,为分析水资源空间分布及其变化规律提供全覆盖、定量化和快速更新的基础信息。对基于卫星遥感影像数据的地表水资源、地下水资源监测研究进展进行综述,分析了卫星遥感影像监测存在的挑战和潜在的研究方向,以期为相关领域研究应用提供参考。

关键词：水资源监测卫星遥感遥感反演进展挑战

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Advanced technology for functionalization of carbon nanotubes

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Progress in Natural Science:Materials International 2009年第7期19卷 801-810页

作者： Lingjie Meng, Chuanlong fu, qinghua Lu School of Chemistry and Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China [a]School of Chemistry and Chemical Technology Shanghai Jiaotong University Shanghai 200240 China

functionalization of carbon nanotubes (CNTs) has attracted considerable interest in the fields of physics, chemistry, material science and biology. The functionalized CNTs exhibit improved properties enabling facile fabrication of novel nanomaterials and *** of the functionalization approaches developed at present could be categorized into the covalent attachment of functional groups and the non-covalent adsorption of various functional molecules onto the surface of CNTs. This review highlights recent development and our work in functionalization of carbon nanotubes, leading to biocompatible CNTs, fluorescent CNTs and transition metal functionalized CNTs. These novel methods possess advantages such as simplified technical procedures and reduced cost of novel nanomaterials and nanodevices fabrication.

关键词： Carbon nanotubes (CNTs) functionalization Bio-compatibility Fluorescence Transition metal

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水泥土搅拌桩加固铁路饱和黄土地基承载特性试验及分析

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黑龙江交通科技 2024年第5期47卷 1-5页

作者：安芃芃杨有海付清华李铁根周贺甘肃交通职业技术学院甘肃兰州730070 兰州交通大学甘肃兰州730070

针对兰州西至中川机场城际铁路沿线分布着大量饱和黄土,天然承载力低,无法满足工程建设要求这一问题,依据复合地基理论,提出用水泥土搅拌桩加固饱和黄土地基。通过FLAC 3D软件建立柔性荷载作用下水泥土搅拌桩复合地基模型,进行承载特性... 详细信息

针对兰州西至中川机场城际铁路沿线分布着大量饱和黄土,天然承载力低,无法满足工程建设要求这一问题,依据复合地基理论,提出用水泥土搅拌桩加固饱和黄土地基。通过FLAC 3D软件建立柔性荷载作用下水泥土搅拌桩复合地基模型,进行承载特性分析。得出以下结论:复合地基承载力为150 kPa,较原位地基土的承载力100.24 kPa有明显的提高;随着上部荷载的增加,沉降量也增大,中桩沉降量最大,边桩次之,角桩最小;桩身轴应力沿深度变化曲线存在一个中性点,此处桩身轴应力达到最大值;桩顶应力、桩间土应力随着荷载增加而增大,荷载为180 kPa是增长幅度发生变化的转折点。

关键词：水泥土搅拌桩铁路复合地基 FLAC 3D 数值模拟

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Progress in the Study of the Left Atrial function Index in Cardiovascular Disease:A Literature Review

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Cardiovascular Innovations and Applications 2021年第2期5卷 227-233页

作者： Pei Huang Yi Zhang Yi Tang qinghua fu Zhaofen Zheng Xiaoyan Yang Yingli Yu Department of Cardiology Hunan Provincial People’s Hospital(The First Affi liated Hospital of Hunan Normal University)Chang Sha410000China Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China

Some studies have shown that left ventricular structure and function play an important role in the risk stratifi cation and prognosis of cardiovascular *** clinical application of left atrial function in cardiovascular disease has gradually attracted attention in the cardiovascular fi *** are many traditional methods to evaluate left atrial *** atrial function related indexes measured by echocardiography has been identifi ed as a powerful predictor of cardiovascular disease in recent years,but they have some *** left atrial function index has been found to evaluate left atrial function more effectively than traditional ***,it is a valuable predictor of the risk stratifi cation and prognosis in patients with clinical cardiovascular disease such as heart failure,atrial fi brillation,hypertension,and coronary heart disease.

关键词： Left atrial function index Left atrial function Cardiovascular disease

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miRNA在胰腺癌诊断、治疗和预后中的作用

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宁夏医科大学学报 2024年第7期46卷 722-728页

作者：姜玲付卿桦陈涛王子帅孙延财高马欣瑶王隽善姜颖黑龙江中医药大学基础医学院哈尔滨150040 黑龙江中医药大学第一临床医学院基础医学院研究生院哈尔滨150040

胰腺癌(PC)因缺乏早期特异性诊断,加上其对大多数可用治疗方案的耐药性,使PC成为一个临床难题。目前,对PC的治疗方法和治疗效果有限,因此需要基于对PC进展相关分子机制的理解,开发新的诊断、治疗策略。microRNA(miRNA)是非编码的小RNA,... 详细信息

胰腺癌(PC)因缺乏早期特异性诊断,加上其对大多数可用治疗方案的耐药性,使PC成为一个临床难题。目前,对PC的治疗方法和治疗效果有限,因此需要基于对PC进展相关分子机制的理解,开发新的诊断、治疗策略。microRNA(miRNA)是非编码的小RNA,通过翻译后过程中可调节多种蛋白的表达,从而影响细胞分化、生物发育、肿瘤发生和发展等方面。随着现代生物技术的不断发展,发现miRNA具有高度的稳定性和组织特异性,符合成为早期生物标志物和预后因子的要求。此外,了解PC中的miRNA发挥的作用及其机制,可能会作为未来分子水平PC治疗的新方法。因此,本研究就miRNA在PC生物标志物、预后标志物和临床靶点治疗中的应用作一综述,拟为将来解决PC诊断、治疗提供研究方向和思路。

关键词： miRNA 胰腺癌诊断治疗生物标志物

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Construction of habitat suitability models(HSMs) for benthic macroinvertebrate and their applications to instream environmental flows:A case study in Xiangxi River of Three Gorges Reservior region,China

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Progress in Natural Science:Materials International 2009年第3期19卷 359-367页

作者： Fengqing Li a,b, qinghua Caia,*, Xiaocheng fu a,b, Jiankang Liu a a State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China b Graduate University of Chinese Academy of Sciences, Beijing 100039, China [a]State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China [b]Graduate University of Chinese Academy of Sciences Beijing 100039 China

Based on a long-term ecological monitoring, the present study chose the most dominant benthic macroinvertebrate (Baetis spp.) as tar- get organisms in Xiangxi River, built the habitat suitability models (HSMs) for water depth, current velocity and substrate, respectively, which is the first aquatic organisms model for habitat suitability in the Chinese Mainland with a long-term consecutive in situ measurement. In order to protect the biointegrity and function of the river ecosystem, the theory system of instream environmental flow should be cat- egorized into three hierarchies, namely minimum required instream flow (hydrological level), minimum instream environmental flow (bio- species level), and optimum instream environmental flow (ecosystem level). These three hierarchies of instream environmental flow models were then constructed with the hydrological and weighted usable area (WUA) method. The results show that the minimum required instream flow of Xiangxi River calculated by the Tennant method (10% of the mean annual flow) was 0.615 m3 s 1; the minimum instream environmental flow accounted for 19.22% of the mean annual flow (namely 1.182 m3 s 1), which was the damaged river channel flow in the dry season; and 42.91% of the mean annual flow (namely 2.639 m3 s 1) should be viewed as the optimum instream environmental flow in order to protect the health of the river ecosystem, maintain the instream biodiversity, and reduce the impact of small hydropower stations nearby the Xiangxi River. We recommend that the hydrological and biological methods can help establish better instream environmental flow models and design best management practices for use in the small hydropower station project.

关键词： Habitat suitability model Weighted usable area Instream environmental flow Benthic macroinvertebrate Xiangxi river Three Gorges reservoir

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Concurrent gemcitabine and cisplatin combined with 3D conformal radiotherapy for stage III non-small cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2009年第3期8卷 156-159页

作者： qinghua Ke Guoquan fu Yaowu Bian Daiwen Jiang Jiyuan Yang Department of Oncology The Oncology Hospital of Jingzhou Jingzhou 434000 China

Objective： To study the toxicities and efficacy of concurrent gemcitabine plus cisplatin combined with three-dimensional conformal radiotherapy for stage Ⅲ non-small cell lung cancer （NSCLC）. Methods： Thirty-six patients with pathologically diagnosed NSCLC received radiotherapy and concurrent chemotherapy. There were 22 patients with stage Ilia and 14 patients with IIIb. Radiotherapy was given a total of 60-70 Gy in conventional fractionation. Chemotherapy included gemcitabine （600 mg/m^2） and cisplatin （20 mg/m^2）, once per week. Results： Thirty-two patients received a total dose of 60-72 Gy. Two patients received 56 Gy and another two patients received 58 Gy. Thirty-four patients received 4-6 weeks of chemotherapy, while two patients received only 2 weeks of chemotherapy. The overall response rate （CR ＋ PR）, complete response rate （CR）, partially response rate （PR） were 83.3% （30/36）, 11.1% （4/36） and 72.2% （26/36） respectively. The median follow-up duration was 18.4 months. The 1- and 2-year overall survival rates were 77.8% （28/36） and 55.6% （20/36）, respectively. Conclusion： Concurrent gemcitabine and cisplatin combined with three-dimensional conformal radiotherapy for stage III non-small cell lung cancer is effective and well tolerated. Lone-term results need further study.

关键词： non-small cell lung cancer (NSCLC) three-dimensional conformal radiotherapy (3DCRT) chemotherapy gemcitabine cispiatin prognosis

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