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May Traditional Chinese Medicine Reduce the Risk of Developing Rheumatoid Arthritis?An One-armed Prospective Study

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 10-18页

作者： Kaixin Gao Qi Liang Dongyun Li Chuanning Li Maojie Wang Xiumin Chen qingchun huang Zehuai Wen Per-Johan Jakobsson Runyue huang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510006GuangdongChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510006GuangdongChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120GuangdongChina Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510403GuangdongChina Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou 510000GuangdongChina The key unit of methodology of clinical research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000GuangdongChina Rheumatology Unit Department of Medicine SolnaKarolinska InstituteKarolinska University HospitalStockholm 17177Sweden Department of Doctor-Patient Relationship The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongChina

Background:Rheumatoid arthritis(RA)is a worldwide public health *** and prevention before the onset of rheumatic diseases is a new direction in current ***:The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine(TCM)in the prevention of ***:This was a single-armed prospective clinical *** participants were recruited from a single center in Guangdong,*** who were tested positive for anti-cyclic citrullinated peptide antibody(anti-CCP)and/or rheumatoid factor(RF),had no synovitis and never been treated with disease-modifying anti-rheumatic drugs(DMARDs),were enrolled to take the Huayu-Qiangshen-Tongbi(HQT)decoction orally twice daily,200 mL each time for 24 *** outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism)classification criteria of RA during *** outcomes included levels of anti-CCP,RF,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),assessment of signs and symptoms,and radiographic progression by magnetic resonance imaging(MRI).Results:19 individuals were enrolled in the study,4 of which withdrew because of the epidemic of *** the observation period,3 individuals(20%)developed RA and they had longer morning stiffness(P=0.009)and more obvious synovial enhancement in MRI(P=0.041)at baseline when compared with those who did not develop *** 24 weeks of intervention,there were improvements in 28-swollen joint count(SJC28)(P=0.046),Visual Analog Scale(VAS)(P=0.019),Patient’s Global Assessment(PtGA)(P=0.019)and Physician’s Global Assessment(PGA)(P=0.031),but no statistical significance was observed in the levels of anti-CCP,RF,ESR,CRP,morning stiffness,28-tender joint count(TJC28),Health Assessment Questionnaire(HAQ)and magnetic resonance imaging(MRI)analysis(P>0.05).Conclusion:The HQT formula is safe and could improve joint symptoms and s

关键词： Rheumatoid arthritis(RA) Prevention Traditional Chinese medicine(TCM) Huayu-Qiangshen-Tongbi decoction(HQT) Clinical trial

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高效液相色谱法测定酱油中三氯蔗糖含量不确定度的评定

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食品工业科技 2024年第7期45卷 270-275页

作者：崔婷婷祁伟何文江张家琪黄青春中国地质调查局呼和浩特自然资源综合调查中心内蒙古呼和浩特010010 内蒙古自治区特种设备检验研究院乌兰察布分院内蒙古乌兰察布012000

目的:建立一种高效液相色谱法测定酱油中三氯蔗糖的不确定度的评定方法。方法:按照食品安全国家标准GB 22255-2014进行检测,依据国家计量技术规范JJF 1059.1-2012分析酱油中三氯蔗糖的含量,建立不确定度评定数学模型,分析测量过程中的... 详细信息

目的:建立一种高效液相色谱法测定酱油中三氯蔗糖的不确定度的评定方法。方法:按照食品安全国家标准GB 22255-2014进行检测,依据国家计量技术规范JJF 1059.1-2012分析酱油中三氯蔗糖的含量,建立不确定度评定数学模型,分析测量过程中的不确定度因素,通过样品重复测定、标准溶液纯度、标准曲线、玻璃器具、称量过程、回收率、检测仪器对检测结果不确定度进行评定,并且进行计算。结果:按置信区间为95%,酱油中三氯蔗糖含量为(0.048±0.007)g/kg,k=2。结论:建立了高效液相色谱法测定酱油中三氯蔗糖的不确定度的评定方法,最终确定酱油中三氯蔗糖的含量测定结果的不确定度来源主要有:三氯蔗糖标准溶液建立的标准曲线的拟合、回收率,明确检测酱油中三氯蔗糖含量过程中带来的各种不确定度评定因素的占比。

关键词：高效液相色谱酱油三氯蔗糖不确定度评定

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电感耦合等离子体质谱法测定大批量钼多金属矿中钼及4种主要伴生元素的含量

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理化检验（化学分册） 2024年第3期60卷 260-265页

作者：贾雷李俊东黄青春祁伟何文江左修源中国地质调查局呼和浩特自然资源综合调查中心呼和浩特010010 营口理工学院化学与环境工程学院辽宁省化学助剂合成与分离重点实验室营口115014

目前采用电感耦合等离子体质谱法(ICP-MS)测定大批量常量元素时存在检测器信号强、稳定性差、准确度低等问题,为此优化了分析条件,提出了题示方法。取0.05 g样品,用少量水润洗,加入4 mL硫酸和8 mL硝酸的混合溶液,混匀后,于250℃加热18 ... 详细信息

目前采用电感耦合等离子体质谱法(ICP-MS)测定大批量常量元素时存在检测器信号强、稳定性差、准确度低等问题,为此优化了分析条件,提出了题示方法。取0.05 g样品,用少量水润洗,加入4 mL硫酸和8 mL硝酸的混合溶液,混匀后,于250℃加热18 h蒸干溶液,冷却至室温,用3~4 mL的10%(体积分数)硝酸溶液溶解,并用水定容至25 mL,利用自动稀释系统将样品溶液稀释100倍后采用ICP-MS测定其中Mo、W、Cu、Zn、Ag的含量,以0.6 mL·min^(-1)的稀释气流量来降低物理干扰。结果表明,5种元素的质量浓度在1.00 mg·L^(-1)内与对应的响应值呈线性关系,检出限(3 s)为0.006~0.201 mg·kg^(-1)。方法用于分析钼矿石国家标准物质GBW 07142、GBW 07143,测定值与认定值基本一致,测定值的相对标准偏差(n=8)均小于8.0%。仪器稳定性试验表明,进行大批量长时间测试时,需及时重新更换零件和重新校正标准曲线。

关键词：钼矿石 Mo W Cu Zn Ag 电感耦合等离子体质谱法(ICP-MS)

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Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors

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Science China(Life Sciences) 2024年第3期67卷 518-528页

作者： Meimei Liao Xinwei Gao Chen Chen Qi Li qingchun Guo He huang Erquan Zhang Dapeng Ju College of Biological Sciences China Agriculture UniversityBeijing 100193China National Institute of Biological Sciences(NIBS) Beijing 102206China Chinese Institute for Brain Research Beijing 102206China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Department of Anesthesiology The Second Affiliated HospitalChongqing Medical UniversityChongqing 401336China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 102206China

The circadian clock coordinates rhythms in numerous physiological processes to maintain organismal homeostasis. Since the suprachiasmatic nucleus(SCN) is widely accepted as the circadian pacemaker, it is critical to understand the neural mechanisms by which rhythmic information is transferred from the SCN to peripheral clocks. Here, we present the first comprehensive map of SCN efferent connections and suggest a molecular logic underlying these projections. The SCN projects broadly to most major regions of the brain, rather than solely to the hypothalamus and thalamus. The efferent projections from different subtypes of SCN neurons vary in distance and intensity, and blocking synaptic transmission of these circuits affects circadian rhythms in locomotion and feeding to different extents. We also developed a barcoding system to integrate retrograde tracing with in-situ sequencing, allowing us to link circuit anatomy and spatial patterns of gene expression. Analyses using this system revealed that brain regions functioning downstream of the SCN receive input from multiple neuropeptidergic cell types within the SCN, and that individual SCN neurons generally project to a single downstream brain *** map of SCN efferent connections provides a critical foundation for future investigations into the neural circuits underlying SCNmediated rhythms in physiology. Further, our new barcoded tracing method provides a tool for revealing the molecular logic of neuronal circuits within heterogeneous brain regions.

关键词： circadian rhythms SCN output circuit neural tracing barcoded GFP in situ sequencing

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Effectiveness and safety of tripterygium glycosides tablet(雷公藤多苷片)for lupus nephritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2022年第5期42卷 671-680页

作者： ZHOU Yingyan LIANG Huasheng YAN Jingyao HE Xiaohong PAN Lili LI Xue CHEN Xianghong CHEN Xiumin YANG Aicheng huang qingchun Department of Rheumatology the Second Affiliated HospitalGuangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510006China Department of Nephrology Jiangmen Hospital of Chinese Medicine Affiliated to Jinan UniversityJiangmen 529000China

OBJECTIVE:To investigate the effectiveness and safety of tripterygium glycosides(TG)tablet(雷公藤多苷片)for the treatment of Lupus nephritis(LN).METHODS:Several databases were systematically searched including Pub Med,Embase,Cochrane,Wiley,China National Knowledge Infrastructure Database,Sino Med and Wanfang Library till June 20,***5.3 was utilized to analyze the data according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses ***:In total,8 randomized controlled trials involving 583 participants were ***-analyses showed that,compared with glucocorticoids(GC)alone,the combination with TG tablet provided a statistically significant improvement in total remission(TR)(RR=1.27,95%CI:1.08–1.50,P=0.004),complete remission(CR)(RR=1.61,95%CI:1.05–2.47,P=0.03)and C3 levels(WMD=0.27,95%CI:0.14–0.39,P<0.0001),C4 levels(WMD=0.12,95%CI:0.07–0.17,P<0.00001).No significant differences were seen in TR,CR,proteinuria,serum creatinine,C3 and C4(TR:RR=1.00,95%CI:0.87–1.16,P=0.95;CR:RR=1.10,95%CI:0.78–1.56,P=0.58;proteinuria levels:WMD=-0.06,95%CI:-0.13 to 0.01,P=0.10;serum creatinine levels:WMD=-0.01,95%CI:-7.36 to 7.35,P=1.00;C3 levels:WMD=0.01,95%CI:-0.06 to 0.07,P=0.84;C4 levels:WMD=-0.01,95%CI:-0.03 to 0.01,P=0.49)between azathioprine(AZA)/leflomit(LEF)+GC and TG tablet+*** events(hepatic dysfunction,nausea,vomitting)showed no statistical differences between the TG tablet+GC group and the GC *** were more new onset of irregular menstruation in the TG tablet+GC group than those in the AZA+GC(RR=3.57,95%CI:1.40–9.11,P=0.008)/LEF+GC(RR=6.69,95%CI:2.42-18.46,P=0.0002)group,but leucopenia lower than those in AZA+GC group(RR=0.38,95%CI:0.17-0.85,P=0.02)and alopecia(RR=0.14,95%CI:0.03-0.77,P=0.02)and rash(RR=0.09,95%CI:0.01-0.69,P=0.02)lower than those in LEF+GC ***:This review indicates that TG tablet maybe effective in LN ***,adverse events cannot be *** sample,multi-center,hig

关键词： tripterygium glycosides lupus nephritis treatment outcome safety systematic review Meta-analysis

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轧辊埋弧堆焊过程多场耦合数值模拟方法研究

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中国表面工程 2021年第4期34卷 117-128页

作者：李昌黄庆春陈馨雪刘兆泰韩兴辽宁科技大学机械工程与自动化学院鞍山114051

埋弧堆焊是冶金行业轧辊修复的重要方法,目前多是对轧辊埋弧堆焊过程中温度场或应力场的单一场进行研究,而埋弧堆焊流场的研究极少。堆焊中的电磁力、温度梯度与熔池内流动密切相关,基于热-弹-塑性理论和流体动力学计算方法(CFD),建立... 详细信息

埋弧堆焊是冶金行业轧辊修复的重要方法,目前多是对轧辊埋弧堆焊过程中温度场或应力场的单一场进行研究,而埋弧堆焊流场的研究极少。堆焊中的电磁力、温度梯度与熔池内流动密切相关,基于热-弹-塑性理论和流体动力学计算方法(CFD),建立轧辊堆焊过程热-弹-塑-流多场耦合模型,获取堆焊过程温度场、应力场和流场的演变规律,分析表面张力、电磁力、浮力对堆焊熔池流动状态及形貌的影响规律,同时对堆焊工艺进行材料学表征分析。研究成果对预测埋弧堆焊过程多物理场的变化规律、熔池流场演变机理和有效预防堆焊开裂具有一定的实践意义。

关键词：埋弧堆焊温度场流场应力场

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Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT

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Chinese Medical Journal 2024年第10期137卷 1249-1251页

作者： Yingwen Lin Hengli Zhao Dongtu Hu Jia huang You Peng Juncong Li Dingli Xu qingchun Zeng State Key Laboratory of Organ Failure Research Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Clinical Pharmacology Medical Research InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510515China Department of Radiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic *** recently,there have been few studies directly evaluating how volume status impacts future cardiac events for patients with *** supporting the application of spironolactone in HFpEF is mainly derived from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist(TOPCAT)*** though primary analysis of the trial reached a neutral result,subgroup and subsequent post hoc analyses have confirmed its efficacy in selected groups of patients,suggesting that identifying the potential subgroups of patients who would benefit from spironolactone treatment is important.[1]Data regarding the impact of congestion status on the efficacy of spironolactone in HFpEF are lacking.

关键词： function. fraction impaired

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行书《晁冲之词一首》

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现代艺术 2021年第12期 124-125页

作者：黄清春不详

获奖/呈现情况 AWARD/PRESENTATION2021年8月,该作品入展由中国书法家协会主办的2020 "中国书法·年展"全国书法作品展,并进入综合评审前101名。释文:潇洒江梅,向竹梢疏处,横两三枝。东君也不爱惜,雪压霜欺。

关键词：中国书法家协会书法作品展综合评审晁冲之行书雪压霜欺

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农村初中学困生的学习特点及矫正研究

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天津教育 2021年第33期 4-5页

作者：黄清春福建省宁德市寿宁县托溪中学

受制于经济发展水平、教育资源不均衡等问题的影响,农村初中学困生问题普遍存在。农村初中学困生缺乏学习兴趣、学习态度消极、知识基础不牢,这些问题直接影响农村初中的教学质量,也关乎学生的未来发展。本文将从农村初中学困生的学习... 详细信息

受制于经济发展水平、教育资源不均衡等问题的影响,农村初中学困生问题普遍存在。农村初中学困生缺乏学习兴趣、学习态度消极、知识基础不牢,这些问题直接影响农村初中的教学质量,也关乎学生的未来发展。本文将从农村初中学困生的学习特点出发,探讨学困生的矫正方式和注意事项。

关键词：农村初中学困生矫正方法

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对称故障下变流器控制对差动保护影响及优化策略

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中国电机工程学报 2024年第13期44卷 5063-5072,I0004页

作者：黄涛谢华徐晓春赵青春南京南瑞继保电气有限公司江苏省南京市211102

变流器输出故障特征的强可控性给交流系统继电保护带来了严峻挑战。该文分析并网线路发生对称故障时跟网型变流器的控制响应过程,从故障期间变流器电流控制目标不能自动匹配故障回路功率需求的角度,分析推导变流器网侧电压相位发生跳变... 详细信息

变流器输出故障特征的强可控性给交流系统继电保护带来了严峻挑战。该文分析并网线路发生对称故障时跟网型变流器的控制响应过程,从故障期间变流器电流控制目标不能自动匹配故障回路功率需求的角度,分析推导变流器网侧电压相位发生跳变并不断旋转的变化特征。受故障回路阻抗约束,变流器输出短路电流相位与网侧电压相位同步变化,造成并网线路差动保护性能严重下降。基于变流器网侧电压相位变化机理,从电流控制目标与锁相环控制两个维度,提出兼顾保护需求和供电需求的变流器控制优化策略。仿真结果表明,并网线路对称故障时所提策略能有效抑制两侧电流相位差,显著提升了差动保护动作性能。

关键词：变流器差动保护相位受控控制目标锁相环

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