检索结果-南通市图书馆

Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang HUANG Zheng HUANG Peiyan YANG Mengning ZHANG Zhihui ni Guangxia College of Acupuncture-Moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FTH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FTH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FTH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 688-697页

作者： Shuai Hou Chutong Lai Yukun Song Haitao Wang Jialu ni Mingqian Tan Academy of Food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116044China National Engineering Research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend *** natural flavonol fisetin has been shown to antagonize senescence in vitro and increases longevity in vivo,but has poor water solubility and limited *** this study,a food-grade and senescent cell-targeted delivery system for fisetin was developed based on whey protein isolate-galactooligosaccharides(WPI-GOS)Maillard conjugate,which could recognize senescence associatedβ-galactosidase in senescent *** fisetin nanoparticles possessed a high encapsulation efficiency,excellent dispersibility in water,good storage stability and well ***,they could effectively accumulate and retain in senescent cells with excellent senescent cell-targeting efficacy,and inhibit the oxidative stress-induced cellular senescence in ***,this novel nanoparticle system based on WPI-GOS Maillard conjugate showed promise to deliver hydrophobic bioactive ingredients like fisetin to senescent cells to improve their bioavailability and anti-senescence effect.

关键词： Fisetin Nanoparticle Cellular senescence Targeted delivery

Three-year field study on grass growth and soil hydrological properties in biochar-amended soil

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2764-2774页

作者： Haowen Guo Charles Wang Wai Ng Junjun ni Qi Zhang Yuchen Wang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina School of Transportation Southeast UniversityNanjingChina

Field monitoring was conducted to investigate and quantify the long-term effects of peanut shell biochar on soil-grass interaction over three *** 10 m5 m grassed plots were constructed in completely decomposed granitic *** of them were amended,respectively,with 5%and 10%biochar contents(m^(3)/m^(3))for grass growth,while the third was without biochar *** the threeyear monitoring,plant characteristics,saturated water permeability(k_(s))of grassed soil and soil suction were *** monitored results show that the grass leaf area index(LAI)and root length density(RLD)with biochar amendment were improved by 38%and 200%,*** the grassed plot without biochar,a threshold RLD existed with a value of 1.7 cm/cm^(3),beyond which k_(s) raised *** threshold RLD increased by 52%when biochar content increased from 0%to 10%.This implies that biochar may restrict the increase in k_(s) of grassed soil due to the rise in the threshold *** presence of biochar and grass can retain over 100%higher suction after heavy rainfalls,while 54%lower peak suction under evapotranspiration(ET)compared with the non-amended *** can alleviate the negative effects on hydraulic properties caused by plant growth and reduce ET-induced excessive water loss.A 5%peanut shell biochar content is recommended for the long-term management of vegetated earthen infrastructures.

关键词： Soil-grass interaction Biochar Long-term Water infiltration Soil drying

A highly sensitive ratiometric near-infrared nanosensor based on erbium-hyperdoped silicon quantum dots for iron(Ⅲ) detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第8期45卷 49-58页

作者： Kun Wang Wenxuan Lai Zhenyi ni Deren Yang Xiaodong Pi State Key Laboratory of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Advanced Semiconductors&Zhejiang Provincial Key Laboratory of Power Semiconductor Materials and Devices ZJ-UHangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China

Ratiometric fluorescent detection of iron(Ⅲ)(Fe^(3+))offers inherent self-calibration and contactless analytic ***,realizing a dual-emission near-infrared(niR)nanosensor with a low limit of detection(LOD)is rather *** this work,we report the synthesis of water-dispersible erbium-hyperdoped silicon quantum dots(Si QDs:Er),which emit niR light at the wavelengths of 810 and 1540 nm.A dual-emission niR nanosensor based on water-dispersible Si QDs:Er enables ratiometric Fe^(3+)detection with a very low LOD(0.06μM).The effects of pH,recyclability,and the interplay between static and dynamic quenching mechanisms for Fe^(3+)detection have been systematically *** addition,we demonstrate that the nanosensor may be used to construct a sequential logic circuit with memory functions.

关键词： erbium-hyperdoped silicon quantum dots dual-emission near-infrared nanosensor Fe^(3+)detection sequential logic circuit

A statistical analysis of the Kappa-type energy spectrum distribution of radiation belt electrons observed by Van Allen Probes

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第2期8卷 368-374页

作者： LuHuai Jiao Xin Ma YuanNong Zhang TaiFeng Jin Song Fu BinBin ni Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China

The energy spectrum of energetic electrons is a key factor representing the dynamic variations of Earth’s Van Allen radiation *** measurements have indicated that the commonly used Maxwellian and Kappa distributions are inadequate for capturing the realistic spectral distributions of radiation belt *** we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical analysis to investigate the radiation belt electron flux spectra observed by the Van Allen *** calculating the optimal values of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral shapes,we fit the radiation belt electron fluxes at different L-shells under different geomagnetic *** this manner,we obtain typical values of the KT distribution parameters,which are statistically feasible for modeling the radiation belt electron flux profiles during either geomagnetically quiet or active periods.A comparison of the KT distribution model results with those using the Maxwellian or Kappa distribution reveals the advantage of the KT distribution for studying the overall properties of the radiation belt electron spectral distribution,which has important implications for deepening the current understanding of the radiation belt electron dynamics under evolving geomagnetic conditions.

关键词： radiation belt electron Kappa-type distribution fitting geomagnetic storm

Review of tribological properties of nanoparticle-based lubricants and their hybrids and composites

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第4期12卷 569-590页

作者： Ye Zar ni HTWE Aws.S.AL-JANABI Yasmin WADZER Hussin MAMAT Ku NOORYASMIN School of Materials&Mineral Resources Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia School of Aerospace Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia Universiti Sains Malaysia

Due to their encouraging results,nanolubricants have been revolutionary in the field of *** degree,to which the new material may improve the tribology,energy savings,and durability,is a crucial consideration for any new additive to a conventional *** results of the earlier research on carbon,metal,metal oxide,and their composites and hybrid nanolubricants as well as their effects on tribology,are summarized in this review *** most popular measuring methodologies,the tribology results for lubricants with an oil base,biodegradable base,and a water base,as well as the reasons that explain these tribological advancements,are all included in this ***,prospects for more study in this area are emphasized.

关键词： nanolubricants tribology carbon metal metal oxide hybrid

Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第8期5卷 172-188页

作者： Hu-Jiao Lan Jie Ran Wen-Xu Wang Lei Zhang ni-ni Wu Ya-Ting Zhao Min-Jun Huang Min ni Fen Liu ninghui Cheng Paul A.Nakata Jianwei Pan Steven A.Whitham Barbara J.Baker Jian-Zhong Liu Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants Zhejiang Normal UniversityJinhua 321004China Institute of Plant Genetics and Developmental Biology College of Chemistry and Life SciencesZhejiang Normal UniversityJinhua 321004China College of Life Sciences Lanzhou UniversityLanzhou 730000China Department of Plant Pathology and Microbiology Iowa State UniversityAmesIA 50011USA Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA Plant Gene Expression Center U.S.Department of Agriculture-Agricultural Research ServiceAlbanyCA 94706USA Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332000China U.S.Department of Agriculture-Agricultural Research Service Children’s Nutrition Research CenterDepartment of PediatricsBaylor College of MedicineHoustonTX 77030USA

The crosstalk between clathrin-mediated endocytosis(CME)and the autophagy pathway has been reported in mammals;however,the interconnection of CME with autophagy has not been established in ***,we report that the Arabidopsis CLATHRIN LIGHT CHAIN(CLC)subunit 2 and 3 double mutant,clc2-1 clc3-1,phenocopies Arabidopsis AUTOPHAGY-RELATED GENE(ATG)mutants in both autoimmunity and nutrient ***,the autophagy pathway is significantly compromised in the clc2-1 clc3-1 ***,multiple assays demonstrate that CLC2 directly interacts with ATG8h/ATG8i in a domain-specific *** expected,both GFP-ATG8h/GFP-ATG8i and CLC2-GFP are subjected to autophagic degradation,and degradation of GFP-ATG8h is significantly reduced in the clc2-1 clc3-1 ***,simultaneous knockout of ATG8h and ATG8i by CRISPR-Cas9 results in enhanced resistance against Golovinomyces cichoracearum,supporting the functional relevance of the CLC2-ATG8h/8i *** conclusion,our results reveal a link between the function of CLCs and the autophagy pathway in Arabidopsis.

关键词： autophagy clathrin light chain immunity clathrin-mediated endocytosis senescence cell death

Rational Design of Ruddlesden-Popper Perovskite Ferrites as Air Electrode for Highly Active and Durable Reversible Protonic Ceramic Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 308-324页

作者： Na Yu Idris Temitope Bello Xi Chen Tong Liu Zheng Li Yufei Song Meng ni Department of Building and Real Estate Research Institute for Sustainable Urban Development(RISUD)and Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057GuangdongPeople’s Republic of China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongPeople’s Republic of China

Reversible protonic ceramic cells(RePCCs)hold promise for efficient energy storage,but their practicality is hindered by a lack of high-performance air electrode ***-Popper perovskite Sr_(3)Fe_(2)O_(7−δ)(SF)exhibits superior proton uptake and rapid ionic conduction,boosting ***,excessive proton uptake during RePCC operation degrades SF’s crystal structure,impacting *** study introduces a novel A/B-sites co-substitution strategy for modifying air electrodes,incorporating Sr-deficiency and Nb-substitution to create Sr_(2.8)Fe_(1.8)Nb_(0.2)O_(7−δ)(D-SFN).Nb stabilizes SF’s crystal,curbing excessive phase formation,and Sr-deficiency boosts oxygen vacancy concentration,optimizing oxygen *** D-SFN electrode demonstrates outstanding activity and durability,achieving a peak power density of 596 mW cm^(−2)in fuel cell mode and a current density of−1.19 A cm^(−2)in electrolysis mode at 1.3 V,650℃,with excellent cycling *** approach holds the potential for advancing robust and efficient air electrodes in RePCCs for renewable energy storage.

关键词： Reversible protonic ceramic cells Air electrode Ruddlesden-Popper perovskite Hydration Oxygen reduction reaction

Data Secure Storage Mechanism for IIoT Based on Blockchain

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 4029-4048页

作者： Jin Wang Guoshu Huang R.Simon Sherratt Ding Huang Jia ni School of Computer Science and Mathematics Fujian University of TechnologyFuzhou350118China School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410004China School of Systems Engineering The University of ReadingReadingRG66AYUK School of Computer Nanjing University of Information Science and TechnologyNanjing210044China

With the development of Industry 4.0 and big data technology,the Industrial Internet of Things(IIoT)is hampered by inherent issues such as privacy,security,and fault tolerance,which pose certain challenges to the rapid development of *** technology has immutability,decentralization,and autonomy,which can greatly improve the inherent defects of the *** the traditional blockchain,data is stored in a Merkle *** data continues to grow,the scale of proofs used to validate it grows,threatening the efficiency,security,and reliability of blockchain-based ***,this paper first analyzes the inefficiency of the traditional blockchain structure in verifying the integrity and correctness of *** solve this problem,a new Vector Commitment(VC)structure,Partition Vector Commitment(PVC),is proposed by improving the traditional VC ***,this paper uses PVC instead of the Merkle tree to store big data generated by *** can improve the efficiency of traditional VC in the process of commitment and ***,this paper uses PVC to build a blockchain-based IIoT data security storage mechanism and carries out a comparative analysis of *** mechanism can greatly reduce communication loss and maximize the rational use of storage space,which is of great significance for maintaining the security and stability of blockchain-based IIoT.

关键词： Blockchain IIoT data storage cryptographic commitment