检索结果-南通市图书馆

Journal of Environmental Sciences 2019年第5期31卷 273-279页

作者： Zhihua Lian Wenpo Shan meng Wang Hong He qingcai Feng Center for Excellence in Regional Atmospheric Environment and Key Laboratory of Urban Pollutant Conversion Institute of Urban Environment Chinese Academy of Sciences Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences

The effect of acidity and redox capability over sulfuric acid-modified CeO_2 catalysts were studied for the selective catalytic reduction of NO_x with NH_3(NH_3-SCR). The deposition of sulfate significantly enhanced the catalytic performance over CeO_2. NO_x conversion over4H_2SO_4/CeO_2 at 230–440 °C was higher than 90%. The strong redox capability of CeO_2 could result in unselective NH_3 oxidation and decrease high temperatures catalytic activity and N_2 selectivity. The deposition of sulfate increased the acidity and weakened the redox capability, and then increased the high temperature NO_x conversion and N_2 selectivity. An appropriate level of acidity also promoted the activity at 190–250 °C over ceria-based catalysts, and with further increase in the acidity, the SCR activity decreased slightly. Weak redox capability lowered the low-temperature catalytic activity. Excellent SCR activity requires a balance of acidity and redox capability on the catalysts.

关键词： NH3-SCR CeO2 Acidity Redox capability H2SO4

Regulatory network and genetic interactions established by OsMADS34 in rice inflorescence and spikelet morphogenesis

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2017年第9期59卷 693-707页

作者： qingcai Meng Xiaofeng Li Wanwan Zhu Li Yang Wanqi Liang Ludovico Dreni Dabing Zhang Joint International Research Laboratory of Metabolic&Developmental Sciences State Key Laboratory of Hybrid RiceShanghai Jiao Tong University and University of Adelaide Joint Centre for Agriculture and HealthSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas-Universidad Politécnica de ValenciaValencia 46022Spain School of Agriculture Food and WineUniversity of AdelaideWaite CampusUrrbraeSA 5064Australia

Grasses display highly diversified inflorescence architectures that differ in the arrangement of spikelets and flowers and determine cereal yields. However, the molecular basis underlying grass inflorescence morphogenesis remains largely unknown. Here we investigate the role of a functionally diversified SEPALLATA MADS-box transcription factor, OsMADS34, in regulating rice （Oryza sativa L.） inflorescence and spikelet development. Microarray analysis showed that, at the very early stages of inflorescence formation, dysfunction of OsMADS34 caused altered expression of 379 genes that are associated with protein modification and degradation, transcriptional regulation, signaling and metabolism activity. Genetic analysis revealed that OsMADS34 controls different aspects of inflorescence structure, branching and meristem activity synergistically with LAX PANICLE1 （LAX1） and FLORAL ORGAN NUMBER4 （FON4）, as evidenced by the enhanced phenotypes of osmads34 lax1 and osmads34 fon4 compared with the single mutants. Additionally, double mutant between osmads34 and the sterile lemma defective mutant elongated empty glume （ele） displayed an enhanced phenotype, that is, longer and wider sterile lemmas that were converted into lemma/palea-like organs, suggesting that ELE and OsMADS34 synergistically control the sterile lemma development. OsMADS34 may act together with OsMADS15 in controlling sterile lemma development. Collectively, these findings provide insights into the regulatory function of OsMADS34 in rice inflorescence and spikelet development.

关键词： FLORAL ORGAN IDENTITY MADS-BOX GENES SHOOT APICAL MERISTEM STEM-CELL FATE FLOWER DEVELOPMENT HOMEOTIC GENES ORYZA-SATIVA AXILLARY MERISTEMS ECTOPIC EXPRESSION RECEPTOR KINASE

镇城底矿8#煤层采场顶底板岩层破坏规律研究

在线全文

学校读者我要写书评

暂无评论

江西煤炭科技 2023年第1期 86-89页

作者：孟庆才西山煤电(集团)有限责任公司马兰矿山西古交030205

镇城底矿采用已有规范中的经验公式计算采煤工作面导水裂隙带高度作为防治水评价及设计依据,为验证其可靠性,通过数值模拟、现场实测等手段,探究采场顶底板岩层破坏规律。研究表明,三种方法得到的顶板垮落带、裂隙带、底板破坏带数据均... 详细信息

镇城底矿采用已有规范中的经验公式计算采煤工作面导水裂隙带高度作为防治水评价及设计依据,为验证其可靠性,通过数值模拟、现场实测等手段,探究采场顶底板岩层破坏规律。研究表明,三种方法得到的顶板垮落带、裂隙带、底板破坏带数据均较可靠,结果表明:28103工作面采场垮落带高度15.0~20.2 m之间,裂隙带高度51.9~69.7 m,底板破坏深度12.47~15 m,对镇城底矿各主采煤层有效预测、防治顶底板水害具有重要意义。

关键词：垮落带裂隙带经验公式计算数值模拟瞬变电磁法探测

Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2023年第1期43卷 3-41页

作者： Zengli Fang qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Shanghai Pancreatic Cancer Institute Shanghai 200032P.R.China Pancreatic Cancer Institute Fudan UniversityShanghai 200032P.R.China Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China

As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research.

关键词： Signaling pathways Cancer-associated fibroblasts Cell-cell interaction Tumor microenvironment Therapeutic targets

Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 856-868页

作者： Qijian Liang Yan Zheng Fanli meng Xiaofan Jiang qingcai Zhen Zhongting Lu Shixiu Zhang Lei Du Hao Wu Xin Guo Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Institute of Hepatology Shandong UniversityJinan 250012China

With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic syndrome.Palmitoleic acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing inflammation.However,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin resistance.Here,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before administration.We administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD feeding.We found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing HOMA-IR.Further study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes population.In colon,palmitoleic acid increased intestinal tight junction integrity and reduced inflammation.Moreover,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose tissue.Diacylglycerol(DAG)in tissue(for example,liver)is found to positively correlated with HOMA-IR.HFD enhanced the levels of DAGs in liver but not in adipose tissue in this study.Palmitoleic acid did not reverse the high DAG levels induced by HFD in liver.Therefore,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of DAGs.It might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue.

关键词： Palmitoleic acid High fat diet Insulin resistance Gut microbiota

在线全文

学校读者我要写书评

暂无评论

“尝试成功”体育教学模式探讨

江苏科技信息 2015年第16期32卷 14-16页

作者：孟庆财南京新港中等专业学校江苏南京210046

随着社会的不断发展,良好的身体和参加体育锻炼的意识已显得越来越重要。而这种良好的身体和意识的形成,主要取决于学校体育课的培养。"尝试成功"是根据学生的生理、心理特点,结合学生的兴趣和能力,充分调动学生学习体育的积极性和自觉... 详细信息

随着社会的不断发展,良好的身体和参加体育锻炼的意识已显得越来越重要。而这种良好的身体和意识的形成,主要取决于学校体育课的培养。"尝试成功"是根据学生的生理、心理特点,结合学生的兴趣和能力,充分调动学生学习体育的积极性和自觉性,培养学生"终身体育"意识,并为将来的工作和生活打好基础的一种教学模式。文章从理论和实践两方面对其进行探讨,予以充分的肯定且大力倡导。

关键词：尝试成功成功感激励

Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2011年第5期38卷 217-223页

作者： Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu qingcai Meng Minghong Gu Changjie Yan Jiangsu Key laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics Ministry of Education Agricultural College of Yangzhou University 12# East Wenhui Rd. Jiangsu 225009 China

Panicle architecture is closely related to yield formation. The qPE9-1 gene has been proved to be widely used in high-yield rice cultivar developments, conferring erect panicle character in japonica rice. Recently, qPE9-1 has been successfully cloned; however, the genetic effect on grain yield per plant of the erect panicle allele qPE9-1 is controversial yet. In the present study, a drooping panicle parent Nongken 57, carrying qpe9-1 allele, was used as recurrent parent to successively backcross to a typical erect panicle line from the double haploid （DH） population （Wuyunjing 8/Nongken 57）, which was previously shown to carry qPE9-1 allele. Thus a pair of near-isogenic lines （NILs） was developed. The comparison of agronomic traits between the NILs showed that, when qpe9-1 was replaced by qPE9-1, the panicle architecture was changed from drooping to erect; moreover, the panicle length, plant height, 1000-grain weight and the tillers were significantly decreased, consequently resulting in the dramatic decrease of grain yield per plant by 30%. Therefore, we concluded that the qPE9-1 was a major factor controlling panicle architecture, and qPE9-1 had pleiotropic nature, with negative effects on grain yield per plant. This result strongly suggests that the erect panicle allele qPEg-1 should be used together with other favorable genes in the high-yield breeding practice. In addition, the effect of qPE9-1 on eating and cooking quality was also discussed in the present study.

关键词： Rice Erect panicle Genetic analysis qPE9-1

The transcription factor Gfi1 negatively regulates NLRP3 inflammasome activation via NF-κB dependent and independent pathways

在线全文

学校读者我要写书评

暂无评论

The transcription factor Gfi1 negatively regulates NLRP3 inf...

第九届全国免疫学学术大会

作者： Zhu Liuluan meng qingcai Liang Shuntao Li Guoli Li Rui Zeng Hui Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical University

Background:Innate immune cells initiate an immediate response to pathogens by generating abundant pro-inflammatorycytokines,including interleukin-1β(IL-1β).Production of IL-1βis tightly controlled at the transcriptional and post-translational levels.The NLRP3 inflammasome,a multiprotein complex composed of NOD-like

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

小直径千米立井2套单钩提升快速施工技术

建井技术 2017年第6期38卷 16-19页

作者：孟庆才李渊毅辽宁东煤基本建设有限责任公司辽宁沈阳110122

九道岭煤矿东风井净直径5.0 m,井深1 006 m。井筒施工中,采用2套单钩提升,伞形钻架打眼,中心回转式抓岩机装岩,MJY型4.0m高模板砌壁等立井施工机械化配套设备作业线和中深孔光面爆破技术,实现了安全快速施工,最高月成井达190.6 m,创东... 详细信息

九道岭煤矿东风井净直径5.0 m,井深1 006 m。井筒施工中,采用2套单钩提升,伞形钻架打眼,中心回转式抓岩机装岩,MJY型4.0m高模板砌壁等立井施工机械化配套设备作业线和中深孔光面爆破技术,实现了安全快速施工,最高月成井达190.6 m,创东北地区煤炭行业同井型月成井最高纪录。

关键词：小直径千米立井单钩提升中深孔光面爆破快速施工

关节镜下外侧支持带松解治疗髌骨外侧高压综合征临床疗效观察

在线全文

学校读者我要写书评

暂无评论

新疆医科大学学报 2014年第6期37卷 773-775页

作者：廖军孟庆才新疆医科大学附属中医医院乌鲁木齐830000

目的：探讨关节镜下外侧支持带松解术治疗髌骨外侧高压综合征（EL PS ）的临床疗效。方法选择2009年6月-2013年8月新疆医科大学附属中医医院关节外科收治的100例髌骨外侧高压综合征患者，将其分为两组：关节镜下行外侧支持带松解术58例... 详细信息

目的：探讨关节镜下外侧支持带松解术治疗髌骨外侧高压综合征（EL PS ）的临床疗效。方法选择2009年6月-2013年8月新疆医科大学附属中医医院关节外科收治的100例髌骨外侧高压综合征患者，将其分为两组：关节镜下行外侧支持带松解术58例（ALRR组），保守治疗42例（对照组），参考Lysholm膝关节功能评分评价临床疗效。结果两组患者随访3∽15个月，平均8．6个月，对照组和 ALRR组有效率分别为85．71％和982．8％；两组患者治疗后Lysholm评分均较治疗前提高，差异有统计学意义（P ＜0.05）；两组患者治疗后Lysholm评分差异有统计学意义（P ＜0.05），ALRR组高于对照组。结论关节镜下外侧支持带松解术可有效地减轻髌骨外侧高压导致的髌股关节疼痛，且具备术后康复快、并发症少、膝关节功能恢复好等优势，其远期疗效有待进一步观察。

关键词：外侧支持带松解髌骨外侧高压关节镜