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Chinese Chemical Letters 2008年第9期19卷 1035-1038页

作者： qing Han li zhi Gang Zhao College of Chemistry and Environmental Protection Engineering Southwest University for Nationalities Chengdu 610041 China

Six new N4-[bi-（4-fluorophenyl）-methyl]-piperazine thiosemicarbazones 3a-f have been prepared starting from [bi-（4-fluorophenyl）-methyl]-piperazine in solvent-free condition under microwave irradiation with excell... 详细信息

关键词： bi-(4-Fluorophenyl)-methyl]-piperazine Thiosemicarbazones Microwave irradiation Solvent-free Organic synthese

Anthocyanin Accumulation Mediated by Blue light and Cytokinin in Arabidopsis Seedlings

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Journal of Integrative Plant Biology 2006年第4期48卷 420-425页

作者： Da-qing Chen zhi-Yang li Rui-Chi Pan Xiao-Jing Wang College of life Sciences South China Normal University Guangdong Key Laboratory of Biotechnology for Plant Development Guangzhou 510631 China

It has been reported that pigmentation In plants Is stimulated by light and cytoklnln （CTK）; however, the signaling pathways and the relationship between light and CTK Involved In the regulation of anthocyanln accumulation remain to be elucidated. We Investigated （i） the role of blue light （BL） and CTK In anthocyanln accumulation ; and （ii） the relationship between BL and CTK In wild type （WT） and by4 mutants of Arabidopsis thaiiana. Two-d-old seedlings grown on medium with or without klnetln （KT） or zeatln （ZT） In darkness were Irradiated using BL at different fluence rates for 3 d before the anthocyanln content was determined using a spectrophotometrlc method. Anthocyanln accumulation was strongly Induced by BL In WT seedlings but not In hy4 seedlings, which demonstrated that CRY1 Is the main photoreceptor for BL. Both KT and ZT enhanced the response of the WT seedlings to BL In a dose-dependent manner, whereas they were not sufficient to promote anthocyanln eccumulatlon In darkness. In addition, data from experiments using the hy4 mutant showed that the CTK effect of BL was also CRYl-dependent. The results from experiments with three different treatment programs showed that the relationship between BL and KT In anthocyanln accumulation of Arabidopsis seedlings seems neither muItlpllcatlve nor additive coactlon, but rather Interaction. BL Is necessary for anthocyanln accumulation, and KT might be Involved In the BL signaling pathway.

关键词： anthocyanin Arabidopsis blue light cytokinin by4 mutant.

Temperature dependence of the excitonic spectra of monolayer transition metal dichalcogenides

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Frontiers of physics 2018年第4期13卷 139-143页

作者： Zi-Wu Wang Run-Ze li Xi-Ying Dong Yao Xiao zhi-qing li Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology Department of Physics Tianjin University Tianjin 300354 China

We theoretically study the temperature dependence of the excitonic spectra of monolayer transitionmetal dichaleogenides using the O＇Donnell equation, Eg（T） = Eg（0） - S〈hω〉[coth（〈hω〉/2kBT- 1）]. We develop a theoretical model for the quantitative estimation of the Huang-Rhys factor S and averagephonon energy （hω） based on exciton coupling with longitudinal optical and acoustic phonons in the Frohlich and deformation potential mechanisms, respectively. We present reasonable explanations for the fitted values of the Huang-Rhys factor and average phonon energy adopted in experiments. Com- parison with experimental results reveals that the temperature dependence of the peak position in the excitonic spectra can be well reproduced by modulating the polarization parameter and deformation potential constant.

关键词： transition metal dichalcogenides exciton Huang-Rhys factor

Clinical Features and Treatment of Bronchogenic Cyst in Adults

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Chinese Medical Sciences Journal 2009年第1期24卷 60-63页

作者： Hong-sheng liu Shan-qing li zhi-li Cao zhi-yong Zhang Hua Ren Department of Thoracic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the clinical features and management of bronchogenic cyst in the adults. Methods We retrospectively reviewed 50 patients admitted to our hospital with histopathologically proved bronchogenic cyst from January 1983 to December 2007. Of all the patients, 28 were male and 22 were female, with an average age of 36.9 (range, 18 to 64) years. The symptoms, location of the cysts, imaging evaluation, surgical treatment manner, and outcome of these patients were analyzed. Results Symptoms were present in 33 of the 50 patients, and cough was the most common symptom. Thirteen patients presented with complications: hemoptysis, infected cyst, dysphagia, paralysis, and hoarseness. The locations of the cysts included the mediastinum (28 cases), pulmonary parenchyma (12 cases), hilar area (3 cases), visceral pleura (1 case), and some rare locations including the intestinal mesentery (1 case), retroperitoneum (1 case), adrenal gland (1 case), neck (2 cases), and dura matter of the cervical verte-brae (1 case). Chest X-ray was performed in 36 patients and computed tomography (CT) was performed in 41 patients. The bronchogenic cyst in CT was characterized as a round, well circumscribed, unilocular mass, with density ranging from that of water to high density (0-50 Hu). As for treatment, complete resection of the bronchogenic cyst was performed in 47 (94%) patients, subtotal resection was performed in 3 (6%) patients. Open surgery was performed in 45 (90%) patients, and thoracoscopy (video-assisted thoracic surgery) was performed in 5 (10%) paitients. Of the 12 patients with intrapulmonary cyst, 11 patients underwent lobectomy and 1 patient underwent wedge resection. Postoperative sequelae occurred in 2 patients, 1 with persistent air leakage and 1 with hoarseness. All patients were proved with bronchogenic cyst pathologically. The average follow-up period was 6.5 years (range, 4 months to 10 years), and no late sequelae or recurrence of the cyst occurred. Conc

关键词： bronchogenic cyst lung mediastinum thoracoscopy

Angiography reveals early hiding iris neovascularization after ischemic CRVO

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 253-254页

作者： zhi-qing li Xiao-Xu Zhou Song lin Jun-ling li Jian-Guo Wu Tianjin Medical University Eye Hospital Department of Electron Microscope Tianjin Medical University Basic Medical College

Dear Sir, I am Dr. zhi-qing li from Tianjin Medical University Eye Hospital, Tianjin City, China. I write to present a case with hiding iris neovascularization (INV) following central retinal vein occlusion (CRVO) can... 详细信息

关键词： Angiography reveals early hiding iris neovascularization after ischemic CRVO INV IA NVG Figure

The silkworm homolog of Methoprene-tolerant （Met） gene reveals sequence conservation but function divergence

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Insect Science 2010年第4期17卷 313-324页

作者： zhi-qing li Dao-Jun Cheng ling Wei Ping Zhao Xu Shu lin Tang Zhong-Huai Xiang qing-You Xia The Key Sericultural Laboratory of Agricultural Ministry Southwest University Chongqing School of life Science Southwest University Chongqing The Institute of Agronomy and life Sciences Chongqing University Chongqing China

Methoprene-tolerant （Met） gene has been found to be involved in juvenile hormone （JH） action in insects. Herein, we isolated a silkworm （Bombyx mori） homolog of Met gene from Drosophila melanogaster using bio-informatics analysis and rapid amplification of cDNA ends - polymerase chain reaction method, and defined it as BmMet. The full-length cDNA ofBmMet gene consists of 1 917 nucleotides and includes a 1 368 bp of open reading frame for a deduced protein of 455 amino acids. All deduced protein sequences from Met genes in B. mori and other surveyed insects contain four typical domains ofbHLH, PAS-A, PAS-B and PAC, highlighting a high sequence conservation of Met genes during insect evolution. Also, genomic structure and phylogenic analysis suggested that Met in both B. mori and Drosophila species may originate from an ancestor gene with gce, another member of bHLH-PAS family, via gene duplication. In addition, BmMet was detected in all surveyed tissues and throughout the whole life of silkworm at transcriptional levels. Furthermore, silkworm individuals with RNAi silencing of BmMet gene in the early stage of the fourth instar larvae could molt normally and pupate successfully. This result was different from the observation in T. castaneum but similar to that in D. melanogaster after Met knockdown, revealing that the action mode of Met in B. mori and D. melanogaster should be divergent with that in other insect species.

关键词： Bombyx mori expression pattern genomic structure Methoprene-tolerantgene RNAi

Multimodal imaging of the carriers of choroideremia and X-linked retinitis pigmentosa

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1721-1725页

作者： Jin Yang lin-Ni Wang Rong-Guo Yu li-Ying Hu Xue Gong Lu Chen Bo-Jie Hu Xiao-Rong li zhi-qing li Department of Neuro-ophthalmology and Medical Retinal Tianjin Medical University Eye Hospital

Dear Editor,We are Dr. zhi-qing li and Dr. Jin Yang, from the Neuro-ophthalmology and Medical Retinal Department of Tianjin Medical University Eye Hospital, Tianjin, China. We here present two cases of X-linked inheritable retinal diseases with genetic confirmation of the multimodal imaging findings of the patients, especially the female carriers. This study was approved by the institutional review board of Tianjin Medical University Eye Hospital, and the protocols adhered to the tenets of the Declaration of Helsinki. This letter mainly describes a novel imaging modality, multispectral imaging （MSI）, which appeared to be sensitive in detecting the pattern of chorioretinal degeneration and the tapetal-like reflex.

关键词： Multimodal X-linked pigmentosa choroideremia

Temperature-responded tunable metalenses based on phase transition materials

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Chinese Physics B 2022年第5期31卷 416-421页

作者： Jing-Jun Wu Feng Tang Jun Ma Bing Han Cong Wei qing-zhi li Jun Chen Ning Zhang Xin Ye Wan-Guo Zheng Ri-Hong Zhu School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China MIIT Key Laboratory of Advanced Solid Laser Nanjing University of Science and TechnologyNanjing 210094China Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang 621900China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

Once the metalenses are fabricated,the functions of most metalenses are *** tunability and reconfigurability are useful and cost-saving for metalenses in realistic *** demonstrate this tunability here via a novel hybrid metalens with the strategic placement of an ultra-thin VO;*** hybrid metalens is capable of dynamically modulating the focusing intensity of transmitted light at a wavelength of 1550 nm,and demonstrate a 42.28%focusing efficiency of the incident light and 70.01%modulation *** hybrid metalens’optothermal simulations show an optothermal conversion process of dynamic focusing,and a maximum laser density of 1.76×10^(3)W/cm^(2) can be handled at an ambient temperature lower than 330 *** hybrid metalens proposed in this work,a light-dose sensitive tunable smart metalens that can protect other instruments/systems or materials from being damaged,has its specific applications such as in anti-satellite blinding,bio-imaging,etc.

关键词： temperature-responded tunable metalenses phase change material VO2

Adenovirus-expressed preS2 antibody inhibits hepatitis B virus infection and hepatic carcinogenesis

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World Journal of Gastroenterology 2012年第4期18卷 349-355页

作者： Qian Zhang,Department of Infectious Diseases,Changhai Hospital,Second Military Medical University,Shanghai 200433,China zhi-qing li,Hu liu,Jia-He Yang,Department of Hepatic Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Qian Zhang Department of Infectious Diseases Changhai Hospital Second Military Medical University Shanghai 200433 China.

AIM:To investigate the inhibitory effect of hepatitis B virus (HBV) preS2 antibody (preS2Ab) against HBV in-fection and HBV-associated hepatic ***:An adenoviral vector carrying the full-length light and heavy chains of the HBV preS2Ab gene,Ad315-preS2Ab,was *** linked immunosorbent assay (EliSA) and Western blotting analyses were used to determine the preS2Ab expres-sion levels in *** techniques were used to examine the binding affinity between the expressed HBV preS2Ab and HBV-positive liver *** were also used to determine hepatitis B surface antigen (HBsAg) levels to assess the inhibitory effect of the preS2Ab against HBV infection in L02 *** inhibitory effect of preS2Ab against hepatic carcinogen-esis was studied with diethylnitrosamine (DEN)-induced hepatocellular carcinomas (HCCs) in HBV transgenic ***:The expression of HBV preS2Ab increased with increases in the multiplicity of infection (MOI) of Ad315-preS2Ab in L02 cells,with 350.87 ± 17.37 μg/L of preS2Ab when the MOI was 100 plaque forming units (pfu)/*** expressed preS2Abs could recog-nize liver cells from HBV transgenic *** results showed that L02 cells expressing preS2Ab produced less HBsAg after treatment with the serum of HBV pa-tients than parental L02 cells expressing no *** transgenic mice treated with Ad315-preS2Ab had fewer and smaller cancerous nodes after induction with DEN than mice treated with a blank Ad315 vec-tor or untreated ***,the administration of Ad315-preS2Ab could alleviate hepatic cirrhosis and decrease the serum levels of alanine transaminase and aspartate ***:Adenovirus-mediated HBV preS2Ab expression could inhibit HBV infection in L02 cells,and then inhibit DEN-induced hepatocellular carcinogenesis and protect hepatic function in HBV transgenic mice.

关键词： Hepatitis B virus Adenoviral vector PreS2 antibody Hepatocellular carcinoma Gene therapy

FEM application to loess slope excavation and support:case study of Dong Loutian coal bunker,Shuozhou,China

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FEM application to loess slope excavation and support:case s...