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Bo’s abdominal acupuncture treatment for adult-onset Still's disease:A case report

World Journal of Clinical Cases 2025年第8期13卷 41-48页

作者： Jia-Min Yang yu Wang yu-qing zhang Hong-Lin zhang Zhi-yun Bo College for People's Livelihood and Well-being Beijing Vocational College of Labor and Social SecurityBeijing 100029China College of Acupuncture and Moxibustion Beijing University of Chinese MedicineBeijing 100029China Guang'Anmen Hospital China Academy of Traditional Chinese MedicineBeijing 100053China Beijing Zhiyuntang Traditional Chinese Medicine Clinic Beijing Bo’s Abdominal Acupuncture Research InstituteBeijing 100122China

BACKGROUND Adult-onset Still's disease(AOSD)is a rare autoinflammatory disease charac-terized by nonspecific symptoms such as fever,rash,sore throat and *** paper reports a clinical case of AOSD successfully treated with Bo’s abdo-minal acupuncture(BAA).CASE SUMMARY We report a 20-year-old man who suffered from cold exposure,presenting with high fever,rash,sore throat,arthralgia,and elevated erythrocyte sedimentation rate,leukocytosis with neutrophilic predominance,elevated ferritin,elevated C-reactive protein,and negative rheumatoid *** was diagnosed with AOSD based on the Yamaguchi *** treatment with traditional Chinese medi-cine(TCM)decoction and prednisone acetate tablets,there was some alleviation of sore throat,joint and muscle pain,and fever,but he still had persistent low-grade fever,rash,sore throat and *** went to the TCM acupuncture outpatient department to receive *** acupoints Zhongwan(CV12),Xiawan(CV10),0.5 cm below Xiawan(CV10),Qihai(CV6),Guanyuan(CV4),bilateral Qixue(KI13),bilateral Huaroumen(ST24),bilateral Shangfengshidian(AB1)and bilateral Daheng(SP15)were *** 3 months treatment,all symptoms disappeared,and the laboratory examination returned to normal *** did not take glucocorticoids or nonsteroidal anti-inflammatory drugs afterwards,and no relapse was observed during the 3-year follow-up *** BAA can be used as a complementary medical approach for treatment of AOSD.

关键词： Adult-onset Still’s disease Bo’s abdominal acupuncture Traditional Chinese medicine Complementary medicine Case report

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Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

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Acta Pharmaceutica Sinica B 2020年第1期10卷 123-135页

作者： Xiaoyu Fan Xinxin Ding qing-yu zhang Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Wadsworth Center New York State Department of HealthSchool of Public HealthUniversity at AlbanyAlbanyNY 12201USA

We examined the impact of gut inflammation on the expression of cytochrome P450(P450)and other biotransformation genes in male mice using a dextran sulfate sodium(DSS)-induced colitis *** P450 isoforms,including CYPIA,CYP2B,CYP2C,and CYP3A,were downregulated,accompanied by decreases in microsomal metabolism of diclofenac and nifedipine,in the liver and small *** impact of the colitis on in vivo clearance of oral drugs varied for four different drugs tested:a small decrease for nifedipine,a relatively large decrease for lovastatin,but no change for pravastatin,and a large decrease in the absorption of cyclosporine *** further assess the scope of influence of gut inflammation on gene expression,we performed genome-wide expression analysis using RNA-seq,which showed down-regulation of many CYPs,non-CYP phase-Ⅰenzymes,phase-Ⅱenzymes and transporters,and up-regulation of many other members of these gene families,in both liver and intestine of adult C57BL/6 mice,by DSS-induced ***,our results indicate that gut inflammation suppresses the expression of many P450s and other biotransformation genes in the intestine and liver,and alters the pharmacokinetics for some but not all drugs,potentially affecting therapeutic efficacy or causing adverse effects in a drug-specific fashion.

关键词： Cytochrome P450 CYP Colitis Intestine Inflammatory bowel disease Drug metabolism Pharmacokinetics Gene expression

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An update on the role of intestinal cytochrome P450 enzymes in drug disposition

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Acta Pharmaceutica Sinica B 2016年第5期6卷 374-383页

作者： Fang Xie Xinxin Ding qing-yu zhang Bioimaging Glaxo Smith KlineKing of Prussia College of Nanoscale Science SUNY Polytechnic Institute Wadsworth Center New York State Department of Health

Oral administration is the most commonly used route for drug *** cytochrome P450(CYP)-mediated metabolism can eliminate a large proportion of some orally administered drugs before they reach systemic circulation,while leaving the passage of other drugs unimpeded.A better understanding of the ability of intestinal P450 enzymes to metabolize various clinical drugs in both humans and preclinical animal species,including the identification of the CYP enzymes expressed,their regulation,and the relative importance of intestinal metabolism compared to hepatic metabolism,is important for improving bioavailability of current drugs and new drugs in ***,we briefly review the expression of drug-metabolizing P450 enzymes in the small intestine of humans and several preclinical animal species,and provide an update of the various factors or events that regulate intestinal P450 expression,including a cross talk between the liver and the *** further compare various clinical and preclinical approaches for assessing the impact of intestinal drug metabolism on bioavailability,and discuss the utility of the intestinal epithelium–specific NADPH-cytochrome P450 reductasenull(IECN) mouse as a useful model for studying in vivo roles of intestinal P450 in the disposition of orally administered drugs.

关键词： Cytochrome P450 Intestine Bioavailability Drug disposition Drug metabolism

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Tunable second-order sideband effects in hybrid optomechanical cavity assisted with a Bose-Einstein condensate

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Chinese Physics B 2022年第10期31卷 389-398页

作者： Li-Wei Liu Chun-Guang Du Guo-Heng zhang Qiong Chen yu-qing Shi Pei-yu Wang yu-qing zhang College of Electrical Engineering Northwest Minzu UniversityLanzhou 730000China Visiting Scholar Department of PhysicsTsinghua UniversityBeijing 100084China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China School of Physics and Electronics Science Hunan University of Science and TechnologyXiangtan 411201China

We theoretically investigated a second-order optomechanical-induced transparency(OMIT) process of a hybrid optomechanical system(COMS), which a Bose-Einstein condensate(BEC) in the presence of atom-atom interaction trapped inside a cavity with a moving end mirror. The advantage of this hybrid COMS over a bare COMS is that the frequency of the second mode is controlled by the s-wave scattering interaction. Based on the traditional linearization approximation, we derive analytical solutions for the output transmission intensity of the probe field and the dimensionless amplitude of the second-order sideband(SS). The numerical results show that the transmission intensity of the probe field and the dimensionless amplitude of the SS can be controlled by the s-wave scattering frequency. Furthermore, the control field intensities,the effective detuning, the effective coupling strength of the cavity field with the Bogoliubov mode are used to control the transmission intensity of the probe field and the dimensionless amplitude of the SS.

关键词： second-order sideband Bose-Einstein condensate cavity optomechanical

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The different interactions of Colletotrichum gloeosporioides with two strawberry varieties and the involvement of salicylic acid

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Horticulture Research 2016年第1期3卷 277-286页

作者： qing-yu zhang Li-qing zhang Li-Li Song Ke Duan Na Li Yan-Xiu Wang qing-Hua Gao Shanghai Key Laboratory of Protected Horticultural Technology Forestry and Fruit Tree Research InstituteShanghai Academy of Agricultural Sciences(SAAS)Shanghai 201403China College of Landscape Architecture and Arts Northwest A&F UniversityYanglingShanxi 712100China College of Agricultural Sciences Gansu Agricultural UniversityLanzhou 730000China School of Life Science Taizhou UniversityTaizhou 318000China

The disease symptoms recognized as‘Anthracnose’are caused by Colletotrichum *** lead to large-scale strawberry(Fragaria×ananassa Duchesne)losses worldwide in terms of both quality and *** is known regarding the mechanisms underlying the genetic variations in the strawberry–Colletotrichum *** this work,Colletotrichum gloeosporioides(***)infection was characterized in two varieties exhibiting different susceptibilities,and the involvement of salicylic acid(SA)was *** microscopic observation showed that *** conidia germinated earlier and faster on the leaf surface of the susceptible cultivar compared with the less-susceptible *** PR genes were differentially expressed,with higher-amplitude changes observed in the less-susceptible *** less-susceptible cultivar contained a higher level of basal SA,and the SA levels increased rapidly upon infection,followed by a sharp decrease before the necrotrophic *** SA pretreatment reduced susceptibility and elevated the internal SA levels in both varieties,which were sharply reduced in the susceptible cultivar upon *** less-susceptible cultivar also displayed a more sensitive and marked increase in the transcripts of NB-LRR genes to ***,and SA pretreatment differentially induced transcript accumulation in the two varieties during ***,SA directly inhibited the germination of *** conidia;NB-LRR transcript accumulation in response to SA pretreatment was both dose-and *** results demonstrate that the less-susceptible cultivar showed reduced conidia *** contribution of SA might involve microbial isolate-specific sensitivity to SA,cultivar/tissue-specific SA homeostasis and signaling,and the sensitivity of R genes and the related defense network to SA and pathogens.

关键词： cultivar straw gloeosporioides

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Modelling of urban ambient N,N-dimethylformamide concentrations in a small-scale synthetic leather industrial zone

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第5期12卷 374-389页

作者： yu-mei WEI Wei-li TIAN Ying-yue ZHENG qing-yu zhang Lei JIANG Zu-cheng WU Department of Envtronmental Engineering Zhejiang University Hangzhou 310027 China Zhejiang Provincial Engineering Research Center of Industrial Boiler & Furnace Flue Gas Pollution Control Hangzhou 311202 China

A method to model small-scale ambient concentrations of N, N-dimethylformamide (DMF) in a synthetic leather industrial zone was developed. Longwan, a district of Wenzhou City in Southeast China, was selected as the study area. DMF emissions at the synthetic leather industrial zone were inventoried, during 2007, and an AMS/EPA regulatory model (AERMOD) was used to simulate DMF concentrations using 10 000 100 m×100 m grids for the 2006 period. In 2007, actual DMF concentrations were recorded at seven DMF monitoring stations, and were compared with simulated results for the same timeframe. Simulated DMF concentrations were predicted to be in the range of 0.012-2.31 mg/m3, which is similar to the range of the monitored dataset results. A large majority (93%) of relative errors (REs) between simulated and monitored concentrations ranged from 0.48% to 189.4%. While DMF emissions within factories did not exceed the regulated emission limit, simulations indicated that, in 2006, 20% of the daily average ambient DMF concentrations exceeded this limit. This Modelling method could be applied in evaluating regional atmospheric environmental capacities and human exposure to DMF.

关键词： N N-dimethylformamide (DMF) Geographic information system (GIS) Emission inventory AERMOD Small-scale

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Chronic Toxicity of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats

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Chinese Medical Sciences Journal 2011年第1期26卷 20-27页

作者： Fei Xia qing-yu zhang Yong-ping Jiang Biopharmaceutical R&D Center Chinese Academy of Medical Sciences & Peking Union Medical College Suzhou 215126 China Biopharmagen Corporation Suzhou 215126 China

Objective To assess the severity and reversibility of the chronic toxicity of a novel recombinant human granulocyte colony-stimulating factor (rhG-CSFa) in rats and the dose-effect *** A total of 100 Sprague-Dawley rats (equal numbers of male and female) were randomly divided into five groups (20 rats in each group):four groups were treated with rhG-CSFa at 500,100,10,1 μg/kg,respectively,and one group was treated with vehicle only to serve as the *** rats were received subcutaneous injections of rhG-CSFa or vehicle daily for 13 *** the course of the chronic toxicity study,the physical status,body weight,and food consumption were *** of the rats in each group (n=10) were sacrificed after the last rhG-CSFa administration,and the other half were sacrificed at five weeks after the last rhG-CSFa ***,blood biochemistry,hematological analysis,histopathological examination,and immunological tests were performed for each of the *** The hematological analyses revealed that the mean white blood cells count,neutrophils count,and neutrophils percentage were increased in male rats at the dose of 10 μg/kg or higher,and these were related with the biological activity of *** small abnormalities were observed in the spleen of a few rats when used highest dose (500 μg/kg,a dosage of 200 folds higher than the normal clinical dosage),but these abnormalities were recovered within 5-week recovery *** other rhG-CSFa-related abnormalities were observed in this chronic toxicity *** No significant toxicity and immunogenicity are observed with rhG-CSFa administration to rats in the chronic toxicity studies.

关键词： chronic toxicity Sprague-Dawley rat novel recombinant human granulocytecolony-stimulating factor

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The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3820-3835页

作者： Yisheng He Jiang Ma Xiaoyu Fan Liang Ding Xinxin Ding qing-yu zhang Ge Lin School of Biomedical Sciences Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Pharmacology&Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA

Pyrrolizidine alkaloids(PAs) are the most common phytotoxins with documented human *** require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts,thereby causing *** study investigated the role of the gut-liver axis in PA intoxication and the underlying *** exposed mice to retrorsine(RTS),a representative PA,and for the first time found RTS-induced intestinal epithelium damage and disruption to intestinal barrier *** mice with tissue-selective ablation of P450 activity,we found that hepatic P450 s,but not intestinal P450 s,were essential for PA ***,in RTS-exposed,bile duct-cannulated rats,we found the liver-derived reactive PA metabolites were transported by bile into the intestine to exert *** impact of gut-derived pathogenic factors in RTS-induced hepatotoxicity was further studied in mice with dextran sulfate sodium(DSS)-induced chronic *** treatment increased the hepatic endotoxin level and depleted hepatic reduced glutathione,thereby suppressing the PA detoxification *** to RTS-exposed normal mice,the colitic mice displayed more severe RTS-induced hepatic vasculature damage,fibrosis,and ***,our findings provide the first mode-of-action evidence of PA-induced enterotoxicity and highlight the importance of gut barrier function in PA-induced liver injury.

关键词： Pyrrolizidine alkaloid Cytochrome P450 Inflammatory bowel disease Intestinal injury Liver injury Gut-liver axis

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Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation

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World Journal of Diabetes 2022年第2期13卷 97-109页

作者： Wen-qing Shi Mou-Xin zhang Li-Ying Tang Lei Ye yu-qing zhang Qi Lin Biao Li Yi Shao Yao yu Department of Endocrinology and Ophthalmology The First Affiliated Hospital of Nanchang UniversityJiangxi clinical research center for endocrine and metabolic diseaseNanchang 330006Jiangxi ProvinceChina Xiamen Eye Center of Xiamen University School of MedicineXiamen UniversityXiamen 361001Fujian ProvinceChina Department of Ophthalmology Zhongshan Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361001Fujian ProvinceChina

BACKGROUND Diabetes mellitus is a metabolic disorder characterized by prolonged elevation of blood glucose due to various ***,the relationship between diabetic retinopathy(DR)and altered connectivity of brain function is *** To investigate the relationship between this brain activity and clinical manifestations and behaviors of DR patients by using the amplitude of low-frequency fluctuation(ALFF)*** Twenty-four DR patients and 24 healthy controls(HCs)matched for age and gender were *** measured and recorded average ALFF values of DR patients and HCs and then classified them using receiver operating characteristic(ROC)*** ALFF values of both left and right posterior cerebellar lobe and right anterior cingulate gyrus were remarkably higher in the DR patients than in the HCs;however,DR patients had lower values in the bilateral calcarine *** curve analysis of different brain regions demonstrated high accuracy in the area under the curve *** was no significant relationship between mean ALFF values for different regions and clinical presentations in DR *** synchronization abnormalities in some brain regions of DR patients were associated with cognitive and visual *** Abnormal spontaneous brain activity was observed in many areas of DR patients’brains,which may suggest a possible link between clinical manifestations and behaviors in DR patients.

关键词： Amplitude of low-frequency fluctuation Functional magnetic resonance imaging Diabetic retinopathy Resting-state Diabetes mellitus Spontaneous activity

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Fault tolerant controlled quantum dialogue against collective noise

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Chinese Physics B 2020年第1期29卷 128-139页

作者： Li-Wei Chang yu-qing zhang Xiao-Xiong Tian yu-Hua Qian Shi-Hui Zheng College of Information Shanxi University of Finance and EconomicsTaiyuan 030006China Institute of Big Data Science and Industry Shanxi UniversityTaiyuan 030006China School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing 100876China

Quantum system is inevitably affected by the external environment in the real *** controlled quantum dialogue protocols are put forward based on logicalχ-type states under collective noise *** is against collectivedephasing noise,while the other is against collective-rotation *** with existing protocols,there exist several outstanding advantages in our proposed protocols:Firstly,theχ-type state is utilized as quantum channels,it possesses better entanglement properties than GHZ state,W state as well as cluster state,which make it difficult to be destroyed by local ***,two kinds of logicalχ-type states are constructed by us in theory,which can be perfectly immune to the effects of collective ***,the controller can be offline after quantum distribution and permission announcement,without waiting for all the participants to complete the information ***,the security analysis illuminates that our protocols can not only be free from the information leakage,but also resist against the interceptand-resend attack,the entanglement-and-measure attack,the modification attack,the conspiring attack,and especially the dishonest controller’s attacks.

关键词： controlled quantum dialogue collective noise logicalχ-type state dishonest controller’s attacks

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