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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge yueyang Zhao yuanjie liu qinghua Zeng qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

湿法脱硫浆液中Hg^(2+)的还原机制研究

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燃料化学学报 2017年第6期45卷 755-760页

作者：赵莉何青松刘宇吴洋文陆强刘松涛董长青华北电力大学生物质发电成套设备国家工程实验室北京102206 华北电力大学环境科学与工程学院河北保定071003

针对燃煤电厂湿法脱硫浆液中Hg^(2+)易被还原的特性,研究Hg^(2+)在模拟湿法脱硫系统中的迁移机制,考察了浆液温度、pH值以及SO_3^(2-)、Cl^-、Ca^(2+)、Mg^(2+)浓度等因素对Hg^(2+)还原性能的影响。结果表明,Hg^(2+)还原率随着浆液中SO_... 详细信息

针对燃煤电厂湿法脱硫浆液中Hg^(2+)易被还原的特性,研究Hg^(2+)在模拟湿法脱硫系统中的迁移机制,考察了浆液温度、pH值以及SO_3^(2-)、Cl^-、Ca^(2+)、Mg^(2+)浓度等因素对Hg^(2+)还原性能的影响。结果表明,Hg^(2+)还原率随着浆液中SO_3^(2-)浓度的增大而降低;pH值对Hg^(2+)的还原呈先增加后降低的趋势,在pH值为5.5时还原率最高;温度的升高不利于浆液中稳定的二价汞盐络合物存在,导致Hg^(2+)还原率增加;Ca^(2+)、Mg^(2+)以及Cl^-浓度的增加有利于形成稳定化合物,从而抑制Hg^(2+)的还原。

关键词： Hg^2+还原 pH值浆液温度离子浓度湿法脱硫

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

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Nano Research 2025年第1期18卷 50-75页

作者： Jingwen yu yunliang liu Naiyun liu Yaxi Li yuanyuan Cheng Peng Cao Yixian liu Xinya yuan Xinyue Zhang Haitao Li Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

Characterization on Jointed Rock Masses Based on PFC2D

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Characterization on Jointed Rock Masses Based on PFC2D

2012颗粒材料计算力学会议

作者： Wang Pei-Tao Yang Tian-Hong yu qing-Lei liu Hong-Lei Zhang Peng-Hai P.O.Box 138, Northeastern University, Shenyang 110819, China

Geometrical parameters of discontinuities, such as spacing, length, dip and fault throw between joints have a great influence on the mechanical behavior of jointed rock masses. Accurate characterization for discontinuities is important for investigate the stability of rock masses. In this paper, the PFC2D is combined with joint network generation method to examine the mechanical behaviors of jointed mass. Taking Miaogou Open-pit Mine as an example, the information and statistical distributions of discontinuities of the slope rock masses are measured by ShapeMetriX3D measuring tool. Then, the automatic generation algorithm of random joints network based on the Monte-Carlo method is proposed using the programming language (FISH) embedded within PFC2D. This algorithm could represent the discontinuities compared with the geological surveys. In simulating the compression test of a jointed rock sample, the mechanical behavior and crack propagation were investigated. The results reveal that the failure mode and crack propagation of the jointed rock are dominated by the distribution of joints in addition to the intact rock properties. The simulation result shows the feasibility of the joints generating method in application to jointed rock mass.

关键词： jointed rock masses shape metrix3D monte-carlo stochastic simulation method PFC2D

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舰艇振动声学特性数值分析

上海交通大学学报 2002年第11期36卷 1537-1539,1543页

作者：杨德庆王德禹刘洪林上海交通大学船舶与海洋工程学院上海200030

交替运用结构有限元法与声学边界元法 ,对某型艇振动声学特性数值计算问题进行了研究 .建立了全船三维有限元分析模型 ,通过频响分析计算 ,获得结构振动响应特性参数 .以船体结构频响分析计算结果为声学边界条件 ,建立了全船三维边界元... 详细信息

交替运用结构有限元法与声学边界元法 ,对某型艇振动声学特性数值计算问题进行了研究 .建立了全船三维有限元分析模型 ,通过频响分析计算 ,获得结构振动响应特性参数 .以船体结构频响分析计算结果为声学边界条件 ,建立了全船三维边界元声学分析模型 ,并采用直接边界元法 ,对全船近场声学特性进行了计算 .对比计算结果与实测数据表明 ,该计算方法是可行的。

关键词：船舶振动声学数值分析

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-Cheng liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li qing-Fang Guan Shu-Hong yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

Enhanced electrochemical CO_(2)reduction coupled with urea oxidation using bifunctional atomically dispersed CuNi catalysts

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Nano Research 2025年第1期18卷 208-216页

作者： Wenjie Wu Haoyang Zhou Ying liu Yifei Pan qingqing Chen yu Zhang Junjie Mao Wenjie Ma Ping yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China University of Chinese Academy of Sciences Beijing 100049China

The electrochemical conversion of carbon dioxide(CO_(2))into chemical fuels represents a promising approach for addressing global carbon balance ***,this process is hindered by the kinetic limitations of anodic reactions,usually the oxygen evolution reaction,resulting in less efficient production of high value-added ***,we report an integrated electrocatalytic system that couples CO_(2)reduction reaction(CO_(2)RR)with urea oxidation reaction(UOR)using a bifunctional electrocatalyst with atomically dispersed dual-metal CuNi sites anchored on bamboo-like nitrogen-doped carbon nanotubes(CuNi-CNT),which were synthesized through a one-step pyrolysis *** bifunctional CuNi-CNT catalyst exhibits a near 100%CO Faraday efficiency for CO_(2)RR over a wide potential range and outstanding UOR performance with a negatively shifted potential of 210 mV at 10 mA·cm^(-2).In addition,we assemble a two-electrode electrolyzer using bifunctional CuNi-CNT-modified carbon fiber paper electrodes as both cathode and anode,capable of operating at a remarkably low cell voltage of 1.81 V at 10 mA·cm-2,significantly lower than conventional *** study provides a novel avenue to achieving an efficient carbon cycle with reduced electric power consumption.

关键词： electrochemical conversion bimetallic site catalyst bifunctional electrocatalyst carbon dioxide reduction urea oxidation

Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging

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Nano Research 2025年第1期18卷 675-683页

作者： Xue Li Yanan Guo Guoying Tan qingyi liu Nan Song yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China

Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and ***,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical *** this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic *** from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in ***,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)***,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell ***,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关键词： aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-yu liu Sha-Sha Cui Ting-Ting Li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species