检索结果-南通市图书馆

Effect of Hirudin on farnesol X receptor pathway during acute intrahepatic cholestasis

Gastroenterology & Hepatology Research 2022年第2期4卷 29-35页

作者： yu-qing liu Yao Wang Wen-qian Tang Xin Cai Ren-wu Qin Lei Luo Fan Yang School of First Clinical Medicine Hubei University of Chinese MedicineHubei Wuhan 430061China Department of Infectious Diseases Renmin Hospital of Wuhan UniversityHubei Wuhan 430060China Yichang Hospital of TCM Affiliated to Clinical Medical College of TCM of China Three Gorges University Hubei Yichang 443003China The Second People’s Hospital of China Three Gorges University Hubei Yichang 443000China Department of Hepatology Hubei Provincial Hospital of Chinese MedicineHubei Wuhan 430061China

Objective:The purpose of this study is to explore the effect of Hirudin on the farnesoid X receptor(FXR)pathway during acute intrahepatic cholestasis in vivo and in ***:In vivo,sixty male Sprague-Dawley rats were randomly divided into six groups:regular group,model group,ursodeoxycholic acid(UDCA)group(60 mg/kg),hirudin treatment group(84 u/kg),hirudin treatment group(63 u/kg)and hirudin treatment group(42 u/kg).The male Sprague-Dawley rats of UDCA group were intragastrically administered with a corresponding concentration of 0.005 mL/g body weight for seven days,once a day;and the hirudin treatment group was injected subcutaneously with different concentrations of Hirudin for seven days,once a day;Except for the normal group,other groups of rats were given 100 mg/kg ANIT by gavage on the 5th *** model was administered by gavage once a day for three *** vitro,(Z)-Guggulsterone was used to stimulate the L02 cells(0.05μmol/ml),with or without different concentrations of Hirudin(2,4 and 8 u/ml)for 24 *** liver tissue was examined by HE microscope and the pathological state of the rat liver was observed;FXR,Small heterodimeric chaperone receptor(SHP),uridine diphosphate glucuronide transfer 2B4(UGT2B4),bile salt output pump(BSEP)mRNA and protein expressions were tested by real-time fluorescent quantitative PCR and Western blot *** immunohistochemistry(IHC)was used to analyze the expression of ***:Compared with the model group,the hirudin group can improve liver tissue damage,and promote FXR,SHP,BSEP and UGT2B4 proteins and mRNA expression in vivo and in ***:Hirudin can alleviate intrahepatic cholestasis,reduce liver tissue *** can up-regulate the expression of FXR gene,promote the up-regulation of SHP,BSEP and UGT2B4 genes,and inhibit the cholestasis pathway to protect liver *** study may provide an effective drug for clinical treatment of intrahepatic cholestasis.

关键词： hirudin (Z)-Guggulsterone α-isothiocyanate(ANIT) cholestasis FXR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remote Sensing CO,CO_2 in Vehicle Emissions Based on TDLAS

引用

光机电信息 2007年第5期24卷 25-30页

作者： WANG Tie-dong liu Wen-qing ZHANG yu-jun liu Jian-guo DONG Feng-zhong WANG Min WANG Xiao-mei XU Min Key Laboratory of Environment Optics and Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of SciencesHefei 230031China

Knowing the quantity of pollutants that the vehicle fleet is emitting to the air has become a vital problem in almost every major city in China. Finding and fixing gross polluters is therefore very important to control the urban air quality and protect the human health and the environment. Remote sensing is an important advance in the technology of on-road vehicle emissions testing because it is fast, mobile, and unobtrusive. This on-road vehicle emissions remote system is designed to measure the carbon monoxide, carbon dioxide and opacity from the vehicles's tailpipe based on the Tunable Diode Laser Absorption Spectroscopy (TDLAS). There are several advantages of this system such as compact design and easy of use. The measurement principle and optical layout of the instrument has been described in this paper. Field testing at Beijing and Hefei were conducted over one year, more than 6 000 vehicles were tested. This vehicle emissions remote system has been shown to be able to measure CO,CO2 and opacity from individual at highway speeds. In parallel, the plate license, speed, acceleration and length of vehicle are recognised by computer so that the owners of vehicles exceeding the permissible level of emissions can be identified.

关键词：车辆排放一氧化碳排放二氧化碳排放遥感 TDLAS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tongue reconstruction with anterolateral thigh flap for middle-late stage tongue cancer patients

引用

中国口腔颌面外科杂志 2008年第B5期6卷 203-204页

作者： Liao Gui-qing Su yu-xiong liu Hai-chao Wang Qin Ou De- ming Zhang Tong-han Department of Oral and Maxillofacial Surgery Guanghua Schoolof Stomatolog% Sun Yat-sen University Guangzhou 510055China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

引用

Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang liu yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于软件定义无线网络的云业务上行调度方案

引用

通信学报 2016年第12期37卷 21-31页

作者：潘甦肖榜陈宇青刘胜美南京邮电大学宽带无线通信与传感网技术教育部重点实验室江苏南京210003

针对无线云计算的业务特点,基于软件定义无线网络(SDWN,software-defined wireless network),提出了一种新的能适配云业务特点的LTE上行调度方案,该方案首先将资源分配问题归纳成二进制整数规划问题进行求解,然后利用动态规划计算出每... 详细信息

针对无线云计算的业务特点,基于软件定义无线网络(SDWN,software-defined wireless network),提出了一种新的能适配云业务特点的LTE上行调度方案,该方案首先将资源分配问题归纳成二进制整数规划问题进行求解,然后利用动态规划计算出每个调度时隙内云业务的最佳发送速率,最后通过SDWN框架下的Qo S控制方法动态调节云业务的发送速率,使云业务的发送速率与当前信道条件成正比,从而在保障多业务速率需求的同时,满足云业务能量消耗最小的需求,通过仿真验证算法的性能。

关键词： SDWN 无线云 LTE调度最优化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

密实型沥青混合料裂缝感应热自愈合性能研究

引用

中国公路学报 2017年第1期30卷 17-24页

作者：何亮赵龙凌天清马育刘全涛重庆交通大学交通土建工程材料国家地方联合工程实验室重庆400074 长沙理工大学道路结构与材料交通行业重点实验室湖南长沙410004 长安大学特殊地区公路工程教育部重点实验室陕西西安710064 武汉理工大学硅酸盐建筑材料国家重点实验室湖北武汉430070

为给沥青路面电磁感应自修复技术提供参考依据,通过掺加钢丝绒制备了可用于感应加热的密实型沥青混合料小梁,研究其裂缝感应热自愈合性能。对不同类型、不同掺量钢丝绒的混合料试件进行了电磁感应加热试验,研究了感应加热试件的升温速率... 详细信息

为给沥青路面电磁感应自修复技术提供参考依据,通过掺加钢丝绒制备了可用于感应加热的密实型沥青混合料小梁,研究其裂缝感应热自愈合性能。对不同类型、不同掺量钢丝绒的混合料试件进行了电磁感应加热试验,研究了感应加热试件的升温速率,并进一步开展了裂缝自愈合能力试验以及混合料的路用性能试验,对混合料进行了综合优化设计。研究结果表明:电磁感应加热是对混合料中的沥青加热而非集料加热,热量由沥青胶结料转移到集料中,加热迅速,能耗低;加热温度不能高于100℃,否则混合料会膨胀松散;钢丝绒越长,掺量越高,密实型钢丝绒沥青混合料试件的电磁感应平均加热速率越高;2~#钢丝绒(6.5mm)掺量为4%的试件在顶面加热至90℃时表现出最佳的愈合率(96.7%),顶面加热至75℃时同样具有理想的愈合率(95.4%),且此温度下能够节约能耗和避免试件松散;2~#钢丝绒(3.5mm)掺量为2%的密实型沥青混合料具有最优良的路用性能;结合混合料路用性能和感应热自愈合能力分析,2~#钢丝绒(3.5mm)掺量为4%的密实型沥青混合料在顶面电磁感应加热到75℃时具有94.6%的理想自愈合率和良好的路用性能,且能耗经济。

关键词：路面工程密实型沥青混合料试验研究裂缝自愈合感应加热钢丝绒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

引用

Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-qing Chen Yong-Qi Li yu-Long Wang Mei-Chen liu yun-Bo Ruan Yang Zhang Shu-Juan liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

引用

Journal of Energy Chemistry 2025年第1期100卷 458-468页

作者： Peng Zhu Cun liu Yiren yu Guoshu Gao yumeng Zhao Xiongfu Zhang Guodong liu Guohui Yang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. Here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silicalite-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive colloidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classical oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles facilitated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-scale production of ZSM-5 nanosheets was successfully carried out in a 3 L highpressure autoclave, yielding samples consistent with those from laboratory-scale synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Scale-up synthesis Aromatic alkylation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一种近红外荧光蛋白PAiRFP1及其突变体V276G的光活化效率研究

引用

光谱学与光谱分析 2017年第11期37卷 3379-3385页

作者：白英男冯娟胡奇洲吴清勤周雨刘贻尧电子科技大学生命科学与技术学院四川成都610054

PAiRFP1是一种以根癌农杆菌中细菌光敏色素Agp2为基础,经过蛋白工程手段改造后获得的近红外荧光蛋白。与其他近红外荧光蛋白不同,PAiRFP1具有光活化行为。这一特性可以有效改善近红外荧光蛋白在体内的成像信噪比。然而,关于光活化行为... 详细信息

PAiRFP1是一种以根癌农杆菌中细菌光敏色素Agp2为基础,经过蛋白工程手段改造后获得的近红外荧光蛋白。与其他近红外荧光蛋白不同,PAiRFP1具有光活化行为。这一特性可以有效改善近红外荧光蛋白在体内的成像信噪比。然而,关于光活化行为的影响因素却研究甚少。主要采用荧光光谱学手段研究了PAiRFP1蛋白浓度、pH、金属离子、氧化还原环境对于PAiRFP1光活化行为的影响,结果发现:(1)PAiRFP1的最大光活化效率与该近红外荧光蛋白的浓度不呈线性关系;(2)随着pH从6.5升高至7.8和9.0,PAiRFP1的最大光活化效率从36.8%提高至52.0%和60.8%;(3)金属离子K^+,Na^+,Ca^(2+)的加入对于PAiRFP1的最大光活化效率没有显著影响;类似现象在H_2O_2和DTT的处理的情况下也被观察到。除了上述影响因素外,还发现当PAiRFP1中276位的缬氨酸被突变为甘氨酸产生V276G突变体后,蛋白的最大光活化效率从~50.0%下降至19.4%。DTT处理后导致V276G突变体最大光活化效率从19.4%提高到了27.1%。此外,比较研究了各种影响因素对于光活化速率的影响。以上结果为今后更好地将此类光激活的近红外蛋白应用于活体成像中提供了更好地理论指导和优化解决方案。

关键词：细菌光敏色素近红外荧光蛋白光活化效率突变体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ALLELOPATHIC RESEARCH AMONG SEVERAL PASTURE SPECIES DURING GERMINATION STAGE

ALLELOPATHIC RESEARCH AMONG SEVERAL PASTURE SPECIES DURING G...

引用

中国第三届植物化感作用学术研讨会、第八届全国杂草科学大会、联合国粮农组织——中国“水稻化感作用论坛”

作者： Yi-ming QIN,yu-qing HUANG,liu-wang NIE College of Life Science,Anhui Normal University,Wuhu 241000,China

Allelopathy is the chemical inhibition of one organism by *** effects are often observed between plant species at *** plants contain biologically active substances that are allelopathic to intra- and *** study was conducted to investigate varietals differences in allelopathic potential in pastures *** common varieties of pasture plants seeds of Sorghum sudanense(Piper) Stapf)(Gramineae),Cichorium intybus Linn.)(Compositae),Medicago sativa L.(Leguminosae),Lolium perenne Linn. (Gramineae) and Trrifolium repens L.(Leguminosae),were grown by mix culture of each other species and bioassayed of exudates from germinated seeds against other *** demonstrated that the allelopathic effect in every plant species was existent whether in seeds mix-cultured or in the exudates from seeds *** degree of inhibition or promotion of seeds germination and growth of seedling varied with the variety of pasture *** results suggested that some pasture species cultivation conditions should be based on the varieties of allelopathic characteristics of difference pastures species as their various allelopathic potentials.

关键词： Allelopathic effects seed exudates seeds germination pasture species bioassay

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：