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Prevention and control strategies for antibiotic resistance:from species to community level

Soil Ecology Letters 2024年第3期6卷 17-34页

作者： Yan-Zi Wang Hu Li qing-Lin Chen Ting pan Yong-Guan Zhu Dirk Springael Jian-Qiang Su Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Division of Soil and Water Management KU LeuvenKasteelpark Arenberg 20 Box 24593001 HeverleeBelgium

Antibiotic resistance genes(ARGs)and antibiotic resistant bacteria(ARB)in the environment pose serious threats to environmental security and public *** is an urgent need for methods to specifically and effectively control environmental pollution or pathogen infection associated with ARGs and *** review aims to provide an overview of methods abating the prevalence and spread of ARGs and ARB from species to community *** the species level,species-specific technologies,such as nanoparticle-,photosensitizer-,CRISPR-Cas-,and phage-related technology can be utilized to clear a particular class of ARGs or ARB,and in combination with low-dose antibiotics,a higher removal efficiency can be ***,the combination of antibiotics can be used to reverse microbial resistance and treat recurrent antibiotic resistant pathogen *** the community level,community-specific strategies,such as biochar,hyperthermophilic compost,and fecal microbiota transplantation can eradicate most types of ARGs or ARB in one shot,reducing the probability of resistance *** some progress has been made to eliminate ARGs and ARB in disease treatment or decontamination scenarios,further research is still needed to elucidate their mechanisms of action and scopes of application,and efforts should be made to explore novel strategies to counter the prevalence of antibiotic resistance.

关键词： antibiotic resistance genes antibiotic resistant bacteria treatment strategy disinfection

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Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： Xi Yang Changkun pan Meitong Ye Jinshuo Liang Haoyang Cheng qing Liang Shu Huang Jianshu Wang Hoi Yee Chow Haihuai He Cancer Center and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

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Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

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Petroleum Science 2024年第3期21卷 1915-1927页

作者： pan Wang Yu-Hang Hu Liao-Yuan Zhang Yong Meng Zhen-Fu Ma Tian-Ru Wang Zi-Lin Zhang Ji-Chao Fang Xiao-Qiang Liu qing You Yan Zhang Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences(Beijing)Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Petroleum Engineering Technology Research Institute Sinopec Shengli Oilfield CompanyDongying257000ShandongChina Hekou Oil Production Plant Sinopec Shengli Oilfield CompanyDongying257200ShandongChina Petroleum Exploration and Production Research Institute SINOPECBeijing102206China CNPC Engineering Technology R&D Company Limited Beijing102206China

Nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability *** are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their *** study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core *** pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and ***,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability *** work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

关键词： Nanoparticle Pressure reduction Augmented injection Ultra-low permeability reservoir

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The association and underlying mechanism of the digit ratio(2D:4D)in hypospadias

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Asian Journal of Andrology 2024年第4期26卷 356-365页

作者： Yu Ding Zu-Quan Chen Wen-Feng pan Hao-Jie Chen Min Wu Yi-qing Lyu Hua Xie Yi-Chen Huang Zhong-Zhong Chen Fang Chen Department of Urology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Urogenital Development Research Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Clinical Research Center for Hypospadias Pediatric CollegeShanghai Jiao Tong University School of MedicineShanghai 200062China.

The second-to-fourth digit(2D:4D)ratio is thought to be associated with prenatal androgen ***,the relationship between the 2D:4D ratio and hypospadias is poorly understood,and its molecular mechanism is not *** this study,by analyzing the hand digit length of 142 boys with hypospadias(23 distal,68 middle,and 51 proximal)and 196 controls enrolled in Shanghai Children’s Hospital(Shanghai,China)from December 2020 to December 2021,we found that the 2D:4D ratio was significantly increased in boys with hypospadias(Ppancy was mainly caused by a shift in *** characterization of a mouse model validated that low testosterone levels during pregnancy can impair the growth and development of *** mechanistic explorations revealed that during the androgen-sensitive window,the downregulation of the androgen receptor(AR)caused by low testosterone levels,as well as the suppressed expression of chondrocyte proliferation-related genes such as Wnt family member 5a(Wnt5a),Wnt5b,Smad family member 2(Smad2),and Smad3;mitochondrial function-related genes in cartilage such as AMP-activated protein kinase(AMPK)and nuclear respiratory factor 1(Nrf-1);and vascular development-related genes such as myosin light chain(MLC),notch receptor 3(Notch3),and sphingosine kinase 1(Sphk1),are responsible for the limitation of 4D growth,which results in a higher 2D:4D ratio in boys with hypospadias via decreased endochondral *** study indicates that the ratio of 2D:4D is a risk marker of hypospadias and provides a potential molecular mechanism.

关键词： androgen receptor digit ratio(2D:4D) endochondral ossification hypospadias testosterone level

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Rare variants in FANCJ induce premature ovarian insufficiency in humans and mice

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Journal of Genetics and Genomics 2024年第2期51卷 252-255页

作者： Xi Yang Shuting Ren Jialin Yang Yuncheng pan Zixue Zhou qing Chen Yunzheng Fang Lingyue Shang Feng Zhang Xiaojin Zhang Yanhua Wu State Key Laboratory of Genetic Engineering at School of Life Sciences Human Phenome InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200438China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentState Key Laboratory of Genetic Engineering at School of Life SciencesFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China State Key Laboratory of Genetic Engineering at School of Life Sciences Obstetrics and Gynecology HospitalFudan UniversityShanghai 200438China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China

Premature ovarian insufficiency(POI)is a severe female reproductive disorder that affects 1%of women in general populations(European Society for Human Reproduction and Embryology[ESHRE]Guideline Group on POI et al.,2016).An increasing prevalence up to 3.7%has been reported in a recent meta-analysis(Golezar et al.,2019).POl can lead to infertility or subfertility,as well as a range of complex complications suffering multi-organ systems,seriously threatening women's health and reducing the life *** contrast,POl is a representative heterogeneous disease with multiple *** more than 70 causative POI genes have been identified,the etiology of more than half of the POI patients is still ambiguous(Jiao et al.,2018).Unreported POI causative genes,therefore,remain to be identified.

关键词： insufficiency fertility

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"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 503-510页

作者： Xiao-Si Hu Yong Wang Hong-Tao pan Chao Zhu Shi-Lei Chen Hui-Chun Liu qing pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and *** To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD *** A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed *** patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were *** relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also *** Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 *** were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct *** BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/*** patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic *** analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection ***,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants

关键词： Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance Laparoscopic pancreaticoduodenectomy

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A biobank of patient derived glioma organoids

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Science China Life Sciences 2024年

作者： Yulin Wen Hongmin Bai qing Li Sainan Huang Xiaokun Jia Guangjin pan Hongjie Yao State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University University of Chinese Academy of Sciences Department of Neurosurgery General Hospital of Southern Theatre Command Department of Basic Research Guangzhou National Laboratory

Dear Editor,Gliomas are the most prevalent malignant tumors affecting the central nervous system (CNS), categorized into low-grade gliomas (LGG) comprising CNS WHO grades 2–3, and high-grade gliomas(HGG) encompassing CNS WHO grade 4(Aldape et al., 2015). The current standard therapeutic approach involves maximal safe margin excision followed by radiotherapy and temozolomide (TMZ)treatment (Armstrong et al., 2020).However, due to the unique site and microenvironment of gliomas, patients experience limited benefits from emerging revolutionary therapies such as targeted therapy and immunotherapy (Sampson et al., 2020; Yang et al., 2022).

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Regulated reaction pathway of CO2 photoreduction into CH4 by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： Dong-Po He Guang-Bing Huang Jun Hu Yang Wu Xiao-Dong Li qing-Xia Chen Shan Zhu Wen-Sheng Yan Jun-Fa Zhu Yang pan Xing-Chen Jiao Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan University Hefei National Research Center for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of China Max Planck Institute of Microstructure Physics State Grid Anhui Electric Power Research Institute

The carbon dioxide （CO2） reduction process involves complex protonation, making the resulting product often unpredictable. To achieve the desired product, it is crucial to manipulate the reaction steps. Herein, we build the metal atom pair sites for selective CO2photoreduction into methane. As a prototype, Ni atom pair sites loaded on the Mo S2nanosheets were synthesized and verified by highresolution transmission electron microscopy （HRTEM）,X-ray photoelectron spectroscopy （XPS） and X-rayabsorption near edge structure spectra （XANES）. In-situ Fourier transform infrared spectroscopy （FTIR） monitors the*CHO group, a crucial intermediate in CH4production,during CO2photoreduction on the Ni-Mo S2nanosheets,whereas this monitoring is not observed for the Mo S2nanosheets. Also, theoretical calculations disclose that over the Ni-Mo S2nanosheet slab, the formation energy of*CHO intermediates is determined to be lower （0.585 e V） than the desorption energy of*CO intermediates for CO production（0.64 e V）, implying the higher selectivity of CH4production. Accordingly, the Ni-Mo S2nanosheets demonstrate a methane formation rate of 27.21μmol·g-1·h-1, coupled with an impressive electron selectivity of 94.2%.

关键词： Nanosheets

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Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator

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CCS Chemistry 2024年第2期6卷 439-449页

作者： Zhen Zou Songlan pan Qian Xue Ting Chen Ziyun Huang Bei qing Pengfei Liu Conghui Zhao Yunlin Sun Erhu Xiong Ronghua Yang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081 School of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of CytochemistryChangsha University of Science and TechnologyChangsha 410114 The Second Xiangya Hospital Central South UniversityChangsha 410011

Targeted protein degradation(TPD)is an emerging tool for degrading proteins of interest,which affords an attractive modality for cancer ***,the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or ***,we report an artificial tractor that can induce endocytosis-mediated protein depletion without hijacking a proteolysis-specific *** this design,bispecific aptamer chimeras(BSACs)are established,which can bridge human epidermal growth factor receptor 2(ErbB-2),an important biomarker in a common important biomarker in cancer,with membrane proteins of *** advantage of the property of aptamer-induced endocytosis and digestion of ErbB-2,another membrane protein is translocated into the lysosome in a hitchhike-like manner,resulting in lysosomal proteolysis along with *** strategy frees the TPD from the fundamental limitation of proteolysis-specific actuator and allows simultaneous regulation of the quantity and function of two oncogenic receptors in a cell-type-specific manner,expanding the application scope of TPD-based therapeutics.

关键词： targeted protein degradation aptamer epidermal growth factor receptor 2 lysosome membrane proteins cancer therapy

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“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-Tao pan Chao Zhu Shi-Lei Chen Shuai Zhou Hui-Chun Liu qing pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

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