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“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-tao Pan Chao Zhu Shi-Lei Chen Shuai Zhou Hui-Chun Liu qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

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利用MODIS数据识别若尔盖草地的沙化--分层分类方法

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自然灾害学报 2009年第1期18卷 133-138页

作者：张顺谦郭海燕卿清涛田宏罗勇四川省气候中心四川成都610071 中国气象局成都高原气象研究所四川成都610071 国家气候中心北京100081

利用2004年9月15日的MODIS数据,应用Jeffries-Matusita距离可分性函数分析了若尔盖沙化地、潜在沙化地、高寒草甸、沼泽草甸和泥炭地在各光谱通道上的可分性,得到了分层分类时每一地类的识别顺序和应当使用的光谱通道序列。对图像的分... 详细信息

利用2004年9月15日的MODIS数据,应用Jeffries-Matusita距离可分性函数分析了若尔盖沙化地、潜在沙化地、高寒草甸、沼泽草甸和泥炭地在各光谱通道上的可分性,得到了分层分类时每一地类的识别顺序和应当使用的光谱通道序列。对图像的分类结果表明:样本总体测试精度达96%,Kappa系数达0.95,沙化地、潜在沙化地面积与当年地面监测结果分别相差-2.71%和0.73%,表明该方法具有较高的沙化面积监测精度。监测结果表明:自2000年以来,若尔盖牧区草地沙化面积仍以年均14.06%的速度增加,湖泊湿地萎缩严重,该区生态恶化的现象仍未得到有效遏制。

关键词：草地沙化 MODIS遥感光谱可分性分层分类

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Stochastic programming based coordinated expansion planning of generation,transmission,demand side resources,and energy storage considering the DC transmission system

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Global Energy Interconnection 2024年第1期7卷 25-37页

作者： Liang Lu Mingkui Wei Yuxuan tao qing Wang Yuxiao Yang Chuan He Haonan Zhang Southwest Branch of State Grid Corporation of China Chengdu 610065P.R.China College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China

With the increasing penetration of wind and solar energies,the accompanying uncertainty that propagates in the system places higher requirements on the expansion planning of power systems.A source-grid-load-storage coordinated expansion planning model based on stochastic programming was proposed to suppress the impact of wind and solar energy *** types of system components,including demand response service entities,converter stations,DC transmission systems,cascade hydropower stations,and other traditional components,have been extensively ***,energy storage systems are considered to improve the accommodation level of renewable energy and alleviate the influence of ***-response service entities from the load side are used to reduce and move the demand during peak load *** uncertainties in wind,solar energy,and loads were simulated using stochastic ***,the effectiveness of the proposed model is verified through numerical simulations.

关键词： Hydro-wind-solar complementary Expansion planning Demand response Energy storage system Source-network-demand-storage coordination

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Fragility crossover mediated by covalent-like electronic interactions in metallic liquids

Materials Futures

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Materials Futures 2024年第2期3卷 117-130页

作者： Hui-Ru Zhang Liang Gao Yu-Hao Ye Jia-Xin Zhang tao Zhang qing-Zhou Bu Qun Yang Zeng-Wei Zhu Shuai Wei Hai-Bin Yu Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Department of Chemistry Aarhus University8000 AarhusDenmark iMAT Centre for Integrated Materials Research Aarhus University8000 AarhusDenmark

Fragility is one of the central concepts in glass and liquid sciences,as it characterizes the extent of deviation of viscosity from Arrhenius behavior and is linked to a range of glass ***,the intervention of crystallization often prevents the assessment of fragility in poor glass-formers,such as supercooled metallic *** experimental data on their compositional dependence are scarce,let alone fundamentally *** this work,we use fast scanning calorimetry to overcome this obstacle and systematically study the fragility in a ternary La–Ni–Al system,over previously inaccessible composition *** observe fragility dropped in a small range with the Al alloying,indicating an alloying-induced fragility *** use x-ray photoelectron spectroscopy,resistance measurements,electronic structure calculations,and DFT-based deep-learning atomic simulations to investigate the cause of this fragility *** results show that the fragility crossover can be fundamentally ascribed to the electronic covalency associated with the unique Al–Al *** findings provide insight into the origin of fragility in metallic liquids from an electronic structure perspective and pave a new way for the design of metallic glasses.

关键词： metallic glass fragility fast scanning calorimetry density functional theory deep learning potential

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Esophageal cancer screening,early detection and treatment:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-tao Qu qing Li Liang Hao Yan-Jing Ni Wen-Yu Luan Zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

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FLNB haploinsufficiency-related short stature:a new syndrome or an expanded spectrum of Larsen syndrome

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World Journal of Pediatrics 2024年第9期20卷 976-980页

作者： qing Wang Hong-Ying Wang Shui-Yan Wu Xue-Qian Wang Hai-Ying Wu Rong-Rong Xie Feng-Yun Wang Xiu-Li Chen Lin-Qi Chen Hai-tao Lv Ting Chen Department of Endocrinology Genetics and MetabolismChildren’s Hospital of Soochow UniversitySuzhouChina Suzhou Clinical Center for Rare Diseases in Children Children’s Hospital of Soochow UniversitySuzhouChina Intensive Care Unit Children’s Hospital of Soochow UniversitySuzhouChina Department of Cardiology Children’s Hospital of Soochow UniversitySuzhouChina Department of Pediatrics Kunshan Sixth People’s HospitalSuzhouJiangsuChina

FLNB encodes the protein filamin B(FLNB),which is expressed in chondrocytes of the human growth plate[1].To date,pathogenic mutations in the FLNB gene have solely been found to cause skeletal deformities,indicating th... 详细信息

关键词： insufficiency skeletal expanded

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Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia

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Translational Neurodegeneration 2019年第1期8卷 230-242页

作者： Qiao Wei Hai-Lin Dong Li-Ying Pan Cong-Xin Chen Yang-Tian Yan Rou-Min Wang Hong-Fu Li Zhi-Jun Liu qing-qing tao Zhi-Ying Wu Department of Neurology and Research Center of Neurology in Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Longyan First Hospital Fujian Medical UniversityLongyanChina Department of Neurology and Institute of Neurology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhouChina

Background:Although many causative genes of hereditary spastic paraplegia(HSP)have been uncovered in recent years,there are still approximately 50% of HSP patients without genetically diagnosis,especially in autosomal recessive(AR)HSP *** studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese ***:In this study,we investigated 24 Chinese index AR/sporadic patients by targeted next-generation sequencing(NGS),Sanger sequencing and multiplex ligation-dependent probe amplification(MLPA).Further functional studies were performed to identify pathogenicity of those uncertain significance ***:We identified 11 mutations in HSP related genes including 7 novel mutations,including two(p.V1979_L1980delinsX,p.F2343 fs)in SPG11,two(p.T55 M,p.S308 T)in AP5Z1,one(p.S242N)in ALDH18A1,one(p.D597fs)in GBA2,and one(p.Q486X)in ATP13A2 in 8 index patients and their family *** in ALDH18A1,AP5Z1,CAPN1 and ATP13A2 genes were firstly reported in the Chinese ***,the clinical phenotypes of the patients carrying mutations were described in *** mutation(p.S242 N)in ALDH18A1 decreased enzyme activity of P5CS and mutations(p.T55 M,p.S308 T)in AP5Z1 induced lysosomal ***:Our results expanded the genetic spectrum and clinical profiles of AR-HSP patients and further demonstrated the efficiency and reliability of targeted NGS diagnosing suspected HSP patients.

关键词： Hereditary spastic paraplegia Autosomal recessive Targeted next-generation sequencing Chinese Genetic spectrum Phenotype

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Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao Zhang Yue-Bin Zhang Duo-Te Cai tao Pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei Huang qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm to<3 mm),moderate(≥3 mm to<10 mm),and severe(≥10 mm)was observed in 17,17,and 2 rats in the surgical group,respectively,while no dilation was observed in the control and sham surgical *** levels of alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

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Negative permittivity of reduced graphene oxide/polyvinylidene fluoride membranous composites adjusted by heat treatment

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Rare Metals 2024年第11期 5964-5974页

作者： Kai Sun Min-Hui Zhao Peng-tao Yang Min Chen qing Hou Wen-Xin Duan Run-Hua Fan College of Ocean Science and Engineering Shanghai Maritime University School of Civil Engineering Shandong Jiaotong University Institute of Photonic Chips University of Shanghai for Science and Technology

Flexible composites with negative permittivity have a very broad development prospect in flexible electronics and wearable ***,how to control the negative permittivity except for from their intrinsic properties of components is still a *** this study,the negative permittivity and frequency dispersion were adjusted by changing the heat treatment *** fluoride(PVDF) was selected as the flexible matrix and reduced graphene oxide(rGO) as the functional filler to prepare rGO/PVDF membranous *** negative permittivity was observed in rGO/PVDF composites film,and the effect of heat treatment temperature on the negative permittivity was further *** indicated that a higher heat treatment temperature contributed to the formation of conductive network,so as to obtaining negative *** the molding temperature was 70 ℃,the negative permittivity spectrum conformed to the Drude model was only observed in the composites with 35 wt% content of *** the heat treatment temperature reached 180 ℃,when the content of rGO decreased to 25 wt%,the composites film achieved negative permittivity(～-10),which had a low-frequency dispersion in the test frequency *** negative permittivity of in composites can be regulated by adjusting the heat treatment temperature,which promotes the application and development of flexible metamaterials in underwater sensing and detection,etc.

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近36a来四川盆地持续霾事件特征及环流分析

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中国环境科学 2019年第9期39卷 3604-3615页

作者：罗玉马振峰赵鹏国卿清涛孙彧刘佳李小兰孙蕊中国气象局成都高原气象研究所高原与盆地暴雨旱涝灾害四川省重点实验室四川成都610072 四川省气候中心四川成都610072 成都信息工程大学大气科学学院四川成都610225 四川省气象灾害防御技术中心四川成都610072

利用1981~2016年四川盆地102个气象观测站逐日霾日观测资料,对四川盆地持续霾事件(定义为连续3d及以上有烟幕或霾发生的天气)的时空分布特征、变化趋势进行分析,然后对冬季霾事件环流场特征进行研究.结果表明:1981~2016年四川盆地持续... 详细信息

利用1981~2016年四川盆地102个气象观测站逐日霾日观测资料,对四川盆地持续霾事件(定义为连续3d及以上有烟幕或霾发生的天气)的时空分布特征、变化趋势进行分析,然后对冬季霾事件环流场特征进行研究.结果表明:1981~2016年四川盆地持续霾事件的年平均日数呈增加趋势,持续霾事件日数占霾总日数的百分比与霾总日数增加趋势较为一致,霾总日数的增加主要是由持续霾事件的增加引起的.四川盆地持续霾事件的空间分布不均匀,与霾日数的大值区的分布较为一致,主要集中在川东北城市群、成都平原城市群以及川南城市群.持续霾事件多发区的范围在1981~2010年呈年代际增大,在2011~2016年范围减少显著.通过分析盆地冬季霾事件的环流场发现,霾事件偏多(少)年时段,四川盆地处于暖(冷)高(低)压大值区域,乌拉尔山阻塞高压偏弱(强),东亚大槽偏弱(强),盆地上空为一定程度的辐合(辐散),存在(不存在)明显逆温结构,垂直上升运动弱(强),这些条件均有利于污染物颗粒聚集在浅薄的边界层内(利于污染物的扩散),造成霾天气的维持(消散).

关键词：四川盆地持续霾事件环流特征

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