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TOPK Activation Exerts Protective Effects on Cisplatin-induced Acute Kidney Injury

Current Medical Science 2022年第4期42卷 742-753页

作者： Hui ZHANG qing-qing dong Hua-pan SHU Yu-chi TU Qian-qian LIAO Li-jun YAO Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:T-LAK-cell-originated protein kinase(TOPK),a PSD95-Disc large-ZO1(PDZ)binding kinase(PBK),is a novel member of the mitogen-activated protein kinase(MAPK)*** have shown that TOPK plays a critical role in the function of tumor cells,including apoptosis and ***,little is known on the effect of TOPK in cisplatin-induced acute kidney injury(CP-AKI).This study aimed to investigate the role and mechanism of TOPK in ***:Cisplatin was administered to C57BL/6 mice and cultured kidney tubular epithelial cells(TECs)to establish the CP-AKI murine or cellular *** were then stimulated with the specific inhibitor of TOPK OTS514 or transfected with the recombinant-activated plasmid TOPK-T9E to inhibit or activate *** TECs were treated with AKT inhibitorⅧfollowing stimulation with OTS514 or *** blotting and flow cytometry were used to evaluate the cell cycle and apoptosis of ***:The analysis revealed that the TOPK activity was significantly suppressed by cisplatin,both in vivo and in ***,the pharmacological inhibition of TOPK by OTS514,a specific inhibitor of TOPK,exacerbated the cisplatin-induced cell cycle arrest in the G2/M phase and apoptosis of cultured ***,the TOPK activation via the TOPK-T9E plasmid transfection could partially reverse the cell cycle arrest at the G2/M phase and apoptosis of cisplatin-treated *** addition,AKT/protein kinase B(PKB),as a TOPK target protein,was inhibited by cisplatin in cultured *** pharmaceutical inhibition of AKT further aggravated the apoptosis of TECs induced by cisplatin or TOPK *** systematically mediated the apoptosis via the AKT pathway in the CP-AKI cell ***:These results indicate that TOPK activation protects against CP-AKI by ameliorating the G2/M cell cycle arrest and cell apoptosis.

关键词： acute kidney injury cisplatin cell cycle apoptosis T-LAK-cell-originated protein kinase/PSD95-Disc large-ZO1 binding kinase

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun dongfang Hou Meidi Wang Xueqian Wu Tao Wu dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu qinghua Zeng qing Tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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CO_2浓度加倍下水氮耦合对黄瓜叶片碳氮代谢及其关键酶活性的影响

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植物生理学报 2017年第9期53卷 1717-1727页

作者：李曼董彦红崔青青张文东艾希珍刘彬彬李清明山东农业大学园艺科学与工程学院山东泰安271018 作物生物学国家重点实验室山东泰安271018 农业部黄淮海设施农业工程科学观测实验站山东泰安271018

以‘津优35号’黄瓜(Cucumis sativus)为试材,采用三裂式裂区试验设计,研究了CO_2浓度加倍下水氮耦合对黄瓜叶片碳、氮代谢及其关键酶活性的影响。主区因素为CO_2浓度,设大气CO_2浓度(400μmol·mol^(-1))和加倍CO_2浓度[(800±20)μmol... 详细信息

以‘津优35号’黄瓜(Cucumis sativus)为试材,采用三裂式裂区试验设计,研究了CO_2浓度加倍下水氮耦合对黄瓜叶片碳、氮代谢及其关键酶活性的影响。主区因素为CO_2浓度,设大气CO_2浓度(400μmol·mol^(-1))和加倍CO_2浓度[(800±20)μmol·mol^(-1)]两个水平;裂区因素为水分处理,设无干旱胁迫(灌水上限为田间持水量的95%)和干旱胁迫(灌水上限为田间持水量的75%)两个水平;再裂区因素为施氮量,设施氮量450 kg·hm-2(低氮)和900 kg·hm^(-2)(高氮)两个水平。结果表明:(1)CO_2浓度加倍提高了干旱和高氮条件下黄瓜的株高,且使高氮下的叶面积显著增加。(2)CO_2浓度加倍显著提高了黄瓜叶片蔗糖、淀粉、还原糖含量,蔗糖合成酶(SS)的活性显著增加;高氮显著增加了CO_2浓度加倍条件下SS和蔗糖磷酸合成酶(SPS)活性,促进蔗糖积累和淀粉分解。干旱胁迫使SS活性显著增加,SPS活性显著降低,CO_2浓度加倍显著提高了干旱胁迫下SS和SPS活性以及蔗糖和还原糖含量,且SS和SPS活性以及蔗糖含量随氮素的增加而显著增加。(3)CO_2浓度加倍显著提高了硝酸还原酶(NR)活性,但是谷氨酰胺合成酶(GS)和谷氨酸合酶(GOGAT)活性并未同步增加。在CO_2浓度加倍条件下,高氮使干旱胁迫的黄瓜叶片NR和GOGAT活性显著提高,GS活性的降低得到缓解。(4)加倍CO_2浓度、无干旱胁迫、高氮处理下产量最高,其次是加倍CO_2浓度、干旱胁迫、高氮处理。在大气CO_2浓度和干旱条件下,低氮处理产量最大,继续增施氮肥产量无显著差异,而在CO_2浓度加倍和干旱条件下,增施氮肥黄瓜产量则显著上升。因此,在CO_2浓度加倍条件下高氮促进了干旱胁迫的光合产物转化,使氮同化能力的降低得到缓解或改变,促进干旱胁迫下黄瓜叶片的碳氮代谢,能在一定程度上缓解干旱胁迫造成的不利影响,从而提高黄瓜生长量和产量,可为设施黄瓜CO_2施肥及水分亏缺等逆境下水氮科学管理提供理论依据和技术参数。

关键词：黄瓜 CO2浓度加倍水氮耦合碳氮代谢

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基于智能手机的车辆行为实时判别与渐进矫正方法研究

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计算机科学 2017年第3期44卷 288-295页

作者：范菁吴青青叶阳董天阳浙江工业大学计算机科学与技术学院杭州310023

目前基于智能手机的车辆行为识别算法存在着鲁棒性较差、识别率较低、无法应用于实时行驶判断等问题。针对上述问题,提出了基于智能手机的车辆行为实时判别与渐进矫正方法,以提高车辆行为识别的准确率和实时性。该方法利用车辆行为发生... 详细信息

目前基于智能手机的车辆行为识别算法存在着鲁棒性较差、识别率较低、无法应用于实时行驶判断等问题。针对上述问题,提出了基于智能手机的车辆行为实时判别与渐进矫正方法,以提高车辆行为识别的准确率和实时性。该方法利用车辆行为发生时存在的渐进变化数据来进行车辆行为的识别与渐进矫正分类,并通过采集过程数据作为分类器训练样本,提高支持向量机(SVM)分类器的车辆行为识别和预测能力。同时,针对传统滑动窗口检测的局限性,该方法采用了端点检测算法,从而能快速地从车辆行驶数据中截取并识别行为轨迹信息,以减少车辆行为的误判。实验结果表明,基于时间分段矫正的行为识别算法能够有效地对车辆行为进行预测,并最终达到较高的识别率,证明了该方法的有效性。

关键词：车辆行为识别 SVM 实时判别

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MnO_2氧化法制备高电容保持率PANI-Co_3O_4

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电池 2012年第3期42卷 126-128页

作者：王芳平李庆余秦庆东杨建红中国铝业股份有限公司郑州研究院河南郑州450041 广西师范大学化学化工学院广西桂林541004

以二氧化锰(MnO2)为氧化剂,通过化学原位聚合法将溶剂热法制备的四氧化三钴(Co3O4)与聚苯胺(PANI)复合,得到PANI-Co3O4复合材料。对产物进行SEM、XRD、循环伏安和恒流充放电测试。Co3O4为立方晶型,被大量纤维状的PANI包裹着。制备的PANI... 详细信息

以二氧化锰(MnO2)为氧化剂,通过化学原位聚合法将溶剂热法制备的四氧化三钴(Co3O4)与聚苯胺(PANI)复合,得到PANI-Co3O4复合材料。对产物进行SEM、XRD、循环伏安和恒流充放电测试。Co3O4为立方晶型,被大量纤维状的PANI包裹着。制备的PANI-Co3O4复合材料的比电容较高,循环性能良好。在电流密度为5 mA/cm2时,单电极比电容为287 F/g,第500次循环的比电容为271 F/g,电容保持率为94.4%。

关键词：聚苯胺(PANI)-四氧化三钴(Co3O4) 超级电容器电化学性能

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某医院新生儿重症监护病房患者感染病原菌种类变迁

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中国消毒学杂志 2017年第5期34卷 462-464,467页

作者：王清清苏卫东张微微薛慧芬温州市儿童医院浙江温州325000

目的研究NICU患者感染病原菌种类的变迁及其耐药情况。方法通过回顾性调查方法,对某医院NICU住院患者连续6年医院感染病原菌种类变化情况及其耐药性进行了调查。结果该医院NICU患者连续6年共送检病原学标本10 971份,分离出病原菌1 876株... 详细信息

目的研究NICU患者感染病原菌种类的变迁及其耐药情况。方法通过回顾性调查方法,对某医院NICU住院患者连续6年医院感染病原菌种类变化情况及其耐药性进行了调查。结果该医院NICU患者连续6年共送检病原学标本10 971份,分离出病原菌1 876株,阳性率17.10%。其中革兰阴性菌占67.86%,革兰阳性菌占26.44%,真菌占5.70%。连续6年中,临床标本分离的革兰阴性菌呈现下降趋势,而革兰阳性菌和真菌分离率则出现上升趋势。革兰阴性菌优势菌为肺炎克雷伯菌和大肠埃希菌,革兰阳性菌优势菌为葡萄球菌和B族链球菌。临床分离的革兰阴性菌对头孢类抗菌药物耐药率较高,保持对碳青霉烯类抗菌药物敏感。结论 NICU患者医院感染病原菌仍以革兰阴性菌为主,但革兰阳性球菌和真菌分离率呈现上升趋势。

关键词：新生儿重症监护医院感染病原均变迁耐药性

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太阳能电池基本特性测定实验

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物理实验 2004年第11期24卷 6-8,11页

作者：茅倾青潘立栋陈骏逸陆申龙复旦大学物理系上海200433

对传统的“太阳能电池伏安特性测量”实验进行改进 ,利用光功率测定仪和滤色片 ,定量分析在不同光强照射下以及在不同截止波长的光照射下 ,太阳能电池特性参量的变化规律 ,并测量了半导体材料的禁带宽度 .

关键词：太阳能电池开路电压短路电流填充因子禁带宽度

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Lattice Boltzmann simulation of flows in bifurcate channel at rotating inflow boundary conditions and resulted different outflow fluxes

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Acta Mechanica Sinica 2011年第4期27卷 510-518页

作者： qing-dong Cai Department of Mechanics and Aerospace Engineering College of Engineering Peking University 100871 Beijing

The Lattice Boltzmann method （LBM） is used to simulate the flow field in a bifurcate channel which is a simplified model of the draft tube of hydraulic turbine machine. According to the simulation results, some qualitative conclusions can be deduced. The reason of uneven flux in different branches of draft tube is given. Not only the vortex rope itself, but also the attenuation of the rotation strength is important in bringing on the uneven flux. The later leads to adverse pressure gradient, and changes the velocity profile. If the outlet contains more than one exit, the one that contains the vortex rope will lose flux because of this adverse pressure gradient. Several possible methods can be used to minimize the adverse pressure gradient domain in order to improve the efficiency of turbine machine.

关键词： Lattice Boltzmann method - Hydraulic turbinemachine Draft tube Vortex rope

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Streamwater chemistry and flow dynamics along vegetation-soil gradient in a subalpine Abies fabri forest watershed, China

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Journal of Environmental Sciences 2004年第5期16卷 722-729页

作者： SHANBao-qing WANGWei-dong YINCheng-qing SKLEAC ResearchCenterforEco-EnvironmentalSciencesChineseAcademyofSciencesBeijing100085China

Streamwater chemistry and spatial flow dynamics from a subalpine Abies fabri forest in an experimental watershed located in the east slope of Gongga Mountain were analyzed to gain insights into the gradient effect of primary community succession on the stream biogeochemical process. Results showed that high sand content(exceeding 80%) and porosity in the soil(exceeding 20% in A horizon and 35% in B horizon), as well as a thick humus layer on the soil surface, made the water exchange quickly in the Huangbengliu(HBL) watershed. Consequently, no surface runoff was observed, and the stream discharge changed rapidly with the daily precipitation. The flow trends of base ions in the stream water were influenced by the Abies fabri succession gradient. Ca 2+ , HCO - 3 and SO 2- 4 were the dominant anions in the streamwater in this region. A significant difference of Ca 2+ , HCO - 3 and SO 2- 4 concentration exported between the succession stages in the watershed can be found. But they had the similar temporal change in the stream flow. Ca 2+ , HCO - 3 and SO 2- 4 showed significantly negative correlations with the daily precipitation and the stream discharge. \;Concentrations of Cl -, Na +, K +, and Mg 2+ were low in all streamwaters monitored and we observed no differences along the Abies fabri succession gradient. Low ratios of Na:(Na+Ca) (range from 0.1 to 0.2) implied cations were from bedrock weathering(internal source process in the soil system) in this region. But, a variance analysis showed there were almost no differences between rainwater and streamwaters for Mg 2+ , Na +, K +, and Cl - concentrations. This indicated that they might be come from rainfall inputs(external source). The highly mobile capacity, rapid water exchange between precipitation and discharge, and long-term export lead to this observed pattern were suggested.

关键词： water chemistry succession subalpine coniferous forest Abies fabri watershed Gongga Mt.

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