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Knowledge about, attitude and acceptance towards, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern China: A cross-sectional survey

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Journal of Integrative Medicine 2022年第1期20卷 34-44页

作者： Jing Hong Xiao-wan Xu Jing Yang Jing Zheng Shu-mei Dai Ju Zhou qing-mei zhang Yi Ruan Chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Integrative Oncology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Oncology The Fint Affiliated HospitalBengbu Medical CollegeBengbu 233010Anhui ProvinceChina Department of Nursing Fuyang Cancer HospitalFuyang 236000Anhui ProvinceChina Department of Cardiac Rehabilitation Shanghai First Rehabilitation HospitalShanghai 200090China Department of Radiation Oncology Anhui Chest HospitalHefei 230022Anhui ProvinceChina Department of Anesthesiology Chaohu HospitalAnhui Medical UniversityHefei 238000Anhui ProvinceChina

Objective: The coronavirus disease 2019(COVID-19) pandemic has had a serious impact on health all over the world. Cancer patient, whose immunity is often compromised, faces a huge ***, some COVID-19 vaccines are being developed and applied on general population;however,whether cancer patients should take COVID-19 vaccine remains unknown. Our study aimed to explore the knowledge, attitude, acceptance, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern ***: A cross-sectional study was conducted in Eastern China from June 17 th to September 3 rd, *** were selected using a convenience sampling method. A self-report questionnaire was developed to assess knowledge about the COVID-19 vaccine, attitude towards the vaccine and acceptance of the vaccine;following a review of similar studies previously published in the scientific literature, multivariate logistic regression analysis was used to determine the predictors associated with COVID-19 vaccine ***: A total of 2158 cancer patients were enrolled in this study. The rate of vaccine hesitancy was 24.05%(519/2158);further, among the participants of vaccine acceptance, 767 had taken COVID-19 vaccine(35.54%), and 872 were willing to get vaccinated(40.01%). A total of 24 variables including demographic characteristics, clinical status of cancer, impact of COVID-19 pandemic on study participants,patients’ knowledge about the COVID-19 vaccine, and attitude towards the vaccine, had significant differences between the ‘‘vaccine hesitancy" population and ‘‘vaccine acceptance" *** logistic regression analysis indicated that parameters including alcohol consumption(odds ratio [OR] = 1.849;95% confidence interval [CI]: 1.375–2.488;P-reference [P-Ref] < 0.001 vs nondrinkers), income impacted by COVID-19 pandemic(OR = 1.930, 2.037 and 2.688 for mild, moderate,and severe impact, respectively;all P-Ref < 0.01 vs no impact), know

关键词： COVID-19 Cancer Vaccine Knowledge Attitude Predictors Intention Vaccine hesitancy

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Gai1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis

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Protein & Cell 2023年第3期14卷 217-222页

作者： Gang Xu Li-na Qi mei-qing zhang Xue-yun Li Jin-long Chai Zhi-qing zhang Xia Chen Qian Wang Ke-ran Li Cong Cao Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhou 215004China Department of Orthopedics The Affliated Lianyungang Hospital of Xuzhou Medical UniversityThe First Affliated Hospital of Kangda College of Nanjing Medical UniversityLianyungang 222002China Department of Anesthesiology Children's Hospital of Soochow UniversitySuzhou215025China The Affliated Eye Hospital Nanjing Medical UniversityNanjing210029China

Dear Editor,R-spondin3(RSPO3)is essential for vascular development and *** RSPO3-knockout embryos revealed severe vascular defects in the placenta(Aoki et al.2007).In both Xenopus and murine embryos,RSPO3 KO led to significant vascular defects(Kazanskaya et al.2008)and embryonic death(Kazanskaya et al.2008).In the placenta,RSPO3 could promote vascular endothelial growth factor(VEGF)expression(Kazanskaya et al.2008).RSPO3 is a ligand of low-density lipoprotein receptor-related protein 6(LRP6)and leucine-rich repeat G protein-coupled receptor 4(LGR4)to form a multiple ligands-receptors-cluster with Wnt and frizzled(FzD),thereby activating and amplifying downstreamβ-catenin signaling(in and Yoon 2012;Tocci et al.2020).

关键词： al. angiogenesis lipoprotein

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Identification of Dysregulated microRNAs in Glioma Using RNA sequencing

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Current Medical Science 2021年第2期41卷 356-367页

作者： Chang LIU Ying-ying GE Xiao-xun XIE Bin LUO Ning SHEN Xing-sheng LIAO Shui-qing BI Tao XU Shao-wen XIAO qing-mei zhang Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China School of Pre-clinical Medicine Guangxi Medical UniversiryNanning 530021China Department of Stomatology the People's Hospital of Guangxi Zhuang Atutonomous RegionNanning 530021China

Glioma is the most common malignant brain tumor in central nervous *** advances in the treatment of glioma such as surgery and chemoradiotherapy,most patients are easy to relapse,resulting in adverse clinical ***,effective molecular=targeting treatment may be one of attractive strategies for glioma *** dysregulated microRNAs(miRNAs),one of the candidates of therapeutic targets,are believed to play an important role in the progression of *** this study,we aimed to examine the expression profile of miRNAs in glioma and provide a reference for glioma ***,expression profile of miRNAs in 5 normal brain tissues,5 low-grade glioma(LGG)tissues and 5 glioblastoma(GBM)tissues was detected by RNA sequencing(RNA-seq).Next,the target genes of differentially expressed miRNAs(DEmiRNAs)were predicted and then GO enrichment and KEGG pathway analysis performed by ***,10 miRNAs which were significantly up-or down-regulated both in GBM and LGG were validated by real-time quantitative PCR(qRT-PCR).RNA-seq results indicated a number of DEmiRNAs in *** were 64 up-regulated miRNAs and 17 down-regulated miRNAs n LGG,and 181 up-regulated miRNAs and 124 down-regulated miRNAs in GBM,*** analysis showed that the target genes of these DEmiRNAs were enriched in various biological processes and signaling pathways such as cell metabolic and developmental *** DEmiRNAs were further confirmed by ***-10b-5p,miRNA-92b-3p and miRNA-455-5p were significantly up-regulated in both GBM and LGG;while miRNA-542-3p was significantly up-regulated in LGG;miRNA-184 and miRNA-206 were significantly down-regulated in both GBM and LGG;miRNA-766-5p and miRNA-1-3p were significantly down-regulated in *** subject of our study demonstrated several dysregulated miRNAs may serve as a potential therapeutic target for gl ioma.

关键词： glioma microRNA RNA-sequencing

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FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy

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Current Medical Science 2022年第4期42卷 803-816页

作者： Shui-qing BI Ya PENG Zong-dang WEI Sheng-zhong YAO Bin LUO Ying-ying GE Xiao-xun XIE Wei-xia NONG Chang LIU Shao-wen XIAO qing-mei zhang Department of Neurosurgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Histology and Embryology School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China Central Laboratory School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China

Objective:Cancer/testis antigen FMR1NB is aberrantly expressed in various types of cancer,but not in normal tissues except for *** study aimed to investigate the expression and functional role of FMR1NB in ***:The expression of FMR1NB mRNA and protein was determined using RT-PCR and immunohistochemistry,respectively,in glioma specimens from 83 patients at *** effects of siRNA-mediated FMR1NB silencing on malignant biological behaviors were evaluated in glioma cell lines Al 72 and ***:FMR1NB mRNA and protein expression was detected in 58.8%(77/131)and 46.34%(57/123)of glioma tissues,***1NB protein was positively correlated with World Health Organization grade and found to be an independent prognostic marker for poor *** of FMR1NB induced apoptosis and suppressed proliferation,adhesion,migration,and invasion by modulating the expression of cyclin A,CDK2,caspase-3,E-cadherin,and N-cadherin in A172 and U251 ***:Our findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.

关键词： cancer/testis antigen FMR1NB glioma

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Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma:Integrating Bioinformatics and Clinical Analyses

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Current Medical Science 2022年第3期42卷 584-596页

作者： Xing WEI qing-mei zhang Chang LIU Song WU Wei-xia NONG Ying-ying GE Li-na LIN Feng LI Xiao-xun XIE Bin LUO Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning 530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Central Laboratory of Pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning 530021China Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Key Laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China

Objective Glioblastoma(GBM)is the most common,invasive,and malignant primary brain tumor with a poor prognosis and high recurrence ***’s known that some microRNAs(miRNAs)which are associated with tumorigenesis and progression can be considered as prognostic and therapeutic targets in tumors including *** study aims to highlight the potential role of the core miRNAs in GBM and their potential use as a prognostic and therapeutic *** Differentially expressed miRNAs(DEmiRNAs)were identified in GBM by integrating miRNA-sequencing results and a GBM microarray dataset from the Gene Expression Omnibus(GEO)database through bioinformatics *** dysregulated miRNAs were identified by survival analysis through Chinese Glioma Genome Atlas(CGGA).Target genes of the dysregulated miRNAs were predicted on MiRWalk and miRTarBase ***2.0 database,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were used to analyze the function of the dysregulated ***,protein-protein interaction(PPI)network analysis was used to identify the top 20 hub targets of the up-regulated and down-regulated miRNAs,***,core miRNAs in GBM were identified by constructing dysregulated miRNA-differentially expressed hub gene *** of the core miRNAs expression was detected in 41 GBM tissues compared to 8 normal brain ***,the potential biomarkers were identified by clinical correlation analysis and survival *** Totally,68 intersecting DEmiRNAs were identified,40 of which were upregulated and the other 28 miRNAs were *** upregulated and 4 downregulated miRNAs showed prognostic *** differentially expressed hub genes were regulated by the miR-28-5p and miR-1224-5p,which were respectively upregulated and downregulated in *** correlation between miR-1224-5p level and recurrence was statistically significant(P=0.011).Survival analysis showed that high

关键词： glioblastoma microRNAs microRNA-1224-5p bioinformatics

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Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma

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Current Medical Science 2020年第4期40卷 719-728页

作者： Bin LUO Xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE Xia ZENG Shui-qing BI Wei-xia NONG qing-mei zhang Xiao-xun XIE School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021China Department of Surgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Clinical Laboratory Chinese Medicine HospitalQuanzhou 362000China School of Basic Medical Sciences Guangxi University of Chinese MedicineNanning 530021China Department of Pathology the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China Guangxi Key Laboratory of Early Prevention and Treatmentfor Regional High Frequency Tumor Guangxi Medical UniversityNanning 530021China Key Laboratory Research on Preclinical Medicine Guangxi Medical UniversityNanning 530021China

Summary:Cancer testis(CT)antigens have received particular attention in cancer ***-TES-1 is a member of CT *** study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time ***-TES-1 protein was subsequently observed on a panel of tissue *** from patients were tested for OY-TES-1 antibody by *** identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in *** results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver ***-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis *** was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy *** specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed *** target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II *** summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in

关键词： cancer testis antigen hepatocelluar cancer tumor immunotherapy

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OXIDATIVE COUPLING OF METHANE IN EMPTY REACTORS

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Journal of Energy Chemistry 1994年第2期 156-162页

作者： QIU Xian-qing zhang mei-Zhen ZHU Qi-Ming department of Chemistry, Tsinghua University Beijing 100084

Gas-phase OCM was investigated with various empty tubular reac-tors（quartz,ceranic and stainless steel tubes）.When temperature is higherthan 680℃,the CHconversions in three kinds of empty reactors are measur-able,and the gas-phase OCM becomes noticeable at 750℃ or higher *** temperature is beneficial to the activation of CHand the dehydro-genation of CNto *** time of reactants in the heated volumeplays an important role in the ags-phase *** indicated that thegas-phase OCM can be minimized by increasing reactant gas velocity or fillingthe free volume of the reactor with inert *** surface has effecton the *** may participate in some surface *** on the ki-netic results and the SEM investigation on the surfaces of reactors,a gas-phasereaction scheme of OCM is assumed.

关键词：山田 CO OXIDATIVE COUPLING OF METHANE IN EMPTY REACTORS

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OXIDATIVE COUPLING OF METHANE OVER Na2O-La2O3/BaCO3 CATALYSTS

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Journal of Energy Chemistry 1994年第2期 150-155页

作者： Q1U Xian-qing zhang mei-Zhen ZHU Qi-Ming Department of Chemistry, Tsinghua University Beijing 100084

The oxidative coupling of methane over various alkali metal oxidespromoted LaOO/BaCOcatalysts and the effects of NaO content on the performance of NaO-LaO/BaCOcatalyst have been *** was found thatNaO promoted LaCO/BaCOcatalyst showed advantages of high CHconver-sion,Cselectivity and CH/CHratio,NaO might affect the properties ofcatalyst through elctronic and geometric *** highest Cyield（19.0一20.6%）over Na-9wt%LaO/BaCOcatalysts was obtained in the NaOcontent range of 1.0—3.0%.Effects of reaction conditions on OCM over3wt% NaO-9wt%LaCO/BaCOcatalyst were also *** catalystswere characterized by BET,TPD,and *** studies on 3wt% NaO-9wt%LaO/BaCOcatalyst demonstrated that CO,*** bestrongly on the *** might be related to the activation of CHand theformation and reseneration of active oxygen soecies.

关键词： Na La OXIDATIVE COUPLING OF METHANE OVER Na2O-La2O3/BaCO3 CATALYSTS

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High Expression of Fibronectin 1 Predicts a Poor Prognosis in Glioblastoma

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Current Medical Science 2022年第5期42卷 1055-1065页

作者： Song WU Chang LIU Xing WEI Wei-xia NONG Li-na LIN Feng LI Xiao-xun XIE Xing-sheng LIAO Bin LUO qing-mei zhang Shao-wen XIAO Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning530021China Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning530021China Central Laboratory of Pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning530021China Key Laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning530021China

Objective Glioblastoma multiforme(GBM),the most malignant intracranial neoplasm,is associated with a high mortality and recurrence rate due to the aggressive nature and heterogeneity of the *** of the molecular markers involved in the tumorigenesis of GBM are essential in prognosis,diagnosis,and *** to the limitations of therapeutic effects,this study aims to explore novel biomarkers with prognostic value and to provide new insights into therapeutic *** The expression profile of mRNAs in GBM was detected by RNA-sequencing,and differentially expressed genes were identified by integrating the data from RNA-seq results and the GEPIA2 *** the total 40 hub genes,FN1,P4HB,and PPIB showed prognostic significance based on both GEPIA2 and CGGA *** validation of FN1,P4HB,and PPIB expression by qPCR and correlation analysis with clinicopathological features were performed in 41 GBM tissues from our *** Kaplan-meier analysis revealed that FN1 and P4HB expressions levels were related to the overall survival(OS)of GBM patients(P<0.05).Multivariate analysis showed that FN1 overexpression(HR=9.199,P=0.002)was an independent and unfavorable prognostic factor for GBM *** median survival time was 8.5 months and 21 months for high and low expressions of FN1,*** It was suggested that FN1 could be an ideal target for prognosis and a potential therapeutic target in GBM.

关键词： glioblastoma FN1 overall survival prognosis

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P26 Study Pharmacology to be a Good Physician

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中国药理通讯 2006年第2期23卷 31-32页

作者： Bin zhang Zi-ying Wang Hui-qing Liu Xiu-mei zhang Institute of Pharmacology School of Medicine Shandong University 44 West Wenhua Road Jinan 250012 China

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