检索结果-南通市图书馆

Chinese Chemical Letters 2017年第8期28卷 1705-1710页

作者： Xian-Hua Meng qing-lan guo Cheng-Gen Zhu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicoChinese Academy of Medical Sciences and PekingUnion Medical CollegeBeijing 100050China

Four structurally unprecedented aconitane-type C_（19）-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D（1–4）, were isolated from an aqueous extract of ＂fu zi＂, the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-a-and 14-O-b-L-arabinopyranosides（1 and 2） and 14-O-a-and 14-O-b-L-arabinofuranosides（3 and 4）, by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic diterpenoid alkaloids.

关键词： Aconitum carmichaelii Ranunculaceae Fu zi Aconitane alkaloid glycoside Neoline 14-O-L-arabinoside Aconicarmichosides A–D

A minor arcutine-type C20-diterpenoid alkaloid iminium constituent of“fu zi”

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第3期28卷 588-592页

作者： Xian-Hua Meng Zhi-Bo Jiang qing-lan guo Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

A rare arcutine-type C_（20）-diterpenoid alkaloid, named aconicarmicharcutinium A and obtained as hydroxide（1） and trifluoroacetate（1a）, was characterized as a minor constituent of ＂fu zi＂（the lateral roots of Aconitum carmichaelii）. The structures of 1 and 1a were elucidated by comprehensive analysis of spectroscopic data including^（19）F and 2D NMR experiments. Compounds 1 and 1a represent the first examples of the arcutine-type C_（20）-diterpenoid alkaloid iminium.

关键词： Aconitum carmichaelii Ranunculaceae Arcutine-type C_(20)-diterpenoid alkaloid iminium Aconicarmicharcutinium A

Isatindigodiphindoside,an alkaloid glycoside with a new diphenylpropylindole skeleton from the root of Isatis indigotica

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第1期29卷 119-122页

作者： Ling-Jie Meng qing-lan guo Cheng-Gen Zhu Cheng-Bo Xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sdences and Peking Union Medical College Belting 100050 China

A novel indole alkaloid glycoside with an unprecedented 2-（diphenylpropyl）indole skeleton, isatindigodiphindoside （1）, was isolated from an aqueous extract of the roots of lsatis indigotica. The structure was determined by extensive spectroscopic studies, especially by 2D NMR data analysis combined with enzymatic hydrolysis and ECD calculations. Plausible biosynthetic pathways of compound 1 are also discussed.

关键词： CruciferaeIsatis indigoticaBan lan genDiphenylpropylindoleAlkaloid glycosidelsatindigodiphindoside

New ent-kaurane-type diterpenoids from Isodon nervosus

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第4期19卷 441-443页

作者： Fu Lin Yan lan qing guo Ji Xia Zhang Su Ping Bai Han Dong Sun Pharmacy College Xinxiang Medical UniversityXinxiang 453003China Kunming Institute of Botany Chinese Academy of SciencesKunming 650204China

Two new ent-kaurane-type diterpenoids,6β,7β,13α-trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one（1）and 15β- hydroxy-6,7-seco-6,11β：6,20-diepoxy-1α,7-olide-ent-kaur-16-ene（2）were isolated from the I... 详细信息

关键词： Labiatae Isodon nervosus ent-Kaurane diterpenoid

Two pairs of unusual scalemic enantiomers from Isatis indigotica leaves

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第12期27卷 1745-1750页

作者： Da-Wei Li qing-lan guo Xian-Hua Meng Cheng-Gen Zhu Cheng-Bo Xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Two pairs of unusual scalemic enantiomers with a dimethoxyphenyl）ethyl]-2-methoxyindolin-3-one, novel carbon skeleton of 2-[1′-（4＂-hydroxy-3＂,5＂- named isatidifoliumindolinones A-D （1-4）, were isolated from an aqueous extract of lsatis indigotica leaves （da qing ye）. Their structures including absolute configurations were determined by spectroscopic data analysis combined with comparison of their experimental CD and calculated ECD spectra. Validity of the ECD spectra calculation to assign the absolute configurations is discussed. Plausible biosynthetic pathways of 1-4 are proposed. Stereochemistry-dependent activity against LPS-induced NO production in BY2 cells was observed, and among the stereoisomers compound 4 is most active.

关键词： Isatis indigotica Cruciferae 2-[ 1′-( 4″-Hydroxy-3″, 5″-dimethoxyphenyl)ethyl]-2-methoxyindolin-3-one Scalemic enantiomerlsatidifoliumindolinones A-D Bioactivity

Gastradefurphenol,a minor 9,9＇-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extract of “tian ma”

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第6期28卷 1185-1189页

作者： Xue Zhou qing-lan guo Cheng-Gen Zhu Cheng-Bo Xu Ya-Nan Wang Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Gastradefurphenol（1）,a minor 9.9＇-neolignan with a novel carbon skeleton substituted by two phydroxybenzyls was isolated from an aqueous extract of the Gastrodia elata rhizomes（tian ma）.Its structure was determined by extensive spectroscopic data ***-dependent free rotational restriction of bonds and equilibrium of two molecular states are discussed by comparison of the NMR spectroscopic data of 1 in acetone-d6 with those in CD3OD.A biogenetic pathway of 1 is postulated to be associated with metabolic processes of L-tyrosine.

关键词： Gastrodia elata Orchidaceae 9 9'-Neolignan Gastradefurphenol Minor constituent

Gastrolatathioneine,an unusual ergothioneine derivative from an aqueous extract of "tian ma":A natural product co-produced by plant and symbiotic fungus

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第10期27卷 1577-1581页

作者： qing-lan guo Sheng Lin Ya-Nan Wang Cheng-Gen Zhu Cheng-Bo Xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Gastrolatathioneine （1）, an unusual natural product derived from ergothioneine, a fungal amino acid containing an imidazole-2-thione moiety, was isolated from an aqueous extract of ＂tian ma＂（the Gastrodia elata rhizomes）. The structure of 1 including the absolute configuration was determined by extensive spectroscopic data analysis, combined with comparison of an experimental circular dichroism spectrum and calculated electronic circular dichroism spectra of stereoisomers, and confirmed by X-ray crystallography. The natural origin of 1 was proved by HPLC-ESIMS analysis of the crude extract. A biogenetic pathway of I is proposed on the basis of metabolic post-modification of ergothioneine that is biosynthesized by a symbiotic fungus. The plant and symbiotic fungus are co-uroducers of 1.

关键词： Gastrodia elataOrchidaceaeErgothioneine(+)-L-N N-bis(4-hydroxybenzyl)ergothioneineGastrolatathioneine

Napelline-type C_(20)-diterpenoid alkaloid iminiums from an aqueous extract of ‘‘fu zi'': Solvent-/base-/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第7期27卷 993-1003页

作者： Xian-Hua Meng Zhi-Bo Jiang Cheng-Gen Zhu qing-lan guo Cheng-Bo Xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Three new napelline-type C20-diterpenoid alkaloids,named aconicarmichinium A and B trifluoroacetates（1 and 2） and aconicarmichinium C chloride（3）,were isolated from an aqueous extract of ＂fu zi＂,the lateral roots of Aconitum *** structures were elucidated by extensive spectroscopic data *** 1-3 represent the first examples of napelline-type C20 diterpenoid alkaloid alcohol iminiums,of which the structures were fully *** addition,transformation and equilibration between the alcohol iminiums（1-3） and the aza acetals la-3a were investigated by measurements of the NMR spectra in protic and aprotic deuterium solvents including alkali pyridine-d5,along with evaporation under reduced pressure and gradual additions of TFA,AcOH,and *** results demonstrated that the transformation and equilibration were solvent-,base-,and ***,in aqueous biological fluid,these C20-diterpenoid alkaloids would more likely exist as the alcohol iminiums accompanied by anion counterparts in biosystems to increase their solubility, bioavailability, transportations, and *** absolute configurations of 1-3 were confirmed by X-ray crystallographic analysis of 2a.

关键词： Aconitum carmichaelii Ranunculaceae Napelline-type C20-diterpenoid alkaloid Aconicarmichiniums A–C Alcohol iminium and aza acetal forms of the diterpenoid alkaloid Transformation and equilibration

Editorial:special topic on advanced energy catalytic materials

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2024年第6期67卷 1681-1683页

作者： Shaojun guo Yaqian lan School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Chemistry South China Normal UniversityGuangzhou 510630China

Aiming to lowering the society’s dependence on fossil fuels,energy catalysis stands at the forefront of technological advancement,which promises to revolutionize the way we harness,convert,and utilize renewable *** current special topic of our journal,titled"Advanced Energy Catalytic Materials",aims to highlight the latest innovations,challenges,and opportunities in this exciting field.

关键词： field utilize catalysis

Gastrodin Derivatives from Gastrodia elata

在线全文

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2019年第6期9卷 393-404页

作者： Cheng-Bo Xu qing-lan guo Ya-Nan Wang Sheng Lin Cheng-Gen Zhu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Nine new gastrodin derivatives,including seven p-hydroxybenzyl-modified gastrodin ethers(1-7),6′-O-acetylgastrodin(8),and 4-[α-d-glucopyranosyl-(1→6)-β-d-glucopyranosyloxy]benzyl alcohol(9),together with seven known derivatives,were isolated from an aqueous extract of Gastrodia elata(“tian ma”)*** structures were determined by spectroscopic and chemical methods as well as single crystal X-ray *** 1-4,7,10,and 11 were also isolated from a reaction mixture by refluxing gastrodin and p-hydroxybenzyl alcohol in *** both gastrodin and p-hydroxybenzyl alcohol exist in the plant,the reaction results provide evidence for the production and increase/decrease of potential effective/toxic components when“tian ma”is decocted solely or together with ingredients in Chinese traditional medicine formulations,though the isolates were inactive in the preliminarily cell-based assays at concentrations of 10μ***,using ultra-performance liquid chromatography high-resolution electrospray ionization mass spectrometry(UPLC-HRESIMS),4,7,10,and 11,as well as component variations,were detectable in the freshly prepared extracts of different types of samples,including the freeze-dried fresh *** rhizomes.

关键词： Orchidaceae Gastrodia elata Blume p-Hydroxybenzyl gastrodin ethers Reaction of gastrodin with p-hydroxybenzyl alcohol Component variation during decocting