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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fan Geng Meng-Meng Zhu Fu-Ling Yan Zhi-Jun Zhang qing-guo ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

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ON THE PROBLEM OF INSTABILITY IN THE DIMENSIONS OF SPLINE SPACES OVER T-MESHES WITH T-CYCLES

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Journal of Computational Mathematics 2015年第3期33卷 248-262页

作者： qing-Jie guo ren-Hong Wang Chong-Jun Li School of Mathematical Sciences Dalian University of Technology Dalian 116024 China

The T-meshes are local modification of rectangular meshes which allow T-junctions. The splines over T-meshes are involved in many fields, such as finite element methods, CAGD etc. The dimension of a spline space is a basic problem for the theories and applications of splines. However, the problem of determining the dimension of a spline space is difficult since it heavily depends on the geometric properties of the partition. In many cases, the dimension is unstable. In this paper, we study the instability in the dimensions of spline spaces over T-meshes by using the smoothing cofactor-conformality method. The modified dimension formulas of spline spaces over T-meshes with T-cycles are also presented. Moreover, some examples are given to illustrate the instability in the dimensions of the spline spaces over some special meshes.

关键词： Spline space Smoothing cofactor-conformality method Instability in the dimension T-meshes.

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Multispectral ErBO_(3)@ATO porous composite microspheres with laser and electromagnetic wave compatible absorption

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Rare Metals 2023年第7期42卷 2406-2418页

作者： Song-Song guo Jian-Ping Zhu Zhi Song qing-guo ren Tong Feng Qi-Tu Zhang Li-Xi Wang College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing211816China

The high-speed advances in electromagnetic(EM)wave and laser detection technology have accelerated the innovation of absorbing materials toward specific multi-band *** is difficult to achieve dual absorption of EM waves and near-infrared lasers by absorbing materials in a single frequency band;the design of high-performance laser-EM wave multi-band compatible absorbing materials is ***,ErBO_(3)@ATO(erbium borate/antimony-doped tin oxide)porous composite microspheres with an average size of 15-20μm are produced solvothermal method and self-assembly,which exhibit excellent laser-EM wave compatible *** porous structure on the surface of ErBO_(3)microspheres provides heterogeneous nucleation sites for ATO particle *** minimum reflectivity of the composite for1.06 and 1.54μm lasers is 9.59%and 4.79%,which is0.57%and 3.78%lower than those of pure ATO particles,*** composites containing 70 wt%porous ErBO_(3)@ATO reveal the minimum reflection loss(RL)value of-31.6 dB,and an effective absorption band width reaches 2.08 GHz at 2.5 mm *** mechanism of near-infrared laser and EM wave compatible absorption is the synergistic effect of the energy level transition of ErBO_(3)and the dielectric loss of ATO,coupled with the large surface area and porous structure of the micro ***,the designed porous ErBO_(3)@ATO composite microspheres can be an attractive choice for lasers and EM wave high-quality compatible absorption.

关键词： Core-shell ErBO_(3)@antinomy-doped tin oxide(ATO) Porous microsphere Laser reflection Electromagnetic(EM)wave loss

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Abnormal mechanical property evolution induced by heat treatment for a semi-solid forming hypereutectic Al-Fe base alloy

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China Foundry 2015年第3期12卷 208-213页

作者： Run-xia Li qing Li guo-qing ren Yan-jiao Tong Bao-yi Yu Xiao-guang Yuan Shenyang University of Technology School of Materials Science and Engineering

In the present study, Al-5.5Fe-4Cu-2Zn-0.4Mg-0.5Mn al oy samples were prepared by electromagnetic stirring and semi-solid forming processing, and then the effects of T6 and T1 heat treatments on the microstructures and mechanical properties of the semi-solid forming samples were investigated. The results indicate that after semi-solid forming, the mechanical properties of the sample improved significantly compared to that of the merely electromagnetically stirred sample. The grains of semi-solid forming alloy became almost fine equiaxed; big long strip-shaped Al3 Fe phases became short rod-like morphology and distributed uniformly in the matrix. However, the mechanical properties of the T6-treated semi-solid forming sample decreased significantly instead of increasing and, with solution temperature rising, the tensile strength of the al oy decreased further. The results of EDS show that after high temperature solid-solution treatment, the Cu element in the semi-solid forming alloy sample is mainly concentrated at the boundaries of the Al3 Fe phases instead of being dissolved in the matrix. At the same time, the grains of the semi-solid forming sample grew slightly after solid-solution treatment. Therefore, the growth of the grains and the accumulation of Cu element at Al3 Fe phase boundaries during solution treatment of the semi-solid forming alloy were the main reasons for the mechanical properties decreasing after T6 treatment. The mechanical properties of the alloy were improved after T1 heat treatment due to aging strengthening phase being precipitated in the matrix.

关键词： Al-Fe base alloys semi-solid forming heat treatment microstructures

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Submucosal esophageal abscess evolving into intramural submucosal dissection:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10695-10700页

作者： Yang Jiao Yin-He Sikong Ai-Jun Zhang Xiu-Li Zuo Pu-Yue Gao qing-guo ren Ru-Yuan Li Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina Department of Gastroenterology Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina Department of Gastroenterology Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Radiology Shandong University of Qilu HospitalShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Here we report a rare case of submucosal esophageal abscess evolving into intramural submucosal *** SUMMARY An 80-year-old woman was admitted to our emergency department with a chief complaint of dysphagia and *** tests showed mild leukocytosis and elevated C-reactive protein *** tomography showed thickening of the esophageal *** endoscopy showed a laceration of the esophageal mucosa and a submucosal *** drainage occurred,and we could see purulent exudate from the *** closed the laceration with endoscopic *** patient did not remember swallowing a foreign body;however,she ate crabs before the symptoms *** prescribed the patient with antibiotic,and the symptoms were gradually *** months later,upper endoscopy showed that the laceration was healed,and the submucosal abscess ***,intramural esophageal dissection was *** performed endoscopic incision of the septum using dual-knife *** In conclusion,we are the first to report the case of esophageal submucosal abscess evolving into intramural esophageal *** significance of this case lies in clear presentation of the evolution process between two *** addition,we recommend that endoscopic incision be considered as one of the routine therapeutic modalities of intramural esophageal dissection.

关键词： Submucosal esophageal abscess Intramural esophageal dissection Endoscopic incision Case report

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Research on light dark matter particle from evaporating primordial black hole in CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 168-169页

作者： qing-guo Huang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Dark matter is an essential component of the universe,accounting for approximately 85%of all ***,what the nature of dark matter actually is remains a huge *** far,all evidence for the existence of dark matter has come from gravitational *** gravitational interactions are universal,it is challenging to reveal the nature of dark matter through gravitational *** unravel the mystery of dark matter,it is essential to directly detect dark matter.

关键词： approximate particle gravitational

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Hepatocellular carcinoma:An analysis of the expression status of stress granules and their prognostic value

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2571-2591页

作者： qing-Shuai ren Qiu Sun Shu-Qin Cheng Li-Ming Du Ping-Xuan guo Department of Cardiovascular Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina Department of Hepatobiliary Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjin 300000China Department of Traditional Chinese Medicine Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Anesthesiology Kailuan General HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is *** To analyze the impacts of stress granule(SG)genes on overall survival(OS),survival time,and prognosis in *** The combined The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC),GSE25097,and GSE36376 datasets were utilized to obtain genetic and clinical *** hub gene numbers and corresponding coefficients were determined using the Least absolute shrinkage and selection operator model approach,and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate Cox regression,*** prognostic model’s receiver operating characteristic(ROC)curve was produced and plotted utilizing the time ROC software *** models were constructed to predict the outcomes at 1,3,and 5-year OS prognostications with good prediction *** We identified seven SG genes(DDX1,DKC1,BICC1,HNRNPUL1,CNOT6,DYRK3,CCDC124)having a prognostic significance and developed a risk score *** findings of Kaplan-Meier analysis indicated that the group with a high risk exhibited significantly reduced OS in comparison with those of the low-risk group(P<0.001).The nomogram model’s findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC *** Ontology and Gene Set Enrichment Analysis suggested that these SGs might be involved in the cell cycle,RNA editing,and other biological *** Based on the impact of SG genes on HCC prognosis,in the future,it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.

关键词： Stress granule genes Hepatocellular carcinoma Gastrointestinal neoplasms Bioinformatics prognosis Prognostic value

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Activity promotion of anti-sintering Au■MgGa_2O_4 using ceria in the water gas shift reaction and catalytic combustion reactions

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Chinese Journal of Catalysis 2019年第4期40卷 600-608,M0006页

作者： guo-qing ren Guang-Xian Pei Jing-Cai Zhang Wei-Zhen Li Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy CASDalian 116023LiaoningChina

Heterogeneous gold nanocatalysts have both inspired researchers with their unique catalytic performance and frustrated them due to the contradictions observed in their activities and stabilities.A recent breakthrough has shown that gold nanoparticles(NPs)can retain their catalytically active size over a MgGa2O4 spinel support upon sintering at high ***,we report the catalytic activity of anti-sintering AuGMgGa2O4 for use in water gas shift reaction(WGSR)and catalytic combustion reactions,and the promoting effect of *** adding ceria to 800℃-aged AuGMgGa2O4,the CO conversion in the WGSR was increased from ~1.5% to ~34.0% at 450 ℃,and the “light-off” temperatures(T50)for methane combustion and CO oxidation were decreased by ~80 and ~100 ℃,*** using XRD,HAADF-STEM,EDS mapping,H2-TPR,XPS,and DRIFTs confirmed the proximate contact of Au with ceria and their significant synergistic effect,which thereby combined the benefits of ceria toward the dissociation of H2O or O2 and the Au NPs toward activating CO or *** results show that this stepwise stabilization-activation strategy is efficient for rationally constructing stable and active gold nanocatalysts,which may open up possibilities for the wide application of gold nanocatalysts at elevated temperatures.

关键词： Gold nanocatalyst CeO2 promoter Magnesium gallate spinel Water gas shift Catalytic combustion

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Escape probability for isotropic emitters near Kerr black hole with astrometric

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Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： Yu-Xuan Han qing-Hua Zhu qing-guo Huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

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Integral precession calibration method of PIGA on linear vibration table

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Chinese Journal of Aeronautics 2024年第3期37卷 219-236页

作者： Chuang SUN Shun-qing ren Jun-wei CAO Ru HUO Department of Automation Tsinghua UniversityBeijing 100084China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Faculty of Information technology Beijing University of TechnologyBeijing 100124China

Linear vibration table can provide harmonic accelerations to excite the nonlinear error terms of Pendulous Integrating Gyro Accelerometer(PIGA).Integral precession calibration method is proposed to calibrate PIGA on a linear vibration table in this *** on the precise expressions of PIGA’s inputs,the error calibration model of PIGA is *** angular velocity errors of PIGA are suppressed by integer periodic precession and the errors caused by non-integer periods vibrating are *** complete calibration process,including planning,preparation,PIGA testing,and coefficient identification,is designed to optimize the test operations and evaluate the calibration *** effect of the main errors on calibration uncertainty is analyzed and the relative sensitivity function is proposed to further optimize the test *** and simulation results verify that the proposed 10-position calibration method can improve calibration uncertainties after compensating for the related *** order of calibration uncertainties of the second-and third-order coefficients are decreased to 10^(-8)(rad.s^(-1))/g^(2)and 10^(-8)(rad.s^(-1))/g3,*** with the other two classical calibration methods,the calibration uncertainties of PIGA’s nonlinear error coefficients can be effectively reduced and the proportional residual errors are decreased less than 3×10-6(rad.s^(-1))/g by using the proposed calibration method.

关键词： PIGA Linear vibration table Vibration measurement Calibration Error analysis Uncertainty analysis

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