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Neuroscience Bulletin 2019年第3期35卷 507-518页

作者： Ying-Zhe Cui Si-Ying Qu Lu-Lu Chang Jia-Rui Zhao Lili Mu Bo Sun Hu-Lun Li Tong-Shuai Zhang Guang-You Wang qing-fei kong Department of Neurobiology Heilongjiang Provincial Key Laboratory of Neurobiology Harbin Medical University

Myasthenia gravis(MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper(Tfh) cells have been implicated in many autoimmune diseases. However, whether and how Tfh cells are involved in MG remain ***, we established and studied a widely-used and approved animal model of human MG, the rat model with acetylcholine receptor alpha(AChRa) subunit(RAChR97–116)-induced experimental autoimmune myasthenia gravis(EAMG). This model presented mild bodyweight loss 10 days after the first immunization(representing the early stage of disease) and more obvious clinical manifestations and body-weight loss 7 days after the second immunization(representing the late stage of disease). AChR-specific pre-Tfh cells and mature Tfh cells were detected in these two stages, respectively. In cocultures of Tfh cells and B cells, the number of IgG2 bsecreting B cells and the level of anti-AChR antibodies in the supernatant were higher in the cultures containing EAMG-derived Tfh cells. In immunohistochemistry and immunofluorescence assays, a substantial number of CD4^+/Bcl-6^+ T cells and a greater number of larger germinal centers were observed in lymph node tissues resected from EAMG rats. Based on these results, wehypothesize that an AChR-specific Tfh cell-mediated humoral immune response contributes to the development of EAMG.

关键词： Follicular helper T cells Experimental autoimmune myasthenia gravis Acetylcholine receptor Germinal center

A novel detection method for warhead fragment targets in optical images under dynamic strong interference environments

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Defence Technology(防务技术) 2025年第1期43卷 252-270页

作者： Guoyi Zhang Hongxiang Zhang Zhihua Shen Deren kong Chenhao Ning fei Shang Xiaohu Zhang Sun Yat-Sen University Guangzhou 510275China Nanjing University of Science and Technology Nanjing 210094China

A measurement system for the scattering characteristics of warhead fragments based on high-speed imaging systems offers advantages such as simple deployment,flexible maneuverability,and high spatiotemporal resolution,enabling the acquisition of full-process data of the fragment scattering ***,mismatches between camera frame rates and target velocities can lead to long motion blur tails of high-speed fragment targets,resulting in low signal-to-noise ratios and rendering conventional detection algorithms ineffective in dynamic strong interference testing *** this study,we propose a detection framework centered on dynamic strong interference disturbance signal separation and *** introduce a mixture Gaussian model constrained under a joint spatialtemporal-transform domain Dirichlet process,combined with total variation regularization to achieve disturbance signal *** results demonstrate that the proposed disturbance suppression method can be integrated with certain conventional motion target detection tasks,enabling adaptation to real-world data to a certain ***,we provide a specific implementation of this process,which achieves a detection rate close to 100%with an approximate 0%false alarm rate in multiple sets of real target field test *** research effectively advances the development of the field of damage parameter testing.

关键词： Damage parameter testing Warhead fragment target detection High-speed imaging systems Dynamic strong interference disturbance suppression Variational bayesian inference Motion target detection Faint streak-like target detection

Mn/S diatomic sites in C3N4 to enhance O2 activation for photocatalytic elimination of emerging pollutants

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Journal of Environmental Sciences 2025年第3期149卷 512-523页

作者： Chengji Sui Zixuan Nie Xiaobin Xie Yifeng Wang Lingshuai kong Shou-qing Ni Jinhua Zhan Key Laboratory for Colloid&Interface Chemistry of Education Ministry School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China Institute of Eco-Environmental Forensics School of Environmental Science and EngineeringShandong UniversityQingdao 266237China

Oxygen activation leading to the generation of reactive oxygen species(ROS)is essential for photocatalytic environmental *** limited efficiency of O_(2)adsorption and reductive activation significantly limits the production of ROS when employing C_(3)N_(4)for the degradation of emerging *** with metal single atoms may lead to unsatisfactory efficiency,due to the recombination of photogenerated electron-hole ***,Mn and S single atoms were introduced into C_(3)N_(4),resulting in the excellent photocatalytic ***/S-C_(3)N_(4)achieved 100%removal of bisphenol A,with a rate constant 11 times that of pristine C_(3)N_(4).According to the experimental results and theoretical simulations,Satoms restrict holes,facilitating the photo-generated carriers’***-atom Mn acts as the O_(2)adsorption site,enhancing the adsorption and activation of O_(2),resulting the generation of *** study presents a novel approach for developing highly effective photocatalysts that follows a new mechanism to eliminate organic pollutants from water.

关键词： Photocatalytic degradation O_(2)activation Reactive oxygen species Emerging pollutants Single-atom catalyst

High-frequency enhanced ultrafast compressed active photography

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Opto-Electronic Advances 2025年第1期8卷 32-43页

作者： Yizhao Meng Yu Lu Pengfei Zhang Yi Liu fei Yin Lin Kai qing Yang Feng Chen State Key Laboratory for Manufacturing System Engineering and Shaanxi Key Laboratory of Photonics Technology for Information School of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame ***,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame ***,a high-frequency enhanced compressed active photography(H-CAP)is *** uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling *** sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image *** superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,*** applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.

关键词： ultrafast compressed imaging high-frequency enhanced sampling spectral-temporal transform transient processes high-fidelity reconstruction

The School that Changes Mindsets

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China Today 2025年第1期74卷 62-64页

作者： GUO qing kong SIQI 不详

China’s highest-altitude primary school is not only teaching children of farmers and herders but their parents as *** Sinopec Primary School in Nagqu,a city in Xizang Autonomous Region in southwest China,is known as the school“the closest to the sky”due to its high-altitude location-a breathtaking 4,700 meters above sea *** by oil and gas giant Sinopec as part of its corporate social responsibility,the school opened in 2012 and has since become a microcosm of China’s drive for education,especially in remote and rural areas,to ensure that no one is left behind.

关键词： altitude farmers southwest

POSITIVE GROUND STATE SOLUTIONS FOR A QUASILINEAR SCHRODINGER EQUATION

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数学杂志 2025年第2期45卷 95-110页

作者： JIN qing-fei School of Artificial Intelligence Jianghan UniversityWuhan 430056China

This paper is concerned with the positive ground state solutions for a quasilinear Schrodinger equation with a Hardy-type *** obtain positive ground state solutions for the given quasilinear Schrodinger equation by us... 详细信息

关键词： Quasilinear equation schrodinger equation positive ground state solutions variational methods

Intelligent field monitoring system for cruciferous vegetable pests using yellow sticky board images and an improved Cascade R-CNN

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Journal of Integrative Agriculture 2025年第1期24卷 220-234页

作者： Yufan Gao fei Yin Chen Hong Xiangfu Chen Hang Deng Yongjian Liu Zhenyu Li qing Yao School of Computer Science and Technology Zhejiang Sci-Tech UniversityHangzhou 310018China Collaborative Innovation Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China

Cruciferous vegetables are important edible vegetable ***,they are susceptible to various pests during their growth process,which requires real-time and accurate monitoring of these pests for pest forecasting and scientific *** yellow sticky boards is a common way to monitor and trap those pests which are attracted to the yellow *** achieve real-time,low-cost,intelligent monitoring of these vegetable pests on the boards,we established an intelligent monitoring system consisting of a smart camera,a web platform and a pest detection algorithm deployed on a *** the operator sets the monitoring preset points and shooting time of the camera on the system platform,the camera in the field can automatically collect images of multiple yellow sticky boards at fixed places and times every *** pests trapped on the yellow sticky boards in vegetable fields,Plutella xylostella,Phyllotreta striolata and flies,are very small and susceptible to deterioration and breakage,which increases the difficulty of model *** solve the problem of poor recognition due to the small size and breaking of the pest bodies,we propose an intelligent pest detection algorithm based on an improved Cascade R-CNN model for three important cruciferous crop *** algorithm uses an overlapping sliding window method,an improved Res2Net network as the backbone network,and a recursive feature pyramid network as the neck *** results of field tests show that the algorithm achieves good detection results for the three target pests on the yellow sticky board images,with precision levels of 96.5,92.2 and 75.0%,and recall levels of 96.6,93.1 and 74.7%,respectively,and an F_(1) value of *** with other algorithms,our algorithm has a significant advantage in its ability to detect small target *** accurately obtain the data for the newly added pests each day,a two-stage pest matching algorithm was *** algorithm performed well and achieved

关键词： vegetable pests yellow sticky boards intelligent monitoring system deep learning pest detection

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联络巷防水密闭墙稳定性评价与位置优化研究

工程科学与技术 2025年第1期57卷 264-273页

作者：杜明泽孔繁龙费宇煤炭科学技术研究院有限公司北京100013 煤矿灾害防控全国重点实验室北京100013 国电建投内蒙古能源有限公司察哈素煤矿内蒙古自治区鄂尔多斯017000 中国矿业大学(北京)力学与建筑工程学院北京100083

联络巷防水密闭墙受两次采动的影响,其稳定性关系到相邻工作面的安全回采。针对联络巷防水密闭墙稳定性难以确定这一关键问题,以察哈素煤矿联络巷防水密闭墙为例,采用理论分析,计算分析了不受采动影响下防水密闭墙承受的最大安全水头高... 详细信息

联络巷防水密闭墙受两次采动的影响,其稳定性关系到相邻工作面的安全回采。针对联络巷防水密闭墙稳定性难以确定这一关键问题,以察哈素煤矿联络巷防水密闭墙为例,采用理论分析,计算分析了不受采动影响下防水密闭墙承受的最大安全水头高度,阐明了防水密闭墙与煤岩柱易失稳的结构弱面;采用数值模拟,分析了一次、两次采动和不同水头高度(6.0、9.0、12.0和15.0 m)下防水密闭墙的受力状态、位移情况以及接触面滑移状态。基于结构弱面分析,采用自主研发的井下采空区防水密闭墙应力、位移监测系统,对密闭墙测点进行了合理布设和监测,最终确定了采动和水压作用下防水密闭墙的最大安全水头高度。在此基础上,对3–1工作面开采侧向支承压力分布规律进行了实测,并对防水密闭墙的位置进行了优化。结果表明:不考虑采动影响,防水密闭墙的最大安全水头高度为12.4 m,防水密闭墙体顶底角以及与煤柱相嵌的接触面为结构弱面,易发生破坏;采动对防水密闭墙有一定的损伤,水压作用加剧了密闭墙与煤柱接触面间的滑移;采动和水压作用下防水密闭墙所能承受的最大水头高度为9.0 m,警戒水位线的水头高度为7.2 m;工作面侧向压力峰值区约在10.5~12.5 m处,建议防水密闭墙布置在距离采空区侧大于15.0~20.0 m,以避开支承压力峰值。研究结果可为类似矿井防水密闭墙的稳定性评估与位置优化提供理论基础与应用参考。

关键词：矿井水害联络巷防水密闭墙抗水压能力侧向支承压力位置优化

Efficacy of sodium-glucose cotransporter-2 inhibitors and glucagonlike peptide-1 receptor agonists on proteinuria and weight in a diabetes cohort

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World Journal of Diabetes 2025年第2期16卷 123-132页

作者： Di-fei Lu Rui Zheng Ang Li Jun-qing Zhang Department of Endocrinology Peking University First HospitalBeijing 100034China iHealth Labs China Co. Ltd.Beijing 100034China

BACKGROUND With accumulating evidence showing a benefit in the renal and cardiovascular systems,diabetes guidelines recommend that patients with diabetes and chronic kidney disease(CKD)be treated with sodium-glucose cotransporter-2 inhibitor(SGLT2i)and/or glucagon like peptide-1 receptor agonists(GLP-1RAs)for renal *** real-world efficacy of the two medications on the urinary albumin-creatinine ratio(UACR)and estimated glomerular filtration rate(eGFR)remains to be *** To evaluate the SGLT2i and GLP-1RA application rates and UACR alterations after intervention in a real-world cohort of patients with *** A cohort of 5482 patients with type 2 diabetes were enrolled and followed up at the Integrated Care Clinic for Diabetes of Peking University First Hospital for at least 6 *** score matching was performed,and patients who were not recommended for GLP-1RA or SGLT2i with comparable sex categories and ages were assigned to the control group at a 1:2 *** glucose,body weight,UACR and eGFR were evaluated after 6 months of treatment in real-world clinical *** A total of 139(2.54%)patients started GLP-1RA,and 387(7.06%)received *** 6 months,the variations in fasting blood glucose,prandial blood glucose,and glycosylated hemoglobin between the GLP-1RA group and the SGLT2i and control groups were not significantly *** showed a tendency toward a greater reduction compared with the control group,although this difference was not statistically significant(GLP-1RA vs control,-2.20 vs 30.16 mg/g,P=0.812;SGLT2i vs control,-20.61 vs 12.01 mg/g,P=0.327);eGFR alteration also showed no significant *** weight loss was observed in the GLP-1RA group compared with the control group(GLP-1RA vs control,-0.90 vs 0.27 kg,P<0.001),as well as in the SGLT2i group(SGLT2i vs control,-0.59 vs-0.03 kg,P=0.010).CONCLUSION Compared with patients who received other glucose-lowering drugs,patients recei

关键词： Type 2 diabetes Chronic kidney disease Body weight Sodium-glucose cotransporter-2 inhibitors Glucagon-like peptide-1 receptor agonists

All-trans retinoic acid ameliorates experimental allergic encepha-lomyelitis by affecting dendritic cell and monocyte development

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All-trans retinoic acid ameliorates experimental allergic en...