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More Large Sets of Resolvable MTS and DTS with Even Orders

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 233-252页

作者： qing-de kang Rong-jia Xu Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China Qinhuangdao Radio and TV University Qinhuangdao 066001 China

In this paper, we first introduce a special structure that allows us to construct a large set of resolvable Mendelsohn triple systems of orders 2q ＋ 2, or LRMTS（2q ＋ 2）, where q = 6t ＋ 5 is a prime power. Using a computer, we find examples of such structure for t C T = {0, 1, 2, 3, 4, 6, 7, 8, 9, 14, 16, 18, 20, 22, 24}. Furthermore, by a method we introduced in [13], large set of resolvable directed triple systems with the same orders are obtained too. Finally, by the tripling construction and product construction for LRMTS and LRDTS introduced in [2, 20, 21], and by the new results for LR-design in [8], we obtain the existence for LRMTS（v）and LRDTS（v）, where v = 12（t ＋ 1） mi≥0（2.7mi＋1）mi≥0（2.13ni＋1）and t∈T,which provides more infinite family for LRMTS and LRDTS of even orders.

关键词： Large set resolvable Mendelsohn triple system tripling construction resolvable directed triple system

Large Sets and Overlarge Sets of Triangle-decomposition

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 123-132页

作者： Zi-hong Tian qing-de kang Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China

There are six types of triangles： undirected triangle, cyclic triangle, transitive triangle, mixed-1 triangle, mixed-2 triangle and mixed-3 triangle. The triangle-decompositions for the six types of triangles have already been solved. For the first three types of triangles, their large sets have already been solved, and their overlarge sets have been investigated. In this paper, we establish the spectrum of LTi（v,λ）, OLTi（v）（i = 1, 2）, and give the existence of LT3（v, λ） and OLT3（v, λ） with λ even.

关键词： Triangle-decomposition large set overlarge set

Further Results on Overlarge Sets of Kirkman Triple Systems

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Acta Mathematica Sinica,English Series 2009年第3期25卷 419-434页

作者： Lan Dang YUAN qing de kang College of Career Technology Hebei Normal University Shijiazhuang 050031 P. R. China Institute of Mathematics Hebei Normal University Shijiazhuang 050016 P. R. China

In this paper, we introduce a new concept -- overlarge sets of generalized Kirkman systems （OLGKS）, research the relation between it and OLKTS, and obtain some new results for OLKTS. The main conclusion is： If there exist both an OLKF（6^k） and a 3-OLGKS（6^k-1,4） for all k ∈{6,7,...,40}／{8,17,21,22,25,26}, then there exists an OLKTS（v） for any v ≡ 3 （mod 6）, v ≠ 21. As well, we obtain the following result： There exists an OLKTS（6u ＋ 3） for u = 2^2n-1 - 1, 7^n, 31^n, 127^n, 4^r25^s, where n ≥ 1,r＋s≥ 1.

关键词： Kirkman frame Kirkman triple system overlarge set (2 1)-resolvable Steiner quadruplesystem

Graph designs for all Graphs with Six Vertices and Eight Edges

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Acta Mathematicae Applicatae Sinica 2005年第3期21卷 469-484页

作者： qing-de kang Lan-dang Yuan Shu-xia Liu Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China College of Mathematics & Statistic Hebei University of Economics and Trade Shijiazhuang 050061 China

Graph designs for all graphs with six vertices and eight edges are discussed. The existence of these graph designs are completely solved except in two possible cases of order 32.

关键词： Graph design holey graph design quasi-group

Packings and Coverings of λK_v with 2 Graphs of 6 Vertices and 7 Edges

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维普期刊数据库

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Journal of Mathematical Research and Exposition 2011年第1期31卷 59-66页

作者： Yan Ke DU qing de kang Institute of Applied Mathematics Mechanical Engineering College Hebei 050003 P. R. China Institute of Mathematics Hebei Normal University Hebei 050016 P. R. China

A maximum （v, G, λ）-PD and a minimum （v, G, λ）-CD axe studied for 2 graphs of 6 vertices and 7 edges. By means of ＂difference method＂ and ＂holey graph design＂, we obtain the result： there exists a （v, Gi,... 详细信息

关键词： G-design G-packing design G-covering design.

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying kang Song Qin department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi Lian kang Hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)