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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di Zhao Lemei zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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肉芽肿性乳腺炎的超声表现及临床、病理分析

中国医学影像技术 2011年第11期27卷 2246-2249页

作者：鲁嘉刘赫姜玉新戴晴常晓燕朱庆莉张璟孝梦甦王红燕朱沈玲李娜中国医学科学院北京协和医学院北京协和医院超声诊断科北京100730

目的探讨肉芽肿性乳腺炎(GM)的超声表现及临床病理特征。方法回顾性分析经病理确诊的15例GM患者的超声表现、临床症状及病理特征。结果 12例病灶位于左侧乳房,3例位于右侧;10例为单发,5例为多发;肿块大小2.10～9.70cm,平均(9.38±2.26)c... 详细信息

目的探讨肉芽肿性乳腺炎(GM)的超声表现及临床病理特征。方法回顾性分析经病理确诊的15例GM患者的超声表现、临床症状及病理特征。结果 12例病灶位于左侧乳房,3例位于右侧;10例为单发,5例为多发;肿块大小2.10～9.70cm,平均(9.38±2.26)cm。超声均呈不均质低回声,其中6例可见无回声,4例无回声内可见细点状中-强回声;13例边界不清,形态不规则,其中4例主要表现为多个导管样回声延续,3例主要表现为分叶和成角,1例同时呈现以上2种表现,5例主要表现为弥漫性腺体回声紊乱,余2例边界清晰,为卵圆形。CDFI示12例病灶血流丰富。11例合并同侧腋下淋巴结肿大;3例伴皮肤增厚,其中1例伴皮下积液,1例窦道形成。术后病理显示2例W-S反应阳性,发现特异性猫抓病病原菌。结论 GM的主要超声表现为不均匀、不规则的低回声、多呈管样或结节样肿物内有丰富血流信号,确诊需结合临床表现及病理结果。

关键词：乳腺肉芽肿性乳腺炎超声检查

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei zhu lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

ZnFe_2O_4/ZnO-rGO催化毛棉油制备生物柴油的研究

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金陵科技学院学报 2016年第3期32卷 32-36页

作者：朱庆莉顾恒金陵科技学院公共基础课部江苏南京211169 金陵科技学院机电工程学院江苏南京211169

生物柴油作为一种易降解的、无毒的、环境友好型的燃料,受到人们的高度关注。为了提高制备生物柴油转酯化反应的转化率,简化工艺流程,以ZnO、Zn(NO_3)_2、Fe(NO_3)_3、石墨烯为原料,通过化学沉淀法、氧化还原法制备高活性、易回收、操... 详细信息

生物柴油作为一种易降解的、无毒的、环境友好型的燃料,受到人们的高度关注。为了提高制备生物柴油转酯化反应的转化率,简化工艺流程,以ZnO、Zn(NO_3)_2、Fe(NO_3)_3、石墨烯为原料,通过化学沉淀法、氧化还原法制备高活性、易回收、操作简单的磁性光催化剂——ZnFe_2O_4/ZnO-rGO。并探讨了采用该催化剂进行转酯化反应时,各因素对生物柴油产率的影响,得到了最佳的工艺条件为:催化剂用量4%,醇油摩尔比9∶1,反应2.5h。在此条件下毛棉油的转酯化率可达到97.3%。

关键词：生物柴油磁性光催化剂 ZnFe2O4/ZnO-rGO 毛棉油制备

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基于GIS的洪灾避迁方案的模糊综合评判

中国农村水利水电 2009年第10期 81-83页

作者：田质胜朱庆利李明霞赵芳河海大学南京210098 山东省水利勘测设计院济南250013

洪涝灾害是我国自然灾害中损失最严重的灾害,随着社会经济的发展和城市化进程的加速,洪水造成的损失越来越大,而利用防洪非工程措施一直是防洪救灾工作的薄弱环节。正确迅速的解决防洪决策如此复杂的决策问题非常困难。因此,采用模糊综... 详细信息

洪涝灾害是我国自然灾害中损失最严重的灾害,随着社会经济的发展和城市化进程的加速,洪水造成的损失越来越大,而利用防洪非工程措施一直是防洪救灾工作的薄弱环节。正确迅速的解决防洪决策如此复杂的决策问题非常困难。因此,采用模糊综合评判方法,结合GIS在洪灾避迁决策的应用,利用GIS图层叠加与空间分析,通过相应的约束条件,筛选出满足约束条件的约束集,用模糊相似贴近度物元模型进行方案的评价决策。从而帮助防洪决策人员制定具体防洪决策,减少或避免防洪决策的失误。

关键词： GIS 洪灾避迁模糊综合评判

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原发甲状腺淋巴瘤的超声表现

中华超声影像学杂志 2010年第2期19卷 131-133页

作者：夏宇戴晴姜玉新周静李小毅钟定荣朱庆莉杨萌张波李文波北京协和医院超声诊断科 100730

目的探讨原发甲状腺淋巴瘤的超声表现。方法回顾性分析20例原发甲状腺淋巴瘤的超声表现。结果20例原发甲状腺淋巴瘤后方回声均可见增强（100％），17例（85％）甲状腺腺体增大。13例（65％）表现为单发或多发低回声结节，边界不规则，... 详细信息

目的探讨原发甲状腺淋巴瘤的超声表现。方法回顾性分析20例原发甲状腺淋巴瘤的超声表现。结果20例原发甲状腺淋巴瘤后方回声均可见增强（100％），17例（85％）甲状腺腺体增大。13例（65％）表现为单发或多发低回声结节，边界不规则，肿瘤后方回声增强，归为结节型。3例（15％）表现为甲状腺一侧腺体增大，回声减低，后方回声增强，归为弥漫型。4例（20％）表现介于前两类表现之间，与桥本氏病表现相似，回声不均匀，片状减低，后方回声增强，归为混合型。结论原发甲状腺淋巴瘤超声表现多样，甲状腺增大、淋巴瘤病灶后方回声增强是其主要超声特点。

关键词：超声检查甲状腺肿瘤淋巴瘤

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

超声引导下细针吸取活检对甲状腺囊实性结节与实性结节的诊断价值比较

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中华超声影像学杂志 2011年第8期20卷 680-683页

作者：李文波朱庆莉姜玉新张波戴晴高嫔杨堤孙健邢小平连小兰中国医学科学院北京协和医学院北京协和医院超声诊断科北京100730 中国医学科学院北京协和医学院北京协和医院病理科北京100730 中国医学科学院北京协和医学院北京协和医院内分泌科北京100730

目的比较超声引导下细针吸取细胞学检查（US-FNA）对不同大小的甲状腺囊实性及实性结节的诊断价值。方法对168例患者的i75个甲状腺结节进行US-FNA检查。将穿刺细胞学及组织学的诊断资料与手术病理及临床随访结果进行对照分析。63例患者... 详细信息

目的比较超声引导下细针吸取细胞学检查（US-FNA）对不同大小的甲状腺囊实性及实性结节的诊断价值。方法对168例患者的i75个甲状腺结节进行US-FNA检查。将穿刺细胞学及组织学的诊断资料与手术病理及临床随访结果进行对照分析。63例患者获得手术病理，其余病例进行临床随访，随访时间2年3个月至6年2个月。结果175个甲状腺结节中实性及囊实性结节分别为115个和60个。US-FNA检查均未出现严重并发症。经手术及随访证实实性结节中甲状腺癌36例，囊实性结节中甲状腺癌3例。实性结节及囊实性结节涂片不满意率分别为7％和8％。US-FNA对囊实性和实性甲状腺癌的诊断准确性相近（88．8％对94．6％，），但前者诊断敏感性较低。对≤1cm及〉1cm实性甲状腺癌诊断敏感性及准确性相似（敏感性75．0％对83．9％，准确性94．1％对86．3％）。结论US-FNA对不同大小的甲状腺实性及囊实性结节取材满意，诊断准确性好，有较高的临床应用价值。

关键词：超声检查活组织检查,针吸甲状腺肿瘤