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Journal of Integrative Medicine 2021年第6期19卷 469-477页

作者： jia-jia Li qing Liang Guang-chun Sun Department of Pharmacy Shanghai Fifth People’s HospitalFudan UniversityShanghai 200240China

Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers *** transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of *** cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug ***,exploring and evaluating new therapies is an urgent *** Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against *** evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in ***,studies on the effects of TCM on EMT in HCC are *** this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.

关键词： Traditional Chinese medicine Chinese medicine formulae Hepatocellular carcinoma Epithelial-mesenchymal transition Metastasis Cancer therapy

Stress-corrosion behavior and characteristics of the friction stir welding of an AA2198-T34 alloy

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 774-782页

作者： quan-qing Zeng Song-sheng Zeng Dong-yao Wang Research Institute of Light Alloy Central South UniversityChangsha 410083China Key Laboratory of the Ministry of Education of Nonferrous Metals Central South UniversityChangsha 410083China Technology Center Valin ArcelorMittal Automotive Steel Co.Ltd.Loudi 417009China

To better understand the stress-corrosion behavior of friction stir welding(FSW),the effects of the microstructure on the stress-corrosion behavior of the FSW in a 2198-T34 aluminum alloy were *** experimental results show that the low-angle grain boundary(LABs)of the stir zone(SZ)of FSW is significantly less than that of heated affected zone(HAZ),thermo-mechanically affected zone(TMAZ),and parent materials(PM),but the grain boundary precipitates(GBPs)T1(Al2CuLi)were less,which has a slight effect on the stress *** dislocation density in SZ was greater than that in other *** residual stress in SZ was+67 MPa,which is greater than that in the *** residual stress in the HAZ and PM is-8 MPa and-32 MPa,respectively,and both compressive *** corrosion potential in SZ is obviously less than that in other ***,micro-cracks were formed in the SZ at low strain rate,which indicates that the grain boundary characters and GBPs have no significant effect on the crack initiation in the stress-corrosion process of the ***,the residual tensile stress has significant effect on the crack initiation during the stress-corrosion process.

关键词： slow strain rate test residual stress grain boundary characteristic AA2198-T34 alloy friction stir welding

On large action space in EV charging scheduling optimization

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Science China(Information Sciences) 2022年第2期65卷 45-60页

作者： Zhaoyu jiaNG qing-Shan jia Xiaohong GUAN Center for Intelligent and Networked Systems Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University MOE KLINNS Lab Xi'an Jiaotong University

In order to reduce the air pollution by traditional fossil fuel and save the charging cost, much attention has been paid to the charging scheduling of electric vehicles(EVs) in the uncertain supplement of wind power and solar power. Owing to the randomness in the renewable power generation and the EV charging demand, simulation-based policy improvement(SBPI) has been well adopted for making charging decision. However, it is challenging to explore the large action space which grows exponentially with respect to the system scale. We consider this important problem in this paper and make the following ***, we explore the structural property of the problem and develop an urgency index to rank the ***, we apply three methods to search in the action space. Third, we numerically demonstrate the performance of the urgency index and the search methods, and compare the SBPI methods with the CPLEXbased method. It shows that SBPI improves the base policies in all these cases.

关键词： EV simulation-based policy improvement large action space sampling

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Influence of Surface Effects on the Elastic Properties of Silicon Nanowires with Different Cross Sections

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Chinese Physics Letters 2011年第10期28卷 165-168页

作者： GU Fang ZHANG jia-Hong XU Lin-Hua LIU qing-quan LI Min College of Mathematics and Physics Nanjing University of Information Science and TechnologyNanjing 210044 College of Electronic and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044

Based on the anharmonic Keating model and the modified bending theory,an analytical semi-continuum atomistic lattice model is proposed for the size-dependent bending mechanical analysis of silicon nanowires(SiNWs)with different cross-sectional *** semi-continuum model proves that the elastic behavior of SiNWs is size-dependent and predicts softer or stiffer SiNWs which depend on the relaxation coefficient and the surface *** also shows that the size effects of the mechanical responses of SiNWs depend on not only surface effects but also the cross-sectional shapes of SiNWs.

关键词： nanowires bending size

Effect of interface behaviour on damage and instability of PBX under combined tension-shear loading

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Defence Technology（防务技术） 2023年第5期23卷 137-151页

作者： quan-zhi Xia Yan-qing Wu Feng-lei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China

To study the effect of interface behaviour on the mechanical properties and damage evolution of PBX under combined tension-shear loading, the present work establishes the numerical model of a PBX three-phase hybrid system, which introduces a nonlinear plastic damage cohesion model to study the mechanical response and damage process. The parameters in the model were fitted and *** the crack growth rate as the feature, the damage state in each stage was determined, and the damage instability criterion was given. The effects of interfacial tensile strength and shear strength on the damage process of PBX were studied. On this basis, serrated and hemispherical structures interface of PBX has been developed, which affects the damage process and instability during the loading *** results indicate that damage state response of PBX experiences the process of stable load bearing,unstable propagation, and complete failure. At the critical moment of instability, the overall equivalent effective strain of material reaches 3024 με and instability loading displacement reaches 0.39 mm. The increase of interfacial tensile strength and shear strength significantly inhibits the damage of PBX. The effect of interfacial shear strength on critical instability of PBX is approximately 1.7 times that of the interfacial tensile strength. Further, interface opening along the normal direction is the main damage form at the interface. Serrated and hemispherical rough interfaces can significantly inhibit propagation of cracks, and the load bearing capacity is improved by 22% and 9.7%, respectively. Appropriate improvement of the roughness of the interface structure can effectively improve the mechanical properties. It is significantly important to have a better understanding of deformation, damage and failure mechanisms of PBX and to improve our predictive ability.

关键词： PBX explosives Interface behaviour Damage Instability Crack propagation

Dynamics of a spacecraft with large flexible appendage constrained by multi-strut passive damper

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Acta Mechanica Sinica 2013年第2期29卷 294-308页

作者： Ying-Hong jia Shi-Jie Xu quan Hu School of Astronautics Beihang University

This paper is concerned with the dynamics of a spacecraft with multi-strut passive damper for large flexible *** damper platform is connected to the spacecraft by a spheric hinge,multiple damping struts and a rigid *** damping struts provide damping forces while the rigid strut produces a motion constraint of the multibody *** exact nonlinear dynamical equations in reducedorder form are firstly derived by using Kane＇s equation in matrix *** on the assumptions of small velocity and small displacement,the nonlinear equations are reduced to a set of linear second-order differential equations in terms of independent generalized displacements with constant stiffness matrix and damping matrix related to the damping strut *** simulation results demonstrate the damping effectiveness of the damper for both the motion of the spacecraft and the vibration of the flexible appendage,and verify the accuracy of the linear equations against the exact nonlinear ones.

关键词： Dynamics·Motion constraints·Multi-strut passive damper·Kane's equation

Dynamics and adaptive control of a dual-arm space robot with closed-loop constraints and uncertain inertial parameters

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Acta Mechanica Sinica 2014年第1期30卷 112-124页

作者： Ying-Hong jia quan Hu Shi-Jie Xu School of Astronautics Beihang University

A dynamics-based adaptive control approach is proposed for a planar dual-arm space robot in the presence of closed-loop constraints and uncertain inertial parameters of the payload. The controller is capable of controlling the po- sition and attitude of both the satellite base and the payload grasped by the manipulator end effectors. The equations of motion in reduced-order form for the constrained system are derived by incorporating the constraint equations in terms of accelerations into Kane＇s equations of the unconstrained system. Model analysis shows that the resulting equations perfectly meet the requirement of adaptive controller design. Consequently, by using an indirect approach, an adaptive control scheme is proposed to accomplish position/attitude trajectory tracking control with the uncertain parameters be- ing estimated on-line. The actuator redundancy due to the closed-loop constraints is utilized to minimize a weighted norm of the joint torques. Global asymptotic stability is proven by using Lyapunov＇s method, and simulation results are also presented to demonstrate the effectiveness of the proposed approach.

关键词： Space robot Dynamics. Adaptive control Closed-loop constraint Parameter uncertainty - Kane's equation

Study on Atomic Fluorescence Spectrometry Excited by Synchrotron Radiation

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Chinese Journal of Chemical Physics 2008年第5期21卷 427-432页

作者： jia-jia Guo Wu-er Gana Guo-bin Zhang qing-de Sua Department of Chemistry University of Science and Technology of China Hefei 230026 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230027 China

A novel analysis approach using atomic fluorescence excited by synchrotron radiation is presented. A system for synchrotron radiation-atomic fluorescence spectrometry is developed, and experimental conditions such as flow rate, analyte acidity, concentration of pre-reducing and hydrogenation system are optimized. The proposed method is successfully applied to get an excitation spectrum of arsenic. Seven of ten primary spectral lines, four of which have never been reported by means of atomic fluorescence spectrometry, agree well with the existing reports. The other three are proposed for the first time. Excitation potentials and possible transitions are investigated. Especially for the prominent line at 234.99 nm, the mechanism of generation is discussed and a model of energy transition processes is proposed.

关键词： Synchrotron radiation Atomic fluorescence Arsenic Energy transition

Multi-track Storage of 10000 Holograms in a Disk-Type Photorefractive Crystal

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Chinese Physics Letters 2000年第9期17卷 675-677页

作者： TAO Shi-quan XU Min LIU Guo-qing YUAN quan jiaNG Zhu-qing Applied Physics Department Beijing Polytechnic UniversityBeijing 100022

Three-dimensional disk-type holographic storage using spatioangular multiplexing with a spherical reference beam is analyzed and experimentally *** overlapping factors between adjacent holograms in a track and between adjacent tracks in a disk are determined based on the selective angles calculated by coupled-wave *** are 10000 holograms stored along 5 tracks in a sector of a single iron-doped lithium niobate crystal.

关键词： theory. holographic lithium

A novel method to prepare SPR sensor chips based on photografting molecularly imprinted polymer

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Chinese Chemical Letters 2011年第6期22卷 721-724页

作者： qing quan Wei Tian Xin Wei Key Laboratory of Cluster Science of Ministry of Education Beijing Institute of Technology Beijing 100081 China

A novel method to prepare surface plasmon resonance（SPR） sensor chips based on grafted imprinted polymer is explored. Benzophenone photografting system is used to grow molecularly imprinted polymer（MIP） films from the modified surface of gold *** surface morphology and thickness of MIP films were investigated by scanning electronic microscope（SEM）.The adsorption properties of sensor chip were studied by SPR *** results demonstrate that nano-MIP films can be constructed on the surface of gold substrate with the good adsorption of template molecules.

关键词： Surface plasmon resonance Molecularly imprinted polymer Photografting