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Exploring European ancestry among the Kalash population: a mitogenomic perspective

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Zoological Research 2020年第5期41卷 552-556页

作者： Zia Ur Rahman Yu-Chun Li Jiao-Yang Tian qing-peng kong State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China University of Chinese Academy of Sciences Beijing 100049China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

DEAR EDITOR,With a population of around 4000 individuals,the Kalash people have been living in the Hindu-Kush mountain valleys of present-day northern Pakistan for *** to their mysterious origin and fairer European complexion,the genetic history of this ethnic group has been investigated previously using different *** date,however,the maternal genetic architecture has not been systematically dissected based on high-resolution complete mitochondrial genomes(mitogenomes),making their maternal genetic history,especially their genetic connection with Europeans from a matrilineal perspective,*** unravel this issue.

关键词： has dis among

Mitochondrial DNA evidence supports northeast Indian origin of the aboriginal Andamanese in the Late Paleolithic

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Journal of Genetics and Genomics 2011年第3期38卷 117-122页

作者： Hua-Wei Wang Bikash Mitra Tapas Kumar Chaudhuri Malliya gounder Palanichamy qing-peng kong Ya-Ping Zhang Laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming 650091 Yunnan Province China Cellular Immunology Laboratory Department of Zoology University of North Bengal Siliguri West Bengal 734013 India State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 Yunnan Province China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming 650223 Yunnan Province China

In view of the geographically closest location to Andaman archipelago, Myanmar was suggested to be the origin place of aboriginal Andamanese. However, for lacking any genetic information from this region, which has prevented to resolve the dispute on whether the aboriginal Andamanese were originated from mainland India or Myanmar. To solve this question and better understand the origin of the aboriginal Andamanese, we screened for haplogroups M31 （from which Andaman-specific lineage M31al branched off） and M32 among 846 mitochondrial DNAs （mtDNAs） sampled across Myanmar. As a result, two Myanmar individuals belonging to haplogroup M31 were identified, and completely sequencing the entire mtDNA genomes of both samples testified that the two M31 individuals observed in Myanmar were probably attributed to the recent gene flow from northeast India populations. Since no root lineages of haplogroup M31 or M32 were observed in Myanmar, it is unlikely that Myanmar may serve as the source place of the aboriginal Andamanese. To get further insight into the origin of this unique population, the detailed phylogenetic and phylogeographic analyses were performed by including additional 7 new entire mtDNA genomes and 113 M31 mtDNAs pinpointed from South Asian populations, and the results suggested that Andaman-specific M31al could in fact trace its origin to northeast India. Time estimation results further indicated that the Andaman archipelago was likely settled by modem humans from northeast India via the land-bridge which connected the Andaman archipelago and Myanmar around the Last Glacial Maximum （LGM）, a scenario in well agreement with the evidence from linguistic and palaeoclimate studies.

关键词： mtDNA Myanmar Aboriginal Andamanese Northeast India Origin

Targeted multi-agent communication algorithm based on state control

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Defence Technology（防务技术） 2024年第1期31卷 544-556页

作者： Li-yang Zhao Tian-qing Chang Lei Zhang Jie Zhang Kai-xuan Chu De-peng kong Department of Weaponry and Control Army Academy of Armored ForcesBeijing100072China Unit 92942 Beijing100161China

As an important mechanism in multi-agent interaction,communication can make agents form complex team relationships rather than constitute a simple set of multiple independent ***,the existing communication schemes can bring much timing redundancy and irrelevant messages,which seriously affects their practical *** solve this problem,this paper proposes a targeted multiagent communication algorithm based on state control(SCTC).The SCTC uses a gating mechanism based on state control to reduce the timing redundancy of communication between agents and determines the interaction relationship between agents and the importance weight of a communication message through a series connection of hard-and self-attention mechanisms,realizing targeted communication message *** addition,by minimizing the difference between the fusion message generated from a real communication message of each agent and a fusion message generated from the buffered message,the correctness of the final action choice of the agent is *** evaluation using a challenging set of Star Craft II benchmarks indicates that the SCTC can significantly improve the learning performance and reduce the communication overhead between agents,thus ensuring better cooperation between agents.

关键词： Multi-agent deep reinforcement learning State control Targeted interaction Communication mechanism

Absence of mutation in miR-34a gene in a Chinese longevity population

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Zoological Research 2015年第2期36卷 112-114页

作者： Huan WU Yong-Han HE Tian-Rui XU qing-peng kong Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan 650500 China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences KunmingYunnan 650223 China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Yunnan 650223 China

DEAR EDITOR Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer, cardiovascular disease, dementia, and stroke （Andersen et al, 2012）. Though there may be a number of underlying mechanisms behind this longevity, curiously it seems that the survival advantage persists in their offspring （Terry et al, 2003）, suggesting a potentially important role for genetic factors. Previous studies suggested that the heritability of human longevity may be ~25% （Herskind et al, 1996; Mcgue et al, 1993）, whicih is consistent with other studies on model organisms that identified several longevity-related genes, such as age-l, daf-2, daf-16, and sir-2 （Friedman ＆ Johnson, 1988; Kenyon et al, 1993; Lin et al, 1997; Tissenbaum ＆ Guarente, 2001）. Likewise, several studies have reported the existence of many mutations related to human longevity （Holstege et al, 2014; Sebastiani et al, 2012）.

关键词：长寿磁共振成像基因内皮缩血管肽类人口突变亚洲大陆世系人群铍老年人 80以上人类

Distinct enhancer-promoter modes determine Sox2 regulation in mouse pluripotent cells

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Genes & Diseases 2024年第1期11卷 26-29页

作者： Lei Huang Xiusheng Zhu qing Li Dashuai kong Qitong Huang Jing Luo Siyuan kong Yanling peng Yubo Zhang Animal Functional Genomics Group Shenzhen BranchGuangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Livestock and Poultry Multi-omics of MAPAShenzhen Agricultural Genome Research InstituteChinese Academyof Agricultural SciencesShenzhenGuangdong 518120China Animal Breeding and Genomics Wageningen University&ResearchWageningen 6708PBNetherlands College of Life Science and Engineering Foshan UniversityFoshanGuangdong 528231China School of Life Sciences Henan UniversityKaifengHenan 475004China

Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully *** enhancer-promoter interactions are vital for Sox2 transcription activity in ***,how these diverse interactions individually influence Sox2 gene regulation in mouse ESCs remains *** studies found that three distal enhancers(termed E1,E2,and E3)interact with Sox2 promoter?(Fig.1A;Fig.S1A,and Table S1).

关键词： Sox2 regulation distal

rs11046147 mutation in the promoter region of lactate dehydrogenase-B as a potential predictor of prognosis in triple-negative breast cancer

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Cancer Communications 2020年第6期40卷 279-282页

作者： Jia Liu Yue Li Xiao-Qiong Chen Chang Sun Xiu-Li Sun Zheng Yang qing-peng kong State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223P.R.China Department of Pathology the Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhenGuangdong518100P.R.China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases KunmingYunnan650223P.R.China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan650223P.R.China College of Life Science Shanxi Normal UniversityXi’anShanxi710119P.R.China Key Laboratory of Pu-erh Tea Science Ministry of EducationYunnan Agricultural UniversityKunmingYunnan650201P.R.China

Dear Editor,Triple-negative breast cancer(TNBC)is a heterogeneous disease characterized by a deficiency in the expression of three well-known biomarkers of breast cancers,namely estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER2).Its treatment has become an important clinical challenge because TNBC is more aggressive than other breast cancer subtypes,and is usually associated with higher tumor recurrence and lower survival rate[1-3].Breast cancer patients with ER,PR,and/or HER2 positive tumors often respond positively to targeted therapies whereas TNBC patients remain unresponsive to conventional treatment due to lack of specific biomarkers for determining appropriate treatment(***-based therapy).Hence,identifying novel and effective biomarkers for predicting TNBC prognosis and to improve their survival has become an urgent need for developing effective targeted therapy against TNBC.

关键词： breast cancer prognosis

Lightweight Malicious Code Classification Method Based on Improved Squeeze Net

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Computers, Materials & Continua 2024年第1期78卷 551-567页

作者： Li Li Youran kong qing Zhang School of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the growth of the Internet,more and more business is being done online,for example,online offices,online education and so *** this makes people’s lives more convenient,it also increases the risk of the network being attacked by malicious ***,it is important to identify malicious codes on computer systems ***,most of the existing malicious code detection methods have two problems:(1)The ability of the model to extract features is weak,resulting in poor model performance.(2)The large scale of model data leads to difficulties deploying on devices with limited ***,this paper proposes a lightweight malicious code identification model Lightweight Malicious Code Classification Method Based on Improved SqueezeNet(LCMISNet).In this paper,the MFire lightweight feature extraction module is constructed by proposing a feature slicing module and a multi-size depthwise separable convolution *** feature slicing module reduces the number of parameters by grouping *** multi-size depthwise separable convolution module reduces the number of parameters and enhances the feature extraction capability by replacing the standard convolution with depthwise separable convolution with different convolution kernel *** addition,this paper also proposes a feature splicing module to connect the MFire lightweight feature extraction module based on the feature reuse and constructs the lightweight model *** malicious code recognition accuracy of LCMISNet on the BIG 2015 dataset and the Malimg dataset reaches 98.90% and 99.58%,*** proves that LCMISNet has a powerful malicious code recognition *** addition,compared with other network models,LCMISNet has better performance,and a lower number of parameters and computations.

关键词： Lightweight neural network malicious code classification feature slicing feature splicing multi-size depthwise separable convolution

Neolithic millet farmers contributed to the permanent settlement of the Tibetan Plateau by adopting barley agriculture

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National Science Review 2019年第5期6卷 1005-1013页

作者： Yu-Chun Li Jiao-Yang Tian Feng-Wen Liu Bin-Yu Yang Kang-Shu-Yun Gu Zia Ur Rahman Li-Qin Yang Fa-Hu Chen Guang-Hui Dong qing-peng kong State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Key Laboratory of Western China’s Environmental Systems(Ministry of Education) Lanzhou University CAS Center for Excellence in Tibetan Plateau Earth Sciences and Key Laboratory of Alpine Ecology Institute of Tibetan Plateau Research(ITPCAS) Chinese Academy of Sciences

The permanent human settlement of the Tibetan Plateau(TP) has been suggested to have been facilitated by the introduction of barley agriculture ～3.6 kilo-years ago(ka).However, how barley agriculture spread onto the TP remains *** that the lower altitudes in the northeastern TP were occupied by millet cultivators from 5.2 ka, who also adopted barley farming ～4 ka, it is highly possible that it was millet farmers who brought barley agriculture onto the TP ～3.6 *** test this hypothesis, we analyzed mitochondrial DNA(mt DNA) from 8277 Tibetans and 58 514 individuals from surrounding populations,including 682 newly sequenced whole *** lines of evidence, together with radiocarbon dating of cereal remains at different elevations, supports the scenario that two haplogroups(M9a1a1c1b1a and A11a1a), which are common in contemporary Tibetans(20.9%) and were probably even more common(40–50%) in early Tibetans prior to historical immigrations to the TP, represent the genetic legacy of the Neolithic millet *** haplogroups originated in northern China between 10.0–6.0 ka and differentiated in the ancestors of modern Tibetans ～5.2–4.0 ka, matching the dispersal history of millet *** showing that substantial genetic components in contemporary Tibetans can trace their ancestry back to the Neolithic millet farmers, our study reveals that millet farmers adopted and brought barley agriculture to the TP ～3.6–3.3 ka, and made an important contribution to the Tibetan gene pool.

关键词： Tibetans millet farmers barley agriculture archaeology mitochondrial genomes

Vertically grown MoS_(2)nanosheets on graphene with defect-rich structure for efficient sodium storage

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Rare Metals 2024年第3期43卷 1062-1071页

作者： Ying Wang Jia-peng He Han-qing Pan qing-peng Wang Lei Zhang Yong-Chang Liu qing-Hong Wang School of Chemistry&Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional MaterialsJiangsu Normal UniversityXuzhou221116China Institute of Biopharmaceutical Research Liaocheng UniversityLiaocheng252059China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing100083China Centre for Catalysis and Clean Energy Gold Coast CampusGriffith UniversityGold CoastQLD4222Australia

The synthesis of a perpendicular growth structure of MoS_(2)nanosheets on graphene for efficient sodium storage is challenging yet ideal due to the benefits of open ion diffusion channels and high electronic *** this study,we have successfully fabricated a novel structure of vertical MoS_(2)nanosheets on graphene,with ZnS nanoparticles serving as bonding points(MoS_(2)/ZnS/G),through a facile hydrothermal *** the synthesis process,Zn^(2+)not only acts as a landing site for the vertical growth of MoS_(2)nanosheets but also triggers the formation of a defect-rich structure in the final *** unique architecture of MoS_(2)/ZnS/G effectively combines the advantages of a vertically aligned geometry and a defectrich structure for energy *** resulting structure displays shortened transport paths for electrons/ions,enhanced conductivity,improved structural integrity,and an increased number of active sites for promising electrochemical *** expected,when used as anode for sodium-ion batteries,the as-synthesize d MoS_(2)/ZnS/G exhibits excellent rate capability(high capacity of 298 mAh·g^(-1)at 5 A·g^(-1))and good cycling stability(a capacity decay of 0.056%per cycle after 500 cycles at 1 A·g^(-1)).According to the kinetic investigations,the electrochemical process of the MoS_(2)/ZnS/G sample is primarily governe d by a pseudocapacitive behavior,which enhances the charge/discharge kinetics and allows the MoS_(2)/ZnS/G structure to remain intact during cycling.

关键词： MoS_(2) Perpendicular growth Graphene Sodium storage Electrochemical performance