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Girard Subquantales

工程数学学报 2007年第3期24卷 567-570页

作者：龙飞李庆国湖南大学数学与计量经济学院

Girard quantales是研究计算机科学的线性逻辑的有力工具。它为线性命题公式提供了理论基础;特别是Girard quantales中的“■”运算,它在线性逻辑的一些运算中有着广泛的运用,本文研究了Girard quantales中运算“■”的一些新的性质,给... 详细信息

Girard quantales是研究计算机科学的线性逻辑的有力工具。它为线性命题公式提供了理论基础;特别是Girard quantales中的“■”运算,它在线性逻辑的一些运算中有着广泛的运用,本文研究了Girard quantales中运算“■”的一些新的性质,给出了Girard quantales的Sub- quantales亦是Girard quantales的充分条件。

关键词：对偶子 Girard quantales “ ”运算

Genome-and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus

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Molecular Plant 2021年第3期14卷 470-487页

作者： Shan Tang Hu Zhao Shaoping Lu Liangqian Yu guofang Zhang Yuting Zhang qing-Yong Yang Yongming Zhou Xuemin Wang Wei Ma Weibo Xie Liang guo National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanChina Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhanChina Department of Biology University of Missouri-St.LouisSt.LouisMO 63121USA Donald Danforth Plant Science Center St.LouisMO 63132USA School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore

Seed oil content(SOC)is a highly important and complex trait in oil ***,we decipher the genetic basis of natural variation in SOC of Brassica napus by genome-and transcriptome-wide association studies using 505 inbred *** mapped reliable quantitative trait loci(QTLs)that control SOC in eight environments,evaluated the effect of each QTL on SOC,and analyzed selection in QTL regions during ***-hundred and ninety-two genes and four gene modules significantly associated with SOC were identified by analyzing population transcriptomes from seeds.A gene prioritization framework,POCKET(prioritizing the candidate genes by incorporating information on knowledge-based gene sets,effects of variants,genome-wide association studies,and transcriptome-wide association studies),was implemented to determine the causal genes in the QTL regions based on multi-omic datasets.A pair of homologous genes,BnPMT6s,in two QTLs were identified and experimentally demonstrated to negatively regulate *** study provides rich genetic resources for improving SOC and valuable insights toward understanding the complex machinery that directs oil accumulation in the seeds of *** and other oil crops.

关键词： Brassica napus seed oil content QTL GWAS TWAS gene module

Observation of the BEC-BCS crossover in a degenerate Fermi gas of lithium atoms

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Chinese Physics B 2022年第1期31卷 480-484页

作者： Xiang-Chuan Yan Da-Li Sun Lu Wang Jing Min Shi-guo Peng Kai-jun Jiang State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

We observe characteristic atomic behaviors in the Bose-Einstein-condensation-Bardeen-Cooper-Schrieffer(BEC-BCS)crossover,by accurately tuning the magnetic field across the Feshbach resonance of lithium *** magnetic field is calibrated by measuring the Zeeman shift of the optical transition.A non-monotonic anisotropic expansion is observed across the Feshbach *** density distribution is explored in different interacting regimes,where a condensate of diatomic molecules forms in the BEC limit with the indication of a bimodal *** also measure the three-body recombination atom loss in the BEC-BCS crossover,and find that the magnetic field of the maximum atom loss is in the BEC limit and gets closer to the Feshbach resonance when decreasing the atom temperature,which agrees with previous experiments and theoretical *** work builds up a controllable platform for the study on the strongly interacting Fermi gas.

关键词： BEC-BCS crossover three-body recombination anisotropic expansion

Autologous sclera-muscle flaps technique in evisceration with hydroxyapatite implantation

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 714-718页

作者： Ying Zhu Hong Zhang Yin-Wei Song Jing-Min guo Xiao-Lan Xu jun-Ming Wang Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

·AIM: To provide superior cosmetic results and reduce complications, unlike traditional evisceration coupled with implant insertion technique and its modifications,we have developed a novel and simple technique for anophthalmic patients.·METHODS: All patients who underwent the scleral-muscle flaps procedure in evisceration with the placement of hydroxyapatite implant were included in the study. Main outcome measures were complications such as exposure, infection, chemosis, conjunctival inclusion cysts, granulomas. Meanwhile, implant motility was indirectly measured and the results were collected and analyzed.· RESULTS: A total of twenty-eight patients were enrolled in the study. Eighteen were men(64.29%) and ten were women(35.71%). Ages ranged from 18 to 65y(mean age, 32 years old). Mean follow-up was 12.32mo(range, 9-16mo). All patients received a hydroxyapatite implant. The average diameter of the implant was 19.29 ±1.36 mm(range, 18-22 mm). Minor complications occurred in 3 patients, and a major complication was observed in 1 patient. Mean motility were 11.04 ±1.45 mm horizontally(range, 7-14 mm) and 8.57 ±1.50 mm vertically(range, 5-12 mm).·CONCLUSION: The sclera-muscle flaps technique in evisceration with hydroxyapatite implantation is simple and practical that eases the surgical procedure, enables a proper size hydroxyapatite implantation, distinctively reduces complications and provides superior surgery results, especially the motility of the implant.

关键词： sclera-muscle flaps hydroxyapatite implantation evisceration

Effect of TRPV1 combined with lidocaine on cell state and apoptosis of U87-MG glioma cell lines

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 283-287页

作者： jun Lu You-Ting Ju Chang Li Fu-Zhou Hua guo-Hai Xu Yan-Hui Hu Department of Anesthesiology The Second Affiliated Hospital to Nanchang University

Objective:To study the effects of Transient receptor potential cation channel,subfamily V,member 1(TRPV1) combined with lidocaine on status and apoptosis of U87-MG glioma cell line,and explore whether local anesthetic produces neurotoxicity by ***:U87-MG cells were divided into control group,gene silencing group,empty vector group and TRPV gene up-rcgulation *** cells in each group,flow cytometry was employed to detect the intracellular calcium ion concentration and mitochondrial membrane potential at different lime point from cellular *** apoptosis of U87-MG was assayed by flow cytometry and MTT from a holistic ***:Calcium ion concentration increased along with *** concentration in TRPV1 gene up-regulation group was significantly higher than those in other groups at each time point(P<0.05).After adding *** membrane potential in U87-MG significantly increased(P<0.05).This increasing trend in TRPV1 gene up-regulation group was more significant than other groups(P<0.05).while in TRPV1 gene silencing group,the trend significantly decreased(P<0.05).Flow cytometry result and MTT result both showed that cell apoptosis in each group significantly increased after lidocaine was added(P<0.05).This increasing trend in TRPV1 gene up-regulation group was more significant than other groups(P<0.05),while in TRPV1 gene silencing group,the trend significandy decreased(P<0.05).Moreover,apoptosis was more severe along with the increasing concentration of lidocaine(P<0.05).Conclusions:In this study,it was proved that lidocaine could dose-dependently induce the increase of intracellular calcium ion concentration,mitochondrial membrane potential and apoptosis in U87-MG glioma cell *** up-regulation of TRPV1 enhanced cytotoxicity of lidocaine,which revealed the correlations between *** might have increased intracellular calcium ion concentration by activating TRPVI gene and induced apoptosis of U87-GM gli

关键词： TRPV1 Lidocaine U87-MG Glioma Cell state Apoptosis

Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma

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Current Medical Science 2020年第4期40卷 719-728页

作者： Bin LUO Xiang YUN Jing LI Rong FAN Wen-wen guo Chang LIU Yong-da LIN Ying-ying GE Xia ZENG Shui-qing BI Wei-xia NONG qing-mei ZHANG Xiao-xun XIE School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021China Department of Surgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Clinical Laboratory Chinese Medicine HospitalQuanzhou 362000China School of Basic Medical Sciences Guangxi University of Chinese MedicineNanning 530021China Department of Pathology the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China Guangxi Key Laboratory of Early Prevention and Treatmentfor Regional High Frequency Tumor Guangxi Medical UniversityNanning 530021China Key Laboratory Research on Preclinical Medicine Guangxi Medical UniversityNanning 530021China

Summary:Cancer testis(CT)antigens have received particular attention in cancer ***-TES-1 is a member of CT *** study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time ***-TES-1 protein was subsequently observed on a panel of tissue *** from patients were tested for OY-TES-1 antibody by *** identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in *** results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver ***-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis *** was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy *** specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed *** target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II *** summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in

关键词： cancer testis antigen hepatocelluar cancer tumor immunotherapy

Role of nitric oxide and peroxynitrite anion in lung injury induced by intestinal ischemia-reperfusion in rats

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World Journal of Gastroenterology 2003年第6期9卷 1318-1322页

作者： jun-LinZhou guo-HuaJin Yi-LingYi jun-LanZhang Xin-LiHuang DepartmentofHandSurgery ThirdAffiliatedHospitalHebeiMedicalUniversityShijiazhuang050051HebeiProvinceChina DepartmentofLiverMedicine ThirdAffiliatedHospitalHebeiMedicalUniversityShijiazhuang050051HebeiProvinceChina DepartmentofPathophysiology HebeiMedicalUniversityShijiazhuang050017HebeiProvince.China

AIM: To evaluate effects of nitric oxide (NO) and peroxynitrite anion (ONOO-) on lung injury following intestinal ischemia-reperfusion (IR) in rats.METHODS: A rat model of intestinal ischemia was made by clamping superior mesenteric artery and lung injury was resulted from reperfusion. The animals were randomly divided into 3 groups: sham operation (Sham), 2 h ischemia followed by 2 h reperfusion (IR) and IR pretreated with aminoguanidine (AG) - an inhibitor of inducible NO synthase (iNOS) 15 minutes before reperfusion (IR+AG). The lung malondialdehyde (MDA) and nitrate/nitrite (NO2/NO3)contents and morphological changes were *** blot was used to detect the iNOS protein *** staining was used to determine the change of nitrotyrosine (NT)- a specific 'footprint' of ONOO-.RESULTS: The morphology revealed evidence for lung edema, hemorrhage and polymorphonuclear sequestration after intestinal IR. Compared with sham group, lung contents of MDA and NO2-/NO3- in IR group were significantly increased (12.00±2.18 vs23.44±1.25 and 76.39±6.08 vs140.40±4.34,P＜0.01) and the positive signals of iNOS and NT were also increased in the lung. Compared with IR group, the contents of MDA and NO2/NO3 in IR+AG group were significantly decreased (23.44±1.25 vs14.66±1.66 and 140.40±4.34 vs 80.00±8.56, P＜0.01) and NT staining was also decreased.CONCLUSION: Intestinal IR increases NO and ONOO production in the lung, which may be involved in intestinal IR-mediated lung injury.

关键词：一氧化氮肠缺血再灌注损伤肺损伤动物实验

HBV genotype C is independently associated with cirrhosis in community-based population

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World Journal of Gastroenterology 2010年第3期16卷 379-383页

作者： Yin, Jian-Hua Zhao, jun Zhang, Hong-Wei Xie, Jia-Xin Li, Wei-Ping Xu, guo-Zhang Shen, Jie Dong, Hong-jun Zhang, jun Wang, Lin Han, Jian-Kang Wang, Hong-Yang Cao, Guang-Wen Second Mil Med Univ Dept Epidemiol Shanghai 200433 Peoples R China Second Mil Med Univ Affiliated Hosp 3 Dept Hepatobiliary Surg Shanghai 200438 Peoples R China Second Mil Med Univ Dept Ultrasonog Affiliated Hosp 1 Shanghai 200433 Peoples R China Municipal Ctr Dis Control & Prevent Ningbo Ningbo 315010 Zhejiang Peoples R China Municipal Ctr Dis Control & Prevent Soochow Suzhou 215007 Jiangsu Peoples R China Dist Ctr Dis Control & Prevent Yangpu Shanghai 200090 Peoples R China Municipal Ctr Dis Control & Prevent Huzhou Huzhou 313000 Zhejiang Peoples R China Second Mil Med Univ Lab Signal Transduct Affiliated Hosp 3 Shanghai 200438 Peoples R China

AIM:To determine the association of hepatitis B virus (HBV) genotypes with probable cirrhosis and fatty liver in community-based ***: A multi-stage cluster probability sampling method was applied to recruit 10 167 subjects aged between 6 and 72 years from our epidemiological bases in Eastern China. After excluding the subjects co-infected with hepatitis C or hepatitis D viruses, the hepatitis B surface antigen (HBsAg)-positive subjects were examined for HBV genotype, serum viral load, alanine aminotransferase (ALT), hepatitis B e antigen (HBeAg) status, and ultrasonographic changes. Logistic regression models were used to determine the factors associated with probable cirrhosis and fatty ***: Of 634 HBsAg-positive subjects with HBV genotype determined, 82 had probable cirrhosis (ultrasonographic score ≥5), 42 had ultrasonographic fatty liver. Probable cirrhosis was only found in the HBeAg-negative subjects, and more frequently found in the subjects with genotype C than in those with genotype B (14.8% vs 8.0%, P=0.018). In HBeAg-negative subjects, high viral load was frequently asso-ciated with abnormal ALT level, while ALT abnormality was more frequent in those with probable cirrhosis than those without (19.5% vs 7.8%, P=0.001). Univariate analysis showed that age, sex, HBV genotypes, and viral load were not significantly associated with ultrasonographic fatty liver, whereas ALT abnormality was significantly related to ultrasonographic fatty liver (OR=4.54,95% CI:2.11-9.75, P<0.001). Multivariate analysis demonstrated that HBV genotype C, age (≥45 years), male sex, and ALT abnormality were independently associated with probable cirrhosis (AOR=2.30,95% CI:1.26-4.19; AOR =1.81,95% CI:1.10-2.99;AOR=1.74,95% CI:1.03-2.95; AOR=2.98,95% CI:1.48-5.99, respectively).CONCLUSION: A crude prevalence of probable cirrhosis is 12.9% in the community-based HBV-infected subjects. HBV genotype C is independently associated with probable cirrhosis in the HBe

关键词： Hepatitis B virus Genotype Viral load Alanine aminotransferase Probable cirrhosis Ultrasonography

Diode-Laser-Array Single-End-Pumped 5W Nd:YVO_(4)/KTP Continuous-Wave Solid-State Green Laser

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Chinese Physics Letters 1999年第7期16卷 508-509页

作者： LIU jun-hai WANG Chang-qing LU jun-hua LI Guang-ming SHAO Zong-shu WANG Ji-yang LIU Yao-gang JIANG Min-hua National Laboratory of Crystal Materials Shandong UniversityJiJnan 250100

Continuous-wave radiation of 5W at 532 nm was produced with an Nd:YVO_(4)/KTP intracavity&equency-doubled laser end-pumped by a diode-laser-array at pump power of 17.2 W,giving optical conversion efRciency of 29.1%.The output power stability was measured to be better than 1.5%in short term *** pump-induced thermal lensing was also measured,showing good agreement with the performance of the laser.

关键词： Nd: pump pumped