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Discovery of a novel 112-type iron-pnictide and La-doping induced superconductivity in Eu_(1-x)La_xFeAs_2(x=0–0.15)

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Science Bulletin 2017年第3期62卷 218-221页

作者： Jia Yu Tong Liu Bo-Jin Pan Bin-Bin Ruan Xiao-Chuan Wang qing-ge mu Kang Zhao gen-Fu Chen Zhi-An Ren Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of Sciences Beijing 100190 China Collaborative Innovation Center of Quantum Matter Beijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences Beijing 100039 China

We report the discovery and characterization of a novel 112-type iron pnictide EuFeAs2, with La-doping induced superconductivity in a series of Eu1- xLaxFeAs2. The polycrystalline samples were synthesized through solid state reaction method only within a very narrow temperature window around 1073 K. Small single crystals were also grown from a flux method with the size about 100μm. The crystal structure was identified by single crystal X-ray diffraction analysis as a monoclinic structure with space group of P2 1/m. From resistivity and magnetic susceptibility measurements, we found that the parent compound EuFeAs2 shows distinct anomalies probably due to the Fe2＋ related antiferromagnetic/structural phase transition near 110K and the Eu2＋ related antiferromagnetic phase transition near 40K. La-doping suppressed both phase transitions to lower temperatures and induced superconducting transitions with a Tc - 11 K for Eu0.85La0.15FeAs2.

关键词： EuFeAs2 Superconductivity La-doping Antiferromagnetic transition

Superconductivity at 7.8 K in the ternary LaRu2As2 compound

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Science Bulletin 2016年第12期61卷 921-924页

作者： Qi Guo Bo-Jin Pan Jia Yu Bin-Bin Ruan Dong-Yun Chen Xiao-Chuan Wang qing-ge mu gen-Fu Chen Zhi-An Ren Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100190 China

Here we report the discovery of superconductivity in the ternary LaRu2As2 compound. The polycrystalline LaRu2As2 samples were synthesized by the conventional solid state reaction method. Powder X-ray diffraction analysis indicates that LaRu2As2 crystallizes in the ThCr2Si2-type crystal structure with the space group 14/ mmm （No. 139）, and the refined lattice parameters are a = 4.182（6）A and c = 10.590（3）A. The temperature dependent resistivity measurement shows a clear superconducting transition with the onset Tc （critical tempera- ture） at 7.8 K, and zero resistivity happens at 6.8 K. The upper critical field at zero temperature μ0Hc2（0） was estimated to be 1.6 T from the resistivity measurement. DC magnetic susceptibility measurement shows a bulk superconducting Meissner transition at 7.0 K, and the isothermal magnetization measurement indicates that LaRu2As2 is a type-II superconductor.

关键词： Superconductivity LaRu2As2 - Ternarycompound ThCr2Si2-type Magnetization Uppercritical field

A New Quasi-One-Dimensional Ternary Molybdenum Pnictide Rb2Mo3As3 with Superconducting Transition at 10.5K

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Chinese Physics Letters 2020年第9期37卷 73-77页

作者： Kang Zhao qing-ge mu Bin-Bin Ruan Meng-Hu Zhou qing-Song Yang Tong Liu Bo-Jin Pan Shuai Zhang gen-Fu Chen Zhi-An Ren Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

We report superconductivity in a new ternary molybdenum pnictide Rb2 Mo3 As3,synthesized via the solid state reaction *** x-ray diffraction analysis reveals a hexagonal crystal structure with space group P6 m2(No.187),and the refined lattice parameters are a=10.431(5)A,c=4.460(4)*** images show rod-like grains with good ductility,confirming a quasi-one-dimensional(Q1 D)*** resistivity and dc magnetic susceptibility characterizations exhibit superconductivity with an onset of Tc=10.5 *** upper critical field of Rb2 Mo3 As3 is estimated to be 28.2 T at zero temperature,providing an evidence of possible unconventional *** recent discovery of MoAs-based superconductors above 10 K provides a unique platform for the study of exotic superconductivity in 4 d electron systems with Q1 D crystal structures.

关键词： ductility superconductivity Transition

gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

基于遥感的1984一2019年查干湖及周边湖泊透明度变化

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湖泊科学 2025年第1期37卷 328-338页

作者：赵方睿王强穆春生刘阁温志丹陶慧宋开山东北师范大学生命科学学院长春130024 中国科学院东北地理与农业生态研究所长春130102

湖泊透明度是衡量水质变化和湖泊水生生态系统健康的重要指标。湖泊透明度一般通过塞氏盘现场观测获得,其变化主要由水体中非藻类颗粒物、藻类和黄色物质(CDOM)浓度共同决定,因此可以通过光学遥感进行反演。本研究基于20042009年8次查... 详细信息

湖泊透明度是衡量水质变化和湖泊水生生态系统健康的重要指标。湖泊透明度一般通过塞氏盘现场观测获得,其变化主要由水体中非藻类颗粒物、藻类和黄色物质(CDOM)浓度共同决定,因此可以通过光学遥感进行反演。本研究基于20042009年8次查干湖实地采样获得的132条透明度数据,通过分析同步Landsat天顶反射率产品数据(TOA)不同波段组合与透明度之间的相关性,发现以红波段和蓝波段比值和红绿蓝波段均值AV(B3,B1)组合建立的透明度反演模型精度最高,误差最小,进而基于此模型反演了19842019年查干湖以及周边湖泊透明度。结果表明:查干湖透明度范围在1.0~63.0 cm之间,年均值为17.6 cm。查干湖透明度年均值变化分为两个阶段:19842001年间透明度波动范围较大,没有明显趋势;20022019年期间呈上升趋势(2.3 cm/10 a)。查干湖透明度与风速、降水量、湖泊面积和归一化植被指数具有一定的相关性。通过长时间尺度上遥感监测查干湖水体透明度的时空格局变化,分析其变化特征与规律,可为查干湖流域生态治理提供科学依据。

关键词：查干湖透明度 Landsat 遥感

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Recent progress and perspectives on silicon anode:Synthesis and prelithiation for LIBs energy storage

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Journal of Energy Chemistry 2022年第1期31卷 615-650,I0016页

作者： Yuanxing Zhang Borong Wu ge mu Chengwei Ma Daobin mu Feng Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing Key Laboratory of Environment Science and EngineeringBeijing 100081China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

The ever-increasing environmental/energy crisis as well as the rapid upgrading of mobile devices had stimulated intensive research attention on promising alternative energy storage and conversion *** these devices,alkali metal ion batteries,such as lithium-ion batteries(LIBs) had attracted increasing research attention due to its several advantages including,environmental friendliness,high power density,long cycle life and excellent *** had been widely used in consumer electronics,electric vehicles,and large power grids et ***-based(silicon and their oxides,carbides) anodes had been widely *** several advantages including low cost,high theoretical capacity,natural abundance,and environmental friendliness,which shows great potential as anodes of *** this review,we summarized the recently progress in the synthetic method of silicon matrix *** empirical method for prelithiation of silicon-based materials were also ***,we also reviewed some novel characterization ***,the new design,preparation methods and properties of these nano materials were reviewed and *** hoped that this review can provide a general overview of recent progress and we briefly highlighted the current challenges and prospects,and will clarify the future trend of silicon anode LIBs research.

关键词： Si anodes Lithium-ion batteries Prelithiation Characterization Energy storage and conversion