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A novel alternative for pyrogen detection based on a transgenic cell line

Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang Yong-bo Ni Xiao Guo Zhi-Hao Fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang Chen Xu-Hong Chen bo Chen Jun-Zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

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Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang bo Chen Hong-Yi Zhang Zhen-Hua Chen Yao-bo Huang Xue-qing Ye Ya-Hua Yuan Yu-Xia Duan Jun He Jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

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Spectrally resolved Franson interference

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 11-17页

作者： Rui-bo Jin Zi-Qi zeng Dan Xu Chen-Zhi Yuan Bai-Hong Li You Wang Ryosuke Shimizu Masahiro Takeoka Mikio Fujiwara Masahide Sasaki Pei-Xiang Lu Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China School of Physics and Information Science Shaanxi University of Science and TechnologyXi'an 710021China Southwest Institute of Technical Physics Chengdu 610041China Graduate School of Informatics and Engineering University of Electro-CommunicationsTokyo 182-8585Japan Department of Electronics and Electrical Engineering Keio UniversityKanagawa 223-8522Japan National Institute of Information and Communications Technology Tokyo 184-8795Japan

Franson interference can be used to test the nonlocal features of energy-time entanglement and has become a standard in quantum ***,most of the previous Franson interference experiments were demonstrated in the time domain,and the spectral properties of Franson interference have not been fully ***,we theoretically and experimentally demonstrate spectrally resolved Franson interference using biphotons with different correlations,including positive correlation,negative correlation,and *** is found that the joint spectral intensities of the biphotons can be modulated along both the signal and idler directions,which has potential applications in generating high-dimensional frequency entanglement and time-frequency grid *** work may provide a new perspective for understanding the spectral-temporal properties of the Franson interferometer.

关键词： resolved correlation spectral

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Orientation controlled photogenerated carriers on selfsupporting CdS/Ni_(3)S_(2) paper toward photocatalytic hydrogen evolution and biomass upgrading

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Rare Metals 2024年第5期43卷 2015-2025页

作者： Xiao-Yan Liu qing Cao Gui-Xiang Li Hui Liu Li-Li zeng Li-Li Zhao Bin Chang Xi-Wen Wang Hong Liu Wei-Jia Zhou Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China Institute of Chemical Sciences and Engineering Ecole Polytechnique Federale de Lausanne1015LausanneSwitzerland KAUST Catalysis Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia School of Environment and Energy South China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China State Key Laboratory of Crystal Materials Shandong UniversityJinan250100China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710054China

The appropriate regulation of band structure is an effective strategy in constructing efficient photocatalytic *** photocatalytic system mainly employs powder photocatalysts,which makes their recovery reliant on expensive separation processes and severely limits their industrial ***,we constructed a novel CdS/Ni_(3)S_(2)heterostructure using free-standing and flexible nickel fiber paper as the *** regulated energy band structure achieves effective electron–hole *** as-synthesized flexible photocatalyst exhibits considerable photocatalytic activity toward the H_(2)evolution reaction under visible-light irradiation,with an H_(2)production rate of5.63μmol·cm^(-2)·h^(-1)(14.1 mmol·g^(-1)cat·h^(-1)according to the catalyst loading content).Additionally,the otherwisewasted excited holes simultaneously drive organic transformations to yield value-added organic products,thus markedly improving the photocatalytic H_(2)evolution *** a photocatalytic system is scaled up further,where a self-supported 20 cm×25 cm sample achieves a champion H_(2)production rate of 60-80μmol·h^(-1)under practical sun *** newly developed self-supported photocatalyst produces opportunities for practical solar H2production with biomass upgrading.

关键词： Self-supporting photocatalyst CdS/Ni_(3)S_(2) heterojunction Hydrogen evolution Biomass upgrading Large-scaleapplication

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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Fu-Rec:Multi-Task Learning Recommendation Model Fusing Neighbor-Discrimination and Self-Discrimination

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 134-144页

作者： ZHENG Sirui HUANG bo LIU Jin zeng Guohui YIN Ling LI Zhi SUN Tie School of Electronic and Electrical Engineering Shanghai University of Engineering ScienceShanghai 201600China School of Computer Wuhan UniversityWuhan 430072HubeiChina School of Computer Science and Engineering Guangxi Normal UniversityGuilin 541004GuangxiChina AIoT Manufacturing Solutions Technology Co. Ltd.Hefei 230000AnhuiChina

In recent years,self-supervised learning has achieved great success in areas such as computer vision and natural language processing because it can mine supervised signals from unlabeled data and reduce the reliance on manual ***,the currently generated self-supervised signals are either neighbor discrimination or self-discrimination,and there is no model to integrate neighbor discrimination and *** on this,this paper proposes Fu-Rec that integrates neighbor-discrimination contrastive learning and self-discrimination contrastive learning,which consists of three modules:(1)neighbor-discrimination contrastive learning,(2)selfdiscrimination contrastive learning,and(3)recommendation *** neighbor-discrimination contrastive learning and selfdiscrimination contrastive learning tasks are used as auxiliary tasks to assist the recommendation *** Fu-Rec model effectively utilizes the respective advantages of neighbor-discrimination and self-discrimination to consider the information of the user’s neighbors as well as the user and the item itself for the recommendation,which results in better performance of the recommendation *** results on several public datasets demonstrate the effectiveness of the Fu-Rec proposed in this paper.

关键词： self-supervised learning recommendation system contrastive learning multi-task learning

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Root cause of corrosion failure of tin coating on wire clamp in marine atmosphere

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Journal of Iron and Steel Research(International) 2024年第4期31卷 998-1014页

作者： Zhen Zhong Wang-yan Ly Teng-yuan Liu Yi Xie Yang Yang Zhen-zhu Wang Deng-ke Li Xiao-bo Li Tang-qing Wu School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105HunanChina Electric Power Research Institute of Guangdong Power Grid Co. Ltd.Guangzhou 510080GuangdongChina Shenyang National L aboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering.University of Science and Technology of China Shenyang 110016LiaoningChina Electric Power Research Institute State Grid Hunan Electric Power CompanyChangsha 410007HunanChina School of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan 411105HunanChina School of Information Science and Engineering Changsha Normal UniversityChangsha 410199HunanChina

The failure cause of a tinned copper wire clamp in marine atmosphere was studied systematically by X-ray photoelectron spectroscopy,scanning electron microscopy with energy dispersive spectroscopy and electrochemical *** main components of the green rust on the surface of the damaged wire clamp are SnO_(2),CuO,Cu_(2)Cl(OH)_(3) and CuCO(OH)_(2).Much of green rust distributes at the platform edge along the axial direction on the crimp connection,and severe corrosion and corrosion pits occur at the platform edge zone along the axial *** enriching Cl-at the marine atmosphere and the existing O_(2) in air collectively enhance the corrosion process of the tin coating and the copper *** element model results show that the residual stress and strain of the tin coating are the largest at the platform edge along the axial direction on the crimp connection,and the corresponding electrode potential of the tin coating at this zone drops *** above results indicate that the residual strain increases the driving force of the corrosion electrochemical reactions and accelerates the corrosion rate and the pit corrosion of the tin coating at this zone.

关键词： Tin coating Marine atmosphere Residual strain-Chloride ion Corrosion failure

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Optimized online filter stack spectrometer for ultrashort X-ray pulses

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Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma Ming-Hai Yu Yu-Chi Wu Yong-Hong Yan Shao-Yi Wang Huai-Zhong Gao Lu-Shan Wang Yu-Gang Zhou Qiang Li Yue Yang Fang Tan Xiao-Hui Zhang Jie Zhang Wen-bo Mo Jing-Qin Su Wei-Min Zhou Yu-Qiu Gu Ming zeng Zong-qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

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Gamma/Hadron Separation Method for the HADAR Experiment

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Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： Yang-Zhao Ren Tian-Lu Chen You-Liang Feng Dan-zeng Luo-Bu Yi-qing Guo Cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian Ya-Ping Wang Zi-Hao Zhang Xin-Long Li qing-Yuan Hou Heng-Jiao Liu qing-Qian Zhou Shan-Jie Shu The Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

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Clinical efficacy of Gamma Knife®combined with transarterial chemoembolization and immunotherapy in the treatment of primary liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1601-1608页

作者： Guo-Feng Wang Chang-Xin Shu Xiao-Dong Cai Hong-bo Wang Jian-Hong Xu Yu-qing Jia Department of General Surgery Yangzhou Friendship Hospital Affiliated to Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND This study was designed to investigate the clinical efficacy and safety of Gamma Knife®combined with transarterial chemoembolization(TACE)and immunotherapy in the treatment of primary liver *** To investigate the clinical efficacy and safety of Gamma Knife®combined with TACE and immune-targeted therapy in the treatment of primary liver *** Clinical data from 51 patients with primary liver cancer admitted to our hospital between May 2018 and October 2022 were retrospectively *** patients underwent Gamma Knife®treatment combined with TACE and *** clinical efficacy,changes in liver function,overall survival(OS),and progression-free survival(PFS)of patients with different treatment responses were evaluated,and adverse reactions were *** The last follow-up for this study was conducted on October 31,*** evaluation of the 51 patients with primary liver cancer revealed a partial response(PR)in 27 patients,accounting for 52.94%(27/51);stable disease(SD)in 16 patients,accounting for 31.37%(16/51);and progressive disease(PD)in 8 patients,accounting for 15.69%(8/51).The objective response rate was 52.94%,and the disease control rate was 84.31%.Alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alpha-fetoprotein isoform levels decreased after treatment compared with pretreatment(all P=0.000).The median OS was 26 months[95%confidence interval(95%CI):19.946-32.054]in the PR group and 19 months(95%CI:14.156-23.125)in the SD+PD group,with a statistically significant difference(P=0.015).The median PFS was 20 months(95%CI:18.441-34.559)in the PR group and 12 months(95%CI:8.745-13.425)in the SD+PD group,with a statistically significant difference(P=0.002).Common adverse reactions during treatment included nausea and vomiting(39.22%),thrombocytopenia(27.45%),and leukopenia(25.49%),with no treatment-related deaths *** Gamma Knife®combined with TACE and immune-targeted th

关键词： Gamma Knife® Transarterial chemoembolization Immunotherapy Primary liver cancer Liver function

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