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基于尿素动力学模型评估维持性血液透析患者透析充分性与患者焦虑和抑郁之间的关联性分析

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国际精神病学杂志 2024年第1期51卷 215-218,229页

作者：杨晓翠杜俊林尹青余翼周军都江堰市人民医院都江堰611830

目的探讨基于尿素动力学模型(ureakineticmodel,UKM)评估维持性血液透析(Maintenance hemodialysis,MHD)患者透析充分性与患者焦虑和抑郁之间的关联性分析。方法回顾性分析2021年6月~2022年6月收治的64例MHD患者的临床资料,通过临床资... 详细信息

目的探讨基于尿素动力学模型(ureakineticmodel,UKM)评估维持性血液透析(Maintenance hemodialysis,MHD)患者透析充分性与患者焦虑和抑郁之间的关联性分析。方法回顾性分析2021年6月~2022年6月收治的64例MHD患者的临床资料,通过临床资料将患者分为透析充分组(44例)、透析不充分组(20例),比较两组UKM参数[时间平均尿素浓度(Time-average Concentration of urea,TACurea)、整体尿素清除率(urea clearance index,KT/V)、蛋白质分解代谢率(Protein catabolism rate,PCR)];采用ROC曲线得出UKM参数界值,比较不同UKM参数水平患者焦虑自评量表评分(SAS)、抑郁自评量表评分(SDS)水平,采用Spearman相关分析UKM参数与SAS、SDS评分相关性。结果透析充分组TACurea、PCR值均明显高于透析不充分组(t=20.406、5.390,P0.05)。通过ROC曲线分析可知,TACurea界值为16.23 mmol/L、PCR界值为0.61 g/kg^(-1)·d^(-1)。TACurea≥16.23 mmol/L组患者SAS、SDS评分均明显低于TACurea<16.23 mmol/L组患者(t=3.222、5.209,P<0.05);PCR≥0.61 g/kg^(-1)·d^(-1)组患者SAS、SDS评分均明显低于PCR<0.61 g/kg^(-1)·d^(-1)组患者(t=5.043、3.443,P<0.05)。Spearman相关分析显示,TACurea、PCR与SAS、SDS评分均呈显著负相关(r=-0.367、-0.563,-0.560、-0.410,P<0.01)。结论基于UKM模型可准确评估MHD患者透析充分性,且其透析充分性与患者焦虑和抑郁之间存在明显关联,患者透析越充分焦虑抑郁水平越低。

关键词：尿素动力学模型维持性血液透析透析充分性焦虑抑郁

Perylene Diimide Based Isomeric Conjugated Polymers as Efficient Electron Acceptors for All-polymer Solar Cells

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Chinese Journal of Polymer Science 2019年第1期37卷 18-27,1-5页

作者： Xiao-Cheng Liu qing-Wu yin Zhi-Cheng Hu Zhen-Feng Wang Fei Huang Yong Cao State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology South China Institute of Collaborative Innovation

We present here a series of perylene diimide(PDI)based isomeric conjugated polymers for the application as efficient electron acceptors in all-polymer solar cells(all-PSCs).By copolymerizing PDI monomers with 1,4-diethynylbenzene(para-linkage)and 1,3-diethynylbenzene(meta-linkage),isomeric PDI based conjugated polymers with parallel and non-parallel PDI units inside backbones were *** was found that para-linked conjugated polymer(PA)showed better solubility,strongerπ-πstacking,more favorable blend morphology,and better photovoltaic performance than those of meta-linked conjugated polymers(PM)*** based on PTB7-Th:PA(PTB7-Th:poly{4,8-bis[5-(2-ethylhexyl)-thiophen-2-yl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)-carbonyl]thieno[3,4-b]thiophene-4,6-diyl})showed significantly enhanced photovoltaic performance than that of PTB7-Th:MA(3.29%versus 0.92%).Moreover,the photovoltaic performance of these polymeric acceptors could be further improved via a terpolymeric *** copolymerizing a small amount of meta-linkages into PA,the optimized terpolymeric acceptors enabled to enhance photovoltaic performance with improved the short-circuit current density(Jsc)and fill factor(FF),resulting in an improved power conversion efficiency(PCE)of 4.03%.

关键词： Isomeric conjugated polymers All-polymer solar cells Electron acceptors Perylene diimide

A Near-infrared Non-fullerene Acceptor with Thienopyrrole-expanded Benzo[1,2-b:4,5-b′]dithiophene Core for Polymer Solar Cells

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Chinese Journal of Polymer Science 2021年第1期39卷 35-42,I0005页

作者： Zhen Chen Shan-Shan Ma Kai Zhang Zhi-Cheng Hu qing-Wu yin Fei Huang Yong Cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

A near-infrared non-fullerene acceptor(NFA) BDTIC, based on thienopyrrole-expanded benzo[1,2-b:4,5-b′]dithiophene unit(heptacyclic S,N-heteroacene) as core, is designed and synthesized. The aromatic pyrrole ring with strong electron-donating ability in the core enhances the intramolecular charge transfer effect, finely tunes the optical bandgap and absorption profile of BDTIC, and thus results in a narrowed optical bandgap(E_(g)^(opt)) of 1.38 eV and a near-infrared absorption to 900 nm. When BDTIC is paired with donor polymer PBDB-T to fabricate organic solar cells, the optimized device achieves a best power conversion efficiency of 12.1% with a short-circuit current density of 20.0 mA·cm^(-2) and an open-circuit voltage of 0.88 V. The photovoltaic performance benefits from the broad absorption, weak bimolecular recombination, efficient charge separation and collection, and favorable blend morphology. This work demonstrates that thienopyrroleexpanded benzo[1,2-b:4,5-b′]dithiophene unit(heptacyclic S,N-heteroacene) is a promising building unit to construct high-performance NFAs by enhancing the intramolecular charge transfer effect, broadening absorption as well as maintaining good intermolecular stacking property.

关键词： Organic solar cells(OSCs) Non-fullerene acceptors(NFAs) Heptacyclic S,N-heteroacene

机器人谐波减速机柔性轴承用钢的超高旋转弯曲疲劳强度的研究

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特殊钢 2024年第3期45卷 105-113页

作者：刘烨桂煜琳尹青吴小林缪新德江阴兴澄特种钢铁有限公司研究院江阴214429

采用电弧炉生产工艺,控制废钢/铁水比为80%以上,开发出长寿命机器人谐波减速机柔性轴承用钢,从非金属夹杂物、奥氏体晶粒度、碳化物带状组织方面对比柔性轴承用和传统滚动轴承用钢的冶金质量,并利用旋转弯曲疲劳试验的方法测试柔性轴承... 详细信息

采用电弧炉生产工艺,控制废钢/铁水比为80%以上,开发出长寿命机器人谐波减速机柔性轴承用钢,从非金属夹杂物、奥氏体晶粒度、碳化物带状组织方面对比柔性轴承用和传统滚动轴承用钢的冶金质量,并利用旋转弯曲疲劳试验的方法测试柔性轴承用和传统滚动轴承用钢在107循环周次条件下的疲劳强度。机器人谐波减速机柔性轴承用钢的w[O]<0.0004%,w[Ti]<0.001%,A类硫化物类非金属夹杂物≤1.0级,B类和D类氧化物类非金属夹杂物≤0.5级,极值统计法预测最大球状夹杂物的尺寸<30μm,检验结果表明柔性轴承用钢具备超高纯净度。通过在冶炼过程增加Al和N的元素含量,柔性轴承用钢具有10级的奥氏体晶粒度,远高于传统滚动轴承用钢的8.5级晶粒度。通过延长高温扩散时间,7.1和7.2级别的碳化物带状组织占比要高于传统滚动轴承用钢,超高晶粒度和碳化物带状组织的带宽减小表明柔性轴承用钢具备超高组织均匀性。柔性轴承用钢在107循环周次条件下具有超高旋转弯曲疲劳强度为1016 MPa,疲劳寿命略高于传统滚动轴承用钢。

关键词：谐波减速机柔性轴承晶粒度非金属夹杂物旋转弯曲疲劳超高周疲劳性能

High-precision geochronological constraints on the duration of ‘Dinosaur Pompeii’ and the Yixian Formation

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National Science Review 2021年第6期8卷 117-119页

作者： Yuting Zhong Magdalena H.Huyskens qing-Zhu yin Yaqiong Wang Qiang Ma Yi-Gang Xu State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of Sciences CAS Center for Excellence in Deep Earth Science Department of Earth and Planetary Sciences University of California at Davis State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of Sciences State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of Geosciences

The Early Cretaceous Jehol Biota,renowned for its exceptionally wellpreserved volcanic-influenced ecosystem, was buried in lacustrine and occasionally fluvial sediments. This includes, notably, the Huajiying, Yixian and Jiufotang Formations in northern Hebei and western Liaoning and equivalent ash-interbedding sediments in neighboring areas [1–3](Fig. 1). It harbors many evolutionarily significant taxonomies, e.g. feathered dinosaurs,early birds, mammals and flowering plants, representing one of the most diversified terrestrial biotas of the Mesozoic [1,2,4].

关键词： JEHOL BIOTA

The materials data ecosystem： Materials data science and its role in data-driven materials discovery

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Chinese Physics B 2018年第11期27卷 120-125页

作者： Hai-qing yin Xue Jiang Guo-Quan Liu Sharon Elder Bin Xu qing-Jun Zheng Xuan-Hui Qu Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology Beijing Beijing 100083 China Beijing Key Laboratory of Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China Computer Science and Engineering The Pennsylvania State University University Park PA 16802 USA Kennametal Inc. 1600 Technology Way Latrobe PA 15650 USA Institute of Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China

Since its launch in 2011, the Materials Genome Initiative（MGI） has drawn the attention of researchers from academia,government, and industry worldwide. As one of the three tools of the MGI, the use of materials data, for the first time, has emerged as an extremely significant approach in materials discovery. Data science has been applied in different disciplines as an interdisciplinary field to extract knowledge from data. The concept of materials data science has been utilized to demonstrate its application in materials science. To explore its potential as an active research branch in the big data era, a three-tier system has been put forward to define the infrastructure for the classification, curation and knowledge extraction of materials data.

关键词： Materials Genome Initiative materials data science data classification life-cycle curation

连续性肾脏替代治疗应用于体外膜氧合患者的研究进展

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中国体外循环杂志 2024年第3期22卷 246-250页

作者：朱思敏廖小卒尹晴李斌飞广东医科大学湛江524023 广东省中山市人民医院麻醉科中山528403

体外膜氧合(ECMO)已广泛应用于危重患者的呼吸循环支持,但此类患者常具有发生多器官功能障碍的高风险,包括急性肾损伤(AKI)、液体超负荷(FO)、电解质紊乱、弥散性血管内凝血和神经系统并发症等。连续性肾替代治疗(CRRT)越来越多应用于治... 详细信息

体外膜氧合(ECMO)已广泛应用于危重患者的呼吸循环支持,但此类患者常具有发生多器官功能障碍的高风险,包括急性肾损伤(AKI)、液体超负荷(FO)、电解质紊乱、弥散性血管内凝血和神经系统并发症等。连续性肾替代治疗(CRRT)越来越多应用于治疗ECMO患者的AKI和FO,两者联用可以各自发挥其优势,有可能使危重患者从中受益。目前关于CRRT应用于ECMO患者的研究较少且结论存在较大分歧,本文就ECMO与CRRT两者联合应用的最新进展综述如下。

关键词：体外膜氧合连续性肾脏替代治疗急性肾损伤液体超负荷

Roles of mitochondrial unfolded protein response in mammalian stem cells

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World Journal of Stem Cells 2021年第7期13卷 737-752页

作者： Li-Fang Gu Jia-Qi Chen qing-yin Lin Yan-Zhou Yang Key Laboratory of Fertility Preservation and Maintenance Ministry of EducationKey Laboratory of Reproduction and Genetics in NingxiaDepartment of Histology and EmbryologySchool of Basic MedicineNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Fertility Preservation and Maintenance Ministry of EducationKey Laboratory of Reproduction and Genetics in NingxiaDepartment of Histology and EmbryologySchool of Basic MedicineNingxia Medical UniversityYinchuan 750001Ningxia Hui Autonomous RegionChina

The mitochondrial unfolded protein response(UPRmt)is an evolutionarily conserved adaptive mechanism for improving cell survival under mitochondrial *** physiological and pathological conditions,the UPRmt is the key to maintaining intracellular homeostasis and *** roles of the UPRmt have been demonstrated in a variety of cell types and in cell development,metabolism,and immune *** dysfunction leads to a variety of pathologies,including cancer,inflammation,neurodegenerative disease,metabolic disease,and immune *** cells have a special ability to selfrenew and differentiate into a variety of somatic cells and have been shown to exist in a variety of *** cells are involved in development,tissue renewal,and some disease *** the roles and regulatory mechanisms of the UPRmt in somatic cells have been widely reported,the roles of the UPRmt in stem cells are not fully *** roles and functions of the UPRmt depend on stem cell ***,this paper summarizes the potential significance of the UPRmt in embryonic stem cells,tissue stem cells,tumor stem cells,and induced pluripotent stem *** purpose of this review is to provide new insights into stem cell differentiation and tumor pathogenesis.

关键词： Mitochondrial unfolded protein response Mammals Stem cells Cancer

The roles and regulation of Yes-associated protein 1 in stem cells

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BIOCELL 2023年第1期47卷 33-39页

作者： qing yin CAIHONG LIU WENyinG JIANG HAIHUI GONG CHUNYUN LI ZUPING HE Hunan Normal University School of Medicine Changsha410013China The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Changsha410013China The Manufacture-Based Learning Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University Changsha410013China

Yes-associated protein 1(YAP1)is a downstream effector of the Hippo signaling pathway,and it is involved in tumorigenesis,tissue repair,growth,and *** this review,the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed,including cell proliferation,differentiation,and *** general,YAP1 promotes the proliferation and differentiation of stem cells,including embryonic stem cells and adult stem *** inhibits apoptosis by binding to the transcription factors,e.g.,transcriptional enhanced associate domain(TEAD),Smad,runt-related transcription factor 1/2,p73,p63,and Erb84,to maintain tissue *** translocalization of YAP1 in cellular nuclei and the phosphorylation in the cytoplasm work as important and unusual events for the activation of ***,YAP1 serves as the crosstalk for the Hippo pathway and other signaling pathways,including the Wnt and Notch *** is highlighted in this review that YAP1 is an essential regulator for stem cells that have significant applications in regenerative medicine and reproductive medicine.

关键词： YAP1 Hippo signaling pathway Stem cells Fate determinations