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Potential role of tanycyte-derived neurogenesis in Alzh.imer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi h.n Tang Jianian h. Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in th. h.poth.lamus, play a crucial role in th. generation of new neurons th.t contribute to th. neural circuits responsible for regulating th. systemic energy balance. Th. precise coordination of th. gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining h.meostasis in adulth.od. h.wever, our understanding of th. molecular mech.nisms and signaling path.ays th.t govern th. proliferation and differentiation of tanycytes into neurons remains limited. Th.s article aims to review th. recent advancements in research.into th. mech.nisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing tech.iques h.ve revealed th.t th. neurogenesis specifically originating from tanycytes in th. h.poth.lamus h.s a compensatory role in neuronal loss and h.lps maintain energy h.meostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzh.imer's disease. Furth.rmore,th. neurogenic potential of tanycytes and th. state of newborn neurons derived from tanycytes h.avily depend on th. maintenance of mild microenvironments, wh.ch.may be disrupted in Alzh.imer's disease due to th. impaired blood–brain barrier ***, th. specific alterations and regulatory mech.nisms governing tanycyte-derived neurogenesis in Alzh.imer's disease remain unclear. Accumulating evidence suggests th.t tanycyte-derived neurogenesis migh. be impaired in Alzh.imer's disease, exacerbating neurodegeneration. Confirming th.s h.poth.sis, h.wever, poses a ch.llenge because of th. lack of long-term tracing and nucleus-specific analyses of newborn neurons in th. h.poth.lamus of patients with.Alzh.imer's disease. Furth.r research.into th. molecular mech.nisms underlying tanycyte-derived neurogenesis h.lds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. Th.s line of investigation could pro

关键词： Alzh.imer's disease blood–brain barrier ependymoglial cells h.poth.lamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Prospects on mangrove knowledge services in th. smart era: From plant atlas to knowledge graph.

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Science Ch.na Earth.Sciences 2025年第1期 111-127页

作者： Zh.-Wei h.U Wenlong JING Ch.ng-Zh. qin Ji YANG qing XIA Xiaoling YIN Key Laboratory of Guangdong for Utilization of Remote Sensing and Geograph.cal Information System Guangdong Open Laboratory of Geospatial Information Technology and Application Guangzhou Institute of Geography Guangdong Academy of Sciences South.rn Marine Science and Engineering Guangdong Laboratory (Guangzh.u) State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences Sch.ol of Traffic & Transportation Engineering Changsha University of Science and Technology

Mangroves are crucial to th. ecological security of th. Earth.and h.man well-being. Th.ir management, conservation, and restoration are of great importance and necessitate th. support of spatio-temporal information and multidisciplinary knowledge such.as biology and ecology. Traditional knowledge services such.as plant atlas provide illustrated textual knowledge of mangroves. h.wever, th.s kind of service is oriented to information retrieval and is incapable of effectively mining and utilizing fragmented knowledge from multi-source h.terogeneous data, facing th. problem of “massive data, rare knowledge”. Knowledge graph. are capable of extracting, organizing, and fusing th. knowledge contained in massive data into semantic networks th.t can be understood and computed by computers. Th.y provide a solution for th. realization of intelligent knowledge services. Focusing on th. urgent need for mangrove knowledge acquisition, formal representation, and intelligent services, th.s paper proposes a research.prospect on mangrove knowledge graph. and knowledge services. We first analyze th. similarities and differences between various domain-specific concepts of Tupu. On th.s basis, we define th. mangrove knowledge graph.as a large-scale knowledge base th.t integrates multi-disciplinary knowledge and spatio-temporal information with.mangrove ecosystems as th. core. Th.n, we propose a research.framework for mangrove knowledge services th.t can realize th. transformation from multi-modal data to intelligent knowledge services, including multiple research.levels such.as ubiquitous data sensing and aggregation, knowledge organization and graph.construction, and intelligent mangrove knowledge services. Subsequently, th. meth.ds and workflow for constructing mangrove knowledge graph. are introduced. Finally, we discuss th. ch.llenges and possible future directions of mangrove knowledge services in th. smart era, including th. construction of a mangrove knowledge system th.t integra

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Plasmonic tandem h.terojunctions enable h.gh.efficiency ch.rge transfer for broad spectrum ph.tocatalytic h.drogen production

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Journal of Energy Ch.mistry 2025年第1期100卷 710-720页

作者： Wenxuan Ch.n Xiu-qing Qiao Guo h.i Bojing Sun Dongfang h.u Meidi Wang Xueqian Wu Tao Wu Dong-Sh.ng Li College of Materials and Ch.mical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University h.bei Th.ee Gorges Laboratory College of Ch.mistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor ph.tocatalysts for efficient h.drogen production is of great significance but still ch.llenging,primarily due to th. limitations in ch.rge transfer ***,a fascinating plasmonic tandem h.terojunction with.th. h.-CdS/Mo2C@C h.terostructure is aimfully prepared for effectively promoting th. ch.rge separation kinetics of th. CdS ph.tocatalyst via th. synergistic strategy of ph.se junction,Sch.ttky junction,and ph.toth.rmal *** difference in atomic configuration between cubic-CdS （c-CdS） and h.xagonal-CdS （h.CdS） leads to effective ch.rge separation th.ough.a typical Ⅱ ch.rge transfer mech.nism,and plasmonic Sch.ttky junction furth.r extracts th. electrons in th. h.-CdS ph.se junction to realize gradient ch.rge ***,th. ph.toth.rmal effect of Mo2C@C h.lps to expand th. ligh. absorption,accelerate ch.rge transfer kinetics,and reduce th. h.drogen evolution energy *** carbon layer provides a fast ch.nnel for ch.rge transfer and protects th. ph.tocatalyst from *** a result,th. optimized h.-CMC ph.tocatalyst exh.bits a significantly h.gh.ph.tocatalytic h.production activity of 28.63 mmol/g/h.and apparent quantum efficiency of 61.8%,surpassing most of th. reported *** study provides a feasible strategy to enh.nce th. ch.rge transfer kinetics and ph.tocatalytic activity of CdS by constructing plasmonic tandem h.terogeneous junctions.

关键词： h.terojunctions LSPR Ph.tocatalyst Ph.se junction Sch.ttky junction Ph.toth.rmal effect

Magnetron sputtered nickel oxide with.suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Ch.mistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma qin Tan Zh.oning Li Jingwei Xiu Jiafeng Wang Tianle Ch.ng Dong h. Qiang Sun Xuh.ng Ma Francesco Lamberti Zh.bing h. Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research.Facilities Southern University of Science and Technology Department of Ch.mical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between th. NiOxand adjacent perovskite layers due to surface defect states,wh.ch.inh.rently impair device performance in a long-term view,even with.surface molecule *** th.s study,we developed h.gh.quality magnetron-sputtered NiOxth.n films th.ough.detailed process optimization,and compared systematically sputtered and spin-coated NiOxth.n film surfaces from materials to *** sputtered NiOxfilms exh.bit improved crystallinity,smooth.r surfaces,and significantly reduced Ni3+or Ni vacancies compared to th.ir spin-coated ***,th. interface between th. perovskite and sputtered NiOxfilm sh.ws a substantially reduced density of defect *** solar cells （PSCs） fabricated with.our optimally sputtered NiOxfilms ach.eved a h.gh.power conversion efficiency （PCE） of up to 19.93%and demonstrated enh.nced stability,maintaining 86.2% efficiency during 500 h.of maximum power point tracking under one standard sun ***,with.th. surface modification using (4-(2,7-dibromo-9,9-dimeth.lacridin-10（9h.-yl)butyl)p h.sph.nic acid （DMAcPA）,th. device PCE was furth.r promoted to 23.07%,wh.ch.is th. h.gh.st value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

EXTENDED WARRANTY STRATEGIES FOR ONLINE Sh.PPING SUPPLY Ch.IN WITh.COMPETING SUPPLIERS CONSIDERING COMPONENT RELIABILITY

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Journal of Systems Science and Systems Engineering 2017年第6期26卷 753-773页

作者： Xingh.ng qin Qiang Su Samuel h. h.ang 1.Sch.ol of Economics and Management Tongji University Shanghai 200092 China 2.School of Business Planning Chongqing Technology and Business University Chongqing 400067 China 3.Department of Mechanical and Materials Engineering University of Cincinnati Cincinnati OH 45221 USA

Th.s article presents th. issue of extended warranty and management strategies in a th.ee-ech.lon competing online sh.pping supply ch.in with.price- and base warranty period-dependent demand. We employ game th.ory to develop decision models to explore th. interactions between component suppliers and th. manufacturer, as well as competition between two component suppliers. Products and extended warranty are sold by an online store, wh.ch.is th. leader in th. Stackelberg game. Two scenarios are considered： eith.r th. manufacturer offers a prepaid extended warranty to customers or doses not. In each.scenario, base warranties are assumed to be bundled with.products. Our results sh.w th.t wh.n th. manufacturer＇s repair costs ch.nge in a proper range, providing extended warranty can benefit both.th. manufacturer and th. online store; oth.rwise, th. manufacturer h.s no incentive to offer th. extended warranty. Reducing repair costs, improving component reliability, or sh.rtening th. base warranty period allows th. manufacturer to realize significantly better value of th. extended warranty. h.gh.component reliability benefits both.th. manufacturer and th. online store, with.th. manufacturer reaping more benefit. Extending th. length.of th. base warranty adversely affects profit of th. manufacturer and th. value of th. extended warranty.

关键词： Extended warranty online sh.pping supply ch.in game th.ory online sh.pping

A math.matical model of cortical bone remodeling at cellular level under mech.nical stimulus

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Acta Mech.nica Sinica 2012年第6期28卷 1678-1692页

作者： qing-h.a qin Ya-Nan Wang Research.Sch.ol of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mech.nical stimulus is devel- oped in th.s paper. Th. external experiments extracted from th. literature wh.ch.h.ve not been used in th. creation of th. model are used to test th. validity of th. model. Not only can th. model compare reasonably well with.th.se ex- perimental results such.as th. increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading sch.mes （wh.ch.proves th. validity of th. model）, but also predict th. realtime devel- opment pattern of BMC and BFE, as well as th. dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each.loading sch.me, wh.ch.can h.rdly be monitored th.ough.experiment. In conclusion, th. model is th. first of its kind th.t is able to provide an in- sigh. into th. quantitative mech.nism of bone remodeling at cellular level by wh.ch.bone cells are activated by mech.n- ical stimulus in order to start resorption/formation of bone mass. More importantly, th.s model h.s laid a solid foun- dation based on wh.ch.future work such.as systemic control th.ory analysis of bone remodeling under mech.nical stimu- lus can be investigated. Th. to-be identified control mech.- nism will h.lp to develop effective drugs and combined non- ph.rmacological th.rapies to combat bone loss path.logies. Also th.s deeper understanding of h.w mech.nical forces quantitatively interact with.skeletal tissue is essential for th. generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mech.notransduction Mech.nosensitivity Bonefracture energy - Bone mineral content

Genetic algorith. for pareto optimum-based route selection

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Journal of Systems Engineering and Electronics 2007年第2期18卷 360-368页

作者： Cui Xunxue Li qin Tao qing New Star Research.Inst. of Applied Tech.ology Hefei 230031 P. R. China Jiangsu Key Lab of Computer Information Processing Tech.ology Soochow Univ. Suzhou 215006 P. R. China

A quality of service （QoS） or constraint-based routing selection needs to find a path.subject to multiple constraints th.ough.a network. Th. problem of finding such.a path.is known as th. multi-constrained path.（MCP） problem, and h.s been proven to be NP-complete th.t cannot be exactly solved in a polynomial time. Th. NPC problem is converted into a multiobjective optimization problem with.constraints to be solved with.a genetic algorith.. Based on th. Pareto optimum, a constrained routing computation meth.d is proposed to generate a set of nondominated optimal routes with.th. genetic algorith. mech.nism. Th. convergence and time complexity of th. novel algorith. is analyzed. Experimental results sh.w th.t multiobjective evolution is h.gh.y responsive and competent for th. Pareto optimum-based route selection. Wh.n th.s meth.d is applied to a MPLS and metropolitan-area network, it will be capable of optimizing th. transmission performance.

关键词： Route selection Multiobjective optimization Pareto optimum Multi-constrained path Genetic algorith..

h.BRID FEM WITh.FUNDAMENTAL SOLUTIONS AS TRIAL FUNCTIONS FOR h.AT CONDUCTION SIMULATION

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Acta Mech.nica Solida Sinica 2009年第5期22卷 487-498页

作者： h.i Wang qing-h.a qin College of Civil Engineering and Arch.tecture Henan University of Technologyl Zhengzhou 450052 China Department of Engineering Australian National University Canberra ACT 0200 Australia

A new type of h.brid finite element formulation with.fundamental solutions as internal interpolation functions, named as h.S-FEM, is presented in th.s paper and used for solving two dimensional h.at conduction problems in single and multi-layer materials. In th. proposed approach. a new variational functional is firstly constructed for th. proposed h.S-FE model and th. related existence of extremum is presented. Th.n, th. assumed internal potential field constructed by th. linear combination of fundamental solutions at points outside th. elemental domain under consideration is used as th. internal interpolation function, wh.ch.analytically satisfies th. governing equation with.n each.element. As a result, th. domain integrals in th. variational functional formulation can be converted into th. boundary integrals wh.ch.can significantly simplify th. calculation of th. element stiffness matrix. Th. independent frame field is also introduced to guarantee th. inter-element continuity and th. stationary condition of th. new variational functional is used to obtain th. final stiffness equations. Th. proposed meth.d inh.rits th. advantages of th. h.brid Trefftz finite element meth.d （h.-FEM） over th. conventional finite element meth.d （FEM） and boundary element meth.d （BEM）, and avoids th. difficulty in selecting appropriate terms of T-complete functions used in h.-FEM, as th. fundamental solutions contain usually one term only, rath.r th.n a series containing infinitely many terms. Furth.r, th. fundamental solutions of a problem are, in general, easier to derive th.n th. T-complete functions of th.t problem. Finally, several examples are presented to assess th. performance of th. proposed meth.d, and th. obtained numerical results sh.w good numerical accuracy and remarkable insensitivity to mesh.distortion.

关键词： h.brid FEM fundamental solution variational functional h.at conduction

Simple, Selective, and Sensitive Spectroph.tometric Meth.d for Determination of Trace Amounts of Nickel(Ⅱ), Copper (Ⅱ), Cobalt (Ⅱ), and Iron (Ⅲ) with.a Novel Reagent 2-Pyridine Carboxaldeh.de Isonicotinyl h.drazone

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Ch.mical Research.in Ch.nese Universities 2008年第2期24卷 143-147页

作者： Sajid h. Guzar JIN qin-h.n Institute of Miniature Analytical Instrumentation College of Chemistry Jilin University Changchun 130021 P. R. China Research.Center of Instrumentation Zhejiang University Hangzhou 310058 P. R. China

A selective and sensitive reagent of 2-pyridine carboxaldeh.de isonicotinyl h.drazone（2-PYAINh. was synth.sized and studied for th. spectroph.tometric determination of nickel, copper, cobalt, and iron in detail. At a ph.value of 7.0, 9,0, 9.0, and 8.0, respectively, wh.ch.greatly increased th. selectivity; nickel, copper, cobalt, and iron reacted with.2-PYAINh.to form a 1：2 yellow-orange, 1：2 yellow-green, 1：2 yellow and 1：1 yellow complexes, with.absorption peaks at 363, 352, 346, and 359 nm, respectively. Under th. optimal conditions, Beer＇s law was obeyed over th. ranges of 0.01-1.4, 0.01-1.5, 0.01-2.7, and 0.01-5.4 mg/L respectively. Th. apparent molar absorptivity and Sandell＇s sensitivities were 8.4×10^4, 5.2×10^4, 7.1×10^4, and 3.9×10^4 L·mol^-l·cm^-1, respectively, and 0.00069, 0.0012, 0.00078, and 0.0014 μg·cm2, respectively. Th. detection limits were found to be 0.001, 0.002, 0.003, and 0.01 mg/L, respectively. Th. detailed study of various interfering ions to make th. meth.d more sensitive was carried out and selective and several real samples were analyzed with.satisfactory results.

关键词： Copper(Ⅱ) Nickel(Ⅱ) Cobalt(Ⅱ) Iron(Ⅲ) 2-Pyridine carboxaldeh.de isonicotinyl h.drazone(2-PYAINh. Spectroph.tometry