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Chinese Chemical Letters 1993年第3期4卷 247-250页

作者： qing xiang guo Zi Zhong LI Jun WANG You Cheng LIU National Laboratory of Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou 730000

The formation and breaking of intramolecular hydrogen bonds of bilirubin in CDCl_3-DMSO-d_6 binary solvent have been investigated by means of NMR *** chemical shifts of protons at dipyrrinone lactam C=O and N-H,Pyrrole N-H,C-5,C-15 and methylene groups of 8,12-propionic acid side-chains changed markedly as a function of composition of the binary *** hydrogen bond formation is dependent on the conformation of propionic acid side-chains.

关键词： HNMR A1HNMR STUDY ON THE FORMATION AND BREAKING OF INTRAMOLECULAR HYDROGEN BONDS OF BILIRUBIN IN CDCl3-DMSO-d6 BINARY SOLVENT DMSO 亚砜

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun Liu Shangde guo Rong Liu Minfang guo qing Wang Zhi Chai Baoguo Xiao Cungen Ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

Non-premixed Combustion Model of Fluidized Bed Biomass Gasifier for Hydrogen-Rich Gas

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Chinese Journal of Chemical Physics 2006年第2期19卷 131-136页

作者：周密闫立峰郭庆祥朱清时中国科学技术大学化学物理系和生物质洁净能源实验室合肥微尺度物质科学国家实验室合肥230026

Fluidized bed biomass gasifiers can be employed to produce hydrogen-rich gas. A non-premixed combustion model is used for biomass air-steam gasification in the gasifier, and the simulations were carried out by using the FLUENT 6.0 software. The simulation results are compared with the experimental data. The effects of the steam to biomass ratio （S/B）, the equivalence ratio （ER）, and the size of biomass particles on the hydrogen yield were studied. Meanwhile, the distributions of hydrogen inside the gasifier at different conditions are also described.

关键词： CFD Biomass Gasification Hydrogen

Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

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World Journal of Gastroenterology 2024年第8期30卷 969-983页

作者： Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu qing-Ling Jia Li-Kun guo xiang-xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China Laboratory of Cancer Biology University of OxfordOxford OX37DQUnited Kingdom School of Traditional Chinese Medicine Shanghai University of Chinese MedicineShanghai 200021China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy *** use of gastric organoid models holds significant promise for advancing personalized medicine ***,a comprehensive bibliometric review of this burgeoning field has not yet been *** To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)*** This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the *** and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric ***,co-citation,and burst analysis methodologies were applied to assess the impact and progress of *** A total of 656 relevant studies were *** majority of research was published in gastroenterology-focused ***,Yana Zavros,Hans Clevers,James M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this *** from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant ***,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening *** Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening *** contributions from renowned academic institutions highlight this field’s dynamic growth.

关键词： Gastric organoid Gastric disease Bibliometrics analysis Gastric cancer Gastritis

Inherently Chiral and Symmetrical Heteroatom-Doped Zigzag-Type Hydrocarbon Belts

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CCS Chemistry 2024年第5期6卷 1198-1210页

作者： Xue-Yuan Wang Xin-Yu Zhang Shuo Tong qing-Hui guo Mei-Ling Tan Cheng-Jun Li Mei-xiang Wang Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084

hydrocarbon belts due to their potential applications in carbon *** contrast,heteroatomembedded zigzag hydrocarbon belts as advanced design strategies with fascinating structures and desirable,unique properties have remained largely unexplored,and inherently chiral ones are ***,we report the synthesis of a diversity of symmetric and highly enantiopure inherently chiral O-and N-doped zigzag-type hydrocarbon belts starting from strainless macrocycles based on fjord-stitching *** readily available pertriflated resorcin[6]arene underwent partial hydrolyses and intramolecular S_(N)Ar reactions to form a calix[3](9H-xanthene)derivative and a prochiral half-belt *** transformations of calix[3](9H-xanthene)into C_(3v)-symmetric molecular belts were achieved by closing the rest of the fjords with triple intramolecular S_(N)Ar reactions and Yamamoto homo coupling reactions,as well as palladiumcatalyzed intermolecular acridination reactions with primary *** prochiral half-belt underwent enantioselective desymmetrizative mono-acridination to afford an inherently chiral N,O_(4)-bridged pseudo-belt with an enantiomeric excess(ee)value of>99%under the catalysis of Pd(OAc)_(2)and(R)-*** closure reactions of the pseudo-belt produced diverse heteroatom-inlayed zigzag-type hydrocarbon belts of inherent ***,we showed the unique cavity structures of the belts and demonstrated interesting chiroptic properties of the inherently enantiopure chiral *** research opens the door for the exploration of novel and sophisticated symmetric and inherently chiral molecular nanobelt structures with outstanding physical and chemical properties,as well as potential applications.

关键词： zigzag-type molecular belt heterocycle chiroptical property fjord-stitching strategy resorcinarene

BIO-inspired intelligent navigation: from methodology, system theory, to behavioural science

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Science China(Information Sciences) 2024年第9期67卷 333-335页

作者： Wenshuo LI Xin LIU Pengwei HU Jian YANG xiang YU Lei guo Hangzhou Innovation Institute of Beihang University School of Automation Science and Electrical Engineering Beihang University School of Instrumentation and Optoelectronic Engineering Beihang University

It is crucial for unmanned systems to determine their motion information accurately, reliably, and in real time. This function is accomplished by the autonomous navigation module of the unmanned systems. By analogy to the animals,the autonomous navigation module can be regarded as the“sensory nerve center” of an unmanned system.

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Genetically modified non-human primate models for research on neurodegenerative diseases

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Zoological Research 2024年第2期45卷 263-274页

作者： Ming-Tian Pan Han Zhang Xiao-Jiang Li xiang-Yu guo Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China

Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(HD),and amyotrophic lateral sclerosis(ALS).Currently,there are no therapies available that can delay,stop,or reverse the pathological progression of NDs in clinical *** the population ages,NDs are imposing a huge burden on public health systems and affected *** models are important tools for preclinical investigations to understand disease pathogenesis and test potential *** numerous rodent models of NDs have been developed to enhance our understanding of disease mechanisms,the limited success of translating findings from animal models to clinical practice suggests that there is still a need to bridge this translation *** World nonhuman primates(NHPs),such as rhesus,cynomolgus,and vervet monkeys,are phylogenetically,physiologically,biochemically,and behaviorally most relevant to *** is particularly evident in the similarity of the structure and function of their central nervous systems,rendering such species uniquely valuable for neuroscience ***,the development of several genetically modified NHP models of NDs has successfully recapitulated key pathologies and revealed novel *** review focuses on the efficacy of NHPs in modeling NDs and the novel pathological insights gained,as well as the challenges associated with the generation of such models and the complexities involved in their subsequent analysis.

关键词： Neurodegeneration Non-human primate Macaque monkey Animal model Gene modification

Coordination-driven self-assembly of a molecular 818knot and molecular borromean rings

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Science China Chemistry 2024年第11期67卷 3652-3656页

作者： xiang Gao Dong Liu Hai-Ning Zhang guo-Xin Jin Department of Chemistry Fudan University

We report the facile construction of a molecular 818knot and a molecular Borromean rings assembly through self-assembly directed by Cp*Rh corner units. Two curved ligands of similar size and shape were used in this study. The slight steric differences between the two ligands induce the formation of distinctly different topologies of the assembled products. The structures were confirmed by single-crystal X-ray analysis and nuclear magnetic resonance spectroscopy.

关键词： coordination-driven Cp*Rh 818 knot Borromean rings

Microstructural evolution,mechanical properties and degradation mechanism of PS-PVD quasi-columnar thermal barrier coatings exposed to glassy CMAS deposits

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Rare Metals 2024年第7期43卷 3329-3340页

作者： Zi-Yue Yu Liang-Liang Wei Xing-Ye guo Bao-Peng Zhang qing He Hong-Bo guo School of Materials Science and Engineering Beihang UniversityBeijing100191China Key Laboratory of High-Temperature Structure Materials and Protective Coatings(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China Surface Engineering Research Institute Chinese Academy of Agricultural Mechanization SciencesBeijing 100083China

Thermal barrier coatings(TBCs) applied in aeroengines tend to be attacked by molten calcia-magnesiaalumino-silicate(CMAS) at high operating ***-stabilized zirconia(YSZ) coatings with quasicolumnar microstructure were fabricated by plasma spray physical vapor deposition(PS-PVD) *** chemic al changes,micros tructural transform ation,mechanical properties and degradation mechanisms of the CM AS-interacted TBCs in the thermal cycling tests were *** YSZ grains were dissolved in the CMAS melts,and then the ZrO_(2) grains were reprecipitated with spherical shape,accompanying with phase transformation from tetragonal(t) to monoclinic(m).The thermal cycling tests reveal that the YSZ coating fails at the early stage due to the attack of *** fractures in intracolumns lead to partial spallation of the *** failure of the coating occurs at the interfaces between thermally grown oxides(TGO) layer and YSZ topcoat;especially,the hardness and Young's modulus of the YSZ coatings increase intensively,as the coatings were infiltrated by the CMAS for a long time.

关键词： CMAS Thermal barrier coatings Young's modulus Thermal cycling behavior PS-PVD

Experimental and computational investigation on flow characteristics of rotating cavities with high inlet pre-swirl axial throughflow

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Chinese Journal of Aeronautics 2024年第4期37卷 276-293页

作者： Sipeng WANG xiang LUO Linji guo Zeyu WU Yang BAI Zongchao LI Lichun MA School of Energy and Power Engineering Beihang UniversityBeijing 100191China Research Institude of Aero-Enigine Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China Shenyang Aeroengine Research Institute Aero Engine Corporation of ChinaShenyang 110015China

As an integral part of the internal air system of aero-engines,the axial throughflow of the cooling air can interact with the cavity flow between the rotating compressor disks,forming a threedimensional,unsteady,and unstable flow *** flow characteristics in an engine-like rotating multi-stage cavity with throughflow were investigated using particle image velocimetry,flow visualization technology and three-dimensional unsteady Reynolds-Averaged Navier-Stokes (RANS)*** focus of current research was to understand the distribution of the mean swirl ratio and its variation with a wide range of non-dimensional parameters in the co-rotating cavity with high inlet pre-swirl axial *** maximum axial Reynolds number and rotational Reynolds numbers could reach 4.41×10^(4)and 1.24×10^(6),*** velocity measurement results indicate that the mean swirl ratio is greater than 1 and decreases with an increase in the radial *** flow structure is dominated by the Rossby number,and two different flow patterns (flow penetration and flow stratification) are identified and confirmed by flow visualization *** the absence of buoyancy,the flow penetration caused by the precession of the throughflow makes it easier for the throughflow to reach a high radius *** consistency of results between measurements and numerical calculations is *** study provides a theoretical basis and data support for toroidal vortex breakdown,which is of practical significance for the design of high-pressure compressor cavities.

关键词： Compressor Axial throughflow Rotating cavity flow Particle image velocimetry Unsteady RANS Flow pattern