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Characterization of larval instars of artemisia weevil,Adosomus sp.

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Forestry Studies in China 2009年第1期11卷 20-23页

作者： WANG Jian-wei LUO You-qing ZONG Shi-xiang gao Bi-qiang LI Yue-hua Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 E R.China Forest Pest Control and Quarantine Station of Yanchi County Ningxia Province Yanchi 751500 P. R. China

The artemisia weevil, Adosomus sp., has become an important wormwood （Artemisa ordosoca and A. sphaerocephala） pest in recent years in Ningxia Province, China. The number of larval instars should be determined before further studies on its life history, biology and integrate management of pest （IMP）. In this study, we measured the length and width of head capsule, based on frequency histograms and Dyar＇s law, from which we concluded that the larvae ofAdosomus sp. have four instars. Of the two variables measured, the width of head capsule provided the best division of instars. The average width of head capsule of the 1st instar larvae was 1.348±0.152 mm, the 2nd 2.109±0.199 mm, the 3rd 3.563±0.492 mm and the 4th 5.974±0.581 mm.

关键词： Adosomus sp. larval instars head capsule Dyar's law regression equation

Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration

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Bioactive Materials 2022年第8期7卷 377-388页

作者： Yike gao Zuoying Yuan Xiaojing Yuan Zhuo Wan Yingjie Yu Qi Zhan Yuming Zhao Jianmin Han Jianyong Huang Chunyang Xiong qing Cai Department of Pediatric Dentistry Peking University School and Hospital of StomatologyNational Center of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing100081China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Dental Medical Devices Testing Center Dental Materials LaboratoryPeking University School and Hospital of StomatologyBeijing100081China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhouZhejiang325000China

Exosomes derived from mesenchymal stem cells(MSCs)have demonstrated regenerative potential for cell-free bone tissue engineering,nevertheless,certain challenges,including the confined therapeutic potency of exosomes and ineffective delivery method,are still ***,we confirmed that hypoxic precondition could induce enhanced secretion of exosomes from stem cells from human exfoliated deciduous teeth(SHEDs)via comprehensive proteomics analysis,and the corresponding hypoxic exosomes(H-Exo)exhibited superior potential in promoting cellular angiogenesis and osteogenesis via the significant up-regulation in focal adhesion,VEGF signaling pathway,and thyroid hormone ***,we developed a platform technology enabling the effective delivery of hypoxic exosomes with sustained release kinetics to irregular-shaped bone defects via *** platform is based on a simple adsorbing technique,where exosomes are adsorbed onto the surface of injectable porous poly(lactide-co-glycolide)(PLGA)microspheres with bioinspired polydopamine(PDA)coating(PMS-PDA microspheres).The PMS-PDA microspheres could effectively adsorb exosomes,show sustained release of H-Exo for 21 days with high bioactivity,and induce vascularized bone regeneration in 5-mm rat calvarial *** findings indicate that the hypoxic precondition and PMS-PDA porous microsphere-based exosome delivery are efficient in inducing tissue regeneration,hence facilitating the clinical translation of exosome-based therapy.

关键词： Hypoxic exosomes Stem cells from human exfoliated deciduous teeth Porous microsphere Sustained release Vascularized bone regeneration

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梅花鹿XY精子分选及冷冻精液制备

经济动物学报 2008年第4期12卷 187-189+192页

作者：都惠中魏海军高庆华韩春梅赵伟刚张志国张云梅抚顺市林业科学研究所中国农科院特产研究所塔里木大学动物科技学院中国种畜XY公司

为分选梅花鹿XY精子及制备冷冻精液,2006年9月2129日,对电刺激采集的梅花鹿精液经过长距离运输,流式细胞仪分离,冷冻,解冻后精液重分析和品质鉴定。结果显示:常规冻精和X、Y型冻精性别比分别为50%、91.21%和94.08%,常规冻精与X、Y型冻... 详细信息

为分选梅花鹿XY精子及制备冷冻精液,2006年9月2129日,对电刺激采集的梅花鹿精液经过长距离运输,流式细胞仪分离,冷冻,解冻后精液重分析和品质鉴定。结果显示:常规冻精和X、Y型冻精性别比分别为50%、91.21%和94.08%,常规冻精与X、Y型冻精组间差异显著(P0.05);存活指数分别为0.25、0.05和0.05,常规冻精与X、Y型冻精组间差异显著(P0.05)。用流式细胞技术可以分选获得梅花鹿XY冷冻精液,性别比和品质达到低剂量人工授精的要求。

关键词：梅花鹿精子流式细胞术性别比

Timing of surgery after neoadjuvant chemotherapy for gastric cancer: Impact on outcomes

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World Journal of Gastroenterology 2018年第2期24卷 257-265页

作者： Yi Liu Ke-cheng Zhang Xiao-hui huang hong-qing Xi Yun-he gao Wen-quan Liang Xin-Xin Wang Lin chen Department of General Surgery & Institute of General Surgery Chinese People's Liberation Army General Hospital

AIM To evaluate whether the neoadjuvant chemotherapy(NAc T)-surgery interval time significantly impacts the pathological complete response(pc R) rate and longterm *** One hundred and seventy-six patients with gastric cancer undergoing NAc T and a planned gastrectomy at the chinese p LA General hospital were selected from January 2011 to January 2017. Univariate and multivariable analyses were used to investigate the impact of NAc T-surgery interval time( 6 wk) on pc R rate and overall survival(OS).RESULTS The NAc T-surgery interval time and clinician T stage were independent predictors of pc R. The interval time > 6 wk was associated with a 74% higher odds of pc R as compared with an interval time of 4-6 wk(p = 0.044), while the odds ratio(OR) of clinical T3 vs clinical T4 stage for pc R was 2.90(95%c I: 1.04-8.01, p = 0.041). In cox regression analysis of long-term survival, postneoadjuvant therapy pathological N(yp N) stage significantly impacted OS(N0 vs N3: h R = 0.16, 95%c I: 0.37-0.70, p = 0.015; N1 vs N3: h R = 0.14, 95%c I: 0.02-0.81, p = 0.029) and disease-free survival(DFS)(N0 vs N3: h R = 0.11, 95%c I: 0.24-0.52, p = 0.005; N1 vs N3: h R = 0.17, 95%c I: 0.02-0.71, p = 0.020). The surgical procedure also had a positive impact on OS and DFS. The hazard ratio of distal gastrectomy vs total gastrectomy was 0.12(95%c I: 0.33-0.42, p = 0.001) for OS, and 0.13(95%c I: 0.36-0.44, p = 0.001) for *** The NAc T-surgery interval time is associated with pc R but has no impact on survival, and an interval time > 6 wk has a relatively high odds of pc R.

关键词： Gastric cancer Timing of surgery Neoadjuvant chemotherapy

保留颈外静脉、颈神经丛深支和耳大神经的根治性颈淋巴清扫术疗效评价

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中国口腔颌面外科杂志 2006年第1期4卷 8-13页

作者：温玉明王昌美李龙江唐休发王晓毅华成舸潘剑高庆红宣鸣四川大学华西口腔医学院头颈肿瘤外科四川成都610041

目的:探索一种保证口腔癌颈淋巴结转移手术彻底性和避免并发症,最大限度保存患者术后生存质量和机体功能的最佳颈清扫术式。方法:通过对182例颈淋巴清扫术的回顾性研究,对保留颈外静脉、颈神经丛深支和耳大神经的颈淋巴清扫术式的根治... 详细信息

目的:探索一种保证口腔癌颈淋巴结转移手术彻底性和避免并发症,最大限度保存患者术后生存质量和机体功能的最佳颈清扫术式。方法:通过对182例颈淋巴清扫术的回顾性研究,对保留颈外静脉、颈神经丛深支和耳大神经的颈淋巴清扫术式的根治效果、术中并发症和术后功能障碍进行评价,所得数据进行χ2检验。结果:与常规根治性颈淋巴清扫术相比,保留颈外静脉和颈神经丛深支的根治性颈淋巴清扫术在维持术中较平稳的生命体征、术后恢复等方面具有明显的优势,尤其是接受双侧根治性颈清扫术的病例,保留颈外静脉将降低手术风险和术后护理难度,并有利于患者的尽早恢复,其术后肩功能和耳郭和(或)耳后区皮肤感觉功能明显优于根治性颈清术式(P0.05)。结论:保留颈外静脉和颈神经丛深支的根治性颈淋巴清扫术是一种比较合理的术式,在保证颈清扫根治性的前提下,减轻和避免了术中、术后的颅内高压并发症和肩功能损伤及耳部感觉障碍。本术式适应证广泛,可作为口腔癌颈淋巴结转移和cN0选择性颈清扫术的常规术式。

关键词：根治性颈淋巴清扫术口腔癌改良术式保留颈外静脉保留颈神经丛深支保留耳大神经

Individualized minimally invasive treatment for adult testicular hydrocele: A pilot study

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World Journal of Clinical Cases 2019年第6期7卷 727-733页

作者： Le Lin Huai-Shan Hong Yun-Liang gao Jin-Rui Yang Tao Li qing-Guo Zhu Lie-Fu Ye Yong-Bao Wei Shengli Clinical Medical College of Fujian Medical University Department of Urology Fujian Provincial Hospital Department of Urology the Second Xiangya HospitalCentral South University

BACKGROUND Hydrocelectomy is the gold standard for the treatment of hydrocele,but it often causes complications after surgery,including hematoma,infection,persistent swelling,hydrocele recurrence,and chronic pain. In recent years,several methods for minimally invasive treatment of hydrocele have been introduced,but they all have limitations. Herein,we introduce a new method of individualized minimally invasive treatment for *** To present a new method for the treatment of adult testicular *** Fifty-two adult patients with idiopathic testicular hydrocele were included. The key point of this procedure was that the scope of the resection of the sheath of the tunica vaginalis was determined according to the maximum diameter(d) of the effusion measured by ultrasound and the maximum diameter of the portion of the sheath pulled out of the scrotum was approximately πd/2. The surgical procedure consisted of a 2-cm incision in the anterior wall of the scrotum,drainage of the effusion,and dissection of part of the sheath of the tunica vaginalis. After the sheath was peeled away to the predetermined target extent,the pulled-out sheath was removed. The intraoperative findings and postoperative complications were *** All patients were successfully treated with a median operation time of 18 *** median maximum diameter of the effusion on ultrasound was 3.5 cm,and the median maximum diameter of the resected sheath was 5.5 cm. Complications occurred in four(7.7%) patients: two(3.8%) cases of mild scrotal edema,one(1.9%) case of scrotal hematoma,and one(1.9%) case of wound infection. All of the complications were grade I-II. Recurrent hydrocele,chronic scrotal pain,and testicular atrophy were not observed during a median follow-up of 12 *** We report a new technique for individualized treatment of testicular hydrocele,which is quantitative and minimally invasive and yields good outcomes. Further study is warranted to verify its potent

关键词： Testicular hydrocele Individual treatment Minimal invasion Complications Scrotoscope

Comparison between laparoscopic and open surgery for large gastrointestinal stromal tumors:A meta-analysis

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 48-55页

作者： Jian-Xin Cui Yun-He gao Hong-qing Xi Ai-Zhen Cai Ke-Cheng Zhang Ji-Yang Li Bo Wei Lin Chen Department of General Surgery Chinese PLA General Hospital

AIM To investigate whether laparoscopic surgery is as safe and feasible as open resection for patients with larger gastrointestinal stromal tumors(GISTs)(≥ 5 cm).METHODS A systematic search of Pub Med, EMBASE, Web of Science and the Cochrane Library database was performed. Relevant studies of laparoscopic and open surgery for GISTs of > 5 cm published before December 2016 were identified from these databases. The quality of the studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The tumor size, operation time, blood loss, postoperative hospital stay, complication rate, and disease-free survival rate were assessed. The software Stata(version 12.0) was used for the *** Five clinical trials comprising 209 patients with GISTs of similar larger sizes were evaluated. The pooled analysis of 100 patients in the laparoscopic resection group and 109 patients in the open resection group demonstrated that laparoscopic surgery was significantly associated with a shorter postoperative hospital stay(P < 0.001)and less blood loss(P = 0.002). Moreover, there were no statistically significant differences in the operation time(P = 0.38), postoperative complication rate(P = 0.88), or disease-free survival rate(P = 0.20) between two groups. CONCLUSION Our findings revealed that for patients with large GISTs of comparable sizes, laparoscopic surgery did not significantly influence the operation factors or clinical outcomes compared with open surgery. This suggests that laparoscopic resection is as acceptable as open surgery for treatment of large gastric GISTs.

关键词： Laparoscopic resection Open resection Gastrointestinal stromal tumor Meta-analysis Clinical outcome

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间二甲苯氨氧化法制备间苯二腈催化剂研究

武汉大学学报（自然科学版） 1999年第6期45卷 821-824页

作者：郑穹黄驰许崇文韩其勇陈高清陈远荫李国珍肖修云黄荣辉武汉大学化学与环境科学学院武汉430072 湖南南天实业股份有限公司湘潭411103

对氨氧化法制备间苯二腈催化剂进行了研究. 在“微反-色谱”联用装置上完成催化剂的评比和筛选后,在内径30 m m 的石英管固定床反应器上印证并进行工艺条件实验. 考察了反应温度、氨比、空气比和空速对反应的转化率,摩尔收率和选择性的... 详细信息

对氨氧化法制备间苯二腈催化剂进行了研究. 在“微反-色谱”联用装置上完成催化剂的评比和筛选后,在内径30 m m 的石英管固定床反应器上印证并进行工艺条件实验. 考察了反应温度、氨比、空气比和空速对反应的转化率,摩尔收率和选择性的影响. 在所确定的工艺条件下使用m -509 号催化剂,转化率高达99.8% 、摩尔收率70.4% ,生成的间苯二腈为白色针状结晶,纯度高于98.5% . 在湖南南天实业股份有限公司的560 m m 工业流化床反应塔上进行了为期6 个月的工业性试验,摩尔收率达66.5% ,间苯二腈含量高于98% ,单腈含量低于0.25% ,性能优于现行工业催化剂.

关键词：氨氧化间二甲苯间苯二腈催化剂制备杀菌剂

基于“脑-心-肾-精室”轴的用药观辨治阴囊湿疹

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北京中医药 2022年第8期41卷 873-876页

作者：崔晗姚春海郎娜宋艳丽迟慧彦陶以成曲韵高庆和郭军中国中医科学院西苑医院皮肤科北京100091 中国中医科学院西苑医院男科北京100091

阴囊湿疹属中医学“肾囊风”“胞漏疮”等范畴,是男科与皮肤科门诊中较为常见的疾病之一。郭军教授认为精室失用为疾病发生的最终环节,以“肾”为脏腑辨证体系的核心,“整体与局部同调”作为辨治特色,提出“脑-心-肾-精室”轴理论。在... 详细信息

阴囊湿疹属中医学“肾囊风”“胞漏疮”等范畴,是男科与皮肤科门诊中较为常见的疾病之一。郭军教授认为精室失用为疾病发生的最终环节,以“肾”为脏腑辨证体系的核心,“整体与局部同调”作为辨治特色,提出“脑-心-肾-精室”轴理论。在该理论指导下,根据阴囊湿疹湿、热、瘀、郁等病理因素归纳出利湿去浊、清热祛湿、活血化瘀、解郁宁神等治法,选用对应脏腑的特色药物构成三味药组合,疗效显著。

关键词：阴囊湿疹 “脑-心-肾-精室”轴用药原则整体观