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More Large Sets of Resolvable MTS and DTS with Even Orders

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 233-252页

作者： qing-de kang Rong-jia Xu Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China Qinhuangdao Radio and TV University Qinhuangdao 066001 China

In this paper, we first introduce a special structure that allows us to construct a large set of resolvable Mendelsohn triple systems of orders 2q ＋ 2, or LRMTS（2q ＋ 2）, where q = 6t ＋ 5 is a prime power. Using a computer, we find examples of such structure for t C T = {0, 1, 2, 3, 4, 6, 7, 8, 9, 14, 16, 18, 20, 22, 24}. Furthermore, by a method we introduced in [13], large set of resolvable directed triple systems with the same orders are obtained too. Finally, by the tripling construction and product construction for LRMTS and LRDTS introduced in [2, 20, 21], and by the new results for LR-design in [8], we obtain the existence for LRMTS（v）and LRDTS（v）, where v = 12（t ＋ 1） mi≥0（2.7mi＋1）mi≥0（2.13ni＋1）and t∈T,which provides more infinite family for LRMTS and LRDTS of even orders.

关键词： Large set resolvable Mendelsohn triple system tripling construction resolvable directed triple system

Large Sets and Overlarge Sets of Triangle-decomposition

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 123-132页

作者： Zi-hong Tian qing-de kang Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China

There are six types of triangles： undirected triangle, cyclic triangle, transitive triangle, mixed-1 triangle, mixed-2 triangle and mixed-3 triangle. The triangle-decompositions for the six types of triangles have already been solved. For the first three types of triangles, their large sets have already been solved, and their overlarge sets have been investigated. In this paper, we establish the spectrum of LTi（v,λ）, OLTi（v）（i = 1, 2）, and give the existence of LT3（v, λ） and OLT3（v, λ） with λ even.

关键词： Triangle-decomposition large set overlarge set

Further Results on Overlarge Sets of Kirkman Triple Systems

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Acta Mathematica Sinica,English Series 2009年第3期25卷 419-434页

作者： Lan Dang YUAN qing de kang College of Career Technology Hebei Normal University Shijiazhuang 050031 P. R. China Institute of Mathematics Hebei Normal University Shijiazhuang 050016 P. R. China

In this paper, we introduce a new concept -- overlarge sets of generalized Kirkman systems （OLGKS）, research the relation between it and OLKTS, and obtain some new results for OLKTS. The main conclusion is： If there exist both an OLKF（6^k） and a 3-OLGKS（6^k-1,4） for all k ∈{6,7,...,40}／{8,17,21,22,25,26}, then there exists an OLKTS（v） for any v ≡ 3 （mod 6）, v ≠ 21. As well, we obtain the following result： There exists an OLKTS（6u ＋ 3） for u = 2^2n-1 - 1, 7^n, 31^n, 127^n, 4^r25^s, where n ≥ 1,r＋s≥ 1.

关键词： Kirkman frame Kirkman triple system overlarge set (2 1)-resolvable Steiner quadruplesystem

Graph designs for all Graphs with Six Vertices and Eight Edges

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Acta Mathematicae Applicatae Sinica 2005年第3期21卷 469-484页

作者： qing-de kang Lan-dang Yuan Shu-xia Liu Institute of Mathematics Hebei Normal University Shijiazhuang 050016 China College of Mathematics & Statistic Hebei University of Economics and Trade Shijiazhuang 050061 China

Graph designs for all graphs with six vertices and eight edges are discussed. The existence of these graph designs are completely solved except in two possible cases of order 32.

关键词： Graph design holey graph design quasi-group

Packings and Coverings of λK_v with 2 Graphs of 6 Vertices and 7 Edges

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Journal of Mathematical Research and Exposition 2011年第1期31卷 59-66页

作者： Yan Ke DU qing de kang Institute of Applied Mathematics Mechanical Engineering College Hebei 050003 P. R. China Institute of Mathematics Hebei Normal University Hebei 050016 P. R. China

A maximum （v, G, λ）-PD and a minimum （v, G, λ）-CD axe studied for 2 graphs of 6 vertices and 7 edges. By means of ＂difference method＂ and ＂holey graph design＂, we obtain the result： there exists a （v, Gi,... 详细信息

关键词： G-design G-packing design G-covering design.

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying kang Song Qin department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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探访高等职业教育本质属性的理论原点

邢台职业技术学院学报 2011年第5期28卷 36-39页

作者：陈亚青李康德杭州科技职业技术学院浙江杭州311604

高等职业教育的本质属性是指它本身必然具有的并决定高等职业教育的性质、面貌和发展,区别于其他教育类型特有的特征、特性,也是高等职业教育质的规定性。这种质的规定性理论原点是教育性与职业性,也是高等职业教育最一般的本质属性。... 详细信息

高等职业教育的本质属性是指它本身必然具有的并决定高等职业教育的性质、面貌和发展,区别于其他教育类型特有的特征、特性,也是高等职业教育质的规定性。这种质的规定性理论原点是教育性与职业性,也是高等职业教育最一般的本质属性。高等性、技能性、应用性、人文性是高等职业教育类的特殊属性。至于实践性、大众性、社会性、就业性、适应性、多样性、导向性、产业性、中介性等,则是高等职业教育本质属性派生出来的从属属性。

关键词：探访高等职业教育本质属性

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高等职业教育本质属性特征应有形态的澄明

邢台职业技术学院学报 2011年第6期28卷 18-22页

作者：陈亚青李康德杭州科技职业技术学院浙江杭州311604

高职的本质属性是教育性与职业性。其教育性的本质属性特征即教育的干预性、关怀性、策略性和系统性等。其职业性的本质属性特征即职业知识教育的认知性,职业技能教育的实践性,职业道德教育的认同性。其实践性特征是"教学----实践----教... 详细信息

高职的本质属性是教育性与职业性。其教育性的本质属性特征即教育的干预性、关怀性、策略性和系统性等。其职业性的本质属性特征即职业知识教育的认知性,职业技能教育的实践性,职业道德教育的认同性。其实践性特征是"教学----实践----教学----实践"的特征。职业道德教育是情感认知与体验的特征。高职教育的职业性,是教育性之下的职业知识认知、技能实践与道德认同的统一。

关键词：高等职业教育本质属性教育性职业性认知性技能性认同性

deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS