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MicroRNA negatively regulates NF-κB-mediated immune responses by targeting NOD1 in the teleost fish Miichthys miiuy

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Science China(Life Sciences) 2021年第5期64卷 803-815页

作者： qing chu Dekun Bi Weiwei Zheng Tianjun Xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Laboratory of Marine Biology and Biotechnology Qingdao Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai 201306China

Inflammation is a self-protection mechanism that can be triggered when innate immune cells detect *** of pathogen infection requires appropriate immune and inflammatory responses,but excessive inflammatory responses can cause uncontrolled inflammation,autoimmune diseases,or pathogen *** evidence has shown that microRNAs(miRNAs)in mammals act as important and versatile regulators of innate immunity and ***,miRNAmediated regulation networks are largely unknown in inflammatory responses in lower ***,miR-144 and miR-217 are identified as negative regulators in teleost inflammatory *** find that Vibrio harveyi and lipopolysaccharide(LPS)treatment significantly upregulate the expression of fish miR-144 and *** miR-144 and miR-217 suppress LPS-induced inflammatory cytokine expression by targeting nucleotide-binding oligomerization domain-containing protein 1(NOD1),thereby avoiding excessive inflammatory *** addition,miR-144 and miR-217 regulate inflammatory responses through NOD1-induced nuclear factor kappa(NF-κB)signaling *** findings demonstrate that miR-144 and miR-217 play regulatory roles in inflammatory responses by modulating the NOD1-induced NF-κB signaling pathway.

关键词： microRNA negative regulation NF-κB NOD1 Miichthys miiuy

Long noncoding RNA AANCR modulates innate antiviral responses by blocking miR-210-dependent MITA downregulation in teleost fish,Miichthys miiuy

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Science China(Life Sciences) 2021年第7期64卷 1131-1148页

作者： qing chu Tianjun Xu Weiwei Zheng Renjie Chang Lei Zhang Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratoiy for Marine Science and TechnologyQingdao 266237China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministiy of EducationShanghai Ocean UniversityShanghai 201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai 201306China

Viral infection induces the initiation of antiviral effectors and cytokines which are critical mediators of innate antiviral *** critical molecular determinants are responsible for triggering an appropriate immune *** noncoding RNAs(lncRNAs)have emerged as new gene modulators involved in various biological processes,while how lncRNAs operate in lower vertebrates are still ***,we discover a long noncoding RNA,termed antiviral-associated long noncoding RNA(AANCR),as a novel regulator for innate antiviral responses in teleost *** results indicate that fish MITA plays an essential role in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus(SCRV)***-210 reduces MITA expression and suppress MITA-mediated antiviral responses,which may help viruses evade host antiviral ***,AANCR functions as a competing endogenous RNA(ceRNA)for miR-210 to control protein abundance of MITA,thereby inhibiting SCRV replication and promoting antiviral *** data not only shed new light on understanding the function role of lncRNA in biological processes in teleost fish,but confirmed the hypothesis that ceRNA networks exist widely in vertebrates.

关键词： long noncoding RNAs microRNA ceRNA MITA antiviral responses teleost fish

Impacts of climate change on drought risk of winter wheat in the North China Plain

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Journal of Integrative Agriculture 2021年第10期20卷 2601-2612页

作者： ZHANG Li chu qing-quan JIANG Yu-lin CHEN Fu LEI Yong-deng College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193P.R.China Key Laboratory of Farming System Ministry of Agriculture and Rural AffairsBeijing 100193P.R.China

Drought is a major natural disaster causing crop yield losses,while its occurrence mechanism and spatiotemporal variations in a changing climate are still not *** on a long-term climatic dataset(during 1958–2015)from weather stations in the North China Plain(NCP),the influencing mechanism of various climatic factors on drought risk of winter wheat was quantified by using sensitivity analysis,Mann-Kendall trend test and slope *** results indicated that climatic factors have changed considerably over the past six decades in the growth season of winter *** a result,winter wheat suffered from severe droughts(with 350 mm of water deficit during its growth season),particularly at the jointing–heading and heading–mature stages,which were critical to crop yield *** were large spatial and temporal variations in drought risk and climatic change factors at different growth stages of winter *** precipitation playing a vital role in determining the spatiotemporal patterns of drought risk,high temperature and low humidity along with other climatic factors at key growth stages of winter wheat aggravated drought ***,temperature at nearly 90%weather stations showed a notablely upward trend,which exacerbated water deficit and drought risk of winter *** the complexity and high uncertainty of climate change,these findings provide important information for adapting crop production to future climate change and accompanied droughts while ensuring food security and agricultural sustainability.

关键词： climate change winter wheat drought risk spatiotemporal variations food security

Study on Rhizoma chuanxiong based on capillary electrophoresis with amperometric detection

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Chinese Chemical Letters 2010年第2期21卷 217-220页

作者： chu, qing Cui Zhang, Dong Li Zhang, Hai Tao Ye, Jian Nong E China Normal Univ Dept Chem Shanghai 200062 Peoples R China

A high-performance capillary electrophoresis with amperometric detection(CE-AD) method has been developed for the analysis of seven bioactive ingredients,namely ferulic acid(FA),vanillin,vanillic acid,p-hydroxybenzoic acid,caffeic acid,gallic acid and protocatechuic acid,in Rhizoma *** effects of several factors such as the acidity and concentration of running buffer,the separation voltage,the applied potential to working electrode and the injection time were *** the optimum condit...

关键词： Capillary electrophoresis Amperometric detection Rhizoma chuanxiong Phenolic acids Electrochemical profiles

Experimental system of coupled map lattices

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Frontiers of physics 2015年第3期10卷 101-104页

作者： Yu-Han Ma Lan-qing Huang chu-Min Sun Xiao-Wen Li Department of Physics Beijing Normal University Beijing 100875 China

We design an optical feedback loop system consisting of a liquid-crystal spatial light modulator （SLM）, a lens, polarizers, a CCD camera, and a computer. The system images every SLM pixel onto one camera pixel. The light intensity on the camera pixel shows a nonlinear relationship with the phase shift applied by the SLM. Every pixel behaves as a nonlinear map, and we can control the interaction of pixels. Therefore, this feedback loop system can be regarded as a spatially extended system. This experimental coupled map has variable dimensions, which can be up to 512 by 512. The system can be used to study high-dimensional problems that computer simulations cannot handle.

关键词： coupled map lattices photoelectric feedback loop

A micro-chip exploding foil initiator based on printed circuit board technology

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Defence Technology（防务技术） 2022年第8期18卷 1435-1444页

作者： Zhi Yang Peng Zhu qing-yun chu Qiu Zhang Ke Wang Hao-tian Jian Rui-qi Shen School of Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Micro-Nano Energetic Devices Key Laboratory Ministry of Industry and Information TechnologyNanjing210094China

Conventional exploding foil initiator (EFI) in ignition or detonation applications hosts many performance advantages, but was hindered by the bulky, inaccurate, inefficient and expensive shortcomings. We highlight a novel micro-chip exploding foil initiator (McEFI) using printed circuit board (PCB) technology. The structural parameters were determined based on energy coupling relationship at the component interfaces. Next, the prototype McEFI has been batch-fabricated using PCB technology, with a monolithic structure of 7.0 mm (l) × 4.5 mm (w) × 4.0 mm (δ). As expected, this PCB-McEFI illustrated the successful firing validations for explosives pellets. This paper has addressed the cost problem in both military munitions and civil markets wherever reliable, insensitive and timing-dependent ignition or detonation are involved.

关键词： Exploding foil initiator Printed circuit board Monolithic structure Firing validations

Entire process of electrocardiogram recording of Wellens syndrome:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6672-6678页

作者： Na Tang Yi-Hua Li Liang Kang Rong Li qing-Min chu The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Cardiovascular Disease The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Wellens syndrome is an electrocardiogram(ECG)pattern seen in high-risk patients with unstable angina *** is characterized by inverted or biphasic T-waves that change into positive or pseudo-normalized waves at precordial leads when the patient experiences an angina attack;however,the mechanism for this condition remains *** SUMMARY A 47-year-old male patient experienced repeated,unprovoked episodes of chest pain for>20 d,with worsening during the previous *** the day of admission,he experienced episodes of paroxysmal chest pain lasting more than 30 min,in addition to radiating pain to the left arm and exertional *** patient presented to the emergency department with no chest pain or other discomfort at that *** at presentation showed sinus tachycardia and Twave changes,which were identified as Wellens syndrome when combined with previous ECG *** and myocardial enzymology examinations were normal when angina was present,but the ECG showed inverted or biphasic Twaves when angina was *** percutaneous coronary intervention,the ECGs demonstrated inverted or biphasic T-waves in the anterior precordial leads on days 0,1,and 2,but normal T-waves on day *** ECGs showed no subsequent ischemic ST-T-wave *** The Wellens syndrome pseudo-normalized T-waves likely reflect development of unstable angina pectoris into the hyperacute phase of ST-segment elevation myocardial infarction.

关键词： Wellens syndrome Pseudo-normalized T-waves Unstable angina pectoris Myocardial ischemia Electrocardiogram Case report

Predicting apical hypertrophic cardiomyopathy using T-wave inversion:Three case reports

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World Journal of Clinical Cases 2023年第25期11卷 5970-5976页

作者： Liang Kang Yi-Hua Li Rong Li qing-Min chu The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Cardiovascular Disease The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Apical hypertrophic cardiomyopathy(AHCM)is a subtype of hypertrophic *** to its location,the thickening of the left ventricular apex can be missed on *** negative T waves(GNTs)in left-sided chest leads are the hallmark electrocardiogram(ECG)change of *** SUMMARY The first patient was a 68-year-old woman complaining of recurrent chest tightness persisting for more than 3 *** second was a 59-year-old man complaining of spasmodic chest tightness persisting for more than 2 *** third was a 55-year-old woman complaining of recurrent chest pain persisting for 4 *** all three cases,GNTs were observed several years prior to apical cardiac hypertrophy after other causes of T-wave inversion were ruled *** Electrophysiological abnormalities of AHCM appear earlier than structural abnormalities,confirming the early predictive value of ECG for AHCM.

关键词： Electrocardiogram Negative T waves Hypertrophic cardiomyopathy Apical hypertrophic cardiomyopathy Echocardiography Case report

A chromosome-level genome assembly of the red drum, Sciaenops ocellatus

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Aquaculture and Fisheries 2021年第2期6卷 178-185页

作者： Tianjun Xu Ye Li qing chu Weiwei Zheng Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of Education201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University201306China

Sciaenops ocellatus,also known as red drum,is a valuable commercial fish that is widely cultured in *** recent years,while the genetic research and molecular breeding on *** has been widely performed,whole-genome resources are *** our study,we assembled the *** genome by high-quality genome sequencing,followed by complete *** size of final genome was 686.62 Mb and N50 length of contig and scaffold is 99.71 Kb and 25.62 Mb,*** the Hi-C technology,we obtained 24 pseudochromosomes containing 87.82%of the total *** annotated 20,053 protein-coding genes in *** genome,of which 99.93%were homologous to proteins in different ***,we detected 133.54 Mb repeat sequences,which accounts for 19.45%of the *** to the phylogenetic analysis,*** is most closed to *** with a divergence time about 30 million years *** assembled a high-quality genome that will be a valuable resource to further study the biology of *** and will inform how to breed the red drum to enhance its economic traits.

关键词： Red drum Whole-genome Chromosomal assembly Phylogenetic Genome evolution