检索结果-南通市图书馆

Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

World Journal of Gastroenterology 2012年第47期18卷 7079-7086页

作者： qing-E Tian Huan-De Li Miao Yan Hua-Lin Cai qin-you tan Wen-Yuan Zhang School of Pharmaceutical Sciences Central South University Xiangtan Central Hospital Clinical Pharmacy and Pharmacology Research Institute the Second Xiangya HospitalCentral South University

AIM:To investigate the adjunct anticancer effect of Astragalus polysaccharides in H22 tumor-bearing ***:To establish a solid tumor model,5.0 × 10 6 /mL H22 hepatoma cells were inoculated subcutaneously into the right armpit region of Kunming mice(6-12 wk old,18-22 g).When the tumors reached a size of 100 mm 3,the animals were treated as indicated,and the mice were randomly assigned to seven groups(n = 10 each).After ten days of treatment,blood samples were collected from mouse eyes,and serum was harvested by *** were sacrificed,and the whole body,tumor,spleen and thymus were weighed *** rate of tumor inhibition and organ indexes were *** expression levels of serum cytokines,P-glycoprotein(P-GP) and multidrug resistance(MDR) 1 mRNA in tumor tissues were detected using enzyme-linked immunosorbent assay,Western blotting,and quantitative myeloid-derived suppressor cells reverse transcription-polymerase chain reaction,***:The tumor inhibition rates in the treatment groups of Adriamycin(ADM) + Astragalus polysaccharides(APS)(50 mg/kg),ADM + APS(100 mg/kg),and ADM + APS(200 mg/kg) were significantly higher than in the ADM group(72.88% vs 60.36%,P = 0.013;73.40% vs 60.36%,P = 0.010;77.57% vs 60.36%,P = 0.001).The spleen indexes of the above groups were also significantly higher than in the ADM group(0.65 ± 0.22 vs 0.39 ± 0.17,P = 0.023;0.62 ± 0.34 vs 0.39 ± 0.17,P = 0.022;0.67 ± 0.20 vs 0.39 ± 0.17,P = 0.012),and the thymus indexes of the ADM + APS(100 mg/kg) and ADM + APS(200 mg/kg) groups were significantly higher than in the ADM group(0.20 ± 0.06 vs 0.13 ± 0.04,P = 0.029;0.47 ± 0.12 vs 0.13 ± 0.04,P = 0.000).APS was found to exert a synergistic antitumor effect with ADM and to alleviate the decrease in the sizes of the spleen and thymus induced by *** expression of interleukin-1α(IL-1α),IL-2,IL-6,and tumor necrosis factor-α(TNF-α) was significantly higher in the ADM + APS(50 mg/kg),ADM + APS(100 mg/kg)

关键词： Astragalus polysaccharides Tumor inhibition rate Cytokines P-glycoprotein Adjunct anticancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A drug-loaded flexible substrate improves the performance of conformal cortical electrodes

引用

Bio-Design and Manufacturing 2024年第4期7卷 399-412页

作者： Rongrong qin Tian Li Yifu tan Fanqi Sun Yuhao Zhou Ronghao Lv Xiaoli you Bowen Ji Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

关键词： Antibacterial Anti-inflammatory Drug loading Cortical electrodes Bacterial cellulose hydrogel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A progressive framework for rotary motion deblurring

引用

Defence Technology（防务技术） 2024年第2期32卷 159-172页

作者： Jinhui qin Yong Ma Jun Huang Fan Fan you Du School of Electronic Information Wuhan UniversityWuhan430072China

The rotary motion deblurring is an inevitable procedure when the imaging seeker is mounted in the rotating *** rotary motion deblurring methods suffer from ringing artifacts and noise,especially for large blur *** solve the above problems,we propose a progressive rotary motion deblurring framework consisting of a coarse deblurring stage and a refinement *** the first stage,we design an adaptive blur extents factor(BE factor)to balance noise suppression and details *** a novel deconvolution model is proposed based on BE *** the second stage,a triplescale deformable module CNN(TDM-CNN)is designed to reduce the ringing artifacts,which can exploit the 2D information of an image and adaptively adjust spatial sampling *** establish a standard evaluation benchmark,a real-world rotary motion blur dataset is proposed and released,which includes rotary blurred images and corresponding ground truth images with different blur *** results demonstrate that the proposed method outperforms the state-of-the-art models on synthetic and real-world rotary motion blur *** code and dataset are available at https://***/Jinhuiqin/RotaryDeblurring.

关键词： Rotary motion deblurring Progressive framework Blur extents factor TDM-CNN

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new type of lipophilic hydrophobic self-repairing cellulose insulating paper developed with ST-110/FAS/PTFE ternary system as coating substrate

引用

High Voltage 2024年第2期9卷 474-483页

作者： Zhenglin Zeng Jinshan qin Zuhao Wang Weimin tan Chao tang College of Engineering and Technology Southwest UniversityChongqingChina International R&D Center for New Technologies of Smart Grid and Equipment ChongqingChina

The moisture generated by the ageing of the oil-paper insulating system can easily lead to the deterioration of the performance of the insulating *** order to alleviate the impact of moisture on the performance of the insulating paper,we developed a kind of lipophilic hydrophobic self-repairing cellulose insulating paper(new insulating paper)based on the ternary system of polytetrafluoroethylene,fluorocarbon surfactant and fluorinated alkyl silane,and accelerated thermal ageing test for 45 days at 130°C was carried *** experimental results show that the new insulating paper with excellent lipophilic property can realise hydrophobic self-repairing through heat treatment after physical *** tensile strength and elongation at break of the new insulating paper increased by 5%–8%and 6.25%–27%respectively compared with the original cellulose insulating *** the end of ageing,the relative dielectric constant and dielectric loss factor of new insulating paper are 10.4%and 9.9%lower than that of the original cel-lulose insulating paper,while the breakdown voltage is 6.8%*** acid and moisture content produced during the ageing process of the insulating oil impregnated with new insulating paper are also less,indicating that the coating can delay the ageing of the insulating paper.

关键词： coating moisture cellulose

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Graphene-anchored sodium single atoms:A highly active and stable catalyst for transesterification reaction

引用

Nano Research 2024年第6期17卷 4979-4985页

作者： Song-Song Peng Yao Nian Xing-Ru Song Xiang-Bin Shao Chen Gu Zhi-Wei Xing Shi-Chao Qi Peng tan you Han Xiao-qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu RoadNanjing 211816China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Solid strong base catalysts have received considerable attention in various organic reactions due to their facile separation,neglectable corrosion,and environmental *** great progress has been made in the preparation of solid strong base catalysts,it is still challenging to avoid basic sites aggregation on support and active sites loss in reaction ***,we report a tandem redox strategy to prepare Na single atoms on graphene,producing a new kind of solid strong base catalyst(Na1/G).The base precursor NaNO_(3)was first reduced to Na2O by graphene(400℃)and successively to single atoms Na anchored on the graphene vacancies(800℃).Owing to the atomically dispersed of basicity,the resultant catalyst presents high activity toward the transesterification of methanol and ethylene carbonate to synthesize dimethyl carbonate(turnover frequency(TOF)value:125.7 h^(−1)),which is much better than the conventional counterpart Na2O/G and various reported solid strong bases(TOF:1.0-90.1 h^(−1)).Furthermore,thanks to the basicity anchored on graphene,the Na1/G catalyst shows excellent durability during *** work may provide a new direction for the development of solid strong base catalysts.

关键词： solid strong base catalyst basic sites redox graphene single Na atoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review

引用

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 261-296页

作者： Chen Guoxing qin you Ma Weijia Liang Ke Wu Qi C.Hsein Juang Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 210009China Civil Engineering and Earthquake Disaster Prevention Center of Jiangsu Province Nanjing 210009China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical *** to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering *** paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three *** focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy *** particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation *** gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjecte

关键词： liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA

引用

National Science Review 2024年第3期11卷 72-91页

作者： Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang tan you Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng qin Peng Zigang Li Hongsheng Wang Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Department of Biomedical Sciences City University of Hong Kong Institute of Systems and Physical Biology Shenzhen Bay Laboratory

Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer（CRC） cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione（GSH） via the upregulation of RRM2B——a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3 UTR of RRM2B increased its m RNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence（CDS） of OPA1——an essential GTPase protein for mitochondrial inner membrane fusion——also increased m RNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.

关键词： m6A mitochondrial fusion glutathione OPA1 colorectal cancer

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

引用

Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-Hui Liu you-Bin Zhang Zhen-Guo Qi Guo-Hui qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-energy-consumption temperature swing system for CO_(2) capture by combining passive radiative cooling and solar heating

引用

Green Energy & Environment 2024年第3期9卷 507-515页

作者： Ying-Xi Dang Peng tan Bin Hu Chen Gu Xiao-qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Temperature-swing adsorption(TSA)is an effective technique for CO_(2) capture,but the temperature swing procedure is ***,we report a low-energy-consumption system by combining passive radiative cooling and solar heating for the uptake of CO_(2) on commercial activated carbons(CACs).During adsorption,the adsorbents are coated with a layer of hierarchically porous poly(vinylidene fluoride-co-hexafluoropropene)[P(VdF-HFP)HP],which cools the adsorbents to a low temperature under sunlight through radiative *** desorption,CACs with broad absorption of the solar spectrum are exposed to light irradiation for *** heating and cooling processes are completely driven by solar *** tests under mimicked sunlight using the CACs show that the performance of this system is comparable to that of the traditional ***,under real sunlight irradiation,the adsorption capacity of the CACs can be well maintained after multiple *** present work may inspire the development of new temperature swing procedures with little energy consumption.

关键词： CO_(2)capture Solar heating Passive radiative cooling Temperature swing adsorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

引用

Regenerative Biomaterials 2024年第1期3卷 82-93页

作者： Jing Zhang Jie Wang Jiayi you Xuan qin Huimin Chen Xiantong Hu Yantao Zhao Yang Xia Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029PR China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjingJiangsu 210029PR China Department of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongHong Kong SARPR China Senior Department of Orthopedics The Fourth Medical Center of PLA General HospitalBeijing100048PR China Beijing Engineering Research Center of Orthopedics Implants Beijing 100048PR China State Key Laboratory of Military Stomatology Xi'an 710032PR China

The removal of a failed implant with high torque causes significant damage to the surrounding tissue,compromising bone regeneration and subsequent osseointegration in the defect ***,we report a case of carrier screw fracture followed by immediate implant removal,bone grafting and delayed reimplantation.A dental implant with a fractured central carrier screw was removed using the bur-forceps *** resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft(SD-FDBA).Cone-beam computerized tomography was performed at 1week,6months and 15months postoperatively and standardized for quantitative *** alveolar bone width and height at 15months post-surgery were about 91%of the original values,with a slightly lower bone density,calculated using the gray value *** graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone *** followed by restoration was performed 8months *** quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and longterm implant *** excellent osteogenic properties of SD-FDBA are attributed to its human origin,cortical bone-like structure,partly demineralized surfaces and bone morphogenetic protein-2-containing *** investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： dental implant implant failure allogeneic bone bone regeneration reimplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：