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Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin qin-yan su Yi-Wu Dang Gang Chen Jia-Liang Wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,Psults showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,Psuch as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing

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Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4244-4263页

作者： Xiao-Wei Wang Yu-Xing Tang Fu-Xi Li Jia-Le Wang Gao-Peng Yao Da-Tong Zeng Yu-Lu Tang Bang-Teng Chi qin-yan su Lin-qing Huang Di-Yuan qin Gang Chen Zhen-Bo Feng Rong-Quan He Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Red Cross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChi Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Computer Science and Technology School of Computer and Electronic InformationGuangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in *** therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is *** Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in ***,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been *** To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated *** This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment *** was used to investigate focal adhesion(FA)pathway *** integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical *** assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and *** ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate *** malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor ***12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse ***12 was also found to be a TKI resistance gene that regulated the FA ***1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk *** expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to *** ARHGAP12 expre

关键词： Hepatocellular carcinoma Focal adhesion Tyrosine kinase inhibitor Rho GTPase activating protein 12 Drug resistance Molecular mechanism Biomarker

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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食物对尼氏真绥螨发育繁殖和朱砂叶螨捕食量的研究

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西南农业大学学报（自然科学版） 2006年第1期28卷 87-88,93页

作者：秦素研刘怀西南大学重庆市昆虫学及害虫控制工程重点实验室重庆400716

在温度22～30℃，相对湿度70％～90％的条件下。以3种食料及组合研完了尼氏真绥螨的发育繁殖情况。并测定了不同螨态对朱砂叶螨不同螨态的捕食量。结果表明，利用朱砂叶螨＋花粉的组合食物更有利于尼氏真绥螨生长发育及繁殖。1个生活周... 详细信息

在温度22～30℃，相对湿度70％～90％的条件下。以3种食料及组合研完了尼氏真绥螨的发育繁殖情况。并测定了不同螨态对朱砂叶螨不同螨态的捕食量。结果表明，利用朱砂叶螨＋花粉的组合食物更有利于尼氏真绥螨生长发育及繁殖。1个生活周期平均为7．08d；每雌平均总产卵量为42．23头，雌螨平均寿命为27．67d，雄螨平均寿命为17．03d。雌成螨对朱砂叶螨各螨态的捕食量最多，对朱砂叶螨卵、幼螨、若螨、成螨的平均捕食量分别为4．07，13．47，12．47．4．73头。

关键词：尼氏真绥螨朱砂叶螨花粉捕食量

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling sun Xiaodan qin Lin Zhu Teng Jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li su yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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贝伐单抗联合不同手术方式治疗晚期新生血管性青光眼的疗效比较

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延安大学学报（医学科学版） 2016年第3期14卷 9-11,16页

作者：冯延琴苏延梅延安大学附属医院眼科陕西延安716000 延长县人民医院陕西延长717100

目的探讨贝伐单抗联合不同手术方式在晚期新生血管性青光眼患者中的应用效果。方法选取自2012-06~2015-08在延大附院接受治疗的晚期新生血管性青光眼患者68例68眼,根据治疗方式的不同把患者分为小梁切除术组（观察组）28例28眼和睫状体... 详细信息

目的探讨贝伐单抗联合不同手术方式在晚期新生血管性青光眼患者中的应用效果。方法选取自2012-06~2015-08在延大附院接受治疗的晚期新生血管性青光眼患者68例68眼,根据治疗方式的不同把患者分为小梁切除术组（观察组）28例28眼和睫状体光凝组（对照组）40例40眼。两组患者均注射贝伐单抗1.5 mg后进行手术治疗。在术后2周和2个月检测患者视力、眼部压力。结果观察组在手术治疗前、治疗后2周及2个月的眼部压力分别是（45.2±7.1）、（16.1±2.4）和（20.6±3.5）mm Hg,对照组眼部压力分别为（43.1±5.0）、（26.7±8.2）和（22.8±6.3）mm Hg。对照组术后2周眼压高于观察组,差异有统计学意义（P〈0.05）;两组患者术前和术后2个月眼压的差异没有统计学意义。对照组使用贝伐单抗后再进行手术治疗的时间与手术后再进一步治疗的时间上都明显的长于观察组患者,两组差异均有统计学意义（P〈0.05）。两组患者均未发生术后的并发症。结论晚期新生血管性青光眼患者采用贝伐单抗联合小梁切除术比贝伐单抗联合睫状体光凝术更利于患者的眼压的控制,尤其近期效果显著。

关键词：贝伐单抗晚期新生血管性青光眼睫状体光凝小梁切除术

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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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综合护理干预对老年慢性肾脏病患者治疗依从性的影响

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安徽卫生职业技术学院学报 2017年第2期16卷 66-67页

作者：黎芳梁艳芳秦素艳广西壮族自治区民族医院肾内科广西南宁530001

目的:探讨综合护理干预对老年慢性肾脏病患者治疗依从性的影响。方法:选取收治的102例经临床确诊的老年慢性肾脏病患者随机分为观察组和对照组,每组各51例。对照组患者给予常规护理,观察组患者在此基础上给予综合护理干预。对两组患者... 详细信息

目的:探讨综合护理干预对老年慢性肾脏病患者治疗依从性的影响。方法:选取收治的102例经临床确诊的老年慢性肾脏病患者随机分为观察组和对照组,每组各51例。对照组患者给予常规护理,观察组患者在此基础上给予综合护理干预。对两组患者治疗依从性进行分析评价。结果:观察组患者治疗总依从率为96.0%,显著高于对照组患者的64.7%,差异有统计学意义(P<0.05)。结论:综合护理干预能够提高老年慢性肾脏病患者治疗依从性,从而提高临床治疗效果。

关键词：慢性肾脏病治疗依从性老年人综合护理干预

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