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Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan qin Xu Xiaoxiang Guan Yujun Song xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

Visible-light-induced decarboxylative alkynylation of carboxylic acids in batch and continuous flow

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Green Synthesis and Catalysis 2024年第1期5卷 20-24页

作者： Longzhou qin xinpeng Zhang Hao Sun Xiu Duan Jie Liu Mengyu Wu xin Yuan Jiangkai Qiu Kai Guo College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 211816China

A green efficient photoredox-catalyzed decarboxylative alkynylation of carboxylic acids with alkynyl bromides has been *** broadly applicable protocol is presented whereinα-amino,aliphatic andα-oxy acids are converted into useful alkynylation *** commercially-available organic photocatalyst 4CzIPN is used as the photocatalyst,organic base DBU is utilized as the base,and DMSO serves as *** strategy features mild conditions,is metal-free,and is environmentally *** batch and continuous-flow protocols described were applied to obtain a broader substrate scope of functionalization(more than 50 examples).Furthermore,we demonstrate that the use of microflow technology enhanced and intensified the reaction process,achieving significantly reduced reaction times(i.e.,10 min of residence time).

关键词： Visible-light-induced Decarboxylative alkynylation Continuous flow Metal-free

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基于传播树的多特征谣言检测方法

电子学报 2024年第5期52卷 1609-1618页

作者：张鑫昕潘善亮茅琴娇宁波大学信息科学与工程学院浙江宁波315211 宁波工程学院网络空间安全学院浙江宁波315211

目前网络谣言的检测方法主要是从传播路径中寻找信息,大多只采用文本信息作为初始传播特征,因此难以捕捉到丰富的传播结构表示.本文根据谣言的传播路径,提取文本和用户可信度特征,构建一种基于传播树的多特征谣言检测模型.模型通过图卷... 详细信息

目前网络谣言的检测方法主要是从传播路径中寻找信息,大多只采用文本信息作为初始传播特征,因此难以捕捉到丰富的传播结构表示.本文根据谣言的传播路径,提取文本和用户可信度特征,构建一种基于传播树的多特征谣言检测模型.模型通过图卷积网络聚合文本传播信息,使用多头注意力机制挖掘文本传播树的层内依赖关系,同时对用户传播树中的每个用户构建可信度序列,并采用M-Attention模块捕获有效的用户可信度特征.实验结果表明,本文提出的方法在Twitter15、Twitter16和Weibo数据集上的检测准确率达到89.3%、91.7%和96.4%,相比当前最优的传播树模型Bi-GCN(Binary Graph Convolutional Network)分别提升4.8%、4.2%和3%.

关键词：谣言检测传播结构图卷积网络注意力机制自然语言处理

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Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)Mo5}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-Lun Wu Jing Du Hai-Ying Zhang Ming-Jun Hou Qiao-Yue Li Wei-Chao Chen Kui-Zhan Shao Bo Zhu Chao qin xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)Mo5}motifs through optimizing the molar ratio of Mo/W,including[Gd_(2)Mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{Mo_(124)W_(14)},1),[Mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{Mo_(126)W_(14)}n,2),and[Mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{Mo_(124)W_(14)}n,3).Such important{(W)Mo5}structural motif brings new reactivity into gigantic Mo blue *** are different numbers and sites of{Mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via Mo-O-Mo covalent bonds driven by{Mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels Mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

Algorithm of automatic identification of diabetic retinopathy foci based on ultra-widefield scanning laser ophthalmoscopy

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 610-615页

作者： Jie Wang Su-Zhen Wang Xiao-Lin qin Meng Chen Heng-Ming Zhang xin Liu Meng-Jun Xiang Jian-Bin Hu Hai-Yu Huang Chang-Jun Lan Aier Eye Hospital(East of Chengdu) Chengdu 610051Sichuan ProvinceChina Department of Ophthalmology Chengdu First People’s HospitalChengdu 610095Sichuan ProvinceChina School of Computer and Artificial Intelligence Southwest Jiaotong UniversityChengdu 610097Sichuan ProvinceChina Chengdu Aier Eye Hospital Chengdu 610041Sichuan ProvinceChina

AIM:To propose an algorithm for automatic detection of diabetic retinopathy(DR)lesions based on ultra-widefield scanning laser ophthalmoscopy(SLO).METHODS:The algorithm utilized the FasterRCNN(Faster Regions with CNN features)+ResNet50(Residua Network 50)+FPN(Feature Pyramid Networks)method for detecting hemorrhagic spots,cotton wool spots,exudates,and microaneurysms in DR ultra-widefield *** segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning *** fusion was carried out by the feature pyramid network FPN,which significantly improved lesion detection rates in SLO fundus ***:By analyzing 1076 ultra-widefield SLO images provided by our hospital,with a resolution of 2600×2048 dpi,the accuracy rates for hemorrhagic spots,cotton wool spots,exudates,and microaneurysms were found to be 87.23%,83.57%,86.75%,and 54.94%,***:The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO,providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.

关键词： diabetic retinopathy ultra-widefield scanning laser ophthalmoscopy intelligent diagnosis system

基于VMD-EWT-QWLSTM-TPE深度学习模型的超短时物流需求多步预测

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控制与决策 2024年第6期39卷 1859-1868页

作者：杨新彪陈彦如秦娟冉茂亮西南交通大学经济管理学院成都610031 服务科学与创新四川省重点实验室成都610031

超短时物流需求预测是企业物流资源智能调度的重要基础,然而,超短时物流需求数据具有强随机性、高波动性、非平稳性等特征,进行多步精确预测较为困难.基于此,构建基于串行数据分解和量子加权深度网络的超短时物流需求多步预测模型.首先... 详细信息

超短时物流需求预测是企业物流资源智能调度的重要基础,然而,超短时物流需求数据具有强随机性、高波动性、非平稳性等特征,进行多步精确预测较为困难.基于此,构建基于串行数据分解和量子加权深度网络的超短时物流需求多步预测模型.首先,通过变分模态分解(VMD)和经验小波变换(EWT)的串行分解方法对超短时物流需求数据的时序特征进行有效提取,以剥离噪声信号,降低原始数据的非平稳性和随机性;然后,构建量子加权长短期记忆神经网络(QWLSTM)深度学习模型,设计多输入多输出策略对分解后的模态分量进行多步预测,并基于树形Parzen评估器(TPE)对QWLSTM的超参数组进行优化;最后,对各模态分量的预测结果进行重构.实验结果表明,所提出模型在平均绝对值误差(MAE)、均方误差(MSE)、加权平均绝对百分比误差(WMAPE)、校正决定系数(R2)方面,均优于其他15种对比模型.

关键词：超短时物流需求多步预测串行数据分解量子加权深度学习模型 TPE参数优化

Clinical and genetic characteristics of a child with Sotos syndrome and attention-deficit/hyperactivity disorder:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5131-5139页

作者： Ya-Jing yang Bei-Yi Li Ke-xin Gan Jing Liu Xiu-qin Lv Dong-Mei Zhang Hui-Juan Ma Department of Internal Medicine North China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Internal Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Endocrinology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of Hebei Medical UniversityShijiazhuang 050023Hebei ProvinceChina

BACKGROUND Sotos syndrome is an autosomal dominant disorder,whereas attention-deficit/hyperactivity disorder(ADHD)is a neurodevelopmental *** report aimed to summarize the clinical and genetic features of a pediatric case of Soros syndrome and ADHD in a child exhibiting precocious *** SUMMARY The patient presented with accelerated growth and advanced skeletal maturation;however,she lacked any distinct facial characteristics related to specific genetic *** analyses revealed a paternally inherited heterozygous synonymous mutation[c.4605C>T(***1535Arg)].Functional analyses suggested that this mutation may disrupt splicing,and bioinformatics analyses predicted that this mutation was likely *** an initial diagnosis of Sotos syndrome,the patient was diagnosed with ADHD during the follow-up period at the age of 8 years and 7 *** The potential for comorbid ADHD in Sotos syndrome patients should be considered to avoid the risk of a missed diagnosis.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Nuclear receptor binding SET domain protein 1 Case report Developmental disabilities Diagnosis Como rbidity Management

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU Zhi-qing qin Ying HUANG Wan-Zhong HUANG Ting ZENG xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

有机小分子探针对过氧亚硝酸根离子的荧光检测响应机理的研究进展

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分析化学 2024年第2期52卷 166-177页

作者：陈佳鑫田秦秦何炜空军军医大学基础医学院学员五大队二十队空军军医大学药学系化学制药学教研室

过氧亚硝酸根离子（ONOO-）是非常活跃的活性氧（ROS）和活性氮（RNS）物种，因具有高氧化性和强硝化性而备受关注。ONOO-作为一种重要的生理活性分子，其在体内的水平异常会损害细胞中的蛋白质和DNA，从而导致生物体内炎症和其它严重... 详细信息

过氧亚硝酸根离子（ONOO-）是非常活跃的活性氧（ROS）和活性氮（RNS）物种，因具有高氧化性和强硝化性而备受关注。ONOO-作为一种重要的生理活性分子，其在体内的水平异常会损害细胞中的蛋白质和DNA，从而导致生物体内炎症和其它严重疾病的发生。近年来，研究者利用荧光检测技术实现了对生物活性分子的快速且灵敏的监测，并借助成像工具进行了高分辨率示踪，其中开发了许多用于检测ONOO-的有机小分子荧光探针。本文评述了近年来基于分子内电荷转移（ICT）、光诱导电子转移（PET）、荧光共振能量转移（FRET）和激发态分子内电荷转移（ESIPT）等多种荧光响应机理构建的ONOO-荧光检测方法的最新研究进展。

关键词：过氧亚硝酸根离子荧光检测荧光响应机理评述

能源利用对城市土地绿色利用效率的影响机制——基于长江经济带的空间计量分析

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长江流域资源与环境 2024年第3期33卷 525-536页

作者：任文琴卢新海杨浩柯善淦华中师范大学公共管理学院湖北武汉430079 广东省农业科学院农业经济与信息研究所广东广州510640 华中科技大学公共管理学院湖北武汉430074

探究能源利用对城市土地利用绿色利用效率的影响,对推动区域资源可持续利用和实现土地绿色利用转型等具有重要现实意义。研究从产业转移、技术创新及投资扩张等角度分析两者的影响机制,借助熵值法和非期望产出超效率SBM模型测算2006~202... 详细信息

探究能源利用对城市土地利用绿色利用效率的影响,对推动区域资源可持续利用和实现土地绿色利用转型等具有重要现实意义。研究从产业转移、技术创新及投资扩张等角度分析两者的影响机制,借助熵值法和非期望产出超效率SBM模型测算2006~2020年长江经济带能源利用与城市土地绿色利用效率的基础上,利用空间杜宾模型分析了能源利用对城市土地绿色利用效率的影响。结果显示:(1)研究期内长江经济带土地绿色利用效率整体呈波动上升趋势,平均效率由0.535上升到0.784,不仅高值城市数量增幅趋势显著,且集中连片分布趋势明显;(2)能源利用对城市土地绿色利用效率存在空间交互作用,直接效应系数为0.136、空间溢出效应系数为-0.203,表明能源利用对中心城市的土地绿色利用效率有推动作用,但其显著抑制了周边城市土地绿色利用效率的提升;(3)政策供给强化了能源利用对土地绿色利用效率的直接影响,同时弱化了能源利用空间溢出效应的负向作用。因此,要积极调整本地区产业结构以降低生产能耗,通过技术创新推动区域能源利用转型,在优化区域能源结构与利用效率的基础上实现区域内城市土地绿色利用效率的同步跃迁。

关键词：土地利用能源利用绿色发展空间杜宾模型长江经济带