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Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review

Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： LIU Gui-hong YAO Ze-qin CHEN Guo-qiang LI Ya-lang LIANG Bing Department of Urology Sanya Central Hospital (The Third People's Hospital of Hainan Province) Department of Urology Yuzhou People's Hospital

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment strategies. Green tea, a well-known beverage derived from the Camellia sinensis plant, contains bioactive compounds with potential health benefits, including catechins and polyphenols. This comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing literature. Green tea possesses antioxidant, anti-inflammatory, and anti-carcinogenic properties attributed to its catechins, particularly epigallocatechin gallate. Epidemiological studies have reported an inverse association between green tea consumption and prostate cancer risk, with potential protection against aggressive forms of the disease. Laboratory studies demonstrate that green tea components inhibit tumor growth, induce apoptosis, and modulate signaling pathways critical to prostate cancer development and progression. Clinical trials and human studies further support the potential benefits of green tea. Green tea consumption has been found to be associated with a reduction in prostate-specific antigen levels, tumor markers, and played a potential role in slowing disease progression. However, challenges remain, including optimal dosage determination, formulation standardization, and conducting large-scale, long-term clinical trials. The review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： epigallocatechin gallate green tea prevention prostate cancer review treatment

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Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li Niu Niu Deliang Wang Xue Liu yi qin Lei Wang Ben Zhong Tang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy

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Multi-state system reliability:An emerging paradigm for sophisticated engineered systems

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Frontiers of Engineering Management 2024年第3期11卷 568-575页

作者： Yu LIU Tangfan XIAHOU qin ZHANG Liudong XING hong-Zhong HUANG School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Center for System Reliability and Safety University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical&Computer Engineering University of Massachusetts DartmouthMA 02747USA

1 Introduction Reliability is defined as the probability that a system or component will perform its required function for a specified period of time under specified operating conditions(Ebeling,2019).Traditional reliability theory assumes that both a system and its components have only two possible states in the operation stage,either perfectly functioning or completely ***,as engineered systems become more sophisticated,involving larger sizes,increased functionality,and greater intelligence,and with advancements in sensing technologies,it has been extensively observed that systems and components exhibit multiple distinct states as they deteriorate over *** failure behavior,damage severity,performance capacity,and operational efficiency of the system and components vary among these states(Lisnianski et al.,2018).It,therefore,necessitates the development of advanced reliability theories and methodologies that are capable of characterizing these systems and components with multi-state nature.

关键词： system state specified

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Recent progress in ternary mixed matrix membranes for CO_(2) separation

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Green Energy & Environment 2024年第5期9卷 831-858页

作者： Zikang qin Yulei Ma Jing Wei hongfang Guo Bangda Wang Jing Deng Chunhai yi Nanwen Li Shouliang yi yi Deng Wentao Du Jian Shen Wenju Jiang Lu Yao Lin Yang Zhongde Dai College of Architecture and Environment Sichuan UniversityChengdu610065China College of Carbon Neutrality Future Technology Sichuan UniversityChengdu610065China National Engineering Research Centre for Flue Gas Desulfurization Chengdu610065China Carbon Neutral Technology Innovation Center of Sichuan Chengdu610065China School of Chemical Biological and Materials EngineeringUniversity of OklahomaNormanOK73019USA Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China US DOE Natl Energy Technol Lab626 Cochrans Mill RdPittsburghPA 15236USA DongFang Boiler Co. Ltd.China Clean Combustion and Flue Gas Purification Key Laboratory of Sichuan Province Chengdu611731China College of Environment and Resources Xiangtan UniversityXiangtan411105China

Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousﬁllers,making them an effective alternative to conventional polymer ***,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsﬁllers and the polymer matrix,currently limit the gas sep-aration performance of *** phase MMMs(consisting of aﬁller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation *** review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanoﬁllers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy *** on this separation data,the challenges of ternary MMMs are also ***,future directions for ternary MMMs are proposed.

关键词： CO_(2) separation Mixed matrix membranes Ternary phase

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Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan JIN yi Chen CAI Chang TANG Hou Lin qin Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

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A bi-functional catalyst strategy to selectively regulate sulfur redox kinetics in lithium-sulfur batteries

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Journal of Materials Science & Technology 2024年第6期173卷 54-62页

作者： Yanan Liu Xiaoxiao Huang honglei Zhang Guangyu qin Xiaoshuang Wang Meixiu Song hongbo Liang Jingzhe hong Yudong Huang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Advanced Structural-Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China

Designing electrochemical catalysts has become a research hotspot due to their accelerating the polysulfide conversion of the sulfur cathode to inhibit the“shuttle effect”in lithium-sulfur ***,it is still a great challenge to design the heterogeneous selective electrochemical catalyst for inhibiting the“shuttle effect”.Herein,nickel cobalt phosphide and cobalt phosphide as the heterogeneous catalyst active sites embedded in the nitrogen-doped hollow carbon nanocages(NiCoP@CoP/NC)are reported,used for multi-step and multi-phase sulfur electrode reaction,and it is found that metal-sulfur d-p hybridization can effectively indicate the intrinsic catalytic activity of metal *** of labor and cooperation of the bi-active NiCoP@CoP as heterogeneous catalysts propel the stepwise polysulfide *** and CoP sites preferentially accelerate the long-chain polysulfide conversion reaction(S_(8)■LiPSs)and the short-chain polysulfide conversion reactions(LiPSs■Li_(2)S),***,the hollow and porous N-doped carbon structure can successfully suppress the volume effect and improve the conductivity of the sulfur *** unique design can obtain an effective inhibition of the shuttle effect and rapid electrode *** a result,Li-S batteries demonstrate a high initial capacity of 1063 mAh g^(-1) and a low-capacity decay of 0.04% per cycle within 1000 *** work provides a feasible idea for the design of host materials in Li-S batteries.

关键词： Shuttle effect d-p hybridization Heterogeneous catalysts Stepwise polysulfide conversion

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Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-Shi Feng Yu Shen Fang Wang Chuan Tian qin-yi Hu Qian Duan Jing-Wei Li Di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects

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Influence of sea-land breeze on the formation and dissipation of severe dense fog and its burst reinforcement in the Yellow Sea coastal area,China

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Science China Earth Sciences 2024年第2期67卷 432-449页

作者： Ya GAO Duanyang LIU Shuqi YAN Wenjun ZHOU hongbin WANG Fan ZU qin MEI Chuanxiang yi Ye SHENG Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing210041China Yancheng Meteorological Bureau Yancheng224000China Nanjing Joint Institute for Atmospheric Sciences Nanjing210041China Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing100086China

Based on the global reanalysis data of the National Centers for Environmental Prediction(NCEP)/National Center for Atmospheric Research,the surface meteorological observation data,sounding data and satellite observation data,this paper comprehensively analyzes the evolution process and formation mechanism of a persistent severe dense fog process occurred on February 15–17,2015 in Yancheng,eastern *** the numerical simulation experiment of Weather Research and Forecast(WRF)model,we further analyze the impact of sea-land breeze on the formation and burst reinforcement of *** show that the precipitation caused by the southwesterly airflow in front of the upper-level trough and the low-pressure inverted trough are conducive to the formation of early rain fog,while the nighttime clear radiance under the control of surface cold high and the infiltration of weak cold advection are conducive to the formation and development of later radiation-advection *** WRF model simulates the fog evolution process,which is basically consistent with the actual fog area,and the simulation results are credible to a certain *** simulation results show that the establishment of sea breeze has an advection cooling effect on the near surface layer,which is conducive to the formation and development of the inversion layer on the near surface,providing stable stratification conditions for the formation and burst reinforcement of *** one hand,the strengthening of sea breeze circulation can continuously transport water vapor to the study *** the other,the occurrence of ultra-low level jet is favorable for the accumulation of low-level water *** the same time,the inversion intensity further strengthens,which is in favor of the burst reinforcement and long-term maintenance of fog.

关键词： Radiation-advection fog Sea-land breeze Atmospheric boundary layer Fog burst reinforcement WRF model

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi qing LIU Li Qun HUANG De qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di SHAO Jia Kang ZHU yi Min CHEN yi Meng LIU Mei ZHAO Wei hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P<0.001).The rate of HER2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,P<0.001,Pearson’s R=0.159,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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Synergy of phosphorus vacancies and build-in electric field into NiCo/NiCoP Mott-Schottky integrated electrode for enhanced water splitting performance

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Chinese Chemical Letters 2024年第2期35卷 604-610页

作者： Xiaochen Zhang Hui Xue Jing Sun Niankun Guo Tianshan Song Jiawen Sun yi-Ru Hao qin Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Vacancy engineering and Mott-Schottky heterostructure can accelerate charge transfer,regulate adsorption energy of reaction intermediates,and provide additional active sites,which are regarded as valid means for improving catalytic ***,the underlying mechanism of synergistic regulation of interfacial charge transfer and optimization of electrocatalytic activity by combining vacancy and Mott-Schottky junction remains ***,the growth of a bifunctional NiCo/NiCoP Mott-Schottky electrode with abundant phosphorus vacancies on foam nickel(NF)has been synthesized through continuous phosphating and reduction *** obtained NiCo/NiCoP heterojunctions show remarkable OER and HER activities,and the overpotentials for OER and HER are as low as 117 and 60 mV at 10 mA/cm^(2) in 1 mol/L KOH,***,as both the cathode and anode of overall water splitting,the voltage of the bifunctional NiCo/NiCoP electrocatalyst is 1.44 V at 10 mA/cm^(2),which are far exceeding the benchmark commercial *** theoretical calculation results confirm that the phosphorus vacancies and build-in electric field can effectively accelerate ion and electron transfer between NiCo alloy and NiCoP semiconductor,tailor the electronic structure of the metal centers and lower the Gibbs free energy of the ***,the unique self-supported integrated structure is beneficial to facilitate the exposure of the active site,avoid catalyst shedding,thus improving the activity and structural stability of NiCo/*** study provides an avenue for the controllable synthesis and performance optimization of Mott-Schottky electrocatalysts.

关键词： Mott-Schottky Build-in electric field Phosphorus vacancies Phosphides Overall water splitting

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