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Petroleum Science 2024年第4期21卷 2475-2484页

作者： Liang Xue Shuai Xu Jie Nie Ji qin Jiang-Xia Han Yue-Tian Liu qin-zhuo Liao State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) Department of Oil-Gas Field Development Engineering College of Petroleum Engineering China University of Petroleum (Beijing) Chuanqing Drilling Engineering Co.Ltd. China National Petroleum Corporation

The shale gas development process is complex in terms of its flow mechanisms and the accuracy of the production forecasting is influenced by geological parameters and engineering parameters. Therefore, to quantitatively evaluate the relative importance of model parameters on the production forecasting performance, sensitivity analysis of parameters is required. The parameters are ranked according to the sensitivity coefficients for the subsequent optimization scheme design. A data-driven global sensitivity analysis(GSA) method using convolutional neural networks(CNN) is proposed to identify the influencing parameters in shale gas production. The CNN is trained on a large dataset, validated against numerical simulations, and utilized as a surrogate model for efficient sensitivity analysis. Our approach integrates CNN with the Sobol' global sensitivity analysis method, presenting three key scenarios for sensitivity analysis: analysis of the production stage as a whole, analysis by fixed time intervals, and analysis by declining rate. The findings underscore the predominant influence of reservoir thickness and well length on shale gas production. Furthermore, the temporal sensitivity analysis reveals the dynamic shifts in parameter importance across the distinct production stages.

关键词： Shale gas Global sensitivity Convolutional neural network Data-driven

肛裂切除加肛门内括约肌切开术治疗肛裂患者的临床效果研究

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中国实用医药 2024年第10期19卷 39-42页

作者：卓芹超金乡县人民医院 272200

目的在肛裂患者手术治疗中,采用肛裂切除加肛门内括约肌切开术治疗,分析其临床效果。方法选取45例肛裂手术治疗患者作为研究对象,所有患者均展开肛裂切除加肛门内括约肌切开术。比较患者手术前后的临床相关指标(疼痛评分、肿胀评分)... 详细信息

目的在肛裂患者手术治疗中,采用肛裂切除加肛门内括约肌切开术治疗,分析其临床效果。方法选取45例肛裂手术治疗患者作为研究对象,所有患者均展开肛裂切除加肛门内括约肌切开术。比较患者手术前后的临床相关指标(疼痛评分、肿胀评分)、炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、 γ干扰素(IFN-γ)]水平、生活质量评分。结果患者手术后疼痛评分(3.32±1.13)分、肿胀评分(1.23±0.21)分均低于手术前的(5.48±1.14)、(2.87±0.23)分,差异具有统计学意义(P<0.05)。患者手术后的hs-CRP(9.62±1.53)mg/L、TNF-α(30.23±3.57)pg/ml、IL-6(66.35±5.08)ng/L、IL-8(32.74±3.17)ng/L、IFN-γ(54.78±2.01)pg/ml均低于手术前的(16.25±2.04)mg/L、(40.15±4.09)pg/ml、(83.37±8.38)ng/L、(45.58±3.45)ng/L、(63.43±3.15)pg/ml,差异具有统计学意义(P<0.05)。患者手术后的躯体功能、心理功能、社会功能、物质生活评分分别为(78.84±2.78)、(77.27±2.23)、(78.83±2.77)、(77.32±2.26)分,均高于手术前的(72.13±2.07)、(71.19±2.28)、(73.19±2.56)、(72.47±2.59)分,差异具有统计学意义(P<0.05)。结论在肛裂患者手术治疗中,采用肛裂切除加肛门内括约肌切开术治疗,能减轻术后疼痛及患处肿胀,减轻体内炎性反应,提高患者生活质量,值得临床推广。

关键词：肛裂切除术肛门内括约肌切开术临床效果观察

超高效液相色谱-串联质谱法测定人体尿液中6种双酚类化合物

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卫生研究 2024年第3期53卷 447-454页

作者：裴紫薇卓勤张磊李敬光赵云峰中国疾病预防控制中心营养与健康所国家卫生健康委公共营养与健康重点实验室北京100050 国家食品安全风险评估中心中国医学科学院创新单元(2019RU014号)北京100021

目的开发并验证测定尿液中6种双酚类化合物(双酚S、双酚F、双酚A、2,2′-亚甲基双酚、双酚AF、双酚AP)的固相萃取-超高效液相色谱-串联质谱检测方法。方法尿样酶解后,经WAX固相萃取柱快速净化和提取目标物,以水和甲醇为流动相在色谱柱AC... 详细信息

目的开发并验证测定尿液中6种双酚类化合物(双酚S、双酚F、双酚A、2,2′-亚甲基双酚、双酚AF、双酚AP)的固相萃取-超高效液相色谱-串联质谱检测方法。方法尿样酶解后,经WAX固相萃取柱快速净化和提取目标物,以水和甲醇为流动相在色谱柱ACQUITY BEH C_(18)(2.1 mm×100 mm,1.7μm)上进行分离,最后在电喷雾负离子模式下进行多反应监测,内标法进行定量。结果目标化合物在0.1~50.0 ng/mL的范围内相关系数(r)均大于0.998,线性良好,检出限均低于0.1 ng/mL。3个加标浓度(0.5、5.0和50.0 ng/mL)下的目标化合物回收率均在80%~120%,相对标准偏差小于20%(n=5)。对标准参考物质进行检测,检出浓度在参考范围内。结论该方法能够对尿液中6种双酚类化合物进行快速、准确的检测,适用于人体尿液中双酚类化合物的痕量分析。

关键词：尿液双酚类化合物固相萃取超高效液相色谱-串联质谱

In vitro study of emodin-induced nephrotoxicity in human renal glomerular endothelial cells on a microfluidic chip

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BIOCELL 2023年第1期47卷 125-131页

作者： zhuo YANG WEN qin DI CHEN JUNSHENG HUO JINGBO WANG LIYUAN WANG qin zhuo JIYONG YIN National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing100050China

Emodin is an effective component of rhubarb with positive pharmacological effects on human ***,it is also toxic to different cells or tissues to varying *** effects of emodin on glomerular endothelial cells(GECs)remain to be tested,and the documented works were always performed in vitro and hardly reflect the real physiological *** study the effects of emodin on GECs in a biomimetic environment,we utilized a microfluidic chip to assess the physiological reaction of human renal glomerular endothelial cells to various concentrations of emodin in this *** results showed that emodin caused cytotoxicity,impaired glomerular filtration barrier integrity to macromolecules,and increased barrier permeability in a dose-dependent *** the increase in emodin concentration,the concentration of the pro-inflammatory cytokine tumor necrosis factor-α,interleukin(IL)-6,transforming growth factor-β1,and monocyte chemoattractant protein(MCP-1)increased while the production of inflammatory cytokine IL-6 first increased and then decreased with the increase in emodin *** findings shed new light on emodin-induced nephrotoxicity and provide insights for the application of microfluidic chip devices to reveal drug-cell interactions.

关键词： Emodin Nephrotoxicity HRGECs Microfluidic chip

Optimization of Three-Dimensional Culture Conditions of HepG2 Cells with Response Surface Methodology Based on the VitroGel System

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Biomedical and Environmental Sciences 2022年第8期35卷 688-698页

作者： WANG Jing Bo qin Wen YANG zhuo SHEN Shi MA Yan WANG Li Yuan zhuo qin GONG Zhao Long HUO Jun Sheng CHEN Chen National Institute for Nutrition and Health Chinese Centre for Disease Control and PreventionBeijing 100050China

Objective This study optimizes three-dimensional(3D) culture conditions of HepG2 using response surface methodology(RSM) based on the VitroGel system to facilitate the cell model in vitro for liver *** HepG2 cell was 3D cultured on the VitroGel *** viability was detected using Cell Counting Kit-8(CCK-8) assay of HepG2 lived cell *** proliferation of HepG2 cell and clustering performance was measured via fluorescence staining *** concentration in the culture medium supernatant as an index of HepG2 cell biological function was measured with ELISA *** factor tests were conducted with three key factors:inoculated cell concentration,cultured time,and dilution degree of the *** preliminary results of independent factor tests were used to determine the levels of factors for *** The selected optimal culture conditions are as follows:concentration of inoculated cells was4.44 × 10^(5)/mL,culture time was 4.86 days,and hydrogel dilution degree was 1:*** result shows that under optimal conditions,the predicted optical density(OD) value of cell viability was 3.10 and measured 2.978 with a relative error of 3.94%.Conclusion This study serves as a reference for the 3D HepG2 culture and constructs liver tissues in ***,it provides the foundation for repeated dose high-throughput toxicity studies and other scientific research work.

关键词： Response surface methodology The three-dimensional culture Hydrogel

Statistical prediction of waterflooding performance by K-means clustering and empirical modeling

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Petroleum Science 2022年第3期19卷 1139-1152页

作者： qin-zhuo Liao Liang Xue Gang Lei Xu Liu Shu-Yu Sun Shirish Patil Department of Petroleum Engineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Petroleum Engineering China University of Petroleum-BeijingBeijing102240China Faculty of Engineering China University of GeosciencesWuhan430074HubeiChina Center for Integrative Petroleum Research King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Petroleum Engineering King Abdullah University of Science and TechnologyThuwalSaudi Arabia

Statistical prediction is often required in reservoir simulation to quantify production uncertainty or assess potential *** existing uncertainty quantification procedures aim to decompose the input random field to independent random variables,and may suffer from the curse of dimensionality if the correlation scale is small compared to the domain *** this work,we develop and test a new approach,K-means clustering assisted empirical modeling,for efficiently estimating waterflooding performance for multiple geological *** method performs single-phase flow simulations in a large number of realizations,and uses K-means clustering to select only a few representatives,on which the two-phase flow simulations are *** empirical models are then adopted to describe the relation between the single-phase solutions and the two-phase solutions using these ***,the two-phase solutions in all realizations can be predicted using the empirical models *** method is applied to both 2D and 3D synthetic models and is shown to perform well in the P10,P50 and P90 of production rates,as well as the probability distributions as illustrated by cumulative density *** is able to capture the ensemble statistics of the Monte Carlo simulation results with a large number of realizations,and the computational cost is significantly reduced.

关键词： Waterflooding Statistical prediction K-means clustering Empirical modeling Uncertainty quantification

Formation Dynamics and Quantitative Prediction of Hydrocarbons of the Superpressure System in the Dongying Sag

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Acta Geologica Sinica(English Edition) 2008年第1期82卷 164-173页

作者： SUI Fenggui HAO Xuefeng LIU qing zhuo qin＇gong ZHANG Shouchun Geological Scientific Research Institute Shengli Oilfield Company of SINOPEC. Dongying Shandong 257015

Based on the theory of formation dynamics of oil/gas pools, the Dongying sag can be divided into three dynamic systems regarding the accumulation of oil and gas： the superpressure closed system, the semi-closed system and the normal pressure open system. Based on the analysis of genesis of superpressure in the superpressure closed system and the rule of hydrocarbon expulsion, it is found that hydrocarbon generation is related to superpressure, which is the main driving factor of hydrocarbon migration. Micro fractures formed by superpressure are the main channels for hydrocarbon migration. There are three dynamic patterns for hydrocarbon expulsion： free water drainage, hydrocarbon accumulation and drainage through micro fissures. In the superpressure closed system, the oil-driving-water process and oil/gas accumulation were completed in lithologic traps by way of such two dynamic patterns as episodic evolution of superpressure systems and episodic pressure release of faults. The oil-bearing capacity of lithologic traps is intimately related to reservoir-forming dynamic force. Quantitative evaluation of dynamic conditions for pool formation can effectively predict the oil-bearing capability of traps.

关键词： superpressure closed system hydrocarbon expulsion dynamics dynamic patterns for pool formation quantitative prediction Dongying sag

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某油田挥发性有机物扩散模拟系统开发与应用

油气田环境保护 2024年第3期34卷 23-27页

作者：刘菊会李朝松卓琴何晨刘超中国石油长庆油田分公司技术监测中心

针对目前小尺度大气扩散模型欠缺和油气田站点挥发性有机物(VOCs)大气污染特点,文章基于空间分析方法和高斯烟羽模型,开发了多物种、多排放方式的小尺度反应性大气扩散模型体系,分别为点源无化学反应、点源有化学反应、面源无化学反应... 详细信息

针对目前小尺度大气扩散模型欠缺和油气田站点挥发性有机物(VOCs)大气污染特点,文章基于空间分析方法和高斯烟羽模型,开发了多物种、多排放方式的小尺度反应性大气扩散模型体系,分别为点源无化学反应、点源有化学反应、面源无化学反应、面源有化学反应四种模型;并选用SharpDev项目开发框架进行系统搭建,Python语言开发后台计算过程,使其能根据用户输入参数自动计算油气田站点源及面源污染扩散情况、并完成可视化展示,该软件系统的开发和应用为类似油气田站点大气污染物扩散、迁移和预判提供了方法基础。

关键词： VOCs 大气扩散模拟地理信息系统小尺度

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各国转基因食品标识制度概况分析

中国食品学报 2014年第8期14卷 16-20页

作者：卓勤中国疾病预防控制中心营养与食品安全所北京100050

虽然转基因食品问世近20年,但是对其安全性的争论从未停止,并且是否要对转基因食品加注标签,也是争论的1个重要内容。支持转基因食品标签的人认为消费者有知情权和选择权,而反对的人认为给转基因食品加标签会意味着它有健康问题。迄今... 详细信息

虽然转基因食品问世近20年,但是对其安全性的争论从未停止,并且是否要对转基因食品加注标签,也是争论的1个重要内容。支持转基因食品标签的人认为消费者有知情权和选择权,而反对的人认为给转基因食品加标签会意味着它有健康问题。迄今已有包括欧盟在内的60多个国家和地区制定了相关转基因食品的标识管理制度,其中大多数国家要求对转基因食品进行强制性标识,有的国家要求对所有转基因食品进行标识,然而也有国家只对主要的转基因食品,如大豆、玉米、土豆等进行标识。有关标识的阈值,多数国家要求为1%,欧盟要求0.9%,韩国、马来西亚等国要求3%,俄罗斯、日本等国家要求5%。对标识的内容、豁免及阴性标识各国的管理也有不同。

关键词：转基因食品食品标识管理

Association between Adiponectin and Metabolic Syndrome in Older Adults from Major Cities of China

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Biomedical and Environmental Sciences 2010年第1期23卷 53-61页

作者： qin zhuo ZHI-qinG WANG PING FU JIAN-HUA PIAO YUAN TIAN JIE XU XIAO-GUANG YANG National Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China Centre for Chrom'c Diseases School of Medicine University of Queensland Brisbane QLD 4072 Australia

Objective To investigate the association between adiponectin and metabolic syndrome （MetS） and related diseases in older adults from major cities of China. Methods A total of 2 049 adults at the age of 60-96 years from18 major cities of China were enrolled in the study. Plasma adiponectin and insulin concentrations were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance （HOMA-IR）. The definitions proposed by International Diabetes Federation （IDF） and American Heart Association/National Heart, Lung, and Blood/nstitute （AHA/NLHBI） were used to identify MetS. Results The adiponectin concentration increased with the advance of age and was higher in women than in men. The sex specific adiponectin concentration was inversely correlated with body mass index （BMI）, waist circumference, diastolic blood pressure, triglycerides, glucose and fasting blood insulin, and positively correlated with HDL-C （P〈0.001）. The adiponectin concentration decreased with increasing MetS components. Compared with the 4th sex-specific adiponectin quartile, the odds ratio （OR） for prevalent MetS-IDF and MetS-AHA/NLHBI in subjects of the 1st quartile group was 3.25 （95% CI： 2.24, 4.71） and 3.21 （95% CI： 2.26, 4.55）, respectively. The association was independent of age, sex, life-style factors, medication, family history of chronic diseases, BMI, and HOMA-IR, The OR for MetS was much higher than those of MetS components and its related diseases. Conclusion Adiponectin is strongly associated with MetS independent of insulin resistance and obesity in older adults from major cities in China. The adiponectin concentration is a useful predictor for the risk of MetS.

关键词： Adiponectin Metabolic syndrome Chinese older adults Obesity Insulin resistance