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瑞马唑仑在临床麻醉中的应用效果

中国实用医药 2024年第15期19卷 105-108页

作者：郑如婷钟帝钦蔡文恒海丰县彭湃纪念医院麻醉科 516400

目的探讨瑞马唑仑在临床麻醉中的应用效果。方法选取需要进行胸腔镜下肺叶切除术的患者82例,依据麻醉方式不同分为对照组与研究组,每组41例。对照组给予常规麻醉药物,研究组应用瑞马唑仑麻醉。对比两组患者麻醉诱导前后的疼痛阈值、脑... 详细信息

目的探讨瑞马唑仑在临床麻醉中的应用效果。方法选取需要进行胸腔镜下肺叶切除术的患者82例,依据麻醉方式不同分为对照组与研究组,每组41例。对照组给予常规麻醉药物,研究组应用瑞马唑仑麻醉。对比两组患者麻醉诱导前后的疼痛阈值、脑电指标以及外周血超氧化物歧化酶、丙二醛水平。结果麻醉诱导后,两组的疼痛阈值较麻醉诱导前明显升高,且研究组的疼痛阈值(3.68±0.26)mA比对照组的(3.09±0.10)mA高(P<0.05)。研究组外周血超氧化物歧化酶水平(90.74±10.21)U/ml比对照组的(70.86±10.37)U/ml高,丙二醛水平(6.07±1.05)nmol/ml比对照组的(7.14±1.25)nmol/ml低(P<0.05)。麻醉诱导后10、20、30 min,两组的脑电频率均低于麻醉诱导前,波幅均高于麻醉诱导前(P<0.05)。研究组麻醉诱导后20 min的脑电频率、波幅高于对照组(P<0.05);研究组麻醉诱导后30 min的脑电频率低于对照组,波幅高于对照组(P<0.05)。结论临床麻醉中应用瑞马唑仑镇静麻醉效果理想,可以降低患者的术后急慢性疼痛感,降低术后创伤后应激反应的发生几率,值得推广应用。

关键词：瑞马唑仑麻醉胸腔镜肺叶切除术丙二醛疼痛阈值超氧化物歧化酶

SLIP VELOCITY MODEL OF POROUS WALLS ABSORBED BY HYDROPHOBIC NANOPARTICLES SIO_2

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Journal of Hydrodynamics 2007年第3期19卷 365-371页

作者： GU Chun-yuan di qin-feng FANG Hai-ping Shanghai Institute of-Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Shanghai Institute of Applied Physics Chinese Academy of Scinese Shanghai 201800 China

According to new slip effects on nanopatterned interfaces, the mechanism of enhancing water injection into hydrophobic nanomaterial SiO2 was proposed. When Hydrophobic Nanoparticles（HNPs）are adsorbed on surfaces of porous walls, hydrophobic nanoparticles layers are formed instead of hydrated layer, and slip effects appear on the pore wall when a driving pressure is applied to the rock cores sample. It makes fluid to move more quickly and the flow capacity increases greatly. Experiments on changing wettability of porous walls were conducted, and the phenomenon that porous walls surfaces were adsorbed by nanoparticles was validated with the Environment Scan Electron Microscopy（ESEM）. The results of displacement experiments show that flowing resistance is greatly reduced, and water-phase effective permeability is increased by 47 % averagely after being treated by nanofluid. These results indicate that the slip effect may occur on nanoparticle film of porous walls. Based on this new mechanism of enhancing water injection about hydrophobic nanomaterial SiO2, a slip velocity model in uniform porous media was introduced, and some formulas for the ratio of slip length to radius, slip length ,stream slip velocity and flux increment were deduced. and calculated results indicate that the ratio of slip length to radius is about 3.54%-6.97%, and the slip length is about 0.024 μ m -0.063 μ m. The proposed model can give a good interpretation for the mechanisms of enhancing water injection with the HNPs.

关键词： hydrophobic nanomaterial SiO2 mechanism of enhancing water injection velocity slip model core displacement experiments adsorption wettability

Preparation and application of polyclonal antibodies against KSHV v-cyclin

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The Journal of Biomedical Research 2013年第5期27卷 421-429页

作者： Min Xue Yuanyuan Guo qin Yan di qin Chun Lu Department of Microbiology and Immunology Nanjing Medical University Department of Physiology Xuzhou Medical College

We prepared rabbit polyclonal antibodies against Kaposi＇s sarcoma-associated herpesvirus （KSHV）-encoded v- cyclin （ORF 72） and detected the natural viral protein using these polyclonal antibodies. Three antigenic polypep- tides of v-cyclin were designed and synthesized. A fragment of the v-cyclin gene was cloned into a eukaryotic expression vector pEF-MCS-Flag-IRES/Puro to construct a recombinant vector, pEF v-cyclin. Then, pEF v-cyclin was transfected into 293T and ***926 cells to obtain v-cyclin-Flag fusion proteins. Six New Zealand white rabbits were immunized with KLH-conjugated peptides to generate polyclonal antibodies against v-cyclin. The polyclonal antibodies were then characterized by ELISA and Western blotting assays. Finally, the polyclonal anti- bodies against v-cyclin were used to detect natural viral protein expressed in BCBL-1, BC-3, and JSC-1 cells. The results showed that using the Flag antibody, v-cyclin-Flag fusion protein was detected in 293T and ***926 cells transfected with pEF-v-cyclin. Furthermore, ELISA showed that the titer of the induced polyclonal rabbit anti-v- cyclin antibodies was higher than 1：8,000. In Western blotting assays, the antibodies reacted specifically with the v-cyclin-Flag fusion protein as well as the natural viral protein. The recombinant expression vector pEF-v-cyclin was constructed successfully, and the polyclonal antibodies prepared can be used for various biological tests in- cluding ELISA and Western blotting assays.

关键词： Kaposi's sarcoma-associated herpesvirus v-cyclin synthesized peptides polyclonal antibody

Resource Allocation in Multi-User Cellular Networks:A Transformer-Based Deep Reinforcement Learning Approach

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China Communications 2024年第5期21卷 77-96页

作者： Zhao di Zheng Zhong qin Pengfei qin Hao Song Bin State Key Laboratory of Integrated Services Networks Xidian University710071China China Academy of Space Technology Beijing 100081China

To meet the communication services with diverse requirements,dynamic resource allocation has shown increasing *** this paper,we consider the multi-slot and multi-user resource allocation(MSMU-RA)in a downlink cellular scenario with the aim of maximizing system spectral efficiency while guaranteeing user *** first model the MSMURA problem as a dual-sequence decision-making process,and then solve it by a novel Transformerbased deep reinforcement learning(TDRL)***,the proposed TDRL approach can be achieved based on two aspects:1)To adapt to the dynamic wireless environment,the proximal policy optimization(PPO)algorithm is used to optimize the multi-slot RA strategy.2)To avoid co-channel interference,the Transformer-based PPO algorithm is presented to obtain the optimal multi-user RA scheme by exploring the mapping between user sequence and resource *** results show that:i)the proposed approach outperforms both the traditional and DRL methods in spectral efficiency and user fairness,ii)the proposed algorithm is superior to DRL approaches in terms of convergence speed and generalization performance.

关键词： dynamic resource allocation multi-user cellular network spectrum efficiency user fairness

Precise quantification of the antibacterial activity of chitosan by NB medium neutralizer

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Journal of Materials Science & Technology 2021年第11期70卷 224-232页

作者： Mengyang Wang Shichao Bi Jianhui Pang Zhongzheng Zhou di qin Honglei Wang Xiaojie Cheng Xiguang Chen College of Marine Life Science Ocean University of ChinaQingdao 266003China qingdao National Laboratory for Marine Science and Technology Qingdao 266000China The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China

In the present research,nutrient broth(NB)medium was identified to be able to neutralize the antibacterial activity of chitosan and its ***,an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of *** minimum bactericidal concentration(MBC)of chitosan was 60μg m L^(-1) against *** and ***,and 0.01%(w/v)chitosan could kill 100%of bacteria within 3 *** another point of view,the neutralizing efficiency of NB could be tripled by adding 25 g L^(-1) of sodium *** the neutralizing mechanism of NB medium was ascribed to flocculation between chitosan and *** extra sodium chloride could significantly reduce the size of floccules,and smaller floccules would lose the ability of binding with bacteria directly,showing higher neutralizing rate on the macro scale.

关键词： Chitosan Antibacterial activity Neutralizer Flocculation

Whole-process case management effects on mental state and selfcare ability in patients with liver cancer

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 833-841页

作者： Man-di Ju qin qin Meng Li Department of Internal Medicine of Abdominal Oncology Hubei Cancer HospitalWuhan 430070Hubei ProvinceChina Department of Hepatological Surgery Wuhan No.1 HospitalWuhan 430000Hubei ProvinceChina Department of Nursing General Hospital of the Yangtze River ShippingWuhan 430014Hubei ProvinceChina

BACKGROUND Regarding the incidence of malignant tumors in China,the incidence of liver cancer ranks fourth,second only to lung,gastric,and esophageal *** case fatality rate ranks third after lung and cervical *** a previous study,the whole-process management model was applied to patients with breast cancer,which effectively reduced their negative emotions and improved treatment adherence and nursing *** In this single-center,randomized,controlled study,60 randomly selected patients with liver cancer who had been admitted to our hospital from January 2021 to January 2022 were randomly divided into an observation group(n=30),who received whole-process case management on the basis of routine nursing mea-sures,and a control group(n=30),who were given routine nursing *** compared differences between the two groups in terms of anxiety,depression,the level of hope,self-care ability,symptom distress,sleep quality,and quality of *** Post-intervention,Hamilton anxiety scale,Hamilton depression scale,memory symptom assessment scale,and Pittsburgh sleep quality index scores in both groups were lower than those pre-intervention,and the observation group had lower scores than the control group(P<0.05).Herth hope index,self-care ability assessment scale-revision in Chinese,and quality of life measurement scale for patients with liver cancer scores in both groups were higher than those pre-intervention,with higher scores in the observation group compared with the control group(P<0.05).CONCLUSION Whole-process case management can effectively reduce anxiety and depression in patients with liver cancer,alleviate symptoms and problems,and improve the level of hope,self-care ability,sleep quality,and quality of life,as well as provide feasible nursing alternatives for patients with liver cancer.

关键词： Liver cancer Mental state Self-care ability Whole-process case management Life quality Nursing

基于双端数据时频相关的输电线路故障定位方法

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自动化技术与应用 2024年第8期43卷 91-94页

作者：韩绍禹秦迪韩雨彤朱皓然国网吉林省电力有限公司四平供电公司吉林四平136000

在实际工程中,输电线路长度误差、授时误差、站内线缆等因素会影响输电线路行波故障定位的精度及可靠性。对此,提出基于两端数据时频相关性的故障定位方法,利用两端反射波的对称性及波形相似性,而谐振、相邻线路反射波等干扰量互不相关... 详细信息

在实际工程中,输电线路长度误差、授时误差、站内线缆等因素会影响输电线路行波故障定位的精度及可靠性。对此,提出基于两端数据时频相关性的故障定位方法,利用两端反射波的对称性及波形相似性,而谐振、相邻线路反射波等干扰量互不相关的特点,通过两端时频相关性分析抑制谐振及干扰影响,解决反射波识别可靠性问题,提高定位的可靠性及精度。通过仿真及现场数据对故障定位方法的有效性进行验证。

关键词：行波定位时频相关性反射波识别故障诊断

甲状腺功能亢进及甲状腺功能减退诱发老年骨质疏松的机制分析

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中国实验诊断学 2024年第3期28卷 312-318页

作者：刘瑶秦迪刘东明王岩陈雷黄丽红吉林大学中日联谊医院老年病科吉林长春130033 内蒙古民族大学附属医院内分泌科内蒙古自治区通辽028000 吉林大学中日联谊医院科研中心吉林长春130033 白城市医院急诊科吉林白城137000

目的通过对生信数据的挖掘来探究甲状腺功能亢进及甲状腺功能减退与老年骨质疏松之间的关联及治疗靶点。方法通过GEO数据库去挖掘老年骨质疏松症的差异表达基因,以及借助人类疾病数据库筛选骨质疏松、甲亢及甲减的靶基因。将上述基因整... 详细信息

目的通过对生信数据的挖掘来探究甲状腺功能亢进及甲状腺功能减退与老年骨质疏松之间的关联及治疗靶点。方法通过GEO数据库去挖掘老年骨质疏松症的差异表达基因,以及借助人类疾病数据库筛选骨质疏松、甲亢及甲减的靶基因。将上述基因整合映射后分别得出老年骨质疏松与甲亢、甲减的交集靶点基因。借助STRING数据库构建PPI网络,并且应用Cytoscape软件进行关键基因的筛选。通过R软件进行功能富集分析。结果老年骨质疏松分别与甲亢及甲减匹配映射得到67和126个交集靶点基因。PPI网络构建得出TNF、AKT1、ALB、CD4、IL2等关键基因可能与老年骨质疏松合并甲亢相关,并且受到Ⅰ型糖尿病、糖尿病并发症中的AGE-RAGE信号通路、人类T细胞白血病病毒Ⅰ型感染、移植物抗宿主病、EGFR酪氨酸激酶抑制剂耐药性等信号通路的调节;ALB、AKT1、TP53、TNF、CTNNB1等关键基因可能与老年骨质疏松合并甲减相关,并受到糖尿病并发症中的AGE-RAGE信号通路、T17细胞分化、人类T细胞白血病病毒Ⅰ型感染、癌症中的蛋白聚糖、人巨细胞病毒感染等信号通路调节。结论TNF、AKT1、ALB、CD4、IL2可能为老年骨质疏松和甲亢共病机制的基础,ALB、AKT1、TP53、TNF、CTNNB1可能为老年骨质疏松和甲减共病机制的基础。上述发现可能为进一步探究甲亢及甲减诱发老年骨质疏松发病机制和治疗机制提供新的思路。

关键词：老年骨质疏松甲状腺功能亢进甲状腺功能减退生物信息学

Long-term complete response to anti-programmed-death-1 monotherapy in a patient with relapsed and refractory ovarian adenocarcinoma: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1967-1973页

作者： Guang-di Zhou qin Li Affiliated to Shanghai Jiao Tong University School of Medicine Xinhua HospitalShanghai 200092China Department of Obstetrics and Gynecology Shanghai Changhai HospitalShanghai 200433China

BACKGROUND Ovarian cancer is the most common malignant tumor of the female reproductive system,and the survival rate of patients with relapsed and refractory ovarian cancer is very *** SUMMARY Here,we report a case of high-grade serous papillary adenocarcinoma of the ovary that was successfully treated with *** surgery and adjuvant chemotherapy for the 56-year-old patient were successful;however,her tumor *** second-line chemotherapy,targeted agents,and other treatments were ineffective,as the tumor continued to recur and ***-programmed cell death-1(PD-1)monotherapy(tislelizumab)completely alleviated the tumor,and the multiple metastatic tumors *** date,the patient has used anti-PD-1 for 32 months,experiencing no disease progression and maintaining good health without additional *** This case suggests that anti-PD-1 immunotherapy may have long-term positive effects on outcomes in some refractory recurrent solid *** research is needed to identify patients most likely to respond to anti-PD-1 therapy.

关键词： Anti-programmed cell death-1 Tislelizumab Ovarian cancer Relapsed cancer treatment Immunotherapy Case report