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National Science Open 2022年第3期1卷 46-58页

作者： Min Chen Zhengfen Wan Hao Dong Qinyu Chen Min Gu qiming zhang Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200090China Centre for Artificial-Intelligence Nanophotonics School of Optical-Electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200090China

A memristor is a promising candidate of new electronic synaptic devices for neuromorphic ***,conventional memristors often exhibit complex device structures,cumbersome manufacturing processes,and high energy ***-based materials show great potential as the building materials of *** direct laser writing technology,this paper proposes a lateral memristor with reduced graphene oxide(rGO)and Pt as electrodes and graphene oxide(GO)as function *** Pt/GO/rGO memristor with a facile lateral structure can be easily fabricated and demonstrates an ultra-low energy consumption of 200 *** synaptic behaviors are successfully ***,the Pt/GO/rGO memristor array is applied in the reservoir computing network,performing the digital recognition with a high accuracy of 95.74%.This work provides a simple and low-cost preparation method for the massive production of artificial synapses with low energy consumption,which will greatly facilitate the development of neural network computing hardware platforms.

关键词： direct laser writing memristor array graphene oxide reservoir computing

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微创技术在肾移植中的应用

器官移植 2022年第1期13卷 38-43页

作者：张启鸣侯小飞北京大学第三医院泌尿外科 100191

进入21世纪以来,微创技术成为外科学发展的一大主线,其临床应用早已渗透到各个外科学分支。在肾移植领域,微创技术的应用主要集中在活体供肾获取、肾移植手术及肾移植术后并发症的处理,不仅增加了供肾来源,也减少了术后并发症的发生率,... 详细信息

进入21世纪以来,微创技术成为外科学发展的一大主线,其临床应用早已渗透到各个外科学分支。在肾移植领域,微创技术的应用主要集中在活体供肾获取、肾移植手术及肾移植术后并发症的处理,不仅增加了供肾来源,也减少了术后并发症的发生率,改善了受者生活质量。微创技术的应用也成为了肾移植领域的研究热点之一。本文将就目前微创技术在活体供肾获取、肾移植手术及肾移植术后并发症处理中的应用进展作一介绍,以期为增加供肾来源、提高肾移植手术成功率及改善肾移植受者预后提供参考,促进微创技术在外科学中的进一步发展。

关键词：肾移植微创技术机器人辅助手术供肾获取术后并发症腹腔镜达芬奇机器人

Electrocaloric and electrostrictive effect of polar P(VDF-TrFE-CFE) terpolymers

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Journal of Advanced Dielectrics 2013年第2期3卷 64-67页

作者： Sheng-Guo Lu Hui Xiong Aixiang Wei Xinyu Li qiming zhang School of Materials and Energy Guangdong University of Technology 100 WaihuanxiluGuangzhou Higher Education Mega CenterGuangzhou 510006P.R.China Materials Research Institute and Electrical Engineering Department University Park Pennsylvania 16802USA

The electrocaloric effect(ECE)is the adiabatic temperature change or isothermal entropy change caused by the polarization change of a dielectric material when subjected to a change of external electric *** electrostrictive effect is a form of elastic deformation of a dielectric induced by an electric field,associated with those components of strain which are independent of reversal field *** was found that both the ECE,e.g.,adiabatic temperature change,and the electrostrictive strain in poly(vinylidene fluoridetrifluoroethylenechlorofluoroethylene)(P(VDF-TrFE-CFE))terpolymers are proportional to the square of the electric *** adiabatic temperature changeΔT of ECE versus electric field can be illustrated using a modified BelovGoryaga equation.ΔT is proportional to E^(2) when E is *** electrostrictive effect,the rigid-ion model assumes that the anharmonic movement of the ions leads to the quadratic strainelectric field *** quotient of electrostrictive coefficient Q over the phenomenological coefficientis empirically a constant,indicating that the larger the electrostrictive coefficient,the larger the ECE,which opens a new way to find out new electrocaloric materials.

关键词： Polar polymers electrocaloric effect electrostrictive properties polarization

几种红边位置算法在潮滩区域的适用性研究——以长江口南汇潮滩为例

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海洋湖沼通报 2015年第4期 49-55页

作者：张启明韩震上海海洋大学海洋科学学院上海201306 远洋渔业协同创新中心上海201306

植被反射率光谱的"红边位置"是判断植被健康状况的重要参数。本文以长江口南汇东滩优势种植被芦苇和海三棱藨草为研究对象,比较和分析了多项式拟合法、四点内插法、一阶导数法、拉格朗日内插法和线性外推法五种红边位置算法提取4个试验... 详细信息

植被反射率光谱的"红边位置"是判断植被健康状况的重要参数。本文以长江口南汇东滩优势种植被芦苇和海三棱藨草为研究对象,比较和分析了多项式拟合法、四点内插法、一阶导数法、拉格朗日内插法和线性外推法五种红边位置算法提取4个试验区域不同土壤湿度的芦苇和海三棱藨草植被红边位置的性能。研究结果表明多项式拟合法获取红边位置精度最高,对土壤湿度敏感性最大;四点内插法对土壤湿度敏感性较大;线性外推法得到的红边位置结果不稳定;一阶导数法和拉格朗日内插法相对于其他方法对土壤湿度敏感性最小,更适合在南汇潮滩这样高湿度土壤区域进行植被红边位置的信息提取。

关键词：红边位置植被潮滩土壤湿度南汇

以教师发展为导向的耦合性教学评价:含义、原则与实施

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课程．教材．教法 2017年第1期37卷 89-94页

作者：毛齐明张正琼华中师范大学教育学院武汉430079

以评促教是一项重要的变革措施,但现行教学评价实际上未能真正发挥促进教师发展的功能。以教师发展为导向的评价要能够为教师发展提供正确导向、具体指导和变革动力。这就要求改变孤立地以教学行为或学生表现为评价对象的现状,基于两者... 详细信息

以评促教是一项重要的变革措施,但现行教学评价实际上未能真正发挥促进教师发展的功能。以教师发展为导向的评价要能够为教师发展提供正确导向、具体指导和变革动力。这就要求改变孤立地以教学行为或学生表现为评价对象的现状,基于两者的对应关系,建构以"教学行为—学生表现"为单位的耦合性教学评价。这种评价需遵循校本性、动态性和长程性等原则,并在评价表的开发和运用等实施过程中贯彻这些原则。

关键词：耦合性教学评价教师发展含义原则

Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial

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Cancer Biology & Medicine 2024年第10期 951-962页

作者： Cuicui zhang Tianqing Chu qiming Wang Ying Cheng Yongxiang zhang Ruili Wang Leilei Ma Chaonan Qian Baohui Han Kai Li Department of Thoracic Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Department of Respiratory Medicine Shanghai Chest Hospital Shanghai Jiaotong University Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Department of Thoracic Medical Oncology Jilin Cancer Hospital Department of Respiratory & Critical Care Medicine Tianjin Chest Hospital Panovue Biotechnology (Beijing) Co. Ltd Medical Affairs Department Chia-Tai Tian Qing Pharmaceutical Co.Ltd. Department of Radiation Oncology Guangzhou Concord Cancer Center

Objective: The possible enhancing effect of anlotinib on programmed death receptor ligand（PD-L1） antibody and the efficacypredicting power of PD-L1 in micro-conduit endothelium, including lymphatic endothelial cells（LECs） and blood endothelial cells（BECs）, were determined to identify patients who would benefit from this ***: PD-L1 positivity in LECs, BECs, and tumor cells（TCs） was assessed using paraffin sections with multicolor immunofluorescence in an investigator's brochure clinical trial of TQB2450（PD-L1 antibody） alone or in combination with anlotinib in patients with non-small cell lung cancer. Progression-free survival（PFS） with different levels of PD-L1 expression was compared between the two ***: Among 75 patients, the median PFS（m PFS） was longer in patients who received TQB2450 with anlotinib [10 and 12 mg（161 and 194 days, respectively）] than patients receiving TQB2450 alone（61 days） [hazard ratio（HR）10 mg= 0.390（95% confidence interval {CI}, 0.201±0.756）, P = 0.005; HR12 mg= 0.397（0.208±0.756）, P = 0.005]. The results were similar among 58 patients with high PD-L1 expression in LECs and TCs [159 and 209 vs. 82 days, HR10 mg= 0.445（0.210±0.939）, P = 0.034; HR12 mg= 0.369（0.174±0.784）, P = 0.009], and 53 patients with high PD-L1 expression in BECs and TCs [161 and 209 vs. 41 days, HR10 mg= 0.340（0.156±0.742）, P = 0.007; HR12 mg= 0.340（0.159±0.727）, P = 0.005]. No differences were detected in the m PFS between the TQB2450 and combination therapy groups in 13 low/no LEC-expressing and 18 low/no BEC-expressing PD-L1 ***: Mono-immunotherapy is not effective in patients with high PD-L1 expression in LECs and/or BECs. Anlotinib may increase efficacy by downregulating PD-L1 expression in LECs and/or BECs, which is presumed to be a feasible marker for screening the optimal immune patient population undergoing anti-angiogenic therapy.

关键词：

Long-Term Trend Analysis of Major Human Helminth Infections — Guangdong Province, China, 1988–2021

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China CDC weekly 2022年第41期4卷 912-919,I0002-I0007页

作者： Yueyi Fang Jiong Wang Guanhao He qiming zhang Jianpeng Xiao Jianxiong Hu Zuhua Rong Lihua Yin Fangfang Zeng Pan Yang Xiaomei Dong Dan Liu Xiaofeng Liang Zhuohui Deng Tao Liu Wenjun Ma Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina School of Public Health Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhou CityGuangdong ProvinceChina Disease Control and Prevention Institute of Jinan University Jinan UniversityGuangzhou CityGuangdong ProvinceChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina.&Joint first authors

Introduction:Although helminth infections threaten millions of people worldwide,the spatiotemporal characteristics remain unclear across *** study systematically describes the spatiotemporal changes of major human helminth infections and their epidemiological characteristics from 1988 to 2021 in Guangdong Province,***:The survey data in Guangdong Province were primarily obtained from 3 national surveys implemented during 1988–1992,2001–2004,and 2014–2016,respectively,and from the China Information System for Disease Control and Prevention during 2019–2021.A modified Kato-Katz technique was used to detect parasite eggs in collected fecal ***:The overall standardized infection rates(SIRs)of any soil-transmitted helminths(STH)and Clonorchis sinensis decreased from 65.27%during 1988–1992 to 4.23%during 2019–*** particular,the SIRs of STH had even more of a decrease,from 64.41%during 1988–1992 to 0.31%during 2019–*** SIRs of Clonorchis sinensis in the 4 surveys were 2.40%,12.17%,5.20%,and 3.93%,*** study observed different permutations of gender,age,occupation,and education level on the SIRs of ***:The infection rate of STH has substantially ***,the infection rate of Clonorchis sinensis has had fewer changes,and it has become the dominant helminth.

关键词： occupation Guangdong education

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健康成人五脏精气变化规律的数学模拟

系统工程理论与实践 1998年第7期18卷 130-135页

作者：张启明韩京清山东中医药大学中国科学院系统科学研究所

类比生态食物链的营养传递方式建立五脏系统数学模型，借用人体生物化学数据仿真显示，模型的季节性准周期波动与健康成人五脏阴精与阳气的实际变化恰好吻合。

关键词：五脏精气准周期波动数学模拟营养学

Mg-9.5Li-2.56Al-2.58Zn合金组织及室温变形行为

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稀有金属材料与工程 2021年第4期50卷 1359-1364页

作者：张金龙路恩皓朱均张莹姜行尹晨张祺铭西安航空学院材料工程学院陕西西安710077

以Mg-9.5Li-2.56Al-2.58Zn合金为对象,研究其组织形貌及相组成。并利用UTM5305电子万能试验机对其进行了不同应变速率以及不同变形量的室温压缩实验,获得真应力-应变曲线,构建合金的室温变形本构方程。研究压缩前后合金的微观组织和压... 详细信息

以Mg-9.5Li-2.56Al-2.58Zn合金为对象,研究其组织形貌及相组成。并利用UTM5305电子万能试验机对其进行了不同应变速率以及不同变形量的室温压缩实验,获得真应力-应变曲线,构建合金的室温变形本构方程。研究压缩前后合金的微观组织和压缩性能演变规律。结果表明,Mg-9.5Li-2.56Al-2.58Zn合金包含α-Mg、β-Li、Al_(12)Mg_(17)、AlLi和MgLiAl_(2) 5相,β-Li为基体相,α-Mg相呈条状或块状,纤维状Al_(12)Mg_(17)相位于α-Mg相内部,颗粒状MgLiAl_(2)相分布在晶界上,晶内相AlLi呈颗粒状。固溶处理后合金组织中析出相的数量明显减少,合金强度得到提升。根据Mg-9.5Li-2.56Al-2.58Zn合金真应力-应变曲线分析了应变速率对流变应力的影响,挤压态和固溶态合金室温压缩都存在峰值应力和峰值后的软化现象,有利于室温成形;并通过线性回归的方式获得不同状态下的材料本构方程常数n以及ln A–(Q/RT)的值,构建了基于Arrhenius模型的本构方程。合金组织随压缩变形量增加被逐渐压扁、拉长,AlLi相有所增多。

关键词： Mg-Li合金显微组织室温变形行为本构方程

以水热炭为模板制备TiO_2光催化剂及其光催化性能研究

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北京大学学报（自然科学版） 2018年第6期54卷 1332-1338页

作者：王晓静张启明刘阳生北京大学环境科学与工程学院北京100871

以水热炭为模板,采用溶胶–凝胶法制备TiO_2光催化剂,并采用X射线衍射(XRD)、傅里叶红外光谱(FTIR)、扫描电子显微镜(SEM)和BET比表面积测定等方法,对催化剂的物相、组成、形貌和比表面积等进行表征。通过光催化降解甲基橙溶液,评价样... 详细信息

以水热炭为模板,采用溶胶–凝胶法制备TiO_2光催化剂,并采用X射线衍射(XRD)、傅里叶红外光谱(FTIR)、扫描电子显微镜(SEM)和BET比表面积测定等方法,对催化剂的物相、组成、形貌和比表面积等进行表征。通过光催化降解甲基橙溶液,评价样品的光催化性能。研究结果表明:与TiO_2相比,以水热炭为模板制备的HTC-TiO_2具有更高的热稳定性,在煅烧温度较高时仍保持锐钛矿型。HTC-TiO_2具有水热炭的片状结构特征,TiO_2颗粒在HTC表面分散较好,晶体粒径更小,比表面积增加,从而提高其光催化活性。当煅烧温度为450oC时,以水热炭为模板制备的HTC-TiO_2对甲基橙的降解率在550 W碘钨灯光照2小时后达到40.6%,光催化效率比TiO_2 (16.2%)提高1.5倍。

关键词：水热炭 TiO2 溶胶–凝胶法甲基橙光催化