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Nano-refinement of the face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles in Zircaloy-4 alloy via localized-shearing/bending-driven fracture under high-temperature compression

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Journal of Materials Science & Technology 2023年第34期165卷 8-16页

作者： Fuzhou Han Geping Li Fusen Yuan Wenbin Guo Jie Ren qichen Wang Yingdong zhang Ali Muhammad Chengze Liu Hengfei Gu Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Nanoparticles are extensively introduced to improve the mechanical,physical,and chemical properties of *** the present study,the underlying nano-refinement mechanisms of face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles(SPPs)that precipitated in Zircaloy-4 alloy under high-temperature compression were investigated in detail by utilizing high-resolution transmission electron microscopy(HRTEM)and conventional TEM *** frequently observed Zr(Fe,Cr)_(2)SPPs were incoherent with the matrix and exhibited brittle fracture behaviors without measurable *** observations revealed two mechanisms underlying the nano-refinement of incoherent micro-sized SPPs via localized shear fracture on{11¯2}SPP and nanoprecipitate-assisted bending fracture,*** latter was,for the first time,found to occur when the movements of large SPPs were blocked by nanometer-sized SPP during alloy ***,two force models were proposed to visualize their potential nano-refinement *** knowledge attained from this study sheds new light on the deformation behaviors of Zr(Fe,Cr)_(2)SPPs and their associated size refinement mechanisms under high-temperature compression,and is expected to greatly benefit the process optimization of zirconium alloys to achieve precipitate nano-refinement.

关键词： Secondary phase particles Nano-refinement mechanism Shearing and bending fracture modes Zirconium alloys High-temperature compression

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Low-coordination environment design of single Co atoms for efficient CO_(2) photoreduction

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Nano Research 2024年第5期17卷 3745-3751页

作者： Zhentao Ma Qingyu Wang Limin Liu Rong-Ao zhang qichen Liu Peigen Liu Lihui Wu Chengyuan Liu Yu Bai Yida zhang Haibin Pan Xusheng Zheng National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China College of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Photocatalytic carbon dioxide(CO_(2))to carbon monoxide(CO)offers a promising way for both alleviating the greenhouse effect and meeting the industrial ***,we constructed a Co single-atom catalyst with intentional low-coordination environment design on porous ZnO(denoted as Co1/ZnO).Impressively,Co1/ZnO exhibited a remarkable activity with a CO yield rate of 22.25 mmol·g^(-1)·h^(-1) and a selectivity of 80.2%for CO_(2) photoreduction reactions under visible *** incorporation of single Co atoms provided an additional photo-generated electron transfer channel,which suppressed the carrier recombination of ***,the unsaturated Co active sites were capable to adsorb CO_(2) molecule spontaneously,thus facilitating the activation of CO_(2) molecule during CO_(2) reduction course.

关键词： photocatalytic CO_(2)reduction single atoms low-coordination CO_(2)adsorption electron transfer

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Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms

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Stroke & Vascular Neurology 2023年第4期8卷 327-334页

作者： Yangyang Zhou Wenqiang Li Chao Wang Ruhang Xie Yongnan Zhu qichen Peng Limin zhang Hongqi zhang Yuxiang Gu Shiqing Mu Jian Liu Xinjian Yang Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Clinical Diagnosis Laboratory Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background and purpose Light transmission aggregometry(LTA)and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial *** aim of this study was to determine which test can predict ischaemic events during these *** Patient demographic information,imaging data,laboratory data and ischaemic complications were *** and CYP2C19 genotype results were compared,and multiple linear regression was performed to examine factors related to platelet *** regression analysis was performed to determine whether LTA and CYP2C19 could predict ischaemic complications and to identify other clinical risk *** operating characteristic curve analysis was conducted to calculate the cut-off value for predicting ischaemic complications.A subgroup analysis was also performed for different CYP2C19 genotype metabolisers,as well as for patients with flow diverters and traditional *** A total of 379 patients were included,of which 22 developed ischaemic *** platelet aggregation induced by ADP(ADP-MPA)could predict ischaemic events(p10 years(p=0.022)were independent risk factors for ischaemic events,while the CYP2C19 genotype was not associated with ischaemic *** the subgroup analysis,ADP-MPA could predict ischaemic events in fast metabolisers(p=0.004)and intermediate metabolisers(p=0.003).The cut-off value for ischaemic events was lower in patients with flow diverters(ADP-MPA=36.4%)than in patients with traditional stents(ADP-MPA=42.9%).Conclusions ADP-MPA can predict ischaemic complications during endovascular treatment of intracranial *** with flow diverters require stronger antiplatelet medication than patients with traditional stents.

关键词： CYP2C19 ischaemic intracranial

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A novel method for identification and relative quantification of N-terminal peptides using metal-element-chelated tags coupled with mass spectrometry

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Science China Chemistry 2014年第5期57卷 708-717页

作者： YAN Hui HAO FeiRan CAO qichen LI JiaBin LI NanNan TIAN Fang BAI HaiHong REN XiaoJun LI XianYu zhang YangJun QIAN XiaoHong Anhui Medical University State Key Laboratory of Proteomics Beijing Proteome Research Center Beijing Institute of Radiation Medicine Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

By means of the reaction between a DOTA-NHS-ester bifunctional reagent and N-terminal peptides of proteins, and then che- lation of lanthanide metal ions as tags, we established a novel method for the identification of N-terminal peptides of proteins and their relative quantification using metal-element-chelated tags coupled with mass spectrometry. The experimental results indicate that metal elements are able to completely label N-terminal peptides at the protein level. The N-terminal peptides are enriched as the peptides digested with trypsin are selectively eliminated by isothiocyanate-coupled silica beads. We success- fully identified the N-terminal peptides of 158 proteins of Thermoanaerobacter tengcongensis incubated at 55 and 75 ℃, among which N-terminal peptides of 24 proteins are partially acetylated. Moreover, metal-element tags with high molecule weights make it convenient for N-terminal peptides consisting of less than 6 amino acids to be identified; these make up 55 percent of the identified proteins. Finally, we developed a general approach for the relative quantification of proteins based on N-terminal peptides. We adopted lysozyme and ribonuclease B as model proteins; the correlation coefficients （R2） of the standard curves for the quantitative method were 0.9994 and 0.9997, respectively, with each concentration ratio ranging from 0.1 to 10 and both relative standard derivations （RSD） measured at less than 5%. In T. tengcongensis at two incubation tem- peratures, 80 proteins possess quantitative information. In addition, compared with the proteins of T. tengcongensis incubated at 55 ℃, in T. tengcongensis incubated at 75 ℃, 7 proteins upregulate whereas 16 proteins downregulate, and most differential proteins are related to protein synthesis.

关键词： metal-element-chelated tags N-terminal peptides proteomics mass spectrometry

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Multi-Agent Collaborative Task Planning with Uncertain Task Requirements

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Journal of Beijing Institute of Technology 2024年第5期33卷 361-373页

作者： Jia zhang Zexuan Jin qichen Dong School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laborary of Autonomous Intelligent Unmanned Systems Beijing Institute of Technol-ogyBeijing 100081China

In response to the uncertainty of information of the injured in post disaster situations,considering constraints such as random chance and the quantity of rescue resource,the split deliv-ery vehicle routing problem with stochastic demands(SDVRPSD)model and the multi-depot split delivery heterogeneous vehicle routing problem with stochastic demands(MDSDHVRPSD)model are established.A two-stage hybrid variable neighborhood tabu search algorithm is designed for unmanned vehicle task planning to minimize the path cost of rescue *** experiments show that the solution obtained by the algorithm can effectively reduce the rescue vehicle path cost and the rescue task completion time,with high optimization quality and certain portability.

关键词： multi-agent collaboration task planning vehicle routing problem stochastic demands

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Nano friction behaviour between magnetic materials and copper considering the inter-diffusion effect

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Friction 2024年第7期12卷 1532-1547页

作者： Zilin LI Lisha DOU Shiyu YANG Huajiang OUYANG qichen ZHU Xiaoyang CHEN Xin JIA Shuaiwei DOU Xiaolong CUI Yudong zhang Jingjiang QIU Guochen QI Bangbang NIE Pan LIU Ronghan WEI School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application Zhengzhou UniversityZhengzhou 450001China Institute of Intelligent Sensing Zhengzhou UniversityZhengzhou 450001China School of Engineering University of LiverpoolLiverpool L693GHUK School of Cyber Science and Engineering&Hanwei Institute of Internet of Things Zhengzhou UniversityZhengzhou 450001China

Copper,permalloy,cobalt,and silicon are the materials that have been widely utilised in magnetic *** the size of interest is down to the nanoscale,the inter-diffusion between certain materials becomes *** paper studies the nanoscale friction characteristics between frictional pairs with and without inter-diffusion properties through the atomic force *** distinct evolution features of nanoscale friction force when inter-diffusion is involved are discovered experimentally,which is also confirmed through theoretical ***,through the thin film deposition method,four pairs of contact materials(Cu–Ni_(81)Fe_(19),Si–Ni_(81)Fe_(19),Cu–Co,Cu–Si)are designed for friction tests,in which diffusion occurs at the interface of Cu–Ni_(81)Fe_(19)***,the effects of sliding velocity and loading force on the nano friction of each pair are *** is found that regardless of the diffusion phenomenon:(1)the adhesion force values exhibit a notable correlation to the values of the friction force;(2)the friction force in all four material pairs consistently increases with the growth of the normal loading force,although the growth rate may *** terms of the sliding velocity effect,the friction forces of immiscible materials(Si–Ni_(81)Fe_(19),Cu–Co,and Cu–Si)are found to increase with the increasing sliding ***,the friction force of Cu–Ni_(81)Fe_(19),decreases with the increasing sliding ***,a compositive friction model considering both the velocity and the normal force effect was proposed,which shows good agreement with the experimental results and explains the nano friction behaviour of both miscible and immiscible metals.

关键词： atomic force microscope friction force normal load sliding velocity

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Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

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Nano Research 2022年第10期15卷 9149-9159页

作者： qichen Chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

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The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy;a meta-analysis

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Frontiers of Medicine 2013年第4期7卷 499-505页

作者： Xiangsong Wu Maolan Li Wenguang Wu Jiasheng Mu Lin zhang qichen Ding Qian Ding Hao Weng Runfa Bao Yijun Shu Ping Dong Jun Gu Jianhua Lu Yingbin Liu Department of General Surgery Xinhua HospitalShanghai JiaoTong University School of Medicine

Pancreatic fistula(PF) is the most frequent complication after distal pancreatectomy(DP).Prophylactic transpapillary pancreatic stenting(PTPS) has been proposed recently for the prevention of PF after *** this meta-analysis,a comprehensive search was performed in the PubMed,Embase,and Cochrane Library *** analyzing the results of PTPS in DP were considered eligible for this *** analyzed outcome variables included PF rate,postoperative morbidity,non-PF-related complications,mortality,operation duration,and hospital *** studies with 200 patients were included in this *** one was a randomized controlled trial(RCT).The results showed that PTPS was associated with less PF formation(odds ratio,0.45;95% confidence interval [CI],0.22–0.94;P = 0.03) and shorter hospital stay(mean difference,– 6.31;95% CI,– 6.99 to – 5.62;P < 0.00001).There was no significant difference in terms of the other *** conclusion,current evidence indicates that PTPS could reduce PF incidence and hospital stay after DP,without increasing other complications or operative ***,the evidence is not solid,because the single RCT conflicted with the other three retrospective ***,considering the limitation,more well-designed RCTs on this topic are needed in the future.

关键词： pancreatic fistula distal pancreatectomy pancreatic stent meta-analysis

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Auxin response factor 6A regulates photosynthesis,sugar accumulation,and fruit development in tomato

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Horticulture Research 2019年第1期6卷 678-693页

作者： Yujin Yuan Xin Xu Zehao Gong Yuwei Tang Mengbo Wu Fang Yan Xiaolan zhang Qian zhang Fengqing Yang Xiaowei Hu qichen Yang Yingqing Luo Lihua Mei Wenfa zhang Cai-Zhong Jiang Wangjin Lu Zhengguo Li Wei Deng Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing University401331 ChongqingChina School of Chemistry and Chemical Engineering Chongqing University400044 ChongqingChina College of Basic Science Tianjin Agricultural University300384 TianjinChina Department of Plant Sciences University of CaliforniaDavisCA 95616USA Crops Pathology and Genetics Research Unit United States Department of AgricultureAgricultural Research ServiceDavisCA 95616USA State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables College of HorticultureSouth China Agricultural University510642 GuangzhouChina

Auxin response factors(ARFs)are involved in auxin-mediated transcriptional regulation in *** this study,we performed functional characterization of SlARF6A in ***6A is located in the nucleus and exhibits transcriptional activator *** of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants,whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type(WT)*** of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated *** of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars,whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and ***-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism,photosynthesis and sugar ***6A directly bound to the promoters of SlGLK1,CAB,and RbcS genes and positively regulated the expression of these *** of SlARF6A also inhibited fruit ripening and ethylene production,whereas downregulation of SlARF6A increased fruit ripening and ethylene ***6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 *** together,these results expand our understanding of ARFs with regard to photosynthesis,sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops.

关键词： sugar metabolism photosynthesis

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过充循环对锂离子电池老化及安全性影响

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高电压技术 2020年第10期46卷 3390-3397页

作者：张青松赵启臣中国民航大学飞机防火与应急研究所天津300300

由于电池组的不一致性以及充电装置的故障,锂离子电池在使用过程中会出现过度充电现象。为探究过充循环对电池老化及安全性影响,基于电化学阻抗谱法对锂离子电池在过充循环下的衰退过程和老化机理进行了定性与定量研究;对新旧锂离子电... 详细信息

由于电池组的不一致性以及充电装置的故障,锂离子电池在使用过程中会出现过度充电现象。为探究过充循环对电池老化及安全性影响,基于电化学阻抗谱法对锂离子电池在过充循环下的衰退过程和老化机理进行了定性与定量研究;对新旧锂离子电池进行了过充安全性测试。结果表明:相比于正常循环,过充循环会使电池容量快速下降,进而加速电池的老化,活性锂离子损失对电池老化影响最大,活性材料损失的影响处于中等水平,而电导率损失对容量衰减的影响较小。随着老化程度的加深,电池的稳定性与安全性变差。在92%SOH后,电池内部在过充测试中出现副反应,并使电池释放的能量大幅增长;79.6%SOH的老化电池最高温度比新鲜电池增长了68%,且实验后电池无法再次使用。电池活性锂离子损失与活性材料损失衰退是引发过充测试中副反应的最相关因素。实验结果可为电池设计和电池管理系统提供参考,以提高电池对过充电的耐受性以及安全性。

关键词：锂离子电池过充循环电化学阻抗谱老化安全性

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