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生命历程理论视角下优秀乡村教师坚守的个案研究

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上海教师

上海教师 2024年第1期14卷 68-77页

作者：李巧智刘胜男广州市黄埔区东荟幼儿园华东师范大学教育学部教育管理学系

乡村教育现代化是我国实现乡村振兴的基石。优秀乡村教师是乡村教育的骨干力量，他们是否愿意扎根乡村关系到乡村教育现代化目标能否实现。本研究基于个案研究法，选取两位优秀乡村教师作为研究对象，通过长时间的纵向观察、深度访谈、... 详细信息

乡村教育现代化是我国实现乡村振兴的基石。优秀乡村教师是乡村教育的骨干力量，他们是否愿意扎根乡村关系到乡村教育现代化目标能否实现。本研究基于个案研究法，选取两位优秀乡村教师作为研究对象，通过长时间的纵向观察、深度访谈、文本档案分析等多样化的资料搜集方法，以生命历程理论为分析框架，从时空性、时间性、嵌入性和能动性四个维度探索影响优秀乡村教师坚守的原因。基于研究结论，进一步提出了留住优秀乡村教师的改进建议，以助推乡村教师队伍高质量发展。

关键词：优秀乡村教师生命历程理论坚守乡村个案研究

2021—2023年中医药防治常见心血管疾病研究述评

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中医杂志 2024年第11期65卷 1189-1195页

作者：王永霞郑佳李巧稚王新陆于瑞毛静远张伯礼朱明军河南中医药大学第一附属医院心脏中心/国家区域(中医)心血管诊疗中心河南省郑州市450000 天津中医药大学第一附属医院天津中医药大学

检索并梳理2021年1月1日至2023年6月30日中国临床试验注册中心和美国临床试验注册中心注册的中医药治疗心血管疾病的临床研究,国家自然科学基金资助的心血管疾病相关研究,以及中国期刊全文数据库、万方数据库、维普网、中国生物医学文... 详细信息

检索并梳理2021年1月1日至2023年6月30日中国临床试验注册中心和美国临床试验注册中心注册的中医药治疗心血管疾病的临床研究,国家自然科学基金资助的心血管疾病相关研究,以及中国期刊全文数据库、万方数据库、维普网、中国生物医学文献数据库、Embase、Medline和Cochrane library等数据库发布的心血管疾病相关研究,分别分析并评价中医药治疗冠心病、高血压病、心力衰竭及心律失常的研究进展,旨在聚焦研究热点、把握研究方向。通过文献分析发现,心血管疾病的中医药研究逐渐深入,高质量证据不断涌现。认为中医药防治常见心血管疾病相关研究体现了现代技术与辨证论治的多角度整合、临床与基础研究结合更加紧密、疾病辨证分型及干预措施进一步优化。在此基础上,今后应进一步规范研究方案及实施过程,注重研究成果转化,促进心血管疾病中医药诊疗的规范应用与推广。

关键词：冠心病高血压病心力衰竭心律失常述评

抗纤益心方逆转扩张型心肌病心室重构的影响因素

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中医学报 2024年第7期39卷 1543-1550页

作者：刘舜禹王素云李梦頔李巧稚王振涛河南中医药大学第二附属医院/河南省中医院河南郑州450002 河南中医药大学河南郑州450046 河南中医药大学第一附属医院河南郑州450000

目的:分析影响抗纤益心方逆转扩张型心肌病(dilated cardiomyopathy,DCM)心室重构的关键因素。方法:选取已完成的《抗纤益心方治疗扩张型心肌病的队列研究》课题中所纳入的抗纤益心方治疗队列中的患者,其中达到DCM左心室逆重构(left ven... 详细信息

目的:分析影响抗纤益心方逆转扩张型心肌病(dilated cardiomyopathy,DCM)心室重构的关键因素。方法:选取已完成的《抗纤益心方治疗扩张型心肌病的队列研究》课题中所纳入的抗纤益心方治疗队列中的患者,其中达到DCM左心室逆重构(left ventricular reverse remodeling,LVRR)标准的患者(LVRR组)30例,按照巢式病例对照研究的方法以及1:4的比例,在同队列中筛选出未发生心室逆重构(no left ventricular reverse remodeling,NLVRR)组(NLVRR组)120例。收集两组患者的入组前一般情况、病程情况、中医证候积分、心脏超声结果、用药情况等信息。采用多因素Logistic回归方法分析抗纤益心方逆转DCM心室重构的影响因素,ROC曲线评价所筛选出的影响因素对LVRR达标的预测价值。结果:多因素Logistic回归分析结果显示,基线收缩压(OR=0.932,95%CI:0.868~1.000,P=0.049)、病程(OR=1.124,95%CI:1.032~1.223,P=0.007)、左室舒张末期内径(left ventricular end diastolic dimension,LVEDD)(OR=3.219,95%CI:1.499~6.913,P=0.003)、β受体阻滞剂目标剂量(OR=0.009,95%CI:0~0.236,P=0.005)是抗纤益心方逆转DCM心室重构的独立影响因素。ROC曲线分析结果显示,LVEDD(AUC=0.958,P<0.001)、病程(AUC=0.828,P<0.001)、β受体阻滞剂目标剂量(AUC=0.667,P=0.005)对抗纤益心方逆转DCM心室重构具有预测价值,其灵敏度分别为82.5%、69.2%、53.3%,特异度分别为100%、83.3%、80%,病程临界值为10.5个月,LVEDD临界值为68.5 mm,收缩压临界值为116 mm Hg(1 mm Hg=0.133 kPa)。对多因素Logistic回归分析中有意义的4个独立预测因子进行联合预测准确率高于单个因素(AUC=0.988,95%CI:0.973~1.000,P<0.001),灵敏度为99.2%,特异度为90%。结论:基线收缩压、病程、LVEDD以及β受体阻滞剂目标剂量是抗纤益心方逆转DCM心室重构的独立影响因素。

关键词：扩张型心肌病抗纤益心方心室重构

Understanding the initial use stage of cement mortar lining in drinking water distribution systems:Silicon and aluminum as stability indicators

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Journal of Environmental Sciences 2024年第1期135卷 495-505页

作者： qiaozhi liu Yuan Zhuang Guiwei li Yao Zhang Marc A.Edwards Baoyou Shi Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Civil and Environmental Engineering Virginia TechBlacksburgVA 24061USA

The cement mortar lining(CML)of commonly used ductile iron pipes can severely deteriorate the drinking water quality at the initial stage of use,but the behavioral characteristics of different elements release from the CML in this stage is still *** this study,dynamic immersion experiments with new cement mortar lined ductile iron pipe reactors were conducted under different feed water hardness and alkalinity *** results showed that the release of alkaline substances from the CML at the initial stage of use could strongly influence the pH of water,which consequently greatly impacted the release/precipitation behaviors of calcium,aluminum and *** pH and aluminum concentration of the effluent water could reach 11.5 and 700μg/L within 24 hr of hydraulic retention time,respectively,under conditions of relatively lower hardness and *** to the pH elevation,calcium carbonate precipitation could occur even at much lower feed water *** the aluminum and silicon could keep release from the CML in soluble form at different hardness and alkalinity levels,and their release rate depended on the amount of calcium carbonate ***,aluminum and silicon were more suitable as indicators of the corrosion intensity at the initial stage of CML use rather than the traditional calcium carbonate precipitation *** feed water hardness and alkalinity levels for mitigating the initial intense corrosion of CML were proposed:hardness>40 mg/L(CaCO_(3)),alkalinity>100 mg/L(CaCO_(3)).

关键词： Cement mortar lining Hardness Alkalinity Elemental release Drinking water supply

Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China

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FRONTIERS OF MEDICINE 2024年第4期18卷 752-756页

作者： Chen, Yihui Cao, qiaozhi Peng, Cong Zhou, Bingjing Jiang, Yu Chen, Xiang li, Jie Cent South Univ Xiangya Hosp Dept Dermatol Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Hunan Key Lab Skin Canc & Psoriasis Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Natl Clin Res Ctr Geriatr Disorders Changsha 410008 Peoples R China Furong Lab Changsha 410008 Peoples R China

Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China

关键词： DOUBLE-BliND PLACEBO ADOLESCENTS ABROCITINIB ADULTS

Comprehensive analysis of advanced glycation end-products in commonly consumed foods:presenting a database for dietary AGEs and associated exposure assessment

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Food Science and Human Wellness 2024年第4期13卷 1917-1928页

作者： qiaozhi Zhang Huatao li Ruixing Zheng lili Cao Shufen Zhang Shuifeng Zhang Huadong Sheng Yuhao Jiang Yanbo Wang linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Ningbo Academy of Product and Food Quality Inspection(Ningbo Fibre Inspection Institute) Ningbo 315048China National Pre-packaged Food Quality Supervision and Inspection Center(Zhejiang) Zhejiang Fangyuan Test Group Co.Ltd.Hangzhou 310018China

Advanced glycation end-products(AGEs)are a group of heterogeneous compounds formed in heatprocessed foods and are proven to be detrimental to human ***,there is no comprehensive database for AGEs in foods that covers the entire range of food categories,which limits the accurate risk assessment of dietary AGEs in human *** this study,we first established an isotope dilution UHPLCQq Q-MS/MS-based method for simultaneous quantification of 10 major AGEs in *** contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations.Nε-Carboxymethyllysine,methylglyoxal-derived hydroimidazolone isomers,and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most *** amounts of AGEs were high in processed nuts,bakery products,and certain types of cereals and meats(>150 mg/kg),while low in dairy products,vegetables,fruits,and beverages(lied that the contribution of food groups to daily AGE intake varied a lot under different eating patterns,and selection of high-AGE foods leads to up to a 2.7-fold higher intake of AGEs through daily *** presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.

关键词： Advanced glycation end-products Maillard reaction Processed foods Dietary database Exposure assessment

Number of COVID-19 cases required in a population to detect SARS-CoV-2 RNA in wastewater in the province of Alberta, Canada:Sensitivity assessment

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Journal of Environmental Sciences 2023年第3期125卷 843-850页

作者： qiaozhi li Bonita E.Lee Tiejun Gao Yuanyuan Qiu Erik Ellehoj Jiaao Yu Mathew Diggle Graham Tipples Rasha Maal-Bared Deena Hinshaw Christopher Sikora Nicholas J.Ashbolt James Talbot Steve E.Hrudey Xiaoli Pang School of Public Health University of AlbertaEdmontonAB T6G 2R3Canada Department of Pediatrics University of AlbertaEdmontonAB T6G 1C9Canada Department of Laboratory Medicine and Pathology University of AlbertaEdmontonAB T6G 2B7Canada University of Alberta Central Receiving EdmontonAlbertaT6G 2R3Canada Provincial Laboratory for Public Health EdmontonAlbertaCanada EPCOR EdmontonAB T5H 0E8Canada Department of Medicine University of AlbertaEdmontonAB T6G 2G3Canada Faculty of Science and Engineering Southern Cross UniversityEast Lismore NSW 2480Australia

With a unique and large size of testing results of 1,842 samples collected from 12 wastewater treatment plants (WWTP) for 14 months through from low to high prevalence of COVID-19,the sensitivity of RT-qPCR detection of SARS-CoV-2 RNA in wastewater that correspond to the communities was computed by using Probit *** study determined the number of new COVID-19 cases per 100,000 population required to detect SARS-CoV-2RNA in wastewater at defined probabilities and provided an evidence-based framework of wastewater-based epidemiology surveillance (WBE).Input data were positive and negative test results of SARS-CoV-2 RNA in wastewater samples and the corresponding new COVID-19 case rates per 100,000 population served by each *** analyses determined that RT-qPCR-based SARS-CoV-2 RNA detection threshold at 50%,80%and 99%probability required a median of 8 (range:4-19),18 (9-43),and 38 (17-97) of new COVID-19 cases/100,000,***,the positive detection rate at 50%,80%and 99%probability were 0.01%,0.02%,and 0.04%averagely for new cases in the *** study improves understanding of the performance of WBE SARS-CoV-2 RNA detection using the large datasets and prolonged study *** COVID-19 burden at a community level that would result in a positive detection of SARS-CoV-2 in wastewater is critical to support WBE application as a supplementary warning/monitoring system for COVID-19 prevention and control.

关键词： SARS-CoV-2 COVID-19 cases Wastewater Probit analysis Probability Detection sensitivity

Dietary polyphenols reduced the allergenicity ofβ-lactoglobulin via non-covalent interactions:a study on the structure-allergenicity relationship

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Food Science and Human Wellness 2024年第5期13卷 2617-2628页

作者： Chi Zhang qiaozhi Zhang Huatao li Zhouzhou Cheng Shiyu Fan Hujun Xie Zhongshan Gao Yan Zhang linglin Fu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310018China Allergy Research Center Zhejiang UniversityHangzhou 310018China Hebei Food Inspection and Research Institute Hebei Food Safety Key LaboratoryKey Laboratory of Special Food Supervision Technology for State Market RegulationHebei Engineering Research Center for Special Food Safety and HealthShijiazhuang 050227China

Studies showed that complexation of polyphenols with milk allergens reduced their immunogenic ***,the relationship between structures of polyphenols and their hypoallergenic effects on milk allergens in association with physiological and conformational changes of the complexes remain *** this study,polyphenols from eight botanical sources were extracted to prepare non-covalent complexes withβ-lactoglobulin(β-LG),a major allergen in *** dominant phenolic compounds bound toβ-LG with a diminished allergenicity were identified to investigate their respective role on the structural and allergenic properties ofβ-*** from Vaccinium fruits and black soybeans were found to have great inhibitory effects on the IgE-and IgG-binding abilities ofβ-*** the fourteen structure-related phenolic compounds,flavonoids and tannins with larger MWs and multi-hydroxyl substituents,notably rutin,EGCG,and ellagitannins were more potent to elicit changes on the conformational structures ofβ-LG to decrease the allergenicity of complexedβ-*** analysis further demonstrated that a destabilized secondary structure and protein depolymerization caused by polyphenol-binding were closely related to the allergenicity property of formed *** study provides insights into the understanding of structure-allergenicity relationship ofβ-LG-polyphenol interactions and would benefit the development of polyphenol-fortified matrices with hypoallergenic potential.

关键词： Cow’s milk allergy β-Lactoglobulin Protein-polyphenol interaction Allergenicity Conformational structure

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真菌蛋白模拟肉研究现状及未来展望

中国食品学报 2023年第12期23卷 323-336页

作者：周凯李乔智胡新周辉徐宝才合肥工业大学食品与生物工程学院合肥230601 合肥工业大学农产品生物化工教育部工程研究中心合肥230601 合肥工业大学动物源食品绿色制造与资源挖掘安徽省重点实验室合肥230601

随着全球人口的快速增长以及人们对优质蛋白需求的增加,传统动、植物蛋白资源“缺口”问题已逐渐显现,开发新型来源的替代蛋白具有重要的战略意义。应用替代蛋白原料生产的模拟肉可以解决传统肉类供应不足、资源消耗和废物排放量大、动... 详细信息

随着全球人口的快速增长以及人们对优质蛋白需求的增加,传统动、植物蛋白资源“缺口”问题已逐渐显现,开发新型来源的替代蛋白具有重要的战略意义。应用替代蛋白原料生产的模拟肉可以解决传统肉类供应不足、资源消耗和废物排放量大、动物福利等问题。真菌蛋白作为一种新兴的替代蛋白,具有氨基酸组成均衡全面、膳食纤维丰富、饱和脂肪酸含量低等优点,并且真菌菌丝体的纤维状结构可以很好地还原肉类质地,用于开发模拟肉的潜力巨大。本文综述真菌蛋白的种类、生产过程、营养与安全特性及模拟肉加工技术研究进展,分析真菌蛋白模拟肉产品与市场现状,所面临的挑战以及未来发展方向。

关键词：真菌蛋白模拟肉加工技术营养安全产品与市场行业挑战