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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu qiao Chun Cui Chenmeng qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

基于氢键和Diels-Alder键双重网络自修复弹性体的合成与性能

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高分子学报 2020年第2期51卷 158-165页

作者：彭燕侯雨佳申巧巧王辉李刚黄光速吴锦荣四川大学高分子科学与工程学院高分子材料工程国家重点实验室成都610065 中国核动力研究设计院反应堆燃料及材料重点实验室成都610041

基于氢键作用和Diels-Alder(DA)交联的双可逆网络,制备了一种高性能、高修复效率的自修复弹性体.首先使用异氰酸正丁酯和N-(2-羟乙基)丙烯酰胺合成氨基甲酸酯小分子(简称为HM),然后将HM、丙烯酸丁酯(BA)及甲基丙烯酸糠酯(FMA)共聚得到... 详细信息

基于氢键作用和Diels-Alder(DA)交联的双可逆网络,制备了一种高性能、高修复效率的自修复弹性体.首先使用异氰酸正丁酯和N-(2-羟乙基)丙烯酰胺合成氨基甲酸酯小分子(简称为HM),然后将HM、丙烯酸丁酯(BA)及甲基丙烯酸糠酯(FMA)共聚得到线形共聚物,最后用双马来酰亚胺(BMI)通过DA反应交联线形共聚物,得到既有氢键交联,又有DA键交联的双网络自修复弹性体.当受到外力时,键能较低的氢键先断裂消耗能量,使得材料的韧性提高了6.2倍,断裂强度提高了12.3倍;而DA键则赋予了材料较高的弹性和形状回复能力.除此之外,两重网络均为可逆网络,使材料的自修复效率高达98%.

关键词：力学性能弹性体双网络自修复

基于响应面法优化豆渣复合天然抗氧化剂配方的研究

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粮食与油脂 2017年第6期30卷 54-57页

作者：曹巧巧沈荣光施昕磊张建群嘉兴职业技术学院农业与环境分院浙江嘉兴314016 嘉兴市真真老老食品有限公司浙江嘉兴314003

以豆渣抗氧化提取物为主,与茶多酚、维生素C等天然抗氧化剂进行复配,研究新型复合抗氧化剂的配方。利用Box-Behnken试验设计并结合响应面分析法,以豆渣抗氧化提取物、茶多酚和维生素C添加量为试验因素,采用Schaal烘箱法,以油脂的诱导期... 详细信息

以豆渣抗氧化提取物为主,与茶多酚、维生素C等天然抗氧化剂进行复配,研究新型复合抗氧化剂的配方。利用Box-Behnken试验设计并结合响应面分析法,以豆渣抗氧化提取物、茶多酚和维生素C添加量为试验因素,采用Schaal烘箱法,以油脂的诱导期为响应值,进行二次回归设计建立模型,得到最佳抗氧化剂组合为豆渣提取物0.57%、茶多酚0.05%和维生素C 0.02%,此时油脂的诱导时间为11.22 d,抗氧化效果最佳。

关键词：豆渣复合天然抗氧化剂响应面法抗氧化性

东北北部黑土水分状况之研究——Ⅱ.黑土农业水分状况及水分循环

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土壤学报 1979年第4期 329-338页

作者：乔樵沈善敏曾昭顺中国科学院林业土壤研究所

田间观测比较证实:耕地黑土的水分状况和农田水分循环过程不仅受气候因素所控制,同时也明显受作物种类不同所影响。因此,不同作物下黑土农田的水分状况,表现在土壤湿度水平、各水分时期出现时间、作物收获后残留土壤中的水量等方面均有... 详细信息

田间观测比较证实:耕地黑土的水分状况和农田水分循环过程不仅受气候因素所控制,同时也明显受作物种类不同所影响。因此,不同作物下黑土农田的水分状况,表现在土壤湿度水平、各水分时期出现时间、作物收获后残留土壤中的水量等方面均有明显区别。小麦地蒸发强度大,蒸发高峰出现早且具有最大的年总蒸发量;大豆、玉米等中耕作物蒸发强度弱,蒸发高峰出现晚且具有较小的年总蒸发量。因此,在同一年里小麦地土壤湿度通常要比大豆、玉米地低,残留在土壤中的水分因而也最少。

关键词：水分状况东北北部作物田间持水量土壤含水量土壤湿度地带性土壤黑土农业

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铂修饰氮化铝纳米管对CO的吸附性能研究

原子与分子物理学报 2025年第1期42卷 88-94页

作者：任舒宁何建桥黄海深沈光先吴波贵州师范大学物理与电子科学学院贵阳550025 遵义师范学院物理与电子科学学院遵义563006

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸... 详细信息

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸附能在1.189-2.940 eV之间,铂原子的修饰有效提高了氮化铝纳米管对CO分子的吸附能力.本研究为实验上开发制备性能更加优良的CO气体传感器提供理论指导.

关键词：氮化铝纳米管第一性原理密度泛函理论

Weierstrass Type Representation of Willmore Surfaces in S^n

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Acta Mathematica Sinica,English Series 2004年第6期20卷 1029-1046页

作者： qiao Ling XIA Yi Bing shen Department of Mathematics Zhejiang University

In this paper,we reformulate the Euler-Lagrange equations of Willmore surfaces in S^n as the flatness of a family of certain loop algebra-valued *** we can give the Weierstrass type representation of conformal Willmore *** also discuss the relations between conformal Willmore surfaces in S^n and minimal surfaces in constant curvature spaces S^n,R^n,H^n,and prove that some special Willmore surfaces can be derived from minimal surfaces in S^n,R^n,H^n.

关键词： Willmore surfaces Extended lift of a conformal Willmore immersion Loop group Weierstrass type representation Minimal surface

E^2KF Based Joint Multiple CFOs and Channel Estimate for MIMO-OFDM Systems over High Mobility Scenarios

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China Communications 2014年第A1期11卷 56-63页

作者： qiao Jing CHEN Qingchun shen Feifei KeyLabofInformationCoding&Transmission SouthwestJiaotongUniversityChengduSichuan610031China

An enhanced extended Kalman filtering （E2KF） algorithm is proposed in this paper to cope with the joint multiple carrier frequency offsets （CFOs） and time-variant channel estimate for MIMO-OFDM systems over high mobility scenarios. It is unveiled that, the auto-regressive （AR） model not only provides an effective method to capture the dynamics of the channel parameters, which enables the prediction capability in the EKF algorithm, but also suggests an method to incorporate multiple successive pilot symbols for the improved measurement update.

关键词： CFO channel estimate MIMO-OFDM

Improved HHT and its application in narrowband radar imaging for precession cone-shaped targets

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Journal of Systems Engineering and Electronics 2014年第6期25卷 977-986页

作者： shen Zhao Jie Niu Xiang Li Chunjie qiao College of Mechatronics and Automation National University of Defense Technology Department of Missile Engineering Ordnance Engineering College College of Electronic Science and Engineering National University of Defense Technology

Imaging the spatial precession cone-shaped targets with narrowband radar is a new technical approach in mid-course recognition problem. However, most existing time-frequency methods still have some inevitable deficiencies for extracting microDoppler information in practical applications, which leads to blurring of the image. A new narrowband radar imaging algorithm for the precession cone-shaped targets is proposed. The instantaneous frequency of each scattering point is gained by using the improved Hilbert-Huang transform, then the positions of scattering points in the parameter domain are reconstructed. Numerical simulation and experiment results confirm the effectiveness and high precision of the proposed algorithm.

关键词： improved Hilbert-Huang transform(HHT) instanta-neous frequency narrowband radar imaging precession cone-shaped targets

Computationally efficient direction finding using polynomial rooting with reduced-order and real-valued computations

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Journal of Systems Engineering and Electronics 2016年第4期27卷 739-745页

作者： Fenggang Yan Yi shen Ming Jin Xiaolin qiao School of Information and Electrical Engineering Harbin Institute of Technology School of Astronautics Harbin Institute of Technology at Weihai

The root multiple signal classification（root-MUSIC） algorithm is one of the most important techniques for direction of arrival（DOA） estimation. Using a uniform linear array（ULA） composed of M sensors, this method usually estimates L signal DOAs by finding roots that lie closest to the unit circle of a（2M-1）-order polynomial, where L 〈 M. A novel efficient root-MUSIC-based method for direction estimation is presented, in which the order of polynomial is efficiently reduced to 2L. Compared with the unitary root-MUSIC（U-root-MUSIC） approach which involves real-valued computations only in the subspace decomposition stage, both tasks of subspace decomposition and polynomial rooting are implemented with real-valued computations in the new technique,which hence shows a significant efficiency advantage over most state-of-the-art techniques. Numerical simulations are conducted to verify the correctness and efficiency of the new estimator.

关键词： direction-of-arrival(DOA) estimation root multiple signal classification(root-MUSIC) real-valued computations reduced-order